Abstract:
:The neuroendocrine system integrates genotype with external factors such as nutrition to regulate animal growth. To investigate the role of somatotropic axis in the interaction of genotype and nutrition, two series of experiments were conducted using broiler and layer chickens as a model. In the first experiment, both strains of chickens were raised on their respective standard diets and the mRNA expressions of somatotropic genes were investigated on day 5 (D5), D21, and D42 after hatching as composites of genotype and nutrition. The hypothalamic somatostatin (SS) and pituitary growth hormone (GH) mRNA expression as well as the plasma GH levels were higher in layer chickens while the opposite was true for hepatic GH receptor (GHR) mRNA. Regulation of GHR mRNA expression was found to be tissue-specific. Hepatic GHR mRNA content increased with age whereas in the muscle, the peak levels of expression were observed at D5 with significantly higher abundance ratio in the layer. To evaluate genotype-diet interaction on growth and the patterns of gene expression of both layer and broiler chickens, layers were fed broiler diet and vice versa from D1 to 42 in the second experiment. The D42 body weight of layer chickens increased by 35% when fed with broiler diet, whereas that of broiler chickens decreased by 51% when fed with layer food. The diet exchange completely reversed the patterns of hypothalamic SS and pituitary GH mRNA expression and the strain differences vanished when the comparison was made on the same diet basis. The hepatic GHR mRNA decreased by 46.1% in broilers fed with layer food, but increased by 45.6% in the layer fed with broiler diet. The strain differences were diminished but did not completely disappear on the same diet basis for hepatic GH receptor mRNA. In contrast, however, the muscle GHR mRNA expression was not affected by diet exchange and thus, was more genotype-specific. The results suggest that genes of the somatotropic axis respond to nutrition differently at the level of transcription.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Zhao R,Muehlbauer E,Decuypere E,Grossmann Rdoi
10.1016/j.ygcen.2003.11.009keywords:
subject
Has Abstractpub_date
2004-03-01 00:00:00pages
2-11issue
1eissn
0016-6480issn
1095-6840pii
S0016648003004064journal_volume
136pub_type
杂志文章abstract::Behavioral, biochemical, and electrophysiological studies suggest that the trihydroxylated progestin steroid, 4-pregnen-17,20beta,21-triol-3-one (20beta-S) stimulates oocyte maturation and pheromone release in the Eurasian ruffe, a freshwater percid fish. Behavioral observations found that female ruffe undergoing oocy...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2004.05.014
更新日期:2004-10-01 00:00:00
abstract::Chemical signals (both volatile and non-volatile) form the major communication channels in animals. These signals are transferred mainly through excretory sources to facilitate inter-individual communication. In particular, the reproductive cycle of female mammals, including goats, exhibits significant changes in the ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.07.028
更新日期:2014-09-15 00:00:00
abstract::Hormone-sensitive lipase (hsl) plays a pivotal role in regulation of lipolysis in mammals, but information is very scarce about its gene structure and function in fish. In this study, two distinct hsl cDNAs, designated hsl1 and hsl2, were firstly isolated and characterized from yellow catfish Pelteobagrus fulvidraco. ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.06.031
更新日期:2014-09-15 00:00:00
abstract::Rhythmic synthesis of moulting hormones (ecdysteroids) by prothoracic glands (PGs) of the insect Rhodnius prolixus during the last larval instar was studied in vitro following explantations every 4-5 hr for up to 96 hr. Ecdysteroid synthesis was measured by radioimmunoassay as the quantity of ecdysteroid produced duri...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(91)90102-c
更新日期:1991-07-01 00:00:00
abstract::In Sphaeroma serratum, the differentiation of the male external sexual characteristics, as a result of an androgenic gland implant, proceeds more easily in females in vitellogenesis than in immature females. On the contrary, the transformation of the gonads is quicker and more obvious in immature females than in matur...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(83)90250-2
更新日期:1983-04-01 00:00:00
abstract::Plasma glucagon levels in 11 different teleosts and in dogfish were evaluated using an adapted classical mammalian radioimmunoassay (RIA). The values obtained are considered relative; sensitivity was inferior to the original method, but the validation experiment results are acceptable. The mean value of the coefficien...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(86)90131-0
更新日期:1986-09-01 00:00:00
abstract::Stress-induced inhibition of innate immune activity has been observed in a variety of wild birds and may increase chances of infection because this activity constitutes the first line of defense against pathogens. We previously reported that the transient elevation of plasma corticosterone (CORT; the primary avian glu...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2019.02.002
更新日期:2019-05-01 00:00:00
abstract::Two types of cDNAs (GTH-I beta and -II beta) that encode the beta subunit of goldfish gonadotropin were cloned from a goldfish pituitary cDNA library. The nucleotide sequence of GTH-I beta cDNA was 616 bp long, encoding 130 amino acids, and that of GTH-II beta was 552 bp long, encoding 140 amino acids. These two types...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1996.6839
更新日期:1997-03-01 00:00:00
abstract::Only recently have the cardiac actions of parathyroid hormone and its N-terminal (1-34) fragment (bPTH(1-34] been examined. Parathyroid hormone was found to exert a positive chronotropic effect on the heart tissue of several mammals and one amphibian in vivo and/or in vitro. The purpose of the present study was to exa...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90037-6
更新日期:1984-11-01 00:00:00
abstract::Recently, we demonstrated high serum leptin and 25(OH)D (calcidiol) in obese animals, with high C/EBPβ and PPARγ expression in adipose tissue. Since the role of vitamin D in adipogenesis remains controversial and hyperleptinemia is found in obesity, we asked if leptin could interfere in vitamin D action on adipocytes....
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2018.01.014
更新日期:2018-09-15 00:00:00
abstract::The possible involvement of calcium in the regulation of steroidogenesis in the goldfish was investigated using preovulatory ovarian follicles incubated in vitro. Incubation of follicles in media deficient in calcium impaired testosterone production in response to human chorionic gonadotropin (hCG) in both the presenc...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(91)90011-t
更新日期:1991-02-01 00:00:00
abstract::Over the last decades, the corticosterone stress response has been suggested as a major physiological tool to understand what strategy an individual might adopt in response to environmental perturbations. More recently, another hormone related to parental care--prolactin--has been suggested as a complementary tool to ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2012.10.008
更新日期:2013-02-01 00:00:00
abstract::Insulin-like growth factor I (IGF-I) plays a key role in the complex system that regulates bony fish growth, differentiation, and reproduction. The major source of circulating IGF-I is liver, but IGF-I-producing cells also occur in other organs, including the gonads. Because no data are available on the potential prod...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2005.11.008
更新日期:2006-05-01 00:00:00
abstract::Catechol-O-methyltransferase (COMT) is involved in the methylation and inactivation of endogenous and xenobiotic catechol compounds, and serves as a common biochemical link in the catecholamine and catecholestrogen metabolism. Studies on cloning, sequencing and function characterization comt gene in lower vertebrates ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2016.12.001
更新日期:2017-05-15 00:00:00
abstract::Pregnancy and lactation are key times in the life of female mammals when energetic resources must be brought to bear to produce and nurture offspring. Changes in glucocorticoid (GC) levels are central to this objective, due to their roles in modulating development and physiology and in mediating energetic tradeoffs. W...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2015.11.004
更新日期:2016-06-01 00:00:00
abstract::Steroid hormones play an important role in modulating behavioral responses to various social stimuli. It has been suggested that variation in the hormonal regulation of behavior across species is associated with social organization and/or mating system. In order to further elucidate the interplay of hormones and behav...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2013.04.031
更新日期:2013-08-01 00:00:00
abstract::Isolated brain-retrocerebral neurohemal complex of the silkworm of Bombyx mori was stimulated electrically and the released bombyxin (an insulin-like neuropeptide) was measured using time-resolved fluoroimmunoassay. The amount of bombyxin release depended on the number of stimulus pulses delivered to the axonal tract ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2004.03.009
更新日期:2004-07-01 00:00:00
abstract::Four monoclonal antibodies (MA-5, MA-10, MA-20, and MA-51) and one polyclonal antibody (ARS-2) against human insulin receptor were used to immunoprecipitate the insulin receptor from several species which had been photolabeled with N epsilon B29-monoazido-benzoyl-[125I]iodoinsulin. All four monoclonal antibodies immun...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1006/gcen.1994.1093
更新日期:1994-06-01 00:00:00
abstract::Ghrelin, a peptide hormone produced by the stomach in mammals, stimulates growth hormone release and food intake. Recently, ghrelin was identified and characterized in chicken proventriculus and shown to stimulate growth hormone release but inhibit feed intake. The purpose of this work was to identify and further char...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2005.09.013
更新日期:2006-02-01 00:00:00
abstract::The distribution of melatonin was studied at midday and midnight in pigeon plasma, pineal, hypothalamus, eyes, Harderian glands, and duodenum. Tissue samples were homogenized, extracted with chloroform, evaporated, and measured by our melatonin radioimmunoassay (RIA). All the extracts gave dilution curves parallel to ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(85)90136-4
更新日期:1985-04-01 00:00:00
abstract::Growth hormone (GH) cells were investigated with the protein A-gold technique on the pituitary glands of tilapia (Sarotherodon mossambicus) and amago salmon (Oncorhynchus rhodurus). By the use of specific antiserum against tilapia GH to both species, the immunoreactive gold particles were demonstrated to be preferenti...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(85)90429-0
更新日期:1985-07-01 00:00:00
abstract::The Lottia gigantea genome was prospected for the presence of genes coding neuropeptides and neurohormones. Four genes code insulin-related peptides: two genes code molluscan insulin-like growth hormones, one gene an insulin very similar to vertebrate insulin, and the fourth a peptide related to drosophila insulin-lik...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2010.02.010
更新日期:2010-05-15 00:00:00
abstract::Thiouracil-induced hypothyroidism reduced the thymus weights of young chickens. Thyroid weights were greater in thiouracil-fed (TF) chicks, and the circulating levels of triiodothyronine and thyroxine were lower. Thiouracil treatment resulted in higher relative adrenal weights and serum corticosterone concentrations. ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(87)90157-2
更新日期:1987-08-01 00:00:00
abstract::The regulated secretory pathway is a hallmark of endocrine and neuroendocrine cells. This process comprises different sequential steps, including ER-associated protein synthesis, ER-to-Golgi protein transport, Golgi-associated posttranslational modification, sorting and packing of secretory proteins into carrier granu...
journal_title:General and comparative endocrinology
pub_type: 杂志文章,评审
doi:10.1016/j.ygcen.2011.08.017
更新日期:2012-01-01 00:00:00
abstract::Prolonged or frequent secretion of adrenal glucocorticoids in response to aversive stimuli can negatively impact reproduction. Because female southern white rhinoceros (Ceratotherium simum simum) reproduce poorly in captivity, we compared fecal corticosterone metabolite concentrations among parous, nulliparous, and ad...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2011.02.010
更新日期:2011-05-01 00:00:00
abstract::The developmental hypothesis proposes that the adrenocortical response to stress during postnatal development in birds should not develop when the benefits of elevated corticosterone do not outweigh the deleterious effects on growth and development. We tested three predictions developed from this hypothesis in free-li...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2010.06.009
更新日期:2010-09-15 00:00:00
abstract::Perchlorate, an environmental contaminant, disrupts normal functioning of the thyroid. We previously showed that perchlorate disrupts behavior and gonad development, and induces external morphological changes in a vertebrate model organism, the threespine stickleback. Whether perchlorate alters these phenotypes via a ...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2014.10.015
更新日期:2015-01-01 00:00:00
abstract::Intact White Leghorn chick embryos were treated daily (on Days 6-13) with bovine prolactin (PRL) or ovine growth hormone (GH) at doses of 4-10 micrograms/g embryo wet wt. A control group received an equal volume of avian saline. [Na+] and [Cl-] were determined in allantoic fluid samples taken on Days 10, 12, and 14, a...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(86)90059-6
更新日期:1986-06-01 00:00:00
abstract::The widespread use of P-nitrophenol (PNP) as a raw material in pesticides, medicines and dyes has led to environmental pollution. PNP is a well-known endocrine disruptor in mammals and quails. This study investigated the effects of long-term PNP exposure on the testicular development and semen quality of roosters. Pub...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/j.ygcen.2020.113656
更新日期:2021-01-15 00:00:00
abstract::The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhi...
journal_title:General and comparative endocrinology
pub_type: 杂志文章
doi:10.1016/0016-6480(84)90233-8
更新日期:1984-01-01 00:00:00