Event-related FMRI study of context processing in dorsolateral prefrontal cortex of patients with schizophrenia.

Abstract:

:Context processing is conceptualized as an executive function involved in voluntary, complex actions such as overcoming automatic responses. The present study tested the hypothesis that context-processing deficits in patients with schizophrenia are associated with a dysfunction of left dorsolateral prefrontal cortex (DLPFC). Using event-related functional magnetic resonance imaging (fMRI), 17 controls and 17 medicated patients performed a version of the AX task in which a learned, automatic response had to be inhibited. In controls, left DLPFC activity increased when preparing to overcome an automatic response, whereas patients with schizophrenia showed no differential activation. In controls, context processing appeared to be associated with the differential representation of cues associated with the need to provide top-down support for overcoming automatic responses. This mechanism appeared to be impaired in patients with schizophrenia.

journal_name

J Abnorm Psychol

authors

MacDonald AW 3rd,Carter CS

doi

10.1037/0021-843X.112.4.689

keywords:

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

689-97

issue

4

eissn

0021-843X

issn

1939-1846

pii

2003-10098-014

journal_volume

112

pub_type

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