Abstract:
:Biologically active recombinant yellowtail kingfish follicle stimulating hormone (rytkFsh) was produced in yeast Pichia pastoris and its biological activity was demonstrated by both in-vitro and in-vivo bioassays. Incubation of ovarian and testicular fragments with the recombinant hormone stimulated E2 and 11-KT secretion, respectively. In-vivo trial in immature female YTK resulted in a significant increase of plasma E2 levels and development of oocytes. In males at the early stages of puberty, advancement of spermatogenesis was observed, however plasma 11-KT levels were reduced when administered with rytkFsh.
journal_name
Gen Comp Endocrinoljournal_title
General and comparative endocrinologyauthors
Sanchís-Benlloch PJ,Nocillado J,Ladisa C,Aizen J,Miller A,Shpilman M,Levavi-Sivan B,Ventura T,Elizur Adoi
10.1016/j.ygcen.2016.03.001subject
Has Abstractpub_date
2017-01-15 00:00:00pages
41-49eissn
0016-6480issn
1095-6840pii
S0016-6480(16)30045-4journal_volume
241pub_type
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