Mechanism of bradykinin-induced cyclic GMP accumulation in bovine tracheal smooth muscle.

Abstract:

:Bradykinin (10(-8) - 10(-5) M) caused a concentration-dependent increase in cyclic GMP (cGMP) production in bovine tracheal smooth muscle in the absence of epithelium. The effect was calcium-dependent and was inhibited by pyrogallol (10 microM) and methylene blue (10 microM). The inhibition of pyrogallol was reversed by superoxide dismutase (100 U/ml). Nitric oxide (NO) synthase inhibitors, NG-methyl-L-arginine (10-100 microM) and NG-nitro-L-arginine (10-100 microM) reduced cGMP accumulation induced by bradykinin in a concentration-dependent fashion, and the inhibition was reversed by L-arginine. Immunohistochemistry with a specific antibody against neuronal NO synthase from rat cerebellum showed positive staining localized in some nerve fibers. Bradykinin-induced cGMP accumulation appears to be related to the release of NO, part of which is probably synthesized in nonadrenergic noncholinergic nerve in bovine trachea.

journal_name

Lung

journal_title

Lung

authors

Sheng H,Ishii K,Förstermann U,Murad F

doi

10.1007/BF00172144

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

373-83

issue

6

eissn

0341-2040

issn

1432-1750

journal_volume

173

pub_type

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