Abstract：
:Bradykinin (10(-8) - 10(-5) M) caused a concentration-dependent increase in cyclic GMP (cGMP) production in bovine tracheal smooth muscle in the absence of epithelium. The effect was calcium-dependent and was inhibited by pyrogallol (10 microM) and methylene blue (10 microM). The inhibition of pyrogallol was reversed by superoxide dismutase (100 U/ml). Nitric oxide (NO) synthase inhibitors, NG-methyl-L-arginine (10-100 microM) and NG-nitro-L-arginine (10-100 microM) reduced cGMP accumulation induced by bradykinin in a concentration-dependent fashion, and the inhibition was reversed by L-arginine. Immunohistochemistry with a specific antibody against neuronal NO synthase from rat cerebellum showed positive staining localized in some nerve fibers. Bradykinin-induced cGMP accumulation appears to be related to the release of NO, part of which is probably synthesized in nonadrenergic noncholinergic nerve in bovine trachea.
journal_name
Lungjournal_title
Lungauthors
Sheng H,Ishii K,Förstermann U,Murad Fdoi
10.1007/BF00172144subject
Has Abstractpub_date
1995-01-01 00:00:00pages
373-83issue
6eissn
0341-2040issn
1432-1750journal_volume
173pub_type
杂志文章相关文献
LUNG文献大全abstract：:Six European treatment centers contributed to a controlled trial to study nocturnal hypoxemia in COPD patients having daytime PaO2 of 60-70 mmHg. The trial is composed of two parts: first, patients inclusion, taking men aged under 70 years, excluding sleep apnea syndrome and all other concomitant pathologies leading t...
journal_title：Lung
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1007/BF02718206
更新日期：1990-01-01 00:00:00
abstract：:Binding characteristics of the alpha 1-adrenergic radioloigand [3H]prazosin, and the muscarinic cholinergic radioligand, [3H]quinuclidinyl benzilate, were determined both in intact cell preparations of rat alveolar type II pneumocytes (TIIPs) and in membrane preparations of rat lung tissue. Binding in adult and neonat...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00165701
更新日期：1993-01-01 00:00:00
abstract：:This study demonstrates for the first time that endothelial cells freshly isolated from small pulmonary arteries of the rat, based on their electrophysiological profile, possess two distinct populations of cells. Immunohistochemical staining revealed the presence of both anti-Kv1.5 and anti-Kir2.1 immunoreactivity in ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s004080000094
更新日期：2002-01-01 00:00:00
abstract：:The severity of chronic obstructive pulmonary disease (COPD) is evaluated not only by airflow limitation but also by factors such as exercise capacity and body mass index. Recent advances in CT technology suggest that it might be a useful tool for evaluating the severity of the disease components of COPD. The aim of t...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-008-9071-0
更新日期：2008-05-01 00:00:00
abstract：:The lung has only a limited pattern of response to injury. Idiopathic interstitial fibrosis is a descriptive term, describing the end stage of one pattern of pulmonary fibrosis in which the inflammation lies within the structure of the alveolar walls and around vessels and bronchioli, in the interstitium. The disease ...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02718237
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Although lung transplantation is the only means of survival for patients with end-stage pulmonary disease, outcomes from this intervention are inferior to other solid organ transplants. The reason for the poor outcomes may be linked to an early reaction, such as primary graft dysfunction, and associated with...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-014-9588-3
更新日期：2014-08-01 00:00:00
abstract：:Long-term treatment studies with formoterol and salmeterol show that these inhaled long-acting beta 2-agonists compared to available beta 2-agonists produce better bronchodilation, decrease the need for additional doses, decrease asthma symptoms, and are strongly preferred by the patients. Development of tolerance has...
journal_title：Lung
pub_type： 临床试验,杂志文章,评审
doi：10.1007/BF02718109
更新日期：1990-01-01 00:00:00
abstract：:In recent years the alveolar macrophage has been found to play a central role in interstitial lung disease. Pulmonary histiocytosis X is characterized by infiltrating fibroblasts, mononuclear cells, and CD-1-positive Langerhans cells. Bronchoalveolar lavage (BAL) fluid displays an increase of CD-1-positive cells and a...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00175659
更新日期：1995-01-01 00:00:00
abstract：:The original version of this article contained an error in the usage of the term "false positive rate". The intention of the authors in those instances was simply to compare the absolute percentage of false positive results in the study vs the NLST, not to make any observations about false positive rate in the strict ...
journal_title：Lung
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00408-019-00269-6
更新日期：2019-10-01 00:00:00
abstract：:The presence and distribution of acetylcholinesterase (AChE) and cholineacetyl transferase activities (Chat) were examined in the bronchus-associated lymphoid tissue (BALT) of juvenile, adult and old rats. Histoenzymatic and immunochemical methods were used in association with quantitative analysis of images and stati...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-003-1042-x
更新日期：2004-01-01 00:00:00
abstract：:This multi-centred, randomised controlled trial explored the effects of adding ongoing feedback to a 12-month unsupervised maintenance walking program, on daily physical activity (PA) in people with chronic obstructive pulmonary disease. Participants were randomised to either an intervention group (IG) or a usual care...
journal_title：Lung
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00408-019-00216-5
更新日期：2019-06-01 00:00:00
abstract：:Diffuse alveolar damage is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). A significant proportion of ARDS survivors have residual pulmonary fibrosis and compromised pulmonary function. On the other hand, heat shock protein 47 (HSP47) is a collagen-binding stress protein that is assumed to...
journal_title：Lung
pub_type： 杂志文章,收录出版
doi：10.1007/s00408-006-0085-1
更新日期：2007-01-01 00:00:00
abstract：BACKGROUND:The right ventricular ejection fraction (RVEF) is a surrogate marker of right ventricular function in pulmonary hypertension (PH), but its measurement is complicated and time consuming. The tricuspid annular plane systolic excursion (TAPSE) measures only the longitudinal component of RV contraction while the...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-018-0089-7
更新日期：2018-04-01 00:00:00
abstract：:The effect of azelastine and some selected compounds on ciliary beating frequency (CBF) was investigated in vitro using human mucosal samples and in vivo using anesthetized guinea pigs. Further influence of azelastine on mucus secretion was evaluated in mice and on mucociliary clearance in anesthetized rabbits. Azelas...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF00174117
更新日期：1992-01-01 00:00:00
abstract：:The effects of a pulmonary rehabilitation program on 44 patients with chronic obstructive pulmonary disease (COPD) were compared to a control group. The treated group was admitted to the program for a period of three months. The program consisted of several parts, such as physical training, health education, and psych...
journal_title：Lung
pub_type： 临床试验,杂志文章
doi：10.1007/BF00203723
更新日期：1993-01-01 00:00:00
abstract：:The aim of our study was to evaluate clinical diagnoses in symptomatic persons exposed to aerosols from humidifiers or air conditioners. In addition, we tried to identify the causative antigens. Results of clinical investigations, including inhalation challenge tests, demonstrated a typical hypersensitivity pneumoniti...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02714035
更新日期：1988-01-01 00:00:00
abstract：INTRODUCTION:Bronchopleural fistula is a rare but potentially fatal complication of pulmonary resections and proper management is essential for its resolution. In this study, we analyzed the incidence of fistula after pulmonary resection and reported data about endoscopic and conservative treatments of this complicatio...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-016-9841-z
更新日期：2016-04-01 00:00:00
abstract：:A multiuser system for whole body plethysmographic measurements and interpretation which has been developed under clinical conditions is described. The following measurements can be carried out in a rapid way and in one session with the patient: specific airway resistance during spontaneous breathing, determination of...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/BF02718260
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Pulmonary hypertension (PH) is a comorbidity associated with increased mortality in chronic obstructive pulmonary disease (COPD) patients. It is not known which clinical markers are predictive of PH in COPD. The goal of this study was to develop a clinical tool to identify patients who should be sent for ini...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-011-9346-8
更新日期：2012-02-01 00:00:00
abstract：:The major goal of all diagnostic and therapeutic efforts in childhood asthma is to prevent progression of lung disease into adulthood. To improve the uncomfortable situation of underdiagnosis and undertreatment and to lower the risk of acquiring irreversible lung damage, an optimal co-working relationship between fami...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718166
更新日期：1990-01-01 00:00:00
abstract：:Eosinophils have been shown to play a role in allergen-induced airway responses. The aim in this study was to examine the effects of TAK-661, a newly developed product as a specific inhibitory agent of eosinophil chemotaxis, on antigen-induced asthmatic responses in allergic sheep model. Seven Ascaris-sensitive, "dual...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s004080000090
更新日期：2002-01-01 00:00:00
abstract：INTRODUCTION:Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal fibrosing lung disease with a median survival of approximately 3 years after diagnosis. The only medical option to improve survival in IPF is lung transplantation (LTX). The purpose of this study was to evaluate trajectory data of IPF patients...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-015-9794-7
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:This study was designed to review outcomes of once- (QD) versus twice-daily (BID) radiotherapy (RT) for limited stage small-cell lung cancer (L-SCLC) treated at Dana-Farber Cancer Institute/Brigham and Women's Hospital. METHODS:We reviewed records for all patients with L-SCLC treated with radical chemoradiothe...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-013-9518-9
更新日期：2014-02-01 00:00:00
abstract：INTRODUCTION:The goal of our systematic review and meta-analysis is to examine the therapeutic effectiveness of bronchoscopic lung volume reduction (BLVR), and to compare it with medical management and lung volume reduction surgery. METHODS:Variables of interest were absolute change in FEV1, 6MWT, and SGRQ. Meta-analy...
journal_title：Lung
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s00408-016-9969-x
更新日期：2017-02-01 00:00:00
abstract：:The pathophysiology of cough variant asthma is poorly understood. In particular, the mechanisms that cause different symptoms in typical asthma (in which wheeze predominates) compared with cough variant asthma (in which cough predominates) have not been determined. Traditional explanations include higher wheezing thre...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-011-9348-6
更新日期：2012-02-01 00:00:00
abstract：STUDY OBJECTIVES:The aim of this study was to determine if electrocardiographically synchronized, prospectively triggered multidetector row computed tomography (ECG-MDR-CT) angiography of the aorta can accurately predict the location of ectopic bronchial arteries in patients with cystic fibrosis (CF) with massive hemop...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-011-9343-y
更新日期：2012-04-01 00:00:00
abstract：:Benralizumab and mepolizumab are new therapies for severe eosinophilic asthma. They are both humanized IgG antibodies, targeting the IL-5 receptor and IL-5, respectively, suppressing the corresponding pathways. No specific biomarkers have been proposed to evaluate treatment response to benralizumab or mepolizumab. The...
journal_title：Lung
pub_type： 杂志文章
doi：10.1007/s00408-020-00379-6
更新日期：2020-10-01 00:00:00
abstract：:Chronic desquamative eosinophilic bronchitis is a characteristic pathologic feature of asthma which may even antedate the onset of symptoms. The pharmacology of asthmatic inflammation has been relatively poorly studied and most of the current data available have been inferred indirectly from studies of bronchial hyper...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/BF02718126
更新日期：1990-01-01 00:00:00
abstract：:Cardiothoracic surgery posits an arrangement of large, significant hemodynamic, and physiologic alterations upon the human body, which predisposes a patient to develop pathology. The care of these patients in the postoperative realm requires an astute physician with deep understanding of the cardiopulmonary system, wh...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-020-00405-7
更新日期：2020-12-01 00:00:00
abstract：:Obstructive sleep apnea syndrome (OSAS) is an independent risk factor for atherosclerosis and arterial thrombosis, which are associated with high cardiovascular (CV) morbidity and mortality. In studies performed in clinical populations with elevated CV event risk profiles, the occurrence of moderate to severe OSAS was...
journal_title：Lung
pub_type： 杂志文章,评审
doi：10.1007/s00408-012-9427-3
更新日期：2013-02-01 00:00:00
