Abstract:
:Borna disease virus (BDV) polymerase can be reconstituted by co-expression of the viral genes N, P and L. N codes for two proteins, p39 and p38, resulting from alternative translation initiation. Using a viral minireplicon system we observed that unlike p39, p38 was almost completely inactive when expressed with P and L alone. Since BDV polymerase requires a 10-20 fold excess of N protein over P for high activity, we determined whether p38 might serve as buffer that influences the viral N:P ratio. We demonstrate that p38 efficiently rescued BDV polymerase activity in cells expressing unfavorably high amounts of P.
journal_name
Arch Viroljournal_title
Archives of virologyauthors
Schneider U,Naegele M,Staeheli Pdoi
10.1007/s00705-004-0327-6keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1409-14issue
7eissn
0304-8608issn
1432-8798journal_volume
149pub_type
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