Abstract:
OBJECTIVES:Environmental factors may play equally critical role as genes in facial embryogenesis. It was suggested that cleft palate occurring in association with cleft lip may result from environmental factors that affect development of both the lip and the palate. Cleft lip forms from the third through seventh week of embryonic development. During these period fetal nutrition is histotrophic, pressure of oxygen is low, genes for antioxidant enzymes are supressed and alpha-tocopherol play an essential role in the fetal tissues antioxidant capacity. Cleft palate forms from the fifth through twelfth weeks of gestation, when hemonutrition and antioxidant enzymes are developing, and hypothetical deficiency of tocopherol is not so crucial. AIM:The goal of the study was to investigate concentrations of alpha-tocopherol in women who gave birth to a child with cleft lip and mothers of children with cleft lip and palate. MATERIAL AND METHODS:Blood samples from 31 healthy mothers of children with isolated cleft lip (CL) and 29 healthy mothers of children with isolated cleft lip and palate (CLP) were collected. Fasting plasma alpha-tocopherol concentrations were measured by the high performance liquid chromatography. Kolmologorov-Smirnov test with Lilefors correction and k-means cluster analysis were applied to determine differences between the groups of women. RESULTS:We found that alpha-tocopherol concentrations were lower in CL compared to CLP, but the difference did not achieve level of statistical significantly (medians: 15.8 micromol/L vs. 20.0 micromol/L; p = 0.066). There were identified three clusters of alpha-tocopherol concentrations: 14.0 micromol/L (19CL+8CLP), 19.6 micromol/L (8CL+13CLP), and 21.1 micromol/L (4CL+8CLP). The distribution of results to the clusters was dependent on type of the orofacial cleft (chi squared = 6.95 with 2 degrees of freedom, p = 0,031). CONCLUSIONS:Analysis for environmental risk factors should be performed separately for cleft lip and cleft lip and palate because these two conditions appear to be etiologically distinct. The role of a higher periconceptional intake of alpha-tocopherol in reduction of risk of giving birth to a child with cleft lip requires further research.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Hozyasz K,Mazur J,Chełchowska Msubject
Has Abstractpub_date
2006-04-01 00:00:00pages
255-62issue
4eissn
0017-0011issn
2543-6767journal_volume
77pub_type
杂志文章abstract:UNLABELLED:The process of carcinogenesis in both types of cervical carcinoma is dependent on the infection of oncogenic types of HPV. HPV infection could be diagnosed on the basis of whether or not the DNA virus in present. In pregnant women the latent-persistent infection easily changes into its active form. This proc...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:Hypertension remains a very serious obstetric problem and a severe pregnancy complication. Hypertension in pregnancy influences the intrauterine fetal growth. Proper monitoring of antihypertensive therapy effects enables us to make suitable modifications of the treatment. The aim of the study was to evaluate...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2008-03-01 00:00:00
abstract::25 ovariectomized women mean age 47 +/- 5 years were treated with transdermal 17 beta Estradiol in the shape of Estraderm TTS 100 plasters. Drugs were administrated in 28 days cycles during 24 weeks. Chlormadinon in daily dose 2 mg was added from 16 to 28th day of the fourth therapeutic cycle. Total cholesterol, trigl...
journal_title:Ginekologia polska
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Emergency cerclage was performed on 27 years old patient with membrane prolapse in 21 weeks' gestation. Ultrasonographically guided amniocentesis was performed intraoperatively in order to decrease intraamniotic pressure. Aggressive prophylactic management (wide spectrum antibiotics and tocolysis-nifedipine) resulted ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::120 adolescent girl suffered from acyclic pelvic pain and dysmenorrhoe (algomenorrhoee) was presented. They were treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and oral contraceptive pills (OCPs) and underwent a laparoscopy to determine the etiology of pelvic pain. Endometriosis was classified according to...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVES:The aim of the research was evaluation of the clinical usefulness of chosen ultrasonographic morphological parameters of the yolk sac in the first trimester of unifetal pregnancies. MATERIAL AND METHOD:Analysis has been done on 391 cases of unifetal pregnancies in the first trimester. Parameters of ultrason...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2004-08-01 00:00:00
abstract::Diagnostic microlaparoscopy was performed on 30 patients aged 17-41. Indications++ for these procedures were: sterility (17), tumor of the ovary (5), endometriosis (3), uterine myoma (2), pelvic pain syndrome++ (1), carcinoma of the ovary--second look procedures (1), operative hysteroscopy (1). During these procedures...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVES:The ultrasound-guided transversus abdominis plane (TAP) block is a supporting method of pain relief after different types of surgical and gynecological procedures. The aim of the present study was to evaluate the analgesic effects of the TAP-block in patients undergoing caesarean section. MATERIAL AND METHO...
journal_title:Ginekologia polska
pub_type: 杂志文章,随机对照试验
doi:10.5603/GP.a2018.0072
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to evaluate the outcome of fetuses with ovarian cysts in relation to fetal echocardiography. MATERIAL AND METHODS:In the Department for Diagnosis and Prophylaxis of Birth Defects at the Polish Mother's Memorial Hospital in Lodz fetal echocardiography was performed in 21 fetuses with...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
abstract::The results of peritoneal cytology obtained during primary surgery for stage I ovarian cancer and "second look" operations was assessed. Positive peritoneal smears were found in 10.7% of patients, while neoplastic cells were present in peritoneal fluid in 32.5% of cases. Of 144 patients undergoing "second look" surger...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::39 normal fetal heart examinations were evaluated since 20 week of gestation to term, and Doppler blood flow was analysed for mitral and tricuspid valves. The measurements were done always in good 4 chamber view and qualitative and quantitative analysis were performed, in terms of describing E and A waves and maximal ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate to what extent sweeping of the membranes contributes to cervical shortening and if cervical shortening is related to the time to onset of labor and duration of the active phase of labor METHODS:This prospective randomized clinical trial was performed at Baskent Univer...
journal_title:Ginekologia polska
pub_type: 杂志文章,随机对照试验
doi:
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:Human papillomavirus (HPV) ranks the first cause of cervical cancer. Cervical cancer has high prevalence rates in women around the world. The HPV-E7 oncoprotein is expressed in cervical cancer and is a target of developing immunotherapies against HPV-associated tumors. However, the antigenicity of this prote...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.2020.0055
更新日期:2020-01-01 00:00:00
abstract:INTRODUCTION:Endometriosis is defined as the appearance of ectopic endometrial cells outside the uterine cavity. Ectopic cells demonstrate functional similarity to eutopic cells, but structural and molecular differences are significant and manifest themselves in gene expression of the metalloproteinase genes, integrin ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/1751
更新日期:2014-06-01 00:00:00
abstract::A group of 15 women between the ages of 24-45 were given intraamiotic does of 40 mg of prostagladin F2alpha (PGF2alpha; Enzaprost) in a single dose so as to terminate pregnancy. These pregnancies, between the 15th- 24th weeks, were terminated for medical reasons. 12 hours elapsed between the time of intraamniotic ad...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVES:Dynamic development of prenatal diagnostics is mostly directed towards search for non-invasive screening. The main role of the screening methods is to select high-risk fetal aneuploidy group of pregnant women. The base for the prenatal screening in modern obstetrics is ultrasound scanning. DESIGN:The aim of...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2007-08-01 00:00:00
abstract::One of the principal features of the malignant process is the ability of the tumor to form metastases. In case of endometrial cancer pelvic and paraaortic lymph nodes and ovaries are the most frequent sites of metastases. In some cases metastases to the distant sites like the lungs and liver occur. The diagnosis of st...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2003-12-01 00:00:00
abstract::Criminal Law Codification Commission, acting at the Ministry of Justice prepared proposals for amendments in the Polish Penal Code, related to offenses against life and health that were presented to the public in 2013. The draft provides for the protection of the child in the prenatal stage, introducing a new category...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/59562
更新日期:2015-10-01 00:00:00
abstract::The HELLP syndrome is a variant of severe preeclampsia. Its leading symptoms are: hemolysis, increased liver enzymes and low platelet count. The treatment of the HELLP syndrome remains controversial as there are no standards of proven efficacy. The article presents a case of a 27- year-old patient, G1P0, 30 wk of gest...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract:CASE REPORT:A 48-year-old woman with acute urinary retention due to a big cervical leiomyoma pressing on the urethra was admitted to the Gynecologic Unit. A Foley catheterization was performed and 1500 mL of urine was drained. The gynecologic examination revealed a cervical tumor 10 cm in diameter. Acute urinary retent...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:10.17772/gp/1904
更新日期:2015-01-01 00:00:00
abstract::Endometrial cancer is one of the most frequently diagnosed malignant neoplasms among women. In Poland, it is in the fourth place in terms of incidence. The highest morbidity concerns women aged 50-70 years, however it may also appear in women in their reproductive period. Endometrial cancer concerns about 3% of premen...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2012-03-01 00:00:00
abstract::We report an unusual case of adenomyosis with asymptomatic thoracic endometriosis. A 30-year old woman had a history of nephroblastoma, two missed abortions and one childbirth by caesarean section. The pregnancy was complicated with asymmetric fetus hipotrophy. Two years after delivery she had assessments for dysmenor...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::The aim of this study was to evaluate the predictive value of respiratory distress syndrome-RDS evidence using amniotic fluid diagnostic tests. 200 amniotic fluid samples obtained by amniocentesis were study to evaluate pulmonary tissue maturity status. The PG test was 30% specific and 100% sensitive; FLM test showed ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:Retrospective clinical and pathomorphological analysis of patients undergoing surgery due to endometrial carcinoma; analysis of the correlation between histological grading of endometrial cancer and selected pathomorphological results. MATERIAL AND METHODS:Statistical analysis was based on the pathomorpholog...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/2419
更新日期:2015-05-01 00:00:00
abstract:UNLABELLED:There are many methods of the growth restriction therapy, but the results are still not satisfactory. Actually, we are conducting a project which main conception is based on the use of the NO donor (L-arginine) in growth retardation therapy. This amino acid is an effective NO donor and has a vasodilating eff...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2004-12-01 00:00:00
abstract:INTRODUCTION:The body mass gain is conditioned by lifestyle, as well as many environmental and genetic factors. Recent studies suggest that renin-angiotensin system (RAS) plays a fundamental role in process of growth and differentiation of adipocytes through the acting of angiotensin II and seems to be a significant fa...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract::The aim of this study was to estimate the utero-ovarian flow velocity waveforms in patients after renal transplantation. The study material consisted of 24 women aged 28-44 years which underwent renal transplantation and 26 healthy controls. All women had normal menstrual cycles. Using transvaginal approach PSV, RI an...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to assess the level of knowledge of problems referring to breastfeeding among women in childbirth. MATERIALS AND METHODS:The study was based on a questionnaire, which consisted of 20 questions with multiple choice answers. 108 women in puerperium were surveyed-54 in the Obstetrical...
journal_title:Ginekologia polska
pub_type: 杂志文章,多中心研究
doi:
更新日期:2004-01-01 00:00:00
abstract::The authors report a case of anorexia nervosa in woman with Turner's syndrome (45, X). In this case there was a low blood concentration of LH and FSH, and there was a lack of reaction to intravenous administration of 100 micrograms of GnRH. Partial syndrome of "empty sella" was found in a presented case by use of magn...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2002-06-01 00:00:00
abstract::Uterine arteriovenous malformations are uncommon but potentially life-threatening conditions. They can be congenital or acquired and should be suspected in cases of severe or persistent uterine bleeding. In recent years, there has been an in-creasing number of reports of acquired vascular lesions of the uterus followi...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:10.5603/GP.a2018.0047
更新日期:2018-01-01 00:00:00