Transferrin receptors of Neisseria meningitidis: promising candidates for a broadly cross-protective vaccine.


:Production of a meningococcal vaccine capable of generating long-lasting immunity in all age groups is still a high priority worldwide. Iron-regulated outer-membrane proteins have attracted considerable attention in recent years and it has become increasingly evident that the meningococcal transferrin-binding proteins, TBP1 and TBP2, have characteristics compatible with a safe and broadly cross-reactive vaccine candidate. Both TBPs are surface-exposed and immunogenic in man and animals, and antibodies to their native structure are bactericidal to homologous and many heterologous strains. These include strains from various serogroups, serotypes and serosubtypes, with no obvious correlation between bactericidal activity and the identity of the strains or the molecular mass of the heterogeneous TBP2 molecule. A meningococcal vaccine based on, or enriched with, undenatured TBPs from one or more strains, in combination with conventional polysaccharide-based vaccines, might increase the spectrum of strains against which protection can be achieved to include serogroup B strains. In this review, the structure-function and immunological properties of TBP1 and TBP2 are discussed.


J Med Microbiol


Ala'Aldeen DA




Has Abstract


1996-04-01 00:00:00












  • A severe outbreak of listeriosis in central Italy with a rare pulsotype associated with processed pork products.

    abstract:PURPOSE:From May 2015 to March 2016, an outbreak due to Listeria monocytogenes serotype 1/2a and clinical pulsotype never previously isolated in Europe occurred in central Italy, involving 24 confirmed clinical cases. The article provides a description of the outbreak and the investigation carried out by a multidiscipl...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Duranti A,Sabbatucci M,Blasi G,Acciari VA,Ancora M,Bella A,Busani L,Centorame P,Cammà C,Conti F,De Medici D,Di Domenico M,Di Marzio V,Filippini G,Fiore A,Fisichella S,Gattuso A,Gianfranceschi M,Graziani C,Guidi F,

    更新日期:2018-09-01 00:00:00

  • In-vitro proteinase production by oral Candida albicans isolates from individuals with and without HIV infection and its attenuation by antimycotic agents.

    abstract::In-vitro proteinase production by oral Candida albicans isolates from patients with and without HIV infection (18 isolates from each group) was assessed by image analysis of a plate assay, with bovine serum albumin (BSA) as a substrate. The effect of sub-minimal inhibitory concentrations (sub-MICs) of nystatin, amphot...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Wu T,Samaranayake LP,Cao BY,Wang J

    更新日期:1996-04-01 00:00:00

  • Induction of granulomas in interferon-gamma gene-disrupted mice by avirulent but not by virulent strains of Mycobacterium tuberculosis.

    abstract::To gain a better understanding of the pathological role of interferon-gamma (IFN-gamma) in specific granuloma formation, IFN-gamma gene-deficient mice (BALB/c and C57BL/6) were produced. The IFN-gamma gene in embryonic stem (ES) cells was disrupted by inserting the beta-galactosidase gene (lacZ) and the neomycin resis...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Sugawara I,Yamada H,Kazumi Y,Doi N,Otomo K,Aoki T,Mizuno S,Udagawa T,Tagawa Y,Iwakura Y

    更新日期:1998-10-01 00:00:00

  • Epidemiological and molecular characteristics of clinical isolates of Streptococcus pyogenes collected between 2005 and 2008 from Chinese children.

    abstract::The aim of this study was to explore the epidemiological and molecular characteristics of Streptococcus pyogenes in children from different cities in mainland China who were diagnosed with scarlet fever, impetigo and pharyngitis, as well as to detect asymptomatic carriers, between 2005 and 2008, and to compare the res...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Liang Y,Liu X,Chang H,Ji L,Huang G,Fu Z,Zheng Y,Wang L,Li C,Shen Y,Yu S,Yao K,Ma L,Shen X,Yang Y

    更新日期:2012-07-01 00:00:00

  • Application of terminal RFLP analysis to characterize oral bacterial flora in saliva of healthy subjects and patients with periodontitis.

    abstract::Terminal restriction fragment-length polymorphism (T-RFLP) analysis was applied to characterize oral bacterial flora in saliva from 18 healthy subjects and 18 patients with periodontitis. The 16S rRNA genes (rDNAs) of oral bacteria and spirochaetes in saliva were amplified by PCR with a 6'carboxy-fluorescein (6-FAM)-l...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Sakamoto M,Takeuchi Y,Umeda M,Ishikawa I,Benno Y

    更新日期:2003-01-01 00:00:00

  • Role of caspases in cleavage of lamin A/C and PARP during apoptosis in macrophages infected with a periodontopathic bacterium.

    abstract::The periodontopathic bacterium Actinobacillus actinomycetemcomitans has been implicated in the pathogenesis of periodontal diseases. It has been reported previously that infection with the organism induced apoptosis in the mouse macrophage cell line J774.1. In the present study, the role of caspases during apoptosis i...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Okinaga T,Kasai H,Tsujisawa T,Nishihara T

    更新日期:2007-10-01 00:00:00

  • Phenotypic and molecular characterization of antimicrobial resistance in Proteus mirabilis isolates from dogs.

    abstract::Large-scale monitoring of resistance to 14 antimicrobial agents was performed using 103 Proteus mirabilis strains isolated from dogs in Japan. Resistant strains were analysed to identify their resistance mechanisms. Rates of resistance to chloramphenicol, streptomycin, enrofloxacin, trimethoprim/sulfamethoxazole, kana...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Harada K,Niina A,Shimizu T,Mukai Y,Kuwajima K,Miyamoto T,Kataoka Y

    更新日期:2014-11-01 00:00:00

  • Introduction of PCR testing reveals a previously unrecognized burden of yersiniosis in Hampshire, UK.

    abstract::Introduction. Current testing practices for yersiniosis mean that its true incidence and epidemiology are not well understood. In mid-2016, the introduction of testing via a multiplex gastrointestinal PCR panel at Portsmouth hospital laboratory in Hampshire, UK, resulted in a marked increase in the number of Yersinia ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Clarke M,Dabke G,Strakova L,Jenkins C,Saavedra-Campos M,McManus O,Paranthaman K

    更新日期:2020-03-01 00:00:00

  • Role of biofilm morphology, matrix content and surface hydrophobicity in the biofilm-forming capacity of various Candida species.

    abstract::The present study aimed to evaluate the role of biofilm morphology, matrix content and surface hydrophobicity in the biofilm-forming capacity of Candida albicans and non-albicans Candida (NAC) spp. Biofilm formation was determined by microtitre plate assay and bright-field and scanning electron microscopy. The matrix ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Kumari A,Mankotia S,Chaubey B,Luthra M,Singh R

    更新日期:2018-06-01 00:00:00

  • Comparison of detection procedures for Chlamydia trachomatis, including enzyme immunoassays, in a mouse model of genital infection.

    abstract::Two chlamydial enzyme immunoassays, Chlamydiazyme and IDEIA, were evaluated in a mouse model of chlamydial genital-tract infection. The Chlamydiazyme assay and the IDEIA were assessed on specimens from 10 and 11 mice, respectively. The animals were infected with Chlamydia trachomatis, strain SA2f, and the results obta...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Taylor-Robinson D,Tuffrey M

    更新日期:1987-09-01 00:00:00

  • Broilers do not play a dominant role in the Campylobacter fetus contamination of humans.

    abstract::Campylobacter fetus causes severe infections in humans and can be isolated from various mammals and reptiles. However, although poultry are considered to be the main reservoir of Campylobacter jejuni, little is known about the presence of C. fetus in poultry. Thus, specific pathogen-free chickens were experimentally i...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Kempf I,Dufour-Gesbert F,Hellard G,Prouzet-Mauléon V,Mégraud F

    更新日期:2006-09-01 00:00:00

  • The incidence of tinea versicolor in central Sweden.

    abstract::In a survey of 3302 people in an area of central Sweden, tinea versicolor was diagnosed in 0.5% of males and 0.3% of females; all those infected were adults. Tinea versicolor is much less common in Sweden than in the tropics. ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Hellgren L,Vincent J

    更新日期:1983-11-01 00:00:00

  • Coxsackie B virus-specific IgM antibody and myocardial infarction.

    abstract::The ELISA technique was shown to be group-specific for the detection of IgM antibodies against coxsackie B viruses, and probably against a wider range of enteroviruses. No evidence was obtained that recent coxsackie B-virus infection predisposes to myocardial infarction. ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Hannington G,Booth JC,Bowes RJ,Stern H

    更新日期:1986-06-01 00:00:00

  • Evaluation of the polymerase chain reaction for early diagnosis of leptospirosis.

    abstract::Early diagnosis of leptospirosis is important because severe leptospiral infection can run a fulminant course. The polymerase chain reaction (PCR) was evaluated for the detection of leptospires in clinical samples from patients with acute leptospiral infection. Blood and urine samples from 71 patients with leptospiros...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Brown PD,Gravekamp C,Carrington DG,van de Kemp H,Hartskeerl RA,Edwards CN,Everard CO,Terpstra WJ,Levett PN

    更新日期:1995-08-01 00:00:00

  • Electron microscopy of the L-cycle in Bacillus licheniformis var. Endoparasiticus (Benedek).

    abstract::Electronmicrographs of sections show that the L-phases of Bacillus licheniformis var. endoparasiticus (Benedek) simulate the various types of micro-organism described by previous workers as associated with ostensibly noninfective conditions, notably cancer and arthritis; e.g., mycoplasmas, mycobacteria, corynebacteria...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Bisset KA,Tallack J,Bartlett R

    更新日期:1979-11-01 00:00:00

  • Bone resorbing activity of surface-associated material from Actinobacillus actinomycetemcomitans and Eikenella corrodens.

    abstract::The results of this study demonstrate that saline extracted surface-associated material (SAM) of Actinobacillus actinomycetemcomitans and Eikenella corrodens stimulates bone resorption at picomolar concentrations. Various inhibitors of known osteolytic mediators--indomethacin, interleukin-1 receptor antagonist (IL-1ra...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Meghji S,Wilson M,Barber P,Henderson B

    更新日期:1994-09-01 00:00:00

  • An erythrocyte-sensitising antigen from Vibrio cholerae.

    abstract::Erythrocyte-sensitising antigens (AE) were prepared from Vibrio cholerae serotypes, from EL-Tor vibrio, Escherichia coli and Salmonella enteritidis by digesting the organisms with NaOH followed by precipitation with alcohol. When AE was used in indirect haemagglutination (IHA) tests, the results in a number of cases w...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Garabedian GA,Barsumian EL,Malakian A

    更新日期:1975-02-01 00:00:00

  • Fatal post-traumatic zygomycosis in an immunocompetent young patient.

    abstract::Zygomycosis, a relatively uncommon infection, usually occurs among immunocompromised individuals. It has been reported only rarely in trauma patients. A fatal case is reported of pulmonary and rapidly progressive cutaneous zygomycosis in a young, otherwise healthy farmer, with multiple bone fractures, wounds and soft ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Kontogiorgi M,Floros I,Koroneos A,Vamvouka C,Paniara O,Roussos C,Routsi C

    更新日期:2007-09-01 00:00:00

  • Non-tuberculous mycobacterial infection of the parotid gland in an immunosuppressed adult.

    abstract::Infections of the parotid gland with non-tuberculous mycobacteria (NTM) are rarely described. Here, we report on an infection of the parotid gland caused by Mycobacterium avium and give a literature-based overview about this entity. In the light of a global increase of mycobacterial infections, unusual manifestations ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Gittinger FS,Raible A,Kempf VAJ

    更新日期:2008-04-01 00:00:00

  • The role of alpha haemolysin in the virulence of Escherichia coli for mice.

    abstract::Transfer of an Hly plasmid determining production of alpha haemolysin to a non-haemolytic strain of Escherichia coli increased the virulence of the strain for mice. Injections of non-toxic amounts of alpha haemolysin, phenylhydrazine, haemoglobin, iron or manganese salts simulated the effect of the Hly plasmid by stim...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Linggood MA,Ingram PL

    更新日期:1982-02-01 00:00:00

  • Heterogeneity within apparently pure cultures of Escherichia coli freshly isolated from significant bacteriuria.

    abstract::Pyrolysis mass spectrometry (PyMS), a highly discriminatory method for comparison of isolates, was used to assess the homogeneity of colonies taken from apparently pure cultures of Escherichia coli in 10 urine specimens. Ten randomly selected colonies were subcultured from each urine for comparison. For six urines, th...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Freeman R,Sisson PR,Burdess D

    更新日期:1996-11-01 00:00:00

  • Growth of Legionella spp. under conditions of iron restriction.

    abstract::The growth inhibiting activity of transferrins, citrate, 2-2' dipyridyl and desferrioxamine methanesulphonate towards Legionella spp. and their serogroups was investigated. The inhibitory activity of all these compounds depended upon the iron-free state of the molecules and was abolished by saturation with iron. No ba...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Goldoni P,Visca P,Pastoris MC,Valenti P,Orsi N

    更新日期:1991-02-01 00:00:00

  • Co-agglutination (Co-A) test for circulating antigen in hydatid disease.

    abstract::A co-agglutination (Co-A) test with Staphylococcus aureus (Cowan's strain I) bearing protein A coated with specific hydatid antibodies, was used to demonstrate circulating hydatid antigen in serum for the diagnosis of hydatid disease. The test had a sensitivity of 95% and specificity of 89% in detecting hydatid antige...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Shariff M,Parija SC

    更新日期:1993-06-01 00:00:00

  • A ten-year surveillance study of carbapenemase-producing Klebsiella pneumoniae in a tertiary care Greek university hospital: predominance of KPC- over VIM- or NDM-producing isolates.

    abstract::Resistance patterns and carbapenemase gene presence among Klebsiella pneumoniae isolates from the University General Hospital of Patras, Greece during a ten-year period were analysed under a surveillance programme for multi-drug-resistant bacteria. From 2005 to 2014, K. pneumoniae isolates from clinically significant ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Spyropoulou A,Papadimitriou-Olivgeris M,Bartzavali C,Vamvakopoulou S,Marangos M,Spiliopoulou I,Anastassiou ED,Christofidou M

    更新日期:2016-03-01 00:00:00

  • The Helicobacter pylori flbA flagellar biosynthesis and regulatory gene is required for motility and virulence and modulates urease of H. pylori and Proteus mirabilis.

    abstract::Helicobacter pylori and Proteus mirabilis ureases are nickel-requiring metallo-enzymes that hydrolyse urea to NH3 and CO2. In both H. pylori and in an Escherichia coli model of H. pylori urease activity, a high affinity nickel transporter, NixA, is required for optimal urease activity, whereas the urea-dependent UreR ...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: McGEE DJ,Coker C,Testerman TL,Harro JM,Gibson SV,Mobley HLT

    更新日期:2002-11-01 00:00:00

  • Comparison of enterotoxins and haemolysins produced by methicillin-resistant (MRSA) and sensitive (MSSA) Staphylococcus aureus.

    abstract::A collection of 201 isolates of Staphylococcus aureus was examined: 152 methicillin-sensitive S. aureus (MSSA) comprised 48 blood culture isolates (BC) and 58 isolates from routine diagnostic specimens (RD) from Glasgow Royal Infirmary (GRI), and 46 strains from nasal swabs of patients attending a general practitioner...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Coia JE,Browning L,Haines L,Birkbeck TH,Platt DJ

    更新日期:1992-03-01 00:00:00

  • Involvement of efflux mechanisms in biocide resistance of Campylobacter jejuni and Campylobacter coli.

    abstract::Active efflux has an important role in the antimicrobial resistance of Campylobacter jejuni and Campylobacter coli. The effects of two putative efflux pump inhibitors (EPIs), phenylalanine-arginine β-naphthylamide and 1-(1-naphthylmethyl)-piperazine, and the effects of inactivation of the cmeB,cmeF and cmeR genes on r...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Mavri A,Smole Možina S

    更新日期:2012-06-01 00:00:00

  • Evaluation of phospholipase activity of Candida albicans and its correlation with pathogenicity in mice.

    abstract::Sixty-one isolates of Candida albicans were tested for their phospholipase activity and this parameter was correlated with pathogenicity in albino mice. Of the isolates tested, 57 (93%) showed appreciable phospholipase activity and of these, 55 (90%) were pathogenic to mice. A significant correlation was found between...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Kothavade RJ,Panthaki MH

    更新日期:1998-02-01 00:00:00

  • Mycobacterium conceptionense infection complicating face rejuvenation with fat grafting.

    abstract::We report a third case of Mycobacterium conceptionense infection, which was found in a 50-year-old female following face rejuvenation surgery with fat grafting. The pathogen was identified using 16S rRNA gene and rpoB gene sequences. The growing diversity of non-tuberculosis mycobacterial species causing human infecti...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Yang HJ,Yim HW,Lee MY,Ko KS,Yoon HJ

    更新日期:2011-03-01 00:00:00

  • Candida auris: a comparison between planktonic and biofilm susceptibility to antifungal drugs.

    abstract::Introduction.Candida auris is a pathogenic yeast that mainly affects immunosuppressed patients and those with implanted medical devices. This pathogen also displays elevated resistance to common antifungals and high survival and spreading capacities. Since no antifungal breakpoints have yet been defined for this patho...

    journal_title:Journal of medical microbiology

    pub_type: 杂志文章


    authors: Romera D,Aguilera-Correa JJ,Gadea I,Viñuela-Sandoval L,García-Rodríguez J,Esteban J

    更新日期:2019-09-01 00:00:00