Abstract：
:Only recently have the cardiac actions of parathyroid hormone and its N-terminal (1-34) fragment (bPTH(1-34] been examined. Parathyroid hormone was found to exert a positive chronotropic effect on the heart tissue of several mammals and one amphibian in vivo and/or in vitro. The purpose of the present study was to examine in vitro the heart tissue of several lower vertebrates, particularly aquatic vertebrates, for responsiveness to bPTH(1-34) and, for comparative purposes, isoproterenol. Heart tissue (atrium or the entire heart) from all the animals studied (trout, mudpuppy, bullfrog tadpole, and adult bullfrog) responded to isoproterenol in a dose-dependent fashion with increased heart rate and contractile force. Only the atria from the adult bullfrog, however, responded in a similar manner to the administration of bPTH(1-34). In all cases propranalol (10(-6) M) was able to block both chronotropic and inotropic effects of isoproterenol but had no effect on the cardiac stimulation induced by bPTH(1-34) in the adult bullfrog atrium. The data suggests that cardiac responsiveness to bPTH(1-34) is associated with a terrestrial as opposed to an aquatic existence.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Furspan PB,Sham JS,Shew RL,Peng G,Pang PKdoi
10.1016/0016-6480(84)90037-6subject
Has Abstractpub_date
1984-11-01 00:00:00pages
246-51issue
2eissn
0016-6480issn
1095-6840journal_volume
56pub_type
杂志文章abstract：:The effect of an exogenous glucocorticoid on the lipid metabolism and fatty acid pattern of skeletal muscle in broiler chickens (Gallus gallus domesticus) was investigated in vivo and in vitro. Male Arbor Acres chickens were subjected to dexamethasone (DEX) treatment for 3days. We found that DEX retarded body growth, ...
journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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journal_title：General and comparative endocrinology
pub_type： 杂志文章,评审
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1016/0016-6480(83)90250-2
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journal_title：General and comparative endocrinology
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doi：10.1016/j.ygcen.2016.03.028
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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更新日期：1992-07-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
doi：10.1016/j.ygcen.2008.07.018
更新日期：2008-09-01 00:00:00
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journal_title：General and comparative endocrinology
pub_type： 杂志文章
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