当前位置： SCI文献检索 > GENERAL AND COMPARATIVE ENDOCRINOLOGY期刊下所有文献 > Rodent insulin receptors are immunologically different from other mammalian insulin receptors.

Rodent insulin receptors are immunologically different from other mammalian insulin receptors.

Abstract：

:Four monoclonal antibodies (MA-5, MA-10, MA-20, and MA-51) and one polyclonal antibody (ARS-2) against human insulin receptor were used to immunoprecipitate the insulin receptor from several species which had been photolabeled with N epsilon B29-monoazido-benzoyl-[125I]iodoinsulin. All four monoclonal antibodies immunoprecipitated human insulin receptor from human placental membranes. MA-10 and MA-51, but not MA-5 or MA-20, immunoprecipitated insulin receptors from liver plasma membranes of rabbit, guinea pig, dog, cattle, pig, and chicken. None of the monoclonal antibodies immunoprecipitated insulin receptors of rat, mouse, hamster, or chinchilla. In contrast, all of the insulin receptors were immunoprecipitated by the polyclonal anti-insulin receptor antibody, ARS-2. MA-10 and MA-51 compared with [125I]iodoinsulin for binding to guinea pig and rabbit liver plasma membranes in a fashion similar to insulin, although less effectively. MA-51 also mimicked the action of insulin by stimulating lipogenesis and autophosphorylation of the insulin receptor beta subunit in isolated rabbit adipocytes. The results suggest that insulin receptors of mammals, other than rodent, share with human insulin receptor the same epitope(s) recognized by MA-10 and MA-51. Rodent insulin receptors, with the exception of guinea pig, are different. We speculate that the difference lies in the amino acid sequence 485-599 of the alpha subunit of the insulin receptor.

journal_name

Gen Comp Endocrinol

journal_title

General and comparative endocrinology

authors

Tong ZQ,Jack E,Moule M,Goldfine ID,Yip CC

doi

10.1006/gcen.1994.1093

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

374-81

issue

3

eissn

0016-6480

issn

1095-6840

pii

S0016-6480(84)71093-8

journal_volume

94

pub_type

杂志文章

相关文献

GENERAL AND COMPARATIVE ENDOCRINOLOGY文献大全
  • Retinal modulation of the hypothalamic sensitivity to testosterone feedback in photoperiodism of quail.

    abstract：:This experiment was performed on two groups of male Japanese quail. One had been maintained in our laboratory as a closed colony (S-group), and the other had been obtained from a commercial source (R-group). Different responses of gonadal function were found between two groups following either testosterone treatment o...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(85)90390-9

    authors： Konishi H,Wada M,Homma K

    更新日期：1985-09-01 00:00:00

  • Sex steroids stimulate leptin gene expression in Atlantic salmon parr hepatocytes in vitro.

    abstract：:In mammals, leptin plays an important role in puberty and reproduction and leptin is regulated by sex steroids. Elevated leptin levels have been associated with sexual maturation in some teleosts such as Atlantic salmon. In the present study, primary cultures of Atlantic salmon hepatocytes were used to investigate the...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2015.01.015

    authors： Trombley S,Rocha A,Schmitz M

    更新日期：2015-09-15 00:00:00

  • Different actions of ecdysis-triggering hormone on the brain and ventral nerve cord of the hornworm, Manduca sexta.

    abstract：:Ecdysis, or the shedding of the old cuticle, depends on coordinated stereotyped behaviors, regulated by a number of neuropeptides. In the hornworm, Manduca sexta, two neuropeptides interact, namely ecdysis-triggering hormone (ETH) and eclosion hormone. We looked at the effects of ETH in vivo and in vitro, on the brain...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2009.08.008

    authors： Asuncion-Uchi M,El Shawa H,Martin T,Fuse M

    更新日期：2010-03-01 00:00:00

  • Autotransplantation of avian parathyroid glands: an animal model for studying parathyroid function.

    abstract：:The parathyroid glands of chickens were autotransplanted and the return of parathyroid function following transplantation was determined. Parathyroidectomy (PTX) resulted in a marked hypocalcemia (5.2 +/- 0.2 mg/dl) 4 hr following PTX. Plasma calcium (PCa) had declined to 4.3 +/- 0.2 mg/dl 24 hr after PTX. Parathyroid...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(89)90142-1

    authors： Cole JA,Forte LR,Thorne PK,Poelling RE,Krause WJ

    更新日期：1989-12-01 00:00:00

  • Frog brain and liver show evolutionary conservation of tissue-specific differences among insulin receptors.

    abstract：:The insulin receptors of frog brain and liver show features typical of other insulin receptors with regard to affinity and specificity of binding to insulins and proinsulin, solubility in Triton X-100, binding to and elution from wheat germ agglutinin, and insulin-sensitive tyrosine kinase activity. Likewise, the brai...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(87)90026-8

    authors： Hart C,Shemer J,Penhos JC,Lesniak MA,Roth J,LeRoith D

    更新日期：1987-11-01 00:00:00

  • In vitro effects of thyroid hormones on gonadotropin-induced estradiol-17 beta secretion by ovarian follicles of rainbow trout, Salmo gairdneri.

    abstract：:Ovarian follicles isolated from rainbow trout during early exogenous vitellogenesis were used to study the in vitro effects of thyroid hormones on salmon gonadotropin (GtH)-induced estradiol-17 beta (E2) secretion. Triiodothyronine (T3) alone did not alter E2 secretion but T3 in the presence of GtH (0.5 micrograms/ml)...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(88)90055-x

    authors： Cyr DG,Eales JG

    更新日期：1988-01-01 00:00:00

  • High temperature attenuates testicular responses in tree sparrow (Passer montanus).

    abstract：:The majority of birds use environmental cues to time their reproduction. Photoperiod is the most dominant cue, but other environmental factors may play a critical role in successful reproduction. Some previous studies show the effect of temperature on the timing of nest building and reproduction. Here we tested if the...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2020.113654

    authors： Renthlei Z,Hmar L,Kumar Trivedi A

    更新日期：2021-01-15 00:00:00

  • Glucose stimulates the release of bombyxin, an insulin-related peptide of the silkworm Bombyx mori.

    abstract：:The effects of starvation and feeding on the release of bombyxin, a peptide of insulin superfamily in insects, from the larval brain of the silkworm Bombyx mori were investigated. Following starvation, the bombyxin titer in the hemolymph of larvae decreased, whereas its content in the brain increased. On the other han...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1999.7438

    authors： Masumura M,Satake S,Saegusa H,Mizoguchi A

    更新日期：2000-06-01 00:00:00

  • Biological indices, energy reserves, steroid hormones and sexual maturity in the infaunal bivalve Scrobicularia plana from three sites differing by their level of contamination.

    abstract：:The aim of this work was to investigate in situ biometric (condition index, hepato-somatic index, gonado-somatic index), biochemical (glycogen, lipids, sexual steroids) and histological (sex, sexual maturation stage) variables in the infaunal bivalve Scrobicularia plana. First, the reproductive cycle of S. plana was a...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2008.04.010

    authors： Mouneyrac C,Linot S,Amiard JC,Amiard-Triquet C,Métais I,Durou C,Minier C,Pellerin J

    更新日期：2008-06-01 00:00:00

  • Thyroidectomy prevents the development of photorefractoriness and the associated rise in plasma prolactin in starlings.

    abstract：:Intact and radiothyroidectomized male starlings were transferred from short (8-hr) to long (16-hr) day lengths and measurements made of testicular development and of plasma prolactin concentrations. In intact birds the testes reached full maturity within 3 weeks and regressed after 6 weeks of photostimulation, indicat...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(84)90179-5

    authors： Goldsmith AR,Nicholls TJ

    更新日期：1984-05-01 00:00:00

  • Thyroid and annual gonad development, body weight, plumage pigmentation, and bill color cycles of lal munia, Estrilda amandava.

    abstract：:Long-term administration of L-thyroxine (T4) in the wax bill (lal munia) inhibited the current gonad development cycle, and the increase in gonadal volume in the second cycle was suppressed only by higher concentrations. Gonadal inhibition by high but not by low doses of L-T4 was associated with a failure in the devel...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(84)90124-2

    authors： Thapliyal JP,Gupta BB

    更新日期：1984-07-01 00:00:00

  • Reproduction in worker honey bees is associated with low juvenile hormone titers and rates of biosynthesis.

    abstract：:Three experiments were performed to determine the role of juvenile hormone (JH) in worker reproduction in queenless colonies of honey bees. In Experiment 1, egg-laying workers had low hemolymph titers of JH, as did bees engaged in brood care, while foragers had significantly higher titers. Experiment 2 confirmed these...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(92)90055-o

    authors： Robinson GE,Strambi C,Strambi A,Huang ZY

    更新日期：1992-09-01 00:00:00

  • The effect of prolactin on calcium homeostasis in coho salmon (Oncorhynchus kisutch).

    abstract：:The response of plasma prolactin (PRL) to manipulations of plasma calcium were investigated in coho salmon. Injection of 3.16 mumol EGTA/10 g body weight (to reduce the plasma calcium activity) resulted in significantly higher plasma PRL levels. Lower doses of EGTA (1.06 and 2.13 mumol/10 g body wt) had no effect on p...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(89)90197-4

    authors： Fargher RC,McKeown BA

    更新日期：1989-03-01 00:00:00

  • Gastroenteropancreatic hormones (insulin, glucagon, somatostatin, and multiple forms of PYY) from the pallid sturgeon, Scaphirhynchus albus (Acipenseriformes).

    abstract：:Insulin, glucagon, somatostatin-14, and three structurally related molecular forms of peptide tyrosine-tyrosine (PYY) were isolated from an extract of the combined pancreas and gastrointestinal tract of the pallid sturgeon, Scaphirhynchus albus. Pallid sturgeon insulin was identical to insulin from the Russian sturgeo...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.2000.7571

    authors： Kim JB,Gadsbøll V,Whittaker J,Barton BA,Conlon JM

    更新日期：2000-12-01 00:00:00

  • Molecular identification, tissue distribution and functional analysis of somatostatin receptors (SSTRs) in red-spotted grouper (Epinephelus akaara).

    abstract：:In the present study, four full-length cDNAs of somatostatin receptor (sstr) were cloned from the forebrain and pituitary of red-spotted grouper. The four full-length cDNAs were designated 2292, 1522, 1873 and 1789 bp and identified as sstr1, sstr2, sstr3, and sstr5 by BLAST analysis; the corresponding sizes of the op...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2019.01.007

    authors： Zhang Y,Tang Z,Lin W,Yuan X,Jia J,Sun C,Li W

    更新日期：2019-04-01 00:00:00

  • Immunochemical and immunocytochemical studies of the crustacean vitellogenesis-inhibiting hormone (VIH).

    abstract：:Immunochemical investigations, using dot immunobinding assay (DIA) and enzyme-linked immunosorbent assay (ELISA), and immunocytochemical studies reveal the following new information about crustacean vitellogenesis-inhibiting hormone (VIH): (1) The structure of VIH is sufficiently different from that of the other sinus...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(87)90187-0

    authors： Meusy JJ,Martin G,Soyez D,van Deijnen JE,Gallo JM

    更新日期：1987-09-01 00:00:00

  • Induction of gamete release by gonadotropin-releasing hormone in a protochordate, Ciona intestinalis.

    abstract：:Gonadotropin-releasing hormone (GnRH) of vertebrates is now believed to have multiple functions in addition to its role as a hypophysiotropic hormone, as originally defined. Recently, it has been shown that GnRH occurs also in the ascidians, which are considered ancestral chordates. Here the author shows that GnRH ind...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.2001.7728

    authors： Terakado K

    更新日期：2001-12-01 00:00:00

  • Characterization of hyperglycemic and molt-inhibiting activity from sinus glands of the penaeid shrimp Penaeus vannamei.

    abstract：:To design a homologous bioassay for the molt-inhibiting hormone and the crustacean hyperglycemic hormone of the shrimp Penaeus vannamei, the effect of sinus gland homogenate (SGh), in vitro, on ecdysteroid production by Y-organs (YOs), and the effect of the injection of SGh, in vivo, on the glycemia of shrimps have be...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1996.0092

    authors： Sefiani M,Le Caer JP,Soyez D

    更新日期：1996-07-01 00:00:00

  • The number of life-history stages does not influence the androgen responsiveness to male-male interactions: sedentary and migratory black redstarts (Phoenicurus ochruros) do not elevate testosterone in response to simulated territorial intrusions.

    abstract：:High plasma levels of testosterone at the beginning of the breeding season adjust male physiology for mating and promote territorial behavior in birds. Conversely intra-sexual competition may elicit a temporary increase in circulating testosterone. Male black redstarts (Phoenicurus ochruros) from migratory populations...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2014.04.017

    authors： Villavicencio CP,Blas J,Goymann W

    更新日期：2014-09-01 00:00:00

  • Influence of thyroid hormones and testosterone on the activities of hepatic mitochondrial enzymes in the Indian garden lizard, Calotes versicolor.

    abstract：:Thyroidectomy and castration in Calotes versicolor significantly decreased the activities of hepatic mitochondrial cytochrome oxidase, alpha-glycerophosphate dehydrogenase (alpha-GPDH), and succinate dehydrogenase (SDH) when compared to sham-operated controls. Administration of thyroid hormones in thyroidectomized liz...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(88)90030-5

    authors： Oommen OV,Sreedeviamma KK

    更新日期：1988-03-01 00:00:00

  • Changes in plasma and gonadal steroid hormones in relation to the reproductive cycle and the sex inversion process in the protandrous seabass, Lates calcarifer.

    abstract：:Plasma and gonadal levels of several gonadal steroids (testosterone, 11-ketotestosterone, androstenedione, 11 beta-hydroxyandrostenedione, 17 beta-estradiol, and estrone) were measured by RIA in the protandrous seabass, Lates calcarifer, throughout an annual reproductive cycle. Twenty to 25 fish were killed every mont...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1006/gcen.1993.1170

    authors： Guiguen Y,Jalabert B,Thouard E,Fostier A

    更新日期：1993-12-01 00:00:00

  • Real-time PCR analysis of cytochrome P450 aromatase expression in zebrafish: gene specific tissue distribution, sex differences, developmental programming, and estrogen regulation.

    abstract：:In teleost fish, the predominant brain form of cytochrome P450 aromatase (P450aromB) is a neural marker of estrogen effect, and an entry point for studying the role of hormonal and environmental estrogens on neurodevelopment and neuroplasticity. As part of a project using zebrafish to investigate these issues, we deve...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2005.12.010

    authors： Sawyer SJ,Gerstner KA,Callard GV

    更新日期：2006-06-01 00:00:00

  • Development of the adrenocortical response to stress in Eurasian kestrel nestlings: defence ability, age, brood hierarchy and condition.

    abstract：:The developmental hypothesis proposes that the adrenocortical response to stress during postnatal development in birds should not develop when the benefits of elevated corticosterone do not outweigh the deleterious effects on growth and development. We tested three predictions developed from this hypothesis in free-li...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2010.06.009

    authors： Müller C,Jenni-Eiermann S,Jenni L

    更新日期：2010-09-15 00:00:00

  • Fecal glucocorticoid metabolites of experimentally stressed captive and free-living starlings: implications for conservation research.

    abstract：:Fecal glucocorticoid metabolite (FGM) analysis has received considerable attention in conservation biology because it has potential to be used as a noninvasive measure of stress in animals. There has been a recent and extensive literature describing the importance of technical, physiological, and biological validation...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2008.05.001

    authors： Cyr NE,Romero LM

    更新日期：2008-08-01 00:00:00

  • Expression and regulation of prolactin-like protein messenger RNA in undifferentiated chicken granulosa cells.

    abstract：:Prolactin-like protein (PRL-L; LOC417800) is a homolog of PRL in non-mammalian vertebrates and can act as a functional ligand of PRL receptor (PRLR). Despite its widespread expression in extrapituitary tissues, mechanisms of regulation of PRL-L in the chicken ovary remain unknown. In this study, we first examined PRL-...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2016.10.013

    authors： Hu S,Duggavathi R,Zadworny D

    更新日期：2017-01-01 00:00:00

  • Yolk androgen deposition in rockhopper penguins, a species with reversed hatching asynchrony.

    abstract：:To maximize fitness, females should invest optimally in the siblings within a litter or brood and adapt this investment to environmental conditions. Chick mass and yolk androgens have been shown to influence the outcome of sibling competition. In birds, asynchronous hatching plays a major role in this process and ofte...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2010.11.027

    authors： Poisbleau M,Demongin L,Chastel O,Eens M,Quillfeldt P

    更新日期：2011-02-01 00:00:00

  • Insulin-like peptides in Spodoptera littoralis (Lepidoptera): Detection, localization and identification.

    abstract：:Insulin is an extensively studied peptide hormone in mammals. However, insulin is not restricted to vertebrates, but has also been identified in invertebrates, among whom several insect species. These insulin-like peptides (ILPs) show structural and-at least some-functional homology with mammalian insulin and act thro...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2007.05.001

    authors： Van de Velde S,Badisco L,Claeys I,Verleyen P,Chen X,Vanden Bosch L,Vanden Broeck J,Smagghe G

    更新日期：2007-08-01 00:00:00

  • Effects of vertebrate prolactins and growth hormones on thyroxine 5'-monodeiodination in the eel (Anguilla anguilla): a potential bioassay for growth hormone.

    abstract：:Growth hormones (GHs) and prolactins (Prls) purified from representatives of each vertebrate class from bony fish onwards were tested for their ability to stimulate in vivo peripheral deiodination of labeled thyroxine (T4*) into triiodo-L-thyronine (T3*) in the eel. Plasma T3*/T4* ratio was used as parameter. All GHs ...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(89)90091-9

    authors： de Luze A,Leloup J,Papkoff H,Kikuyama S,Kawauchi H

    更新日期：1989-02-01 00:00:00

  • TRH receptors in fish.

    abstract：:The brains of goldfish and other teleosts contain high-affinity binding sites for [3H][3-methyl-His2]thyrotropin-releasing hormone [( 3H]MeTRH) which closely resemble TRH receptors in mammalian brain and pituitary gland in apparent dissociation constant (KD = 3-4 nM), in pharmacology for eight TRH analogs, and in exhi...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/0016-6480(84)90233-8

    authors： Burt DR,Ajah MA

    更新日期：1984-01-01 00:00:00

  • Evaluation of Aib and PEG-polymer insect kinin analogs on mosquito and tick GPCRs identifies potent new pest management tools with potentially enhanced biostability and bioavailability.

    abstract：:Insect kinins modulate aspects of diuresis, digestion, development, and sugar taste perception in tarsi and labellar sensilla in mosquitoes. They are, however, subject to rapid biological degradation by endogenous invertebrate peptidases. A series of α-aminoisobutyric (Aib) acid-containing insect kinin analogs incorpo...

    journal_title：General and comparative endocrinology

    pub_type： 杂志文章

    doi：10.1016/j.ygcen.2018.08.002

    authors： Xiong C,Kaczmarek K,Zabrocki J,Pietrantonio PV,Nachman RJ

    更新日期：2019-07-01 00:00:00