Estrogen prevents cardiac and vascular failure in the 'listless' zebrafish (Danio rerio) developmental model.

Abstract:

:The presence of a robust estrogen (E2) response system throughout heart and blood vessel tissues of vertebrates, including humans, has led to the speculation that this ubiquitous hormone may play a prominent role in the health and maintenance of the adult cardiovascular system (CVS). We previously established an embryonic zebrafish model called 'listless', which results from the inhibition of E2 synthesis by treatment with aromatase enzyme inhibitors (AI). These fish have outward symptoms similar to the human condition of congestive heart failure and tamponade. E2 replacement therapy (1) reduced the severity of cardiac sac abnormalities, (2) protected heart function, (3) prevented reduction in heart size, and (4) reduced blood vessel deterioration. Nitric oxide may be a critical downstream mediator of these events. We also demonstrate that removal of fluid around the heart increases survival of AI-treated fish. These results strongly indicate the importance of E2 in the developing CVS of the zebrafish and offer a potential model for the study of its role in CVS development, maintenance, and disease conditions.

journal_name

Gen Comp Endocrinol

authors

Allgood OE Jr,Hamad A,Fox J,Defrank A,Gilley R,Dawson F,Sykes B,Underwood TJ,Naylor RC,Briggs AA,Lassiter CS,Bell WE,Turner JE

doi

10.1016/j.ygcen.2013.04.016

subject

Has Abstract

pub_date

2013-08-01 00:00:00

pages

33-42

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(13)00192-5

journal_volume

189

pub_type

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