Firing properties of dopamine neurons in freely moving dopamine-deficient mice: effects of dopamine receptor activation and anesthesia.

abstract：:The neural cell adhesion molecule N-CAM is a sialic acid-rich, cell surface glycoprotein that mediates cell adhesion by a homophilic mechanism. Its binding function has been implicated in both morphogenesis and histogenesis; during development it changes in amount at the cell surface and perinatally it undergoes a dec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman S,Chuong CM,Edelman GM

更新日期：1984-11-01 00:00:00

abstract：:Bluetongue virus (BTV), a major threat to livestock, is a multilayered, nonturreted member of the Reoviridae, a family of segmented dsRNA viruses characterized by endogenous RNA transcription through an RNA-dependent RNA polymerase (RdRp). To date, the structure of BTV RdRp has been unknown, limiting our mechanistic u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Y,Shivakoti S,Ding K,Cui Y,Roy P,Zhou ZH

更新日期：2019-08-13 00:00:00

abstract：:The hypothesis that intracellular Ca2+ is an essential component of the intracellular mechanism of insulin action in the adipocyte was evaluated. Cells were loaded with the Ca2+ chelator quin-2, by preincubating them with quin-2 AM, the tetrakis(acetoxymethyl) ester of quin-2. Quin-2 loading inhibited insulin-stimulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pershadsingh HA,Shade DL,Delfert DM,McDonald JM

更新日期：1987-02-01 00:00:00

abstract：:Transposable elements make up half of the mammalian genome. One of the most abundant is the short interspersed nuclear element (SINE). Among their million copies, B2 accounts for ∼350,000 in the mouse genome and has garnered special interest because of emerging roles in epigenetic regulation. Our recent work demonstra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hernandez AJ,Zovoilis A,Cifuentes-Rojas C,Han L,Bujisic B,Lee JT

更新日期：2020-01-07 00:00:00

abstract：:The synaptonemal complex (SC) is a conserved meiotic structure that regulates the repair of double-strand breaks (DSBs) into crossovers or gene conversions. The removal of any central-region SC component, such as the Drosophila melanogaster transverse filament protein C(3)G, causes a complete loss of SC structure and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Billmyre KK,Cahoon CK,Heenan GM,Wesley ER,Yu Z,Unruh JR,Takeo S,Hawley RS

更新日期：2019-10-22 00:00:00

abstract：:We used positron emission tomography (PET) to examine the role of the hippocampal formation in implicit and explicit memory. Human volunteers studied a list of familiar words, and then they either provided the first word that came to mind in response to three-letter cues (implicit memory) or tried to recall studied wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schacter DL,Alpert NM,Savage CR,Rauch SL,Albert MS

更新日期：1996-01-09 00:00:00

abstract：:The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pumplin DW,Reese TS,Llinás R

更新日期：1981-11-01 00:00:00

abstract：:Underacetylation of histone H4 is thought to be involved in the molecular mechanism of mammalian X chromosome inactivation, which is an important model system for large-scale genetic control in eukaryotes. However, it has not been established whether histone underacetylation plays a critical role in the multistep inac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wakefield MJ,Keohane AM,Turner BM,Graves JA

更新日期：1997-09-02 00:00:00

abstract：:We have screened about 1.4 million colonies of Escherichia coli K-12 for their ability to grow on nutrient agar at 30 degrees and 41 degrees. Among the 2266 temperature-sensitive mutants found, 110 were defective in DNA synthesis but not in protein synthesis at 41 degrees. Three of these dna mutations mapped at two pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sevastopoulos CG,Wehr CT,Glaser DA

更新日期：1977-08-01 00:00:00

abstract：:Among the earliest and most important stages during tumorigenesis is the activation of the angiogenic process, an event that is termed the "switch to the angiogenic phenotype." We have developed an in vivo system that can reliably recapitulate the stages in tumor development that represent this transition. Using this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fang J,Shing Y,Wiederschain D,Yan L,Butterfield C,Jackson G,Harper J,Tamvakopoulos G,Moses MA

更新日期：2000-04-11 00:00:00

abstract：:Chemokines play a key role in inflammation. They are expressed not only in neuroinflammatory conditions, but also constitutively by different cell types, including neurons in the normal brain, suggesting that they may act as modulators of neuronal functions. Here, we investigated a possible neuroendocrine role of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callewaere C,Banisadr G,Desarménien MG,Mechighel P,Kitabgi P,Rostène WH,Mélik Parsadaniantz S

更新日期：2006-05-23 00:00:00

abstract：:The minimal size of the recombination site required for efficient FLP recombinase-catalyzed recombination in vitro is no more than 28 base pairs, which includes parts of two 13-base-pair inverted repeats and all of an 8-base-pair spacer. The FLP recombinase cleaves the DNA at the boundaries of the spacer, becomes cova...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senecoff JF,Bruckner RC,Cox MM

更新日期：1985-11-01 00:00:00

abstract：:The regulation of cellular protein levels is a complex process involving many regulatory mechanisms, each introducing stochastic events, leading to variability of protein levels between isogenic cells. Previous studies have shown that perturbing genes involved in transcription regulation affects the amount of cell-to-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinott R,Jaimovich A,Friedman N

更新日期：2011-04-12 00:00:00

abstract：:Bacteriophage Mu replicates as a transposable element, exploiting host enzymes to promote initiation of DNA synthesis. The phage-encoded transposase MuA, assembled into an oligomeric transpososome, promotes transfer of Mu ends to target DNA, creating a fork at each end, and then remains tightly bound to both forks. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakai H,Doseeva V,Jones JM

更新日期：2001-07-17 00:00:00

abstract：:Recombination junctions of several Neurospora mitochondrial DNA (mtDNA) mutants and their revertants were identified. Their nucleotide sequences and putative secondary structures were determined in order to understand the nature of the elements involved in intramolecular recombination. Multiple deletions, involving th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Almasan A,Mishra NC

更新日期：1991-09-01 00:00:00

abstract：:Absorbance changes in untreated intact leaf discs, produced upon excitation with high-intensity red light, were shown to be due to the photooxidation of cytochrome b-559. At low intensities (<100 W/m2), photooxidation was almost undetectable. Photooxidation occurred with a half-time of 4.3 sec and an extent of 0.64 mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canaani O,Havaux M

更新日期：1990-12-01 00:00:00

abstract：:Infants' sensitivity to contingent reactivity as an indicator of intentional agency has been demonstrated by numerous referential gaze-following studies. Here we propose that variability of signal sequences in a turn-taking exchange provides an informative cue for infants to recognize interactions that may involve com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tauzin T,Gergely G

更新日期：2019-07-30 00:00:00

abstract：:Carbon nanotube (CNT) membranes were employed as the active element of a switchable transdermal drug delivery device that can facilitate more effective treatments of drug abuse and addiction. Due to the dramatically fast flow through CNT cores, high charge density, and small pore dimensions, highly efficient electroph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Paudel KS,Strasinger C,Hammell D,Stinchcomb AL,Hinds BJ

更新日期：2010-06-29 00:00:00

abstract：:Rare high-3He/4He signatures in ocean island basalts (OIB) erupted at volcanic hotspots derive from deep-seated domains preserved in Earth's interior. Only high-3He/4He OIB exhibit anomalous 182W-an isotopic signature inherited during the earliest history of Earth-supporting an ancient origin of high 3He/4He. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson MG,Blichert-Toft J,Halldórsson SA,Mundl-Petermeier A,Bizimis M,Kurz MD,Price AA,Harðardóttir S,Willhite LN,Breddam K,Becker TW,Fischer RA

更新日期：2020-12-08 00:00:00

abstract：:Global patterns of biodiversity reflect both regional and local processes, but the relative importance of local ecological limits to species coexistence, as influenced by the physical environment, in contrast to regional processes including species production, dispersal, and extinction, is poorly understood. Failure t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ricklefs RE,He F

更新日期：2016-01-19 00:00:00

abstract：:The neotropical Heliconius butterflies are famous examples of Müllerian mimicry, due to the diverse array of shared, brightly colored wing patterns that advertise the butterflies' unpalatability. The parallel geographical variation in these patterns within several widespread species has been invoked to support the con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower AV

更新日期：1994-07-05 00:00:00

abstract：:Circadian rhythms modulate many aspects of physiology. Knowledge of the molecular basis of these rhythms has exploded in the last 20 years. However, most of these data are from model organisms, and translation to clinical practice has been limited. Here, we present an approach to identify molecular rhythms in humans f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anafi RC,Francey LJ,Hogenesch JB,Kim J

更新日期：2017-05-16 00:00:00

abstract：:We have found that 1 of 20 human tumors transplanted and passaged in nude mice was associated with a massive induction of endogenous murine leukemia virus (MuLV). Separation and growth of these viruses on various substrates indicated that both ecotropic and xenotropic MuLV were present in the induced mixture. Tryptic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautsch JW,Knowles AF,Jensen FC,Kaplan NO

更新日期：1980-04-01 00:00:00

abstract：:The nod (no distributive disjunction) and the ncd (non-claret disjunctional) mutations are both female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of nondisjunction at meiosis I and both have been shown to encode kinesin-like proteins. Unlike the nc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knowles BA,Hawley RS

更新日期：1991-08-15 00:00:00

abstract：:Stress can either promote or impair learning and memory. Such opposing effects depend on whether synapses persist or decay after learning. Maintenance of new synapses formed at the time of learning upon neuronal network activation depends on the stress hormone-activated glucocorticoid receptor (GR) and neurotrophic fa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arango-Lievano M,Borie AM,Dromard Y,Murat M,Desarmenien MG,Garabedian MJ,Jeanneteau F

更新日期：2019-06-25 00:00:00

abstract：:Sterigmatocystin (ST), a potent hepatocarcinogen, was covalently bound to calf thymus DNA by incubation in the presence of phenobarbital-induced rat liver microsomes. Acid hydrolysis of ST-modified DNA liberated a major guanine-containing adduct, present in DNA at an estimated level of 1 ST residue per 100-150 nucleot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Essigmann JM,Barker LJ,Fowler KW,Francisco MA,Reinhold VN,Wogan GN

更新日期：1979-01-01 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:We tested the influence of a photothrombotic lesion in somatosensory cortex on plasticity in the mouse visual system and the efficacy of anti-inflammatory treatment to rescue compromised learning. To challenge plasticity mechanisms, we induced monocular deprivation (MD) in 3-mo-old mice. In control animals, MD induced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greifzu F,Schmidt S,Schmidt KF,Kreikemeier K,Witte OW,Löwel S

更新日期：2011-09-13 00:00:00

abstract：:Teratocarcinoma is a germ-line carcinoma giving rise to an embryoid tumor with structures derived from the three embryonic layers: mesoderm, endoderm, and ectoderm. Teratocarcinoma is widely used as an in vitro model system to study regulation of cell determination and differentiation during mammalian embryogenesis. M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trojan J,Johnson TR,Rudin SD,Blossey BK,Kelley KM,Shevelev A,Abdul-Karim FW,Anthony DD,Tykocinski ML,Ilan J

更新日期：1994-06-21 00:00:00

abstract：:Herpes simplex virus type 2 (HSV-2) DNA was treated with four restriction endonucleases (EcoRI, HincIII, Bgl II, and Xba I) and eight fragments were purified and labeled with 32P in vitro. The kinetics of renaturation of each of the fragments was measured in the presence of DNA extracted from 333-8-9, a hamster cell l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galloway DA,Copple CD,McDougall JK

更新日期：1980-02-01 00:00:00