当前位置： SCI文献检索 > GENERAL AND COMPARATIVE ENDOCRINOLOGY期刊下所有文献 > Direct effects of neuropeptide nesfatin-1 on testicular spermatogenesis and steroidogenesis of the adult mice.

Direct effects of neuropeptide nesfatin-1 on testicular spermatogenesis and steroidogenesis of the adult mice.

Abstract：

:Recent studies have revealed nesfatin-1 as a hypothalamic neuropeptide, regulating food intake, energy expenditure and reproduction primarily by acting on the hypothalamic-pituitary-gonadal axis. Nesfatin-1 is also localized in several peripheral tissues including testes. However, functional significance of nesfatin-1 in testicular activities is not yet well documented in mammals. Therefore, this study was aimed to elucidate the direct effects of nesfatin-1 on testicular markers for steroid productions, spermatogenesis, metabolic changes and oxidative stress. The results revealed the expression of both protein and mRNA of nesfatin-1 in the testes of adult mice. The testes treated in vitro with nesfatin-1 showed significant increase in testosterone production, which correlated significantly with increased expression of steroidogenic markers and insulin receptor proteins in the testes. Furthermore, the in vitro treatment with nesfatin-1 showed stimulatory effects on spermatogenesis by promoting cell proliferation (PCNA) and survival (Bcl2), while inhibiting apoptosis (caspase-3) in the testes. The nesfatin-1 treatment in vitro further increased the expression of insulin receptor and GLUT8 proteins, in parallel with increase in the intra-testicular transport of glucose and production of lactate. This nesfatin-1 induced enhanced transport of energy substrate (glucose and lactate) may be responsible for promoting spermatogenesis and steroidogenesis. Nesfatin-1 significantly reduced oxidative stress and nitric oxide, which may also be responsible for stimulatory effects on testicular activities. The present finding suggests that nesfatin-1 acts via paracrine manner to increase sperm count and fertility, thus promoting the testicular function.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Ranjan A,Choubey M,Yada T,Krishna A

doi

10.1016/j.ygcen.2018.10.022

subject

Has Abstract

pub_date

2019-01-15 00:00:00

pages

49-60

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(18)30433-7

journal_volume

271

pub_type

杂志文章

相关文献

GENERAL AND COMPARATIVE ENDOCRINOLOGY文献大全
  • Seasonal patterns of sex steroids determined from feces in different social categories of Greylag geese (Anser anser).

    abstract：:Seasonal patterns of fecal 17beta-OH-androgen, estrogen, and progesterone equivalents of male and female greylag geese (Anser anser) were analyzed in a flock of free-living geese. These were compared among social categories determined by pairbond status and breeding success. The annual cycle was divided into 13 phases...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1998.7236

    authors： Hirschenhauser K,Möstl E,Kotrschal K

    更新日期：1999-04-01 00:00:00

  • GTH I and GTH II secretion profiles during the reproductive cycle in female rainbow trout: relationship with pituitary responsiveness to GnRH-A stimulation.

    abstract：:The recent purification of two gonadotropins, GTH I and GTH II, in teleost fish and the development of their specific radioimmunoassays using antibodies directed against their beta subunits have demonstrated that earlier assays for GTH II also measured GTH I. Most of the results on the gonadotropic control of reproduc...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1998.7088

    authors： Breton B,Govoroun M,Mikolajczyk T

    更新日期：1998-07-01 00:00:00

  • Hypothalamic indolamines during embryonic development and effects of steroid exposure.

    abstract：:The serotonin system has been implicated in the modulation of endocrine and behavioral components of reproduction. In this study, we examined endogenous hypothalamic indolamines during sexual differentiation and long-term effects of exogenous steroids during this time. In Experiment 1, Japanese quail were studied duri...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/s0016-6480(02)00524-5

    authors： Abdelnabi MA,Ottinger MA

    更新日期：2003-01-01 00:00:00

  • Neonatal handling alters the development of the adrenocortical response to stress in a wild songbird (eastern bluebird, Sialia sialis).

    abstract：:Neonatal handling of captive vertebrates can shape the development of their hypothalamo-pituitary-adrenal (HPA) axis and alter their ability to respond to stressful stimuli later in life. However, the long-term effects of such handling on this endocrine axis in free-living species are not well understood. We investiga...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2013.03.004

    authors： Lynn SE,Kern MD,Phillips MM

    更新日期：2013-06-01 00:00:00

  • Seasonal relationship between gonadotropin, growth hormone, and estrogen receptor mRNA expression in the pituitary gland of largemouth bass.

    abstract：:The objectives of this study were to investigate the seasonal changes in pituitary gonadotropins, growth hormone (GH), and estrogen receptor (ER) isoform mRNA in wild female and male largemouth bass (LMB) (Micropterus salmoides) from an unpolluted habitat to better understand reproductive physiology in this ecological...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2009.04.028

    authors： Martyniuk CJ,Kroll KJ,Porak WF,Steward C,Grier HJ,Denslow ND

    更新日期：2009-09-15 00:00:00

  • Characterization of spermatogonial cells and niche in the scorpion mud turtle (Kinosternon scorpioides).

    abstract：:Undifferentiated spermatogonia (Aund) or spermatogonial stem cells (SSCs) are committed to the establishment and maintenance of spermatogenesis and fertility throughout a male's life and are located in a highly specialized microenvironment called niche that regulates their fate. Although several studies have been deve...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.06.019

    authors： Costa GMJ,Sousa AL,Figueiredo AFA,Lacerda SMSN,França LR

    更新日期：2019-03-01 00:00:00

  • Opiate inhibition of growth hormone secretion in young chickens.

    abstract：:Plasma concentrations of growth hormone (GH) were decreased following the intravenous administration of morphine sulfate. Maximum inhibition of GH secretion was observed 40 min after morphine sulfate challenge. At this time, doses of morphine sulfate (at 5 mg and 50 mg/kg) reduced the GH concentrations by 86 and 90%, ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(87)90219-x

    authors： Harvey S,Scanes CG

    更新日期：1987-01-01 00:00:00

  • Role of cortisol in hypoosmoregulation in larvae of the tilapia (Oreochromis mossambicus).

    abstract：:The total cortisol content in tilapia was 55 pg immediately following fertilization, then decreased abruptly and maintained a lower level of 10-20 pg until hatching; after hatching the cortisol content increased to 50 pg by the 7th day. Fertilized eggs were incubated in either 32% saltwater or fresh water and sampled ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1993.1168

    authors： Hwang PP,Wu SM

    更新日期：1993-11-01 00:00:00

  • The type of spawning agent affects the egg composition during out-of-season spawning but not during in-season spawning in Eurasian perch, Perca fluviatilis.

    abstract：:The aim of the study was to verify the effect of various hormonal agents [human chorionic gonadotropin (hCG) and salmon gonadoliberine analogue (sGnRHa)] applied at different stages of maturity of the females [out-of-season (maturation stage I) and in-season spawning (maturation stages II and IV)] on the proximate com...

    journal_title：General and comparative endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.ygcen.2016.04.027

    authors： Żarski D,Palińska-Żarska K,Łuczyńska J,Krejszeff S

    更新日期：2017-05-01 00:00:00

  • Aspartic acid scanning mutation analysis of a goldfish growth hormone-releasing hormone (GHRH) receptor specific to the GHRHsalmon-like peptide.

    abstract：:Growth hormone-releasing hormone (GHRH) plays a pivotal role in the regulation of growth. The study of goldfish GHRH and its receptor is of particular interest as it is so far the only animal model in which two forms of GHRH-like (catfish-like and salmon-like) peptides coexist, and these peptides share only 30-40% of ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2004.09.010

    authors： Kee F,Ng SS,Vaudry H,Pang RT,Lau EH,Chan SM,Chow BK

    更新日期：2005-01-01 00:00:00

  • Natural variability and response interpretation of fecundity, vertebrate-like sex-steroid levels and energy status in the New Zealand mudsnail Potamopyrgus antipodarum (Gray).

    abstract：:Potamopyrgus antipodarum is a promising test organism that is often used in ecotoxicology, both in laboratory and field exposures. As no data are available on the physiological variation range of its life-traits and the biomarkers it uses, we studied the variation of fecundity, steroid levels and energy reserves over ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2011.03.011

    authors： Gust M,Mouthon J,Queau H,Dussart C,Buronfosse T,Garric J

    更新日期：2011-06-01 00:00:00

  • Identification, expression analysis, and functional characterization of motilin and its receptor in spotted sea bass (Lateolabrax maculatus).

    abstract：:Motilin (MLN), an interdigestive hormone secreted by endocrine cells of the intestinal mucosa, binds to a G protein-coupled receptor to exert its biological function of regulating gastrointestinal motility. In the present study, we identified the prepromotilin and mln receptor (mlnr) from the spotted sea bass, Lateola...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2019.02.013

    authors： Zhou Y,Qi X,Wen H,Zhang K,Zhang X,Li J,Li Y,Fan H

    更新日期：2019-06-01 00:00:00

  • A correlation of fecal volatiles and steroid hormone profiles with behavioral expression during estrous cycle of goat, Capra hircus.

    abstract：:Chemical signals (both volatile and non-volatile) form the major communication channels in animals. These signals are transferred mainly through excretory sources to facilitate inter-individual communication. In particular, the reproductive cycle of female mammals, including goats, exhibits significant changes in the ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2014.07.028

    authors： SankarGanesh D,Ramachandran R,Muniasamy S,Saravanakumar VR,Suriyakalaa U,Kannan S,Archunan G,Achiraman S

    更新日期：2014-09-15 00:00:00

  • Molecular cloning, molecular evolution and gene expression of cDNAs encoding thyrotropin-releasing hormone receptor subtypes in a teleost, the sockeye salmon (Oncorhynchus nerka).

    abstract：:Molecular cloning of thyrotropin-releasing hormone receptors (TRHR) was performed in a teleost, the sockeye salmon (Oncorhynchus nerka). Four different TRHR cDNAs were cloned and named TRHR1, TRHR2a, TRHR2b and TRHR3 based on their similarity to known TRHR subtypes in vertebrates. Important residues for TRH binding we...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2011.07.011

    authors： Saito Y,Mekuchi M,Kobayashi N,Kimura M,Aoki Y,Masuda T,Azuma T,Fukami M,Iigo M,Yanagisawa T

    更新日期：2011-11-01 00:00:00

  • Effects of serotonin on gonadotropin and growth hormone release from in vitro perifused goldfish pituitary fragments.

    abstract：:The effects of serotonin (5-HT) on gonadotropin and growth hormone release from perifused goldfish (Carassius auratus, L.) pituitary glands were studied. Serotonin, at micromolar concentrations, caused a dose-related release of gonadotropin and an inhibition of growth hormone release in pituitaries from goldfish at di...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(91)90301-l

    authors： Somoza GM,Peter RE

    更新日期：1991-04-01 00:00:00

  • Isolation and characterization of a mRNA encoding a novel insulin receptor (IR) subtype, IR2, from rainbow trout (Oncorhynchus mykiss) and patterns of expression of the four IR subtypes, IR1-IR4, in tissues and during embryonic development.

    abstract：:Insulin (INS) plays a critical role in the growth, development, and metabolism of vertebrates. In this study, a cDNA encoding a novel insulin receptor (IR) subtype was isolated, cloned, and sequenced from the liver of rainbow trout. A 1525-bp cDNA encoding a partial amino acid sequence of the β-subunit including the t...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2010.09.005

    authors： Caruso MA,Blaufuss PC,Kittilson JD,Raine J,Sheridan MA

    更新日期：2010-12-01 00:00:00

  • Food intake, growth, and expression of neuropeptides regulating appetite in clown anemonefish (Amphiprion ocellaris) exposed to predicted climate changes.

    abstract：:The clown anemonefish (Amphiprion ocellaris) is a common model species in studies assessing the impact of climate changes on tropical coral fish physiology, metabolism, growth, and stress. However, the basic endocrine principles for the control of food intake and energy homeostasis, under normal and elevated sea tempe...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2021.113719

    authors： Pham LP,Olderbakk Jordal AE,Nguyen MV,Rønnestad I

    更新日期：2021-01-18 00:00:00

  • Developmental exposure to endocrine disruptor chemicals alters follicular dynamics and steroid levels in Caiman latirostris.

    abstract：:Human and wildlife are exposed at critical periods of development to endocrine disruptor chemicals (EDC) that may be responsible for reproductive disorders. To test the hypothesis that in ovum exposure to EDC at a critical period for gonadal organogenesis alters post-hatching folliculogenesis and steroidogenesis in Ca...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2008.02.011

    authors： Stoker C,Beldoménico PM,Bosquiazzo VL,Zayas MA,Rey F,Rodríguez H,Muñoz-de-Toro M,Luque EH

    更新日期：2008-05-01 00:00:00

  • In- and outdoor reproduction of first generation common sole Solea solea under a natural photothermal regime: Temporal progression of sexual maturation assessed by monitoring plasma steroids and gonadotropin mRNA expression.

    abstract：:Reproduction of many temperate fishes is seasonal and maturation and spawning of gametes are under photothermal control. Reproductive success of first generation (G1) common sole Solea solea in captivity has been low. In this study, the sexual maturation status has been assessed during the prespawning months in G1 sol...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2014.12.004

    authors： Palstra AP,Blok MC,Kals J,Blom E,Tuinhof-Koelma N,Dirks RP,Forlenza M,Blonk RJ

    更新日期：2015-09-15 00:00:00

  • Molecular cloning of an estrogen receptor beta subtype from the goldfish, Carassius auratus.

    abstract：:The brain of many teleost fish species, including the goldfish Carassius auratus, expresses exceptionally high levels of cytochrome P450 aromatase (estrogen synthetase). To begin investigating the molecular and cellular targets of estrogen action in goldfish brain, a polymerase chain reaction (PCR) cloning strategy wa...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1998.7217

    authors： Tchoudakova A,Pathak S,Callard GV

    更新日期：1999-03-01 00:00:00

  • Reproduction in worker honey bees is associated with low juvenile hormone titers and rates of biosynthesis.

    abstract：:Three experiments were performed to determine the role of juvenile hormone (JH) in worker reproduction in queenless colonies of honey bees. In Experiment 1, egg-laying workers had low hemolymph titers of JH, as did bees engaged in brood care, while foragers had significantly higher titers. Experiment 2 confirmed these...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(92)90055-o

    authors： Robinson GE,Strambi C,Strambi A,Huang ZY

    更新日期：1992-09-01 00:00:00

  • Participation of the cytoskeleton in avian granulosa cell steroidogenesis.

    abstract：:Cytochalasin B (CB) and the more specific cytochalasin D (CD), disruptors of microfilament polymerization, and colchicine, an inhibitor of microtubule polymerization, were studied for their effects on cAMP and steroid production in granulosa cells of domestic fowl. Each agent was incubated with freshly dispersed cells...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(91)90310-3

    authors： Iczkowski KA,Hertelendy F

    更新日期：1991-06-01 00:00:00

  • Effects of thyroxin, cortisol, growth hormone, and prolactin on lipid metabolism of coho salmon, Oncorhynchus kisutch, during smoltification.

    abstract：:Juvenile coho salmon, Oncorhynchus kisutch, were either immersed in thyroxin-containing water (T4; 20 micrograms/ml) or implanted with cortisol (5 mg), bovine growth hormone (GH; 1.5 microgram/g body wt), or ovine prolactin (PRL; 1.5 microgram/g body wt), both early and late in smoltification. T4 and cortisol treatmen...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(86)90007-9

    authors： Sheridan MA

    更新日期：1986-11-01 00:00:00

  • Protein kinase-C mediates chicken vasoactive intestinal peptide stimulated prolactin secretion and gene expression in turkey primary pituitary cells.

    abstract：:This set of experiments investigated the role of protein kinase-C (PKC) as a second messenger in vasoactive intestinal peptide (VIP)-stimulated prolactin (PRL) secretion and PRL mRNA abundance. Dispersed anterior pituitary cells (5 x 10(5) or 10(6) cells/tube) were isolated from laying turkeys and incubated in 1.0 ml ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1995.1112

    authors： Sun S,el Halawani ME

    更新日期：1995-09-01 00:00:00

  • The effect of prolactin on calcium homeostasis in coho salmon (Oncorhynchus kisutch).

    abstract：:The response of plasma prolactin (PRL) to manipulations of plasma calcium were investigated in coho salmon. Injection of 3.16 mumol EGTA/10 g body weight (to reduce the plasma calcium activity) resulted in significantly higher plasma PRL levels. Lower doses of EGTA (1.06 and 2.13 mumol/10 g body wt) had no effect on p...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(89)90197-4

    authors： Fargher RC,McKeown BA

    更新日期：1989-03-01 00:00:00

  • Isolation and structural characterisation of herring gull (Larus argentatus) pancreatic polypeptide.

    abstract：:Pancreatic polypeptide (PP) has been isolated from pancreatic extracts of the herring gull (Larus argentatus) using a radioimmunoassay employing an antiserum (PP 221), generated to the conserved C-terminal hexapeptide amide of mammalian PP. Gel permeation and reverse-phase HPLC fractionation of crude pancreatic extrac...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1994.1029

    authors： Barton CL,Shaw C,Halton DW,Thim L

    更新日期：1994-02-01 00:00:00

  • Rainbow trout (Oncorhynchus mykiss) urotensin-I: structural differences between urotensins-I and urocortins.

    abstract：:In bony fishes, both corticotropin-releasing factor (CRF) and urotensin-I play a role in the regulation of interrenal glucocorticoid release. The rainbow trout, Oncorhynchus mykiss, is a useful model for understanding the mechanisms of stress and the hypothalamo-pituitary-interrenal axis because of its phylogenetic po...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1999.7290

    authors： Barsyte D,Tipping DR,Smart D,Conlon JM,Baker BI,Lovejoy DA

    更新日期：1999-08-01 00:00:00

  • Higher growth rate and gene expression in male zebra finch embryos are independent of manipulation of maternal steroids in the eggs.

    abstract：:Sexual dimorphism in prenatal development is widespread among vertebrates, including birds. Its mechanism remains unclear, although it has been attributed to the effect of maternal steroid hormones. The aim of this study was to investigate how increased levels of steroid hormones in the eggs influence early embryonic ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2017.09.004

    authors： Lutyk D,Tagirov M,Drobniak S,Rutkowska J

    更新日期：2017-12-01 00:00:00

  • Hypothyroidism induced by postnatal PTU (6-n-propyl-2-thiouracil) treatment decreases Sertoli cell number and spermatogenic efficiency in sexually mature pigs.

    abstract：:Studies with 6-n-propyl-2-thiouracil (PTU) in laboratory rodents have shown that transient neonatal hypothyroidism leads to increased Sertoli cell (SC) number, testis size and sperm production. However, scarce and inconclusive data are available for farm animals. In the present study, Piau pigs received PTU in a gel c...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2020.113593

    authors： Lara NLM,Silva VA Jr,Chiarini-Garcia H,Garcia SK,Debeljuk L,Hess RA,França LR

    更新日期：2020-12-01 00:00:00

  • Tissue-specific regulation of the growth hormone/insulin-like growth factor axis during fasting and re-feeding: Importance of muscle expression of IGF-I and IGF-II mRNA in the tilapia.

    abstract：:The effects of prolonged nutrient restriction (fasting) and subsequent restoration (re-feeding) on the growth hormone (GH)/insulin-like growth factor (IGF) axis were investigated in the tilapia (Oreochromis mossambicus). Mean weight and specific growth rate declined within 1 week in fasted fish, and remained lower tha...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2009.11.012

    authors： Fox BK,Breves JP,Davis LK,Pierce AL,Hirano T,Grau EG

    更新日期：2010-05-01 00:00:00