Abstract:
:Tadpoles of Rana catesbeiana at TK stages X-XII, about 9 months old, were laparotomized, and the males were implanted intraperitoneally with silastic tubes containing estradiol (E2) for various periods. Male tadpoles implanted with empty tubes served as the controls. Histology, secretions of E2, and testosterone (T) in the gonads were investigated. A rough estimate of estradiol released from silastic tubes suggested that about 90 micrograms per tadpole in 6 months. Histological observation revealed various degrees of transformation from testes toward ovaries in E2-treated testes. Ten in thirteen (77%), the testes were transformed into ovaries 6 months after the treatment. The testes of the controls, however, displayed normal histology. Radioimmunoassay showed that E2 level was increased while T level was decreased in E2-treated testes. These results indicate that a low dose of exogenous E2 may induce transformation of the testes into ovaries.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Chang LT,Yu NW,Hsu CY,Liu HWdoi
10.1006/gcen.1996.0073subject
Has Abstractpub_date
1996-06-01 00:00:00pages
299-306issue
3eissn
0016-6480issn
1095-6840pii
S0016-6480(96)90073-8journal_volume
102pub_type
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journal_title:General and comparative endocrinology
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journal_title:General and comparative endocrinology
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abstract::Gonadotropin-releasing hormones (GnRH) constitute a family of neuropeptides which are important regulators of reproduction in vertebrates. The effect of mammalian GnRH (mGnRH), salmon GnRH, chicken GnRH-I, chicken GnRH-II, and lamprey GnRH-I on [3H]thymidine incorporation into DNA of dissociated gonadal cells of marin...
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