The Von Sallmann Lecture 1996: an ophthalmological explanation of REM sleep.

abstract：:The phagocytosis of photoreceptor outer segments (OS) by the retinal pigment epithelium (RPE) is a receptor mediated process. A key component of this process is the receptor tyrosine kinase, Mer. RPE cells from the RCS rat, which lacks a functional mer gene, and do not express Mer protein, are able to bind OS, but are...

journal_title：Experimental eye research

authors： Hall MO,Abrams TA,Burgess BL

更新日期：2003-09-01 00:00:00

abstract：:The retinal pigment epithelium is a transporting epithelium that helps regulate the volume and composition of the subretinal space surrounding photoreceptor outer segments. The capacity of the RPE to actively transport Na+ and K+ between the retina and the blood supply depends on the localization of the Na+, K(+)-ATPa...

journal_title：Experimental eye research

authors： Defoe DM,Ahmad A,Chen W,Hughes BA

更新日期：1994-11-01 00:00:00

abstract：:Exfoliation syndrome (XFS) is an important risk factor for glaucoma (XFG) worldwide. LOXL1 variants are highly associated with XFS in most populations; however, the high frequency of risk alleles in normal individuals and the reversal of risk alleles in different ethnic populations suggest that other factors contribut...

journal_title：Experimental eye research

authors： Fan BJ,Pasquale LR,Kang JH,Levkovitch-Verbin H,Haines JL,Wiggs JL

更新日期：2015-10-01 00:00:00

abstract：:The aquaporins (AQPs) are a family of more than 10 homologous water transporting proteins expressed in many mammalian epithelia and endothelia. At least five AQPs are expressed in the eye: AQP0 (MIP) in lens fiber, AQP1 in cornea endothelium, ciliary and lens epithelia and trabecular meshwork, AQP3 in conjunctiva, AQP...

journal_title：Experimental eye research

authors： Verkman AS

更新日期：2003-02-01 00:00:00

abstract：:Rituximab is a monoclonal antibody directed against the CD20 B-cell antigen and is approved for the treatment of B-cell lymphoma. We investigated the pharmacokinetics of rituximab following intravitreal administration to assess the feasibility of treating primary intraocular lymphoma. Intravitreal injections of rituxi...

journal_title：Experimental eye research

authors： Kim H,Csaky KG,Chan CC,Bungay PM,Lutz RJ,Dedrick RL,Yuan P,Rosenberg J,Grillo-Lopez AJ,Wilson WH,Robinson MR

更新日期：2006-05-01 00:00:00

abstract：:Corneal epithelial injury induces release of endogenous metabolites that are cannabinoid receptor 1 (CB1) and transient receptor potential vanilloid 1 (TRPV1) agonists. We determined the functional contributions by CB1 and TRPV1 activation to eliciting responses underlying wound healing in human corneal epithelial cel...

journal_title：Experimental eye research

authors： Yang H,Wang Z,Capó-Aponte JE,Zhang F,Pan Z,Reinach PS

更新日期：2010-09-01 00:00:00

abstract：:The aim of this study was to identify the molecular genetic cause of disease in posterior polymorphous corneal dystrophy (PPCD) probands of diverse origin and to assess the utility of massively parallel sequencing in the detection of ZEB1 mutations. We investigated a total of 12 families (five British, four Czech, one...

journal_title：Experimental eye research

authors： Dudakova L,Evans CJ,Pontikos N,Hafford-Tear NJ,Malinka F,Skalicka P,Horinek A,Munier FL,Voide N,Studeny P,Vanikova L,Kubena T,Rojas Lopez KE,Davidson AE,Hardcastle AJ,Tuft SJ,Liskova P

更新日期：2019-05-01 00:00:00

abstract：:Metabolomics studies in the retina and retinal pigment epithelium (RPE) in animal models or postmortem donors are essential to understanding the retinal metabolism and to revealing the underlying mechanisms of retinal degenerative diseases. We have studied how different methods of euthanasia (CO2 or cervical dislocati...

journal_title：Experimental eye research

authors： Zhu S,Yam M,Wang Y,Linton JD,Grenell A,Hurley JB,Du J

更新日期：2018-09-01 00:00:00

abstract：:Oxidative stress and inflammation are important pathological mechanisms in many neurodegenerative diseases, including age-related macular degeneration (AMD). The very low-density lipoprotein receptor knockout mouse (Vldlr-/-) has been identified as a model for AMD and in particular for retinal angiomatous proliferatio...

journal_title：Experimental eye research

authors： Kyosseva SV,Chen L,Seal S,McGinnis JF

更新日期：2013-11-01 00:00:00

abstract：:Stromal transparency is a critical factor contributing to normal function of the visual system. Corneal injury, surgery, disease and infection elicit complex wound healing responses that serve to protect against insults and maintain the integrity of the cornea, and subsequently to restore corneal structure and transpa...

journal_title：Experimental eye research

authors： Torricelli AA,Wilson SE

更新日期：2014-12-01 00:00:00

abstract：:AII amacrine cells are critical interneurons in the rod pathway of mammalian retina, active primarily in dim lighting conditions. Melatonin, a neuromodulator produced at night in the retina, is believed to induce retinal adaptation to dim lighting conditions in most vertebrate species examined to date, including human...

journal_title：Experimental eye research

authors： Scher J,Wankiewicz E,Brown GM,Fujieda H

更新日期：2003-09-01 00:00:00

abstract：:There is currently no available method to efficiently deliver proteins across the plasma membrane of photoreceptor or retinal pigment epithelium (RPE) cells in vivo. Thus, current clinical application of recombinant proteins in ophthalmology is limited to the use of proteins that perform their biological function extr...

journal_title：Experimental eye research

authors： Leaderer D,Cashman SM,Kumar-Singh R

更新日期：2016-04-01 00:00:00

abstract：:A serum-free culture of chicken retinal pigmented epithelial cells has been established in order to analyse how cell-substrate interactions or environmental factors affect the process of transdifferentiation into lens cells from pigmented epithelial cells. The serum-free culture medium for chicken pigmented epithelial...

journal_title：Experimental eye research

authors： Kosaka J,Watanabe K,Eguchi G

更新日期：1992-08-01 00:00:00

abstract：:Intraocular pressure (IOP) is an important risk factor for glaucoma, and the response of the ONH and surrounding tissues to elevated IOP are often investigated to better understand pathophysiology. In vivo structure including that of the optic nerve head (ONH) and surrounding tissue of the eye are often assessed using...

journal_title：Experimental eye research

authors： Patel N,McAllister F,Pardon L,Harwerth R

更新日期：2018-04-01 00:00:00

abstract：:A technology has recently been developed that allows for the rapid transduction of full-length functionally active proteins into intact tissue through intravenous injection and into cultured cells. This technology involves the fusion of an 11 amino acid sequence of the HIV TAT protein to the protein of interest. In th...

journal_title：Experimental eye research

authors： Guo X,Hutcheon AE,Zieske JD

更新日期：2004-05-01 00:00:00

abstract：:Intravitreal cidofovir has been shown to be a long acting and highly efficacious treatment for CMV retinitis; however decrease in IOP is an adverse effect. We wanted to determine the effect of cidofovir on intraocular pressure (IOP) in the guinea pig, and rabbit eye to develop an animal model of cidofovir induced ocul...

journal_title：Experimental eye research

authors： Taskintuna I,Banker AS,Rao NA,Wiley CA,Flores-Aguilar M,Munguia D,Bergeron-Lynn G,De Clercq E,Keefe K,Freeman WR

更新日期：1997-05-01 00:00:00

abstract：:Hypoxic preconditioning protects photoreceptors against light-induced degeneration preserving retinal morphology and function. Although hypoxia inducible transcription factors 1 and 2 (HIF1, HIF2) are the main regulators of the hypoxic response, photoreceptor protection does not depend on HIF1 in rods. Here we used ro...

journal_title：Experimental eye research

authors： Kast B,Schori C,Grimm C

更新日期：2016-05-01 00:00:00

abstract：:The mechanical, histological and pharmacological properties of the isolated cat ophthalmociliary artery are reported and compared for passively stretched ring segments from three locations on the artery. Ring segments were mounted in a modified myograph system after the method of Hogestatt, Andersson and Edvinsson (19...

journal_title：Experimental eye research

authors： Yu DY,Su EN,Alder VA,Cringle SJ,Mele EM

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Absence of collagen VII causes blistering of the skin, eyes and many other tissues. This disease is termed dystrophic epidermolysis bullosa (DEB). Corneal fibrosis occurs in up to 41% and vision loss in up to 64% of patients. Standard treatments are supportive and there is no cure. The hypomorphic mouse mode...

journal_title：Experimental eye research

authors： Chen VM,Shelke R,Nyström A,Laver N,Sampson JF,Zhiyi C,Bhat N,Panjwani N

更新日期：2018-10-01 00:00:00

abstract：:[3H]-retinol binding to cellular retinol-binding protein (CRBP) increased more than five-fold in developing chicken corneal epithelium at 14 days of incubation, the time when the initial increase in corneal transparency occurs in the developing embryo. In contrast, [3H]-retinoic acid binding to cellular retinoic acid-...

journal_title：Experimental eye research

authors： Wiggert B,Masterson E,Coulombre AJ

更新日期：1983-11-01 00:00:00

abstract：:Lens lipid composition and lipid hydrocarbon chain structure change with age, region and cataract. Since the lens Ca(2+)-ATPase pump is important to the maintenance of calcium homeostasis and lens clarity, muscle sarcoplasmic reticulum Ca(2+)-ATPase was reconstituted with bovine lens lipids and dihydrosphingomyelin, t...

journal_title：Experimental eye research

authors： Zeng J,Zhang Z,Paterson CA,Ferguson-Yankey S,Yappert MC,Borchman D

更新日期：1999-09-01 00:00:00

abstract：:Over the past 40 years, several groups have shown that epithelial debridement results in the death of keratocytes subjacent to the wound area. More recently this cell death has been shown to involve apoptosis. The purpose of this project was to examine the proliferative response of the normally quiescent keratocytes t...

journal_title：Experimental eye research

authors： Zieske JD,Guimarães SR,Hutcheon AE

更新日期：2001-01-01 00:00:00

abstract：:Fiber cells of the ocular lens are arranged in a series of concentric shells. New growth shells are added continuously to the lens surface and, as a consequence, the preexisting shells are buried. To focus light, the refractive index of the lens cytoplasm must exceed that of the surrounding aqueous and vitreous humors...

journal_title：Experimental eye research

authors： Bassnett S,Costello MJ

更新日期：2017-03-01 00:00:00

abstract：:Careful control of iron availability in the retina is central to maintenance of iron homeostasis, as its imbalance is associated with oxidative stress and the progression of several retinopathies. Ferritin, known for its role in iron storage and detoxification, has also been proposed as an iron-transporter protein, th...

journal_title：Experimental eye research

authors： Valença A,Mendes-Jorge L,Bonet A,Catita J,Ramos D,Jose-Cunilleras E,Garcia M,Carretero A,Nacher V,Navarro M,Ruberte J

更新日期：2021-01-01 00:00:00

abstract：:microPx-11, a ferriheme undecapeptide proteolytic degradation product of cytochrome C is shown to be a peroxidase with broad specificity degrading H2O2 and tertiary butyl hydroperoxide. It is also capable of effectively eliminating superoxide and hydroxyl radical. The peroxidase loses activity in the presence of perox...

journal_title：Experimental eye research

authors： Spector A,Ma W,Wang RR,Kleiman NJ

更新日期：1997-10-01 00:00:00

abstract：:This lecture summarizes studies on the effects of some of the neuropeptides which seem to be present in somatosensory and autonomic nerves in the uvea. Release of these peptides is likely to explain nerve induced effects in the eye which are not due to classical transmitters. Trigeminal nerve fibres in the eye seem to...

journal_title：Experimental eye research

authors： Anders B

更新日期：1991-07-01 00:00:00

abstract：:We developed an approach to generate a three-dimensional map that facilitates the assessment of epithelial nerve density in different corneal areas to define aging and gender influence on human corneal nerve architecture. Twenty-eight fresh human eyes from 14 donors of different ages were studied. Corneal nerves were ...

journal_title：Experimental eye research

authors： He J,Bazan NG,Bazan HE

更新日期：2010-10-01 00:00:00

abstract：:The influence of autonomic neurotransmitters on the growth and melanogenesis of cultured uveal melanocytes was studied. Uveal melanocytes were cultured with medium supplemented with cAMP elevating agents and basic fibroblast growth factor (complete medium). The cells were plated into multiple well plates, and various ...

journal_title：Experimental eye research

authors： Hu DN,Woodward DF,McCormick SA

更新日期：2000-09-01 00:00:00

abstract：:Incorporated in the luminal glycocalyx of vascular endothelia (EC) are negatively charged microdomains (anionic sites). These sites are considered functionally important (a) in their interaction with circulating blood constituents, and (b) as a determinant of vascular permeability. The molecular composition of these E...

journal_title：Experimental eye research

authors： Lawrenson JG,Reid AR,Ghabriel MN,Allt G

更新日期：1995-10-01 00:00:00

abstract：:Infection of the corneal endothelial cells by human cytomegalovirus (CMV) is an important cause of corneal endotheliitis. CMV endotheliitis is difficult to completely cure and relapses are frequent. This can cause blinding corneal bullous keratopathy. However, the pathogenesis of CMV endotheliitis remains undetermined...

journal_title：Experimental eye research

authors： Miyazaki D,Uotani R,Inoue M,Haruki T,Shimizu Y,Yakura K,Yamagami S,Suzutani T,Hosogai M,Isomura H,Inoue Y

更新日期：2017-08-01 00:00:00