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Developmental exposure to endocrine disruptor chemicals alters follicular dynamics and steroid levels in Caiman latirostris.

Abstract：

:Human and wildlife are exposed at critical periods of development to endocrine disruptor chemicals (EDC) that may be responsible for reproductive disorders. To test the hypothesis that in ovum exposure to EDC at a critical period for gonadal organogenesis alters post-hatching folliculogenesis and steroidogenesis in Caiman latirostris, we studied the impact of in ovum exposure to 17 beta-estradiol (E2), bisphenol A (BPA), endosulfan (END) and atrazine (ATZ) on gonadal differentiation, follicular dynamics and circulating levels of steroid hormones in neonatal and juvenile caiman. Since C. latirostris is a species with temperature dependent sex determination, eggs were incubated at male (33 degrees C) or female (30 degrees C) producing temperatures and the effect of EDC was evaluated. Neonatal ovaries exhibited germ cells mainly located in clusters evidencing proliferative activity and type I to III follicles. Juvenile ovaries exhibited germ cells and advanced stages of pre-vitellogenic follicles. Prenatal exposure to the highest doses of E2 (1.4 ppm) or BPA (140 ppm) overrode male temperature effect on sex determination. Neonatal females produced by sex reversion lacked type III follicles, while females prenatally exposed to the lowest doses of E2 (0.014 ppm) and BPA (1.4 ppm) or ATZ (0.2 ppm) showed an increase in type III follicles. Juvenile caiman prenatally exposed to E2 or BPA showed an augmented incidence of multioocyte follicles. Neonatal female caiman exposed in ovum to E2 or BPA had higher estrogen serum levels whereas exposure to E2, BPA, ATZ and END decreased T levels. Present data demonstrates that exposure to EDC during gonadal organogenesis alters follicular dynamics and steroid levels later in life. These effects might have an impact on caiman fertility.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Stoker C,Beldoménico PM,Bosquiazzo VL,Zayas MA,Rey F,Rodríguez H,Muñoz-de-Toro M,Luque EH

doi

10.1016/j.ygcen.2008.02.011

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

603-12

issue

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(08)00086-5

journal_volume

156

pub_type

杂志文章

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Developmental exposure to endocrine disruptor chemicals alters follicular dynamics and steroid levels in Caiman latirostris.