Abstract：
:Breast cancer is often relatively slow growing, but at diagnosis about 40% of patients have regional spread to at least one axillary node. It has been shown that unrelated clones are in primary breast carcinomas. There is possibility that only a small subpopulation of the cells of the primary tumour (PT) metastasis. It has been shown that Ki-67 protein is a useful marker in histopathology, which is present during all active phases of the cell cycle and making possibility to assess growth fraction of tumour cells. The purpose of the study was to evaluate the expression of Ki-67 and comparison between the PTs and MRLNs as well as to estimate the relationships between Ki-67 and the chosen anatomoclinical features of the breast cancer. Immunohistochemical analyses for Ki-67 were performed on the PTs (69 cases without primary chemotherapy) and MRLNs (33 cases) of breast cancer. Increased expression of Ki-67 in PTs significantly correlated with pT2 stage of tumours (p < 0.05) and grade G3 (p < 0.04), but there was not relationship with lymph node status. Expression of Ki-67 positively correlated between PTs and MRLNs (p < 0.001). Comparison between PTs and matching MRLNs revealed that 23 (69.7%) cases showed a convergence between PTs and matching MRLNs with regard to negative or positive staining. We would like to emphasize the importance of studies concerning the proteins involved in proliferation in MRLNs, because knowledge about heterogeneity between PTs and MRLNs could shed light on tumour biology and may lead to development of more effective anti-cancer therapies.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Koda M,Jarzabek K,Kańczugakoda L,Przystupa W,Tomaszewski J,Sulkowska M,Wołczyński S,Sulkowski Skeywords:
subject
Has Abstractpub_date
2003-09-01 00:00:00pages
754-60issue
9eissn
0017-0011issn
2543-6767journal_volume
74pub_type
杂志文章abstract：:Conditions under which episodes of eclampsia occurred in puerperal, who were than admitted to the Intensive Care Units for treatment are presentation the paper. Multidirectional diagnostic procedures introduced in those 30 patients are discussed. In the analysed group of patients various types of organ complications w...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：OBJECTIVES AND DESIGN:Leptin, a product of adipocytes, is a cytokine with multiple effects on the reproductive axis. Leptin causes the activation of STAT proteins within target cells. The aromatase gene promoter in adipose stromal cells contains a functional STAT binding region, leading to the hypothesis that leptin ma...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Gestational diabetes (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. Two major metabolic disorders: insulin resistance and β-cells dysfunction, play currently major role in pathogenesis of GDM. Adipose tissue is an organ involved in production of adipokin...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.5603/GP.a2018.0088
更新日期：2018-01-01 00:00:00
abstract：:Sensibility and specificity of transvaginal ultrasonography and diagnostic hysteroscopy were compared in 211 infertile women. Examinations were performed between 1996-2000 in I-st Department of Obstetrics and Gynecology Warsaw Medical University--Poland. Comparing results we concluded high compatibility of transvagina...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：:Bladder Pain Syndrome remains a great challenge for urologists, both in diagnostics and treatment. Etiopathogenesis of the disease is unknown. It is reported that the reason for Bladder Pain Syndrome is the urothelium dysfunction resulting in the destruction of the protective glycosaminoglycan layer/barrier protecting...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2011-03-01 00:00:00
abstract：:The main tests of this writing was defining pregnant vagina ecosystem at hospitalized Clinic patients between 5th and 37th pregnant week. Patients was divided on two group: I-st with miscarriage danger, II-nd with premature delivery danger. Bacterial Vaginosis was recognized based into consideration Amsela criterion a...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：UNLABELLED:The process of carcinogenesis in both types of cervical carcinoma is dependent on the infection of oncogenic types of HPV. HPV infection could be diagnosed on the basis of whether or not the DNA virus in present. In pregnant women the latent-persistent infection easily changes into its active form. This proc...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:Ultrasonic velocimetry of the fetal circulation became a very useful method in assessment of fetal well-being, especially in high risk pregnancies. There are many papers concerning on distribution and regulation of blood flow in umbilical artery, middle cerebral artery, and much less dealing with flow velocity wavefor...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-02-01 00:00:00
abstract：OBJECTIVES:The purpose of the study was to check the conformity of diagnosis based on macroscopic hysteroscopy image with the respective pathology report. MATERIALS AND METHODS:Study population consisted of 160 patients aged 45-86 years, with abnormal uterine bleeding or abnormal ultrasonographic image of endometrium....
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-12-01 00:00:00
abstract：UNLABELLED:THE OBJECTIVES: The aim of this study was to evaluate the clinical value of blood flow indicies for differentiating between benign and malignant ovarian tumours. MATERIALS AND METHODS:Realisation of the aim was based on the analysis of examinations' results of 686 ovarian tumors. For each recorded blood flo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
abstract：OBJECTIVES:To assess the incidence of cervical intraepithelial neoplasia - SIL and cervical cancer in a population of pregnant women with an abnormal cytology. MATERIAL AND METHODS:In pregnant women with abnormal cytology results according to The Bethesda System, a verifying diagnostics was carried out, including colp...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.a2017.0004
更新日期：2017-01-01 00:00:00
abstract：:Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic mar...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2012-07-01 00:00:00
abstract：AIM:To assess the correlation between homocysteine concentrations and gestational age, gender Apgar score, complications in pregnancy delivery modalities and levels of vitamin B12 and foliate. MATERIAL AND METHODS:Concentration of homocysteine, vitamins-B12, foliate were measured in cord blood and mother blood. There ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-10-01 00:00:00
abstract：OBJECTIVES:The most common and generally accepted methods of breast cysts treatment are fine needle aspiration or surgical excision. None of these methods allow to avoid or decrease number of recurrences. Regarding hormonal disturbances as a main reason for breast cysts also conservative treatment should be given. DES...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:A survey throughout world literary output concerning physiology of respiratory system in pregnancy was made in this work. Metabolical changes caused by the increase of progesterone and other substances concentration and changes of the mechanics of ventilation connected by diaphragm raising caused by the growing uterus...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:It was found that amniotic fluid (38-42 Hbd) contains hydroxyproline in concentration about 10 micrograms/ml. Gel filtration and dialysis demonstrated that most of hydroxyproline exists in a form of low molecular weight products. Furthermore, it was found that amniotic fluid contains a protein which eluates during gel...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：OBJECTIVES:There are some data concerning homocysteine influence on fertilization and early embryogenesis, especially in women experiencing recurrent pregnancy loss (RSA). However, limited data support hypothesis that the ovum might be exposed to high homocysteine concentration what may be important in egg-sperm intera...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:The term hypertension in pregnancy stands either for a high blood pressure, which has already developed before pregnancy (i.e., chronic hypertension in pregnancy), or for a pregnancy-associated disease (i.e., pregnancy-induced hypertension). Each form of hypertension may be an isolated phenomenon or constitute a part ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:Environmental factors may play equally critical role as genes in facial embryogenesis. It was suggested that cleft palate occurring in association with cleft lip may result from environmental factors that affect development of both the lip and the palate. Cleft lip forms from the third through seventh week o...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
abstract：OBJECTIVE:Clinical application of minimally invasive surgical techniques in gynecology continuous to increase steadily. Laparoscopic surgery has widely replaced open surgical technique in many routine cases. This method is obviously less traumatic and painful, requires a shorter hospital stay and recovery time. The aim...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-02-01 00:00:00
abstract：:During 1986-87, cervical smears were taken at various phases of menstrual cycles from 63 women aged 25-53 (average age of 34.8 years) wearing IUDs for 3 months to 17 years for the sake of cytological evaluation. 43 patients had Copper T-devices of Finnish make, 8 women had Spider Ws of Polish make, 1 had a Lippes Loo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1988-12-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to investigate to what extent sweeping of the membranes contributes to cervical shortening and if cervical shortening is related to the time to onset of labor and duration of the active phase of labor METHODS:This prospective randomized clinical trial was performed at Baskent Univer...
journal_title：Ginekologia polska
pub_type： 杂志文章,随机对照试验
doi：
更新日期：2014-09-01 00:00:00
abstract：OBJECTIVES:To assess the effectiveness of the donor-block biopsies with a 2 mm-size needle in endometrioid endometrial cancer (EEC) in the tissue microarray (TMA) technique and the application of the TMA for estrogen receptors (ER) and progesterone receptors (PR) expression in EEC. MATERIAL AND METHODS:The study exami...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-05-01 00:00:00
abstract：:26 patients out of 48 (54%) with an advanced ovarian carcinoma (III and IV degree) treated in the first stage by means of Adriablastine, Cisplatin and Cyclophosphamide responded to the therapy. Complete remission was achieved in 24 patients (50%), and partial remission (PR) only in 2 patients. Four patients with CR in...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVES:To establish the appropriate technique for salpingo-oophorectomy via transvaginal natural orifice transluminal endoscopic surgery (NOTES), under gasless laparoscopy. MATERIAL AND METHODS:Ten patients with clinical indication underwent gasless laparoscopic transvaginal salpingo-oophorectomy with concurrent v...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0001
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses. MATERIAL AND METHODS:Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, A...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0045
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:Congenital heart diseases are very serious problem of current perinatology. Early detection of congenital heart diseases and new possibilities of their treatment have decreased mortality rate in neonates. THE AIM OF THE STUDY:Was to present the reasons of the heart murmurs found in newborns, based on postna...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2004-06-01 00:00:00
abstract：:12 male rabbits were administered cyproterone acetate in a dose of 20 mg/kg every 24 hours for the course of 28 days. Typochemical investigations were then carried out on the relative contents of histone and DNA, using the cytophotometric method. The spermatozoid content of DNA was analyzed using the Feulgen stainin...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1975-09-01 00:00:00
abstract：:Worldwide screening for early detection of ovarian cancer in both, the general population and the group of women at high risk for ovarian cancer including BRCA genes mutations carriers, has proven to be ineffective. The recommended screening methods, including a pelvic examination, transvaginal ultrasound, and CA125 p...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1735
更新日期：2014-05-01 00:00:00
abstract：OBJECTIVES:Real influence of urinary incontinence symptoms and adopted modes of treatment on patient's quality of life is not known. DESIGN:Assessment of influence of operative SUI treatment with the use of IVS tape on patient's quality of life. MATERIAL AND METHODS:Prospective study was conducted among 57 patients w...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2007-05-01 00:00:00
