Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice.

abstract：:The distribution of chondroitin sulfate proteoglycans in the mouse interphotoreceptor matrix (IPM) proximal to the retinal pigment epithelium (RPE) was evaluated with EM histochemical techniques using Cupromeronic Blue (CmB) before and after retinal separation. Densely packed, sheet-like processes surrounding vesicle-...

journal_title：Experimental eye research

authors： Iwasaki M,Rayborn ME,Tawara A,Hollyfield JG

更新日期：1992-03-01 00:00:00

abstract：:Two previous studies have shown that N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of neuronal nitric oxide synthase, protects retinas of albino rats and mice from damaging levels of light. The aims of the present study were two-fold: (1) to confirm the protective effect of L-NAME on wild type albino rats ...

journal_title：Experimental eye research

authors： Káldi I,Dittmar M,Pierce P,Anderson RE

更新日期：2003-04-01 00:00:00

abstract：:Analysis of bovine interphotoreceptor matrix and conditioned medium from human Y-79 retinoblastoma cells by gelatin SDS-PAGE zymography reveals abundant activity of a 72-kDa M(r) gelatinase. The 72-kDa gelatinase from either source is inhibited by EDTA but not aprotinin or NEM, indicating that it is a metalloproteinas...

journal_title：Experimental eye research

authors： Jones BE,Moshyedi P,Gallo S,Tombran-Tink J,Arand G,Reid DA,Thompson EW,Chader GJ,Waldbillig RJ

更新日期：1994-09-01 00:00:00

abstract：:Paired human lenses ranging from 2 to 96 yr old (n = 17) were harvested within 2 hr post-mortem and immersed in liquid nitrogen. Phosphorus containing metabolites from perchloric acid extracts were quantitated using phosphorus-31 nuclear magnetic resonance spectroscopy. Low-energy metabolites detected include the phos...

journal_title：Experimental eye research

authors： Merchant TE,Lass JH,Meneses P,Greiner JV,Glonek T

更新日期：1991-06-01 00:00:00

abstract：:Macromolecular cell markers are essential for the classification and characterization of the highly complex and cellularly diverse vertebrate retina. Although a plethora of markers are described in the current literature, the immunoreactivity of these markers in normal human tissue has not been fully determined. This ...

journal_title：Experimental eye research

authors： de Souza CF,Nivison-Smith L,Christie DL,Polkinghorne P,McGhee C,Kalloniatis M,Acosta ML

更新日期：2016-09-01 00:00:00

abstract：:Various concentrations of three dopamine antagonists (fluphenazine, haloperidol and sulpiride) with different affinities to the receptor subtypes were applied in order to test their effect on responses from outer (isolated PIII-component of the ERG), middle (b-wave) and inner (optic nerve response, ONR) retinal layers...

journal_title：Experimental eye research

authors： Schneider T,Zrenner E

更新日期：1991-04-01 00:00:00

abstract：:Superoxide radicals or products generated by these radicals in a xanthine/xanthine oxidase system lyse cultured rat and human corneal epithelial cells as measured in a chromium-51 release assay. Partial protection from this lysis is afforded by superoxide dismutase and complete protection is obtained with catalase. Hy...

journal_title：Experimental eye research

authors： Hayden BJ,Zhu L,Sens D,Tapert MJ,Crouch RK

更新日期：1990-01-01 00:00:00

abstract：:Lens development and transparency have been hypothesized to depend on intercellular gap junction channels, consisting of alpha3 (Cx46) and alpha8 (Cx50) connexin subunits, to transport metabolites, secondary messages and ions between lens cells. To evaluate this hypothesis, we have generated alpha3(-/-) alpha8(-/-) do...

journal_title：Experimental eye research

authors： Xia CH,Cheng C,Huang Q,Cheung D,Li L,Dunia I,Benedetti LE,Horwitz J,Gong X

更新日期：2006-09-01 00:00:00

abstract：:Electrical field stimulation produced contractions of the rabbit isolated iris sphincter muscle which were completely blocked by tetrodotoxin (10(-6) M). Low frequency (0.16-5 Hz) responses were atropine-resistant, but were prevented by sensory (trigeminal) denervation, and were considered to be owing to antidromic st...

journal_title：Experimental eye research

authors： Zhang SQ,Butler JM,Cole DF

更新日期：1984-02-01 00:00:00

abstract：:Recently, a unique distribution, namely a reduction of macular pigment optical density (MPOD) within the central retina with a surrounding ring-like structure of preserved MPOD at about 6 degrees eccentricity was suggested to be a common finding in macular telangiectasia (MacTel) type 2. In order to quantify this redu...

journal_title：Experimental eye research

authors： Charbel Issa P,van der Veen RL,Stijfs A,Holz FG,Scholl HP,Berendschot TT

更新日期：2009-06-15 00:00:00

abstract：:We have reported that the aspartyl (Asp)-151 residue in alphaA-crystallin in human eye lens was inverted to the D-isomer and isomerized to beta-Asp residue with age. We report here that ultraviolet (UV)-B irradiation induces the racemization and isomerization of the Asp-151 residue of alphaA-crystallin from lenses of ...

journal_title：Experimental eye research

authors： Fujii N,Momose Y,Ishibashi Y,Uemura T,Takita M,Takehana M

更新日期：1997-07-01 00:00:00

abstract：:The hyaluronan content during wound healing following excimer laser photoablation was investigated. Rabbit corneas were photoablated (Summit Omnimed, 193 nm, 5 mm diameter, 50 microns and 100 microns depth). Central optical zones of photoablated and contralateral corneas were removed 7, 30 and 90 days after surgery. C...

journal_title：Experimental eye research

authors： Drubaix I,Legeais JM,Robert L,Renard G

更新日期：1997-03-01 00:00:00

abstract：:The authors sought to evaluate the effect of linoleic acid hydroperoxide (18:2/LHP) in promoting choroidal neovascularization (CNV). Albino male rabbits received a subretinal injection of various amounts of LHP (ranging from 5 to 200 microg) dissolved in 50 microl of sodium borate buffer. Control eyes received the buf...

journal_title：Experimental eye research

authors： Tamai K,Spaide RF,Ellis EA,Iwabuchi S,Ogura Y,Armstrong D

更新日期：2002-02-01 00:00:00

abstract：:The results reported here clearly document changes in the properties and the organization of fiber-cell membrane lipids that occur with age, based on electron paramagnetic resonance (EPR) analysis of lens membranes of clear lenses from donors of age groups from 0 to 20, 21 to 40, and 61 to 80 years. The physical prope...

journal_title：Experimental eye research

authors： Raguz M,Mainali L,O'Brien WJ,Subczynski WK

更新日期：2015-03-01 00:00:00

abstract：:Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were isolated from frog retinal rod outer segment (ROS) membranes and their major molecular species determined. Saturated fatty acids are predominantly located on position-1 and polyunsaturates on position-2, although this assignment is not absolute. One-fifth...

journal_title：Experimental eye research

authors： Wiegand RD,Anderson RE

更新日期：1983-08-01 00:00:00

abstract：:A renewed interest in the characteristics and neural basis of corneal and conjunctival sensations is developing in recent years due to the high incidence of discomfort and altered sensitivity of the cornea following refractive surgery, use of contact lenses and dry eyes. Corneal nerves are functionally heterogeneous: ...

journal_title：Experimental eye research

authors： Belmonte C,Acosta MC,Gallar J

更新日期：2004-03-01 00:00:00

abstract：:The rapid increase in popularity of extracapsular cataract extraction may predispose the eye to postoperative bacterial infections by introducing viable organisms through the additional instrumentation and irrigation necessary for the extracapsular technique. Lens protein released into the aqueous humor of the anterio...

journal_title：Experimental eye research

authors： Records RE,Iwen PC

更新日期：1989-11-01 00:00:00

abstract：:Rabbit immunoglobulin G (IgG) binds specifically to the human corneal epithelium. We investigated this phenomenon to identify the binding material in the tissue. Sections of human cornea were immunostained with negative-control grade rabbit IgG, F(ab')(2) (the antigen recognition fragment of IgG yielded by pepsin dige...

journal_title：Experimental eye research

authors： Endo K,Kawasaki S,Nakamura T,Kinoshita S

更新日期：2004-06-01 00:00:00

abstract：:The binding of eight fluorescence-labeled lectins to the photoreceptors of the monkey retina was investigated using a post-embedding staining method. Concanavalin A (specific for mannosyl and glucosyl residues) bound to the outer and inner segments of both rods and cones, while the degree of staining was more intense ...

journal_title：Experimental eye research

authors： Uehara F,Sameshima M,Muramatsu T,Ohba N

更新日期：1983-01-01 00:00:00

abstract：:Abnormal migration and proliferation of endothelial cells (EC) drive neovascular retinopathies. While anti-VEGF treatment slows progression, pathology is often supported by decrease in intraocular pigment epithelium-derived factor (PEDF), an endogenous inhibitor of angiogenesis. A surface helical 34-mer peptide of PED...

journal_title：Experimental eye research

authors： Sheibani N,Wang S,Darjatmoko SR,Fisk DL,Shahi PK,Pattnaik BR,Sorenson CM,Bhowmick R,Volpert OV,Albert DM,Melgar-Asensio I,Henkin J

更新日期：2019-11-01 00:00:00

abstract：:Argon laser energy was applied to the trabecular meshwork of pigmented rabbits in an attempt to develop an animal model of 'glaucoma'. Laser energy was varied to determine the optimal level needed to produce sustained ocular hypertension. An initial response of ocular hypertension followed by hypotension was observed ...

journal_title：Experimental eye research

authors： Gherezghiher T,March WF,Nordquist RE,Koss MC

更新日期：1986-12-01 00:00:00

abstract：:Microvascular dysfunctions due to altered interactions between endothelial cells (ECs) and pericytes are key-events in the pathogenesis of diabetic retinopathy. Extracellular vesicles (EVs) derived from mesenchymal stem cells cultured in diabetic-like conditions enter pericytes, cause their detachment and migration, a...

journal_title：Experimental eye research

authors： Mazzeo A,Lopatina T,Gai C,Trento M,Porta M,Beltramo E

更新日期：2019-07-01 00:00:00

abstract：:Small heat shock proteins and alpha-crystallins are related proteins with several common structural and functional properties including homologous amino acid sequences and similar chaperone-like activity. Furthermore, small heat shock proteins and alpha-crystallins are phosphorylated in vivo at serine residues within ...

journal_title：Experimental eye research

authors： Chiesa R,Noguera I,Sredy J

更新日期：1997-08-01 00:00:00

abstract：:Identification of novel agents to eradicate the residual lens cell population following cataract surgery provides one mode of preventing PCO formation. The present study investigated the biological mechanism of As(2)O(3) cytotoxicity in a human lens cell line and capsular bag system. FHL 124 cell survival was assessed...

journal_title：Experimental eye research

authors： Zhang H,Duncan G,Wang L,Liu P,Cui H,Reddan JR,Yang BF,Wormstone IM

更新日期：2007-12-01 00:00:00

abstract：:We have previously shown that corticotropin-releasing hormone plays an important proinflammatory role in the induction of experimental autoimmune uveoretinitis. In this study, we examined the role of apoptosis in the destruction of the retina during experimental autoimmune uveoretinitis, and the role of corticotropin-...

journal_title：Experimental eye research

authors： Poulaki V,Mitsiades N,Mastorakos G,Caspi RR,Chrousos GP,Bouzas E

更新日期：2001-06-01 00:00:00

abstract：:The presence of eumelanin and pheomelanin in irides from eyes of various colors was determined and quantified by a highly specific microanalytical procedure based on chemical degradation. Significant differences in the type of melanin were observed in the stroma and iris pigment epithelium (IPE) fractions obtained by ...

journal_title：Experimental eye research

authors： Prota G,Hu DN,Vincensi MR,McCormick SA,Napolitano A

更新日期：1998-09-01 00:00:00

abstract：:The expression and intracellular localization of the estrogen receptor (ER) subtypes, ERalpha and ERbeta were examined in cultured human lens epithelial cells (HLE-B3). ERalpha and ERbeta mRNA expression was evaluated by coupled reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot analysis. Subce...

journal_title：Experimental eye research

authors： Cammarata PR,Chu S,Moor A,Wang Z,Yang SH,Simpkins JW

更新日期：2004-04-01 00:00:00

abstract：:The nature and the extent of acute injury to corneal endothelial cells caused by exposure to ultrasound radiation were characterized, as well as the long-term reaction of these cells to this form of injury. It was found that the degree of lethal cell injury induced by ultrasound scaled with exposure intensity and dura...

journal_title：Experimental eye research

authors： Saito K,Miyake K,McNeil PL,Kato K,Yago K,Sugai N

更新日期：1999-04-01 00:00:00

abstract：:The overall importance of the peak or the mean serum concentrations as predictors of ocular drug penetration is unknown. To address this fundamental question with an agent which shows promise as adjunctive therapy in the treatment of endophthalmitis, we studied the penetration of ciprofloxacin into the aqueous and vit...

journal_title：Experimental eye research

authors： Madu AA,Mayers M,Perkins R,Liu W,Drusano GL,Aswani R,Madu CN,Miller MH

更新日期：1996-08-01 00:00:00

abstract：:Certain mutations in optineurin (gene OPTN) are associated with primary open angle glaucoma. Optineurin is ubiquitously expressed but it shows high level of expression in certain cells and tissues including retinal ganglion cells. It interacts with many proteins, often acting as an adaptor to link two or more proteins...

journal_title：Experimental eye research

authors： Sirohi K,Swarup G

更新日期：2016-03-01 00:00:00