Glial fibrillary acidic protein (GFAP) immunoreactivity in rabbit retina: effect of fixation.

abstract：:The mass receptor potential of the excised, superfused retina of the bullfrog was studied. Photoreceptor responses were isolated by addition of sodium aspartate to the Ringer solutions. Responses of the cones were monitored independently from responses of the rods by employing a two-flash method of stimulation which t...

journal_title：Experimental eye research

authors： Sillman AJ,Bolnick DA,Bosettii JB,Haynes LW,Walter AE

更新日期：1984-08-01 00:00:00

abstract：:Previous studies have suggested that abnormal corneal wound healing in patients after photorefractive keratectomy (PRK) is associated with the appearance of myofibroblasts in the stroma between two and four weeks after surgery. The purpose of this study was to examine potential myofibroblast progenitor cells that migh...

journal_title：Experimental eye research

authors： Chaurasia SS,Kaur H,de Medeiros FW,Smith SD,Wilson SE

更新日期：2009-08-01 00:00:00

abstract：:Traumatic optic neuropathy (TON) can occur following blunt trauma to the orbit and can lead to permanent vision loss. In this study, we investigated the effectiveness of elamipretide (MTP-131), a small mitochondrially-targeted tetrapeptide, in conjunction with etanercept, a tumor necrosis factor (TNF) inhibitor, as ne...

journal_title：Experimental eye research

authors： Tse BC,Dvoriantchikova G,Tao W,Gallo RA,Lee JY,Ivanov D,Tse DT,Pelaez D

更新日期：2020-10-01 00:00:00

abstract：:Eleven monoclonal antibodies against different segments of bovine rhodopsin were used with immunogold-dextran markers to label Lowicryl thin sections of bovine and frog retinal photoreceptor cells for visualization by transmission electron microscopy. Antibodies against the C-terminus, F1-F2 loop and N-terminus of rho...

journal_title：Experimental eye research

authors： Hicks D,Molday RS

更新日期：1986-01-01 00:00:00

abstract：:The aqueous humor is produced by the epithelium of the ciliary body, a complex structure encircling the anterior segment of the eye. Aqueous humor production occurs by active transport, but the mechanism of this process is not understood. To produce a preparation in which active transport can be investigated, we have ...

journal_title：Experimental eye research

authors： Cilluffo MC,Fain MJ,Fain GL

更新日期：1993-11-01 00:00:00

abstract：:Biochemical alterations in the composition of retinal capillary basement membrane components were investigated in galactosemic rats, an animal model that develops basement membrane lesions comparable to those of diabetic retinopathy. Normotensive Wistar-Kyoto rats fed a 30% galactose diet for 9 months developed signif...

journal_title：Experimental eye research

authors： Das A,Frank RN,Zhang NL,Samadani E

更新日期：1990-03-01 00:00:00

abstract：:The retinal pigment epithelium (RPE) is essential for maintaining the health of the neural retina. RPE cell dysfunction plays a critical role in many common blinding diseases including age-related macular degeneration (AMD), diabetic retinopathy, retinal dystrophies. Mouse models of ocular disease are commonly used to...

journal_title：Experimental eye research

authors： Wei H,Xun Z,Granado H,Wu A,Handa JT

更新日期：2016-04-01 00:00:00

abstract：:Metabolomics studies in the retina and retinal pigment epithelium (RPE) in animal models or postmortem donors are essential to understanding the retinal metabolism and to revealing the underlying mechanisms of retinal degenerative diseases. We have studied how different methods of euthanasia (CO2 or cervical dislocati...

journal_title：Experimental eye research

authors： Zhu S,Yam M,Wang Y,Linton JD,Grenell A,Hurley JB,Du J

更新日期：2018-09-01 00:00:00

abstract：:Dexamethasone is a glucocorticoid that is widely used in the ophthalmic arena. The recent FDA approved dexamethasone implant can provide a three month efficacy but with high rate of drug related cataract and high intraocular pressure (IOP). It seems that higher steroid in aqueous humor and around lens may be associate...

journal_title：Experimental eye research

authors： Wang C,Hou H,Nan K,Sailor MJ,Freeman WR,Cheng L

更新日期：2014-12-01 00:00:00

abstract：:We investigated the inhibitory action of a synthetic peptidyl hydroxamate inhibitor of matrix metalloproteinase (MMP), Galardin (GM6001), on collagen degradation by rabbit corneal stromal fibroblasts (keratocytes) cultured three-dimensionally in the type I collagen gel with medium containing interleukin 1alpha (IL-1al...

journal_title：Experimental eye research

authors： Hao JL,Nagano T,Nakamura M,Kumagai N,Mishima H,Nishida T

更新日期：1999-05-01 00:00:00

abstract：:Over the past 40 years, several groups have shown that epithelial debridement results in the death of keratocytes subjacent to the wound area. More recently this cell death has been shown to involve apoptosis. The purpose of this project was to examine the proliferative response of the normally quiescent keratocytes t...

journal_title：Experimental eye research

authors： Zieske JD,Guimarães SR,Hutcheon AE

更新日期：2001-01-01 00:00:00

abstract：:The purpose of this study was to investigate the influence of hyperoxia and hypercapnia on fundus pulsations in the macular and optic disc region and determine a potential autoregulative capacity of the choroid under these conditions. In a randomized cross-over study 100% O2 and a mixture of 5% CO2 with air was inhale...

journal_title：Experimental eye research

authors： Schmetterer L,Wolzt M,Lexer F,Alschinger C,Gouya G,Zanaschka G,Fassolt A,Eichler HG,Fercher AF

更新日期：1995-12-01 00:00:00

abstract：:Purpose of the study was to develop and assess a novel controlled drug delivery system of latanoprost acid (LA). Poly(lactide)/Monomethoxy-poly(ethyleneglycol) (PLA-PEG) nanoparticles (NPs) were prepared using an emulsification-solvent evaporation technique. NPs were characterized in vitro according to their size, ζ-p...

journal_title：Experimental eye research

authors： Giarmoukakis A,Labiris G,Sideroudi H,Tsimali Z,Koutsospyrou N,Avgoustakis K,Kozobolis V

更新日期：2013-07-01 00:00:00

abstract：:Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has also been proposed as an iron-transporter protein, th...

journal_title：Experimental eye research

authors： Valença A,Mendes-Jorge L,Bonet A,Catita J,Ramos D,Jose-Cunilleras E,Garcia M,Carretero A,Nacher V,Navarro M,Ruberte J

更新日期：2021-01-01 00:00:00

abstract：:Retinal arrestin is known to participate in the quenching of phototransduction through binding to light-activated and phosphorylated rhodopsin. Recently, a splice variant of retinal arrestin was identified in bovine photoreceptors which could bind unphosphorylated photoactive rhodopsin. In this report, a splice varian...

journal_title：Experimental eye research

authors： Smith WC

更新日期：1996-06-01 00:00:00

abstract：:The suggested common regulator of the eye lens crystallin genes is c-Maf. Maf responsive elements have been detected in a number of crystallin promoters including that of the rat betaB2-crystallin gene. The betaB2-crystallin gene is active in the post-natal lens and its mRNA reaches its maximal level in the rat lens 6...

journal_title：Experimental eye research

authors： Doerwald L,Nijveen H,Civil A,van Genesen ST,Lubsen NH

更新日期：2001-11-01 00:00:00

abstract：:All aqueous humor draining through the conventional outflow pathway must cross the endothelium of Schlemm's canal (SC), likely by passing through micron-sized transendothelial pores. SC pores are non-uniformly distributed along the inner wall endothelium, but it is unclear how the distribution of pores relates to the ...

journal_title：Experimental eye research

authors： Braakman ST,Read AT,Chan DW,Ethier CR,Overby DR

更新日期：2015-01-01 00:00:00

abstract：:Small, experimental, non-rhegmatogenous retinal detachments (blebs) in rabbit eyes resorbed 50% more slowly when filled with autologous serum than with Hanks' solution. To study the fate of large molecules in the subretinal space, carboxyfluorescein and several sizes of FITC-dextrans were injected into blebs and their...

journal_title：Experimental eye research

authors： Marmor MF,Negi A,Maurice DM

更新日期：1985-05-01 00:00:00

abstract：:Much controversy has arisen on the nature and sources of stem cells in the adult human retina. Whilst ciliary epithelium has been thought to constitute a source of neural stem cells, a population of Müller glia in the neural retina has also been shown to exhibit neurogenic characteristics. This study aimed to compare ...

journal_title：Experimental eye research

authors： Bhatia B,Jayaram H,Singhal S,Jones MF,Limb GA

更新日期：2011-12-01 00:00:00

abstract：:We aim to determine whether lymphatic drainage from the eye changes with age. Using quantitative photoacoustic tomography, groups of young and older mice were studied in the live state. 10 CD-1 mice of 2-3 months (5M/5F) were studied in addition to 13 older mice of 12-13 months (6M/7F). In each of 23 mice, near-infrar...

journal_title：Experimental eye research

authors： Yücel YH,Cheng F,Cardinell K,Zhou X,Irving H,Gupta N

更新日期：2020-05-01 00:00:00

abstract：:Various concentrations of three dopamine antagonists (fluphenazine, haloperidol and sulpiride) with different affinities to the receptor subtypes were applied in order to test their effect on responses from outer (isolated PIII-component of the ERG), middle (b-wave) and inner (optic nerve response, ONR) retinal layers...

journal_title：Experimental eye research

authors： Schneider T,Zrenner E

更新日期：1991-04-01 00:00:00

abstract：:The overall importance of the peak or the mean serum concentrations as predictors of ocular drug penetration is unknown. To address this fundamental question with an agent which shows promise as adjunctive therapy in the treatment of endophthalmitis, we studied the penetration of ciprofloxacin into the aqueous and vit...

journal_title：Experimental eye research

authors： Madu AA,Mayers M,Perkins R,Liu W,Drusano GL,Aswani R,Madu CN,Miller MH

更新日期：1996-08-01 00:00:00

abstract：:Myocilin is a 55-57kDa secreted glycoprotein and member of the olfactomedin family, which is mutated in some forms of primary open-angle glaucoma. To assess the effects of elevated amounts of myocilin on aqueous humor outflow dynamics in an in vivo system, transgenic betaB1-crystallin-MYOC mice have been developed tha...

journal_title：Experimental eye research

authors： Paper W,Kroeber M,Heersink S,Stephan DA,Fuchshofer R,Russell P,Tamm ER

更新日期：2008-09-01 00:00:00

abstract：:The vitreous is a clear, gel-like mass in the posterior cavity of the eye. Its major components are type II collagen, hyaluronic acid, and water. A small amount of proteoglycan is also present. All of these molecules are found in cartilage as well. We have now identified a non-collagenous protein in bovine and human v...

journal_title：Experimental eye research

authors： Nguyen BQ,Fife RS

更新日期：1986-09-01 00:00:00

abstract：:This review summarizes the Ernst H. Bárány Prize Lecture given at the meeting of the International Society of Eye Research in Geneva 2002. In the paper the path from the author's early studies on neurogenic inflammation in the eye to the search for a suitable prostaglandin analogue for glaucoma treatment, and the deve...

journal_title：Experimental eye research

authors： Stjernschantz J

更新日期：2004-04-01 00:00:00

abstract：:Diabetic retinopathy is a sight-threatening complication of diabetes, characterized by loss of retinal pericytes and abnormal angiogenesis. We previously demonstrated that extracellular vesicles (EVs) derived from mesenchymal stem cells cultured in diabetic-like conditions are able to enter the pericytes, causing thei...

journal_title：Experimental eye research

authors： Mazzeo A,Beltramo E,Lopatina T,Gai C,Trento M,Porta M

更新日期：2018-11-01 00:00:00

abstract：:Colchicine, a naturally occurring alkaloid, inhibits both fast and slow axoplasmic transport by prevention of microtubule assembly. We have examined the influence of colchicine on the neurogenically mediated acute inflammatory responses to topically administered nitrogen mustard and formaldehyde on the albino rabbit e...

journal_title：Experimental eye research

authors： Williams RN,Bhattacherjee P

更新日期：1984-12-01 00:00:00

abstract：:Giant papillae, characteristic lesions of vernal keratoconjunctivitis, are formed as a result of the proliferation of conjunctival fibroblasts, the deposition of extracellular matrix, and the infiltration of inflammatory cells. The concentration of interleukin (IL)-4 is also increased in the tear fluid of individuals ...

journal_title：Experimental eye research

authors： Fujitsu Y,Fukuda K,Kumagai N,Nishida T

更新日期：2003-01-01 00:00:00

abstract：:Addition of substance P (10(-7) to 10(-6) M) to rabbit iris sphincter muscle induced: (a) a rapid phosphodiesteratic breakdown of phosphatidylinositol 4,5-bisphosphate (PIP2) into 1,2-diacylglycerol (DG), measured as phosphatidic acid, and inositol triphosphate (IP3), measured by anion-exchange chromatography; (b) a r...

journal_title：Experimental eye research

authors： Yousufzai SY,Akhtar RA,Abdel-Latif AA

更新日期：1986-08-01 00:00:00

abstract：:SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein that regulates cellular adhesion and proliferation. In this report, we show that SPARC protein is restricted to epithelial cells of the murine lens and ends abruptly at the equatorial bow region where lens fiber differentiation begins. SPA...

journal_title：Experimental eye research

authors： Bassuk JA,Birkebak T,Rothmier JD,Clark JM,Bradshaw A,Muchowski PJ,Howe CC,Clark JI,Sage EH

更新日期：1999-03-01 00:00:00