Abstract:
:The susceptibility of a strain of Giardia lamblia to benzimidazole carbamates, 5-nitroimidazoles, nitrofurans and other drugs was studied in vitro. Albendazole was the most active compound, with a 50% inhibitory concentration (IC50) of 0.01 mg/L and a minimal lethal concentration (MLC) of less than 0.04 mg/L; the IC50 of mebendazole was 0.06 mg/L and the MLC less than 0.5 mg/L. Among the 5-nitroimidazoles tested, ornidazole was the most effective (IC50 0.12 mg/L); tinidazole, metronidazole, secnidazole and hemezole were less active. Nifuroxazide, etofamide and nalidixic acid exhibited modest anti-giardial activity; quinfamide did not inhibit the growth of the parasite at a concentration of 200 mg/L. Albendazole and mebendazole are promising candidates for clinical use and should be further evaluated.
journal_name
J Med Microbioljournal_title
Journal of medical microbiologyauthors
Cedillo-Rivera R,Muñoz Odoi
10.1099/00222615-37-3-221keywords:
subject
Has Abstractpub_date
1992-09-01 00:00:00pages
221-4issue
3eissn
0022-2615issn
1473-5644journal_volume
37pub_type
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