Evolution of Staphylococcus aureus by large chromosomal replacements.

Abstract:

:Conjugative transfer and replacement of hundreds of kilobases of a bacterial chromosome can occur in vitro, but replacements in nature are either an order of magnitude smaller or involve the movement of mobile genetic elements. We discovered that two lineages of Staphylococcus aureus, including a pandemic methicillin-resistant lineage, were founded by single chromosomal replacements of at least approximately 244 and approximately 557 kb representing approximately 10 and approximately 20% of the chromosome, respectively, without the obvious involvement of mobile genetic elements. The replacements are unprecedented in natural populations of bacteria because of their large size and unique structure and may have a dramatic impact on bacterial evolution.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Robinson DA,Enright MC

doi

10.1128/jb.186.4.1060-1064.2004

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

1060-4

issue

4

eissn

0021-9193

issn

1098-5530

journal_volume

186

pub_type

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