Influence of azelastine and some selected drugs on mucociliary clearance.

Abstract:

:The effect of azelastine and some selected compounds on ciliary beating frequency (CBF) was investigated in vitro using human mucosal samples and in vivo using anesthetized guinea pigs. Further influence of azelastine on mucus secretion was evaluated in mice and on mucociliary clearance in anesthetized rabbits. Azelastine influenced the ciliary beating frequency neither in vitro nor in vivo. Azelastine, similarly to salbutamol, ambroxol, and bromhexine, increased mucus secretion measured by the tracheal output of phenol red. Azelastine dose-dependently enhanced mucociliary clearance measured by elimination of 99mTc-labeled erythrocytes in rabbits. The activity of azelastine proved to be about 10 times stronger than that of bromhexine. Since the ciliary activity remained unchanged under the influence of azelastine, it is likely that azelastine increases the mucociliary clearance by enhancing bronchial secretion. It is possible that the observed increase in mucociliary clearance may contribute to the beneficial effect of azelastine in the treatment of respiratory diseases.

journal_name

Lung

journal_title

Lung

authors

Achterrath-Tuckermann U,Saano V,Minker E,Stroman F,Arny I,Joki S,Nuutinen J,Szelenyi I

doi

10.1007/BF00174117

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

201-9

issue

4

eissn

0341-2040

issn

1432-1750

journal_volume

170

pub_type

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