Abstract:
:The effect of azelastine and some selected compounds on ciliary beating frequency (CBF) was investigated in vitro using human mucosal samples and in vivo using anesthetized guinea pigs. Further influence of azelastine on mucus secretion was evaluated in mice and on mucociliary clearance in anesthetized rabbits. Azelastine influenced the ciliary beating frequency neither in vitro nor in vivo. Azelastine, similarly to salbutamol, ambroxol, and bromhexine, increased mucus secretion measured by the tracheal output of phenol red. Azelastine dose-dependently enhanced mucociliary clearance measured by elimination of 99mTc-labeled erythrocytes in rabbits. The activity of azelastine proved to be about 10 times stronger than that of bromhexine. Since the ciliary activity remained unchanged under the influence of azelastine, it is likely that azelastine increases the mucociliary clearance by enhancing bronchial secretion. It is possible that the observed increase in mucociliary clearance may contribute to the beneficial effect of azelastine in the treatment of respiratory diseases.
journal_name
Lungjournal_title
Lungauthors
Achterrath-Tuckermann U,Saano V,Minker E,Stroman F,Arny I,Joki S,Nuutinen J,Szelenyi Idoi
10.1007/BF00174117keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
201-9issue
4eissn
0341-2040issn
1432-1750journal_volume
170pub_type
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