当前位置： SCI文献检索 > GENERAL AND COMPARATIVE ENDOCRINOLOGY期刊下所有文献 > Biosynthesis and axonal transport of multiple molluscan insulin-related peptides by the neuroendocrine light green cells of Lymnaea stagnalis.

Biosynthesis and axonal transport of multiple molluscan insulin-related peptides by the neuroendocrine light green cells of Lymnaea stagnalis.

Abstract：

:The neuroendocrine light green cells (LGCs) control body growth and metabolism of the freshwater snail, Lymnaea stagnalis. These cells, located in the cerebral ganglia, use the peripheries of the median lip nerves (MLNs) as the neurohemal area. The LGCs express four members of a gene family encoding the precursors of distinct though related molluscan insulin-related peptides (MIPs). The molecular characterization and biosynthesis of MIPs have been investigated. MLN extracts were first size fractionated using gel permeation chromatography, and a major peak that coeluted with bovine insulin was further resolved using reverse phase high performance liquid chromatography. Amino acid composition analysis revealed that the four MIPs were present, as encoded by the MIP genes. Biosynthesis and axonal transport of the MIPs were studied in vitro with LGC systems in a series of pulse-chase incubations in combination with gel permeation chromatography analysis. During the pulse period of 20 min MIP precursors were formed in the LGC cell bodies. During the subsequent chase period these precursors were converted to MIPs and C peptides, which were transported to the LGC axon terminals in the MLNs for storage and release. The MIP precursors seem to be processed similarly to the insulin precursor in pancreatic islets.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Li KW,Geraerts WP,van Loenhout H,Joosse J

doi

10.1016/0016-6480(92)90152-a

keywords:

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

79-86

issue

1

eissn

0016-6480

issn

1095-6840

journal_volume

87

pub_type

杂志文章

相关文献

GENERAL AND COMPARATIVE ENDOCRINOLOGY文献大全
  • Sexual bipotentiality of behavior in male and female goldfish.

    abstract：:It is known that in goldfish Carassius auratus, a non-sex changing fish, prostaglandin (PG) treatment can induce female-typical sex behavior in males, and androgen treatment can induce male-typical sex behavior in females. These facts suggest that goldfish have a sexually bipotential brain even after attaining sexual ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2012.08.022

    authors： Saoshiro S,Kawaguchi Y,Hayakawa Y,Kobayashi M

    更新日期：2013-01-15 00:00:00

  • Identification and characterization of a catechol-o-methyltransferase cDNA in the catfish Heteropneustes fossilis: Tissue, sex and seasonal variations, and effects of gonadotropin and 2-hydroxyestradiol-17β on mRNA expression.

    abstract：:Catechol-O-methyltransferase (COMT) is involved in the methylation and inactivation of endogenous and xenobiotic catechol compounds, and serves as a common biochemical link in the catecholamine and catecholestrogen metabolism. Studies on cloning, sequencing and function characterization comt gene in lower vertebrates ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2016.12.001

    authors： Chaube R,Rawat A,Inbaraj RM,Bobe J,Guiguen Y,Fostier A,Joy KP

    更新日期：2017-05-15 00:00:00

  • Seasonal gonadal recrudescence in song sparrows: response to temperature cues.

    abstract：:Day length predicts changing of seasons at mid-latitudes, but additional environmental cues (e.g., temperature, rainfall) give more precise information about timing of food peaks critical for offspring survival. We tested the effects of temperature on seasonal reproductive development of male song sparrows (Melospiza ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2005.03.004

    authors： Perfito N,Meddle SL,Tramontin AD,Sharp PJ,Wingfield JC

    更新日期：2005-09-01 00:00:00

  • Involvement of Gαs-proteins in the action of relaxin-like gonad-stimulating substance on starfish ovarian follicle cells.

    abstract：:Gonad-stimulating substance (GSS) in starfish is the only known invertebrate peptide hormone responsible for final gamete maturation, rendering it functionally analogous to gonadotropins in vertebrates. In breeding season (stage V), GSS stimulates oocyte maturation to induce 1-methyladenine (1-MeAde) by ovarian follic...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2014.06.003

    authors： Mita M,Haraguchi S,Watanabe M,Takeshige Y,Yamamoto K,Tsutsui K

    更新日期：2014-09-01 00:00:00

  • Characterization of stress response involved in chicken myopathy.

    abstract：:Myopathies (Woody Breast (WB) and White Striping (WS)) of broiler chickens have been correlated with fast growth. Recent studies reported that localized hypoxia and metabolic impairment may involve in these myopathies of birds. In order to better understand the stress response mechanisms affecting myopathies of broile...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2020.113526

    authors： Kang SW,Kidd MT Jr,Kadhim HJ,Shouse S,Orlowski SK,Hiltz J,Anthony NB,Kuenzel WJ,Kong BC

    更新日期：2020-09-01 00:00:00

  • Docosahexaenoic acid induces PPARγ-dependent preadipocytes apoptosis in grass carp Ctenopharyngodon idella.

    abstract：:Our previous study showed that docosahexaenoic acid (DHA) plays an important role in decreasing lipid accumulation by inducing apoptosis of the adipocytes in grass carp. However, the mechanism involved remains unclear. DHA has been reported as the natural ligand of PPARγ. The present study aimed to assess whether PPAR...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.05.020

    authors： Jin A,Shi XC,Liu Y,Sun J,Ji H

    更新日期：2018-09-15 00:00:00

  • Developmental changes in the properties of gonadotropin receptors in the ovarian follicles of amago salmon (Oncorhynchus rhodurus) during oogenesis.

    abstract：:The presence of specific, saturable, high-affinity gonadotropin receptors was demonstrated in membrane preparations from preovulatory ovarian follicles of amago salmon (Oncorhynchus rhodurus), including intact follicles, isolated thecal layers, and isolated granulosa cells. Optimum conditions for the binding study usi...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(88)90177-3

    authors： Kanamori A,Nagahama Y

    更新日期：1988-10-01 00:00:00

  • Snow cover and snowfall impact corticosterone and immunoglobulin a levels in a threatened steppe bird.

    abstract：:Birds use both the corticosterone stress response and immune system to meet physiological challenges during exposure to adverse climatic conditions. To assess the stress level and immune response of the Asian Great Bustard during conditions of severe winter weather, we measured fecal corticosterone (CORT) and Immunogl...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.02.014

    authors： Liu G,Hu X,Kessler AE,Gong M,Wang Y,Li H,Dong Y,Yang Y,Li L

    更新日期：2018-05-15 00:00:00

  • Identification of 17,20β,21-trihydroxy-4-pregnen-3-one (20β-S) receptor binding and membrane progestin receptor alpha on southern flounder sperm (Paralichthys lethostigma) and their likely role in 20β-S stimulation of sperm hypermotility.

    abstract：:The existence of direct progestin actions on teleost sperm to stimulate hypermotility is not widely acknowledged because it has only been demonstrated in members of the family Sciaenidae. In the present study, progestin stimulation of sperm hypermotility was investigated in a non-sciaenid, southern flounder, and the p...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2010.12.005

    authors： Tubbs C,Tan W,Shi B,Thomas P

    更新日期：2011-02-01 00:00:00

  • Further EST analysis of endocrine genes that are preferentially expressed in the neural complex of Ciona intestinalis: receptor and enzyme genes associated with endocrine system in the neural complex.

    abstract：:Identification of orthologs of vertebrate neuropeptides and hypothalamic hormones in the neural complex of ascidians suggests integral roles of the ascidian neural complex in the endocrine system. In the present study, we investigated endocrine-related genes expressed in the neural complex of Ciona intestinalis. Compr...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2006.08.010

    authors： Sekiguchi T,Kawashima T,Satou Y,Satoh N

    更新日期：2007-01-15 00:00:00

  • Fecal corticosterone concentrations and reproductive success in captive female southern white rhinoceros.

    abstract：:Prolonged or frequent secretion of adrenal glucocorticoids in response to aversive stimuli can negatively impact reproduction. Because female southern white rhinoceros (Ceratotherium simum simum) reproduce poorly in captivity, we compared fecal corticosterone metabolite concentrations among parous, nulliparous, and ad...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2011.02.010

    authors： Metrione LC,Harder JD

    更新日期：2011-05-01 00:00:00

  • Photoperiodic regulation of plasma gonadotropin levels in previtellogenic greater amberjack (Seriola dumerili).

    abstract：:In Seriola species, exposure to a long photoperiod regime is known to induce ovarian development. This study examined photoperiodic effects on pituitary gene expression and plasma levels of follicle-stimulating hormone (Fsh) and luteinizing hormone (Lh) in previtellogenic greater amberjack (Seriola dumerili). The fish...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.09.007

    authors： Nyuji M,Hamada K,Kazeto Y,Mekuchi M,Gen K,Soyano K,Okuzawa K

    更新日期：2018-12-01 00:00:00

  • Effects of vertebrate prolactins and growth hormones on thyroxine 5'-monodeiodination in the eel (Anguilla anguilla): a potential bioassay for growth hormone.

    abstract：:Growth hormones (GHs) and prolactins (Prls) purified from representatives of each vertebrate class from bony fish onwards were tested for their ability to stimulate in vivo peripheral deiodination of labeled thyroxine (T4*) into triiodo-L-thyronine (T3*) in the eel. Plasma T3*/T4* ratio was used as parameter. All GHs ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(89)90091-9

    authors： de Luze A,Leloup J,Papkoff H,Kikuyama S,Kawauchi H

    更新日期：1989-02-01 00:00:00

  • Variation in thyroid response to thyroid-stimulating hormone in juvenile coho salmon (Oncorhynchus kisutch).

    abstract：:Changes in the circulating levels of thyroid hormones measured by radioimmunoassay in yearling coho salmon in response to injection of bovine thyroid-stimulating hormone (TSH) were evaluated from January through August. Doses of TSH ranging from 0.2 to 6.4 micrograms/g body wt were ineffective in stimulating T4 in Jan...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(87)90087-6

    authors： Swanson P,Dickhoff WW

    更新日期：1987-12-01 00:00:00

  • Use of ethanol for preserving steroid and indoleamine hormones in bird plasma.

    abstract：:Endocrinological research on wild animals inhabiting remote areas has been hampered by the need to store plasma samples at subzero temperatures. In an attempt to remedy this logistical issue, we here investigate the use of ethanol as an alternative to freezing for the preservation of steroid and indoleamine hormones i...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2006.09.014

    authors： Goymann W,Schwabl I,Trappschuh M,Hau M

    更新日期：2007-01-15 00:00:00

  • Melatonin counteracts the stimulatory effects of blinding or exposure to red light on reproduction in the skipper frog Rana cyanophlyctis.

    abstract：:An earlier study reported that blinding or exposure to red light stimulates reproduction in R. cyanophlyctis. The present study investigates whether melatonin counteracted blinding- or red-light-induced ovarian stimulation. The study consisted of two experiments carried out during the prebreeding (March/April) and bre...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1999.7443

    authors： Joshi BN,Udaykumar K

    更新日期：2000-04-01 00:00:00

  • Neurohormonal control of growth and carbohydrate metabolism by the light green cells in Lymnaea stagnalis.

    abstract：:The neuroendocrine light green cells (LGCs), 4 clusters of together approximately 150 giant neurons in the cerebral ganglia of the freshwater gastropod, Lymnaea stagnalis, have been suggested to be involved in the control of growth. The present study examines in greater detail this role and possible actions on energy ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(92)90068-u

    authors： Geraerts WP

    更新日期：1992-06-01 00:00:00

  • Anandamide modulates the expression of GnRH-II and GnRHRs in frog, Rana esculenta, diencephalon.

    abstract：:In the hypothalamus, endocannabinoids affect neuroendocrine activity by means of Gonadotropin-Releasing-Hormone-I (GnRH-I) inhibition. Since most vertebrates, human included, possess at least two GnRH molecular forms, the aim of this work was to investigate the effect of endocannabinoids on GnRH molecular forms other ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2011.07.001

    authors： Chianese R,Ciaramella V,Fasano S,Pierantoni R,Meccariello R

    更新日期：2011-09-15 00:00:00

  • Changes in hormone levels in relation to breeding behavior in male bullfrogs (Rana catesbeiana) at the individual and population levels.

    abstract：:Fluctuations in plasma androgen (testosterone and 5 alpha-dihydrotestosterone), corticosterone (B), and luteinizing hormone (LH) of male bullfrogs in central California were measured during the spring mating season. Androgen and LH levels generally increased in the population prior to the initiation of chorusing and e...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(85)90343-0

    authors： Mendonça MT,Licht P,Ryan MJ,Barnes R

    更新日期：1985-05-01 00:00:00

  • Teleost maturation-inducing hormone, 17,20β-dihydroxypregn-4-en-3-one, peaks after spawning in Tinca tinca.

    abstract：:During an eight month study of the reproductive cycle in two age groups, and in both sexes, of tench (Tinca tinca L.), it was found that plasma concentrations of the presumptive 'maturation inducing hormone (MIH)' 17,20β-dihydroxypregn-4-en-3-one (17,20β-P) did not reach a peak during the spawning season, but as much ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2011.03.008

    authors： Antonopoulou E,Tsikliras AC,Kocour M,Zlábek V,Flajšhans M,Gela D,Piačková V,Scott AP

    更新日期：2011-06-01 00:00:00

  • T3 fails to restore mitochondrial thiol redox status altered by experimental hypothyroidism in rat testis.

    abstract：:Oxidative stress impaired sperm function might lead to infertility. The objective of this study was to evaluate the effects of altered thyroid hormone levels on regulation of mitochondrial glutathione redox status and its dependent antioxidant defense system in adult rat testis and their correlation with testicular fu...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2010.07.014

    authors： Chattopadhyay S,Choudhury S,Roy A,Chainy GB,Samanta L

    更新日期：2010-10-01 00:00:00

  • In silico analysis, seasonal variation and gonadotropic regulation of jag1 and its receptor notch1 in testis of spotted snakehead Channa punctatus.

    abstract：:The present study in seasonally breeding spotted snakehead Channa punctatus, for the first time in nonmammalian vertebrates, demonstrated correlation between reproductive phase-dependent testicular expression of ligand Jag1/receptor Notch1 and spermatogenic events. Testicular transcriptome sequencing data from our ear...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.05.014

    authors： Roy A,Basak R,Rai U

    更新日期：2018-09-15 00:00:00

  • Gene expression during ovarian differentiation in parasitic and non-parasitic lampreys: implications for fecundity and life history types.

    abstract：:Lampreys diverged from the jawed vertebrate lineage approximately 500million years ago. Lampreys undergo sex differentiation much later than most other vertebrates, and ovarian differentiation occurs several years before testicular differentiation. The genetic basis of lamprey sex differentiation is of particular inte...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2014.08.019

    authors： Spice EK,Whyard S,Docker MF

    更新日期：2014-11-01 00:00:00

  • Receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide in turkey cerebral cortex: characterization by [125I]-VIP binding and effects on cyclic AMP synthesis.

    abstract：:Receptors for vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) in turkey cerebral cortex were characterized using two approaches: (1) in vitro radioreceptor binding of [125I]-VIP, and (2) effects of peptides from the PACAP/VIP/secretin family on cyclic AMP formation. T...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2004.03.007

    authors： Zawilska JB,Niewiadomski P,Nowak JZ

    更新日期：2004-06-01 00:00:00

  • Effects of glucocorticoids on cartilage growth and response to IGF-I in the tilapia (Oreochromis mossambicus).

    abstract：:To study the effects of glucocorticoids and IGF-I on the modulation of growth in the tilapia Oreochromis mossambicus, we employed an epiceratobranchial cartilage radioisotope incorporation assay, wherein radiolabeled sulfate and thymidine uptakes are measured in vitro to indicate proteoglycan synthesis and cell prolif...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.2000.7599

    authors： Datuin JP,Ng KP,Hayes TB,Bern HA

    更新日期：2001-03-01 00:00:00

  • Gonadotrophin-releasing hormone in winter flounder (Pseudopleuronectes americanus): molecular characterization, distribution and effects of fasting.

    abstract：:Gonadotrophin-releasing hormone (GnRH) is primarily related to reproductive processes in vertebrates. However other physiological roles, including functions in food intake regulation and energy status, have been demonstrated for GnRH in animals. The ten amino acid active peptide is relatively conserved throughout chor...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2012.12.010

    authors： Tuziak SM,Volkoff H

    更新日期：2013-04-01 00:00:00

  • Differences in binding characteristics of sex steroid binding protein in reproductive and nonreproductive female rainbow trout (Oncorhynchus mykiss), black bream (Acanthopagrus butcheri), and greenback flounder (Rhombosolea tapirina).

    abstract：:The binding characteristics of sex steroid binding protein (SBP) were investigated in vitellogenic and nonreproductive female rainbow trout (Oncorhynchus mykiss), black bream (Acanthopagrus butcheri), and greenback flounder (Rhombosolea tapirina). The binding capacity of rainbow trout and black bream SBP was significa...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.2000.7554

    authors： Hobby AC,Geraghty DP,Pankhurst NW

    更新日期：2000-12-01 00:00:00

  • Behavioral and hormonal basis of polygynous breeding in male bush warblers (Cettia diphone).

    abstract：:Plasma levels of testosterone and corticosterone were measured in free-living male bush warblers captured on their breeding ground at different times of the breeding season. Their territoriality was also estimated from their singing response to song playbacks. The pattern of change detected in the levels of plasma tes...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1999.7381

    authors： Wada M,Shimizu T,Kobayashi S,Yatani A,Sandaiji Y,Ishikawa T,Takemure E

    更新日期：1999-12-01 00:00:00

  • Ontogeny of insulin-like growth factors (IGF-I and IGF-II) and IGF-binding proteins in the chicken following hatching.

    abstract：:The present study examined plasma concentrations of insulin-like growth factor (IGF)-I, IGF-II and IGF-binding proteins (IGFBPs) during posthatch growth and development in chickens. Three distinct proteins which bound 125I-IGF-I were observed irrespective of age or sex, these having apparent molecular weights of 22, 2...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1997.6898

    authors： Radecki SV,Capdevielle MC,Buonomo FC,Scanes CG

    更新日期：1997-07-01 00:00:00

  • No evidence for sex-specific effects of the maternal social environment on offspring development in Japanese quail (Coturnix japonica).

    abstract：:The social environment of reproducing females can cause physiological changes, with consequences for reproductive investment and offspring development. These prenatal maternal effects are often found to be sex-specific and may have evolved as adaptations, maximizing fitness of male and female offspring for their futur...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.04.015

    authors： Langen EMA,von Engelhardt N,Goerlich-Jansson VC

    更新日期：2018-07-01 00:00:00