Abstract：
OBJECTIVES:Human papillomavirus (HPV) ranks the first cause of cervical cancer. Cervical cancer has high prevalence rates in women around the world. The HPV-E7 oncoprotein is expressed in cervical cancer and is a target of developing immunotherapies against HPV-associated tumors. However, the antigenicity of this protein is low. Due to this reason, potent adjuvants are required to enhance its therapeutic efficacy. This preliminary study aims to evaluate whether lymphotoxin (LT) could act as an effective immune adjuvant for HPV infection in mice models. MATERIAL AND METHODS:Intranasal immunization was used to explore the effect of HPV-E7 and/or LT immune response. After the third intranasal immunization, the titer for the HPV-E7 antibody was detected in serum and vaginal washing fluid. Also, we assessed the expression of chemokine ligand 13 (CXCL13) and Peripheral Node Addressin (PNAd) in the lymph nodes after intranasal immunization with immunohistochemical analysis. RESULTS:compared to HPV-E7 immunization, intranasal immunization with HPV-E7 plus LT significantly increased HPV-E7-specific serum IgG and vaginal IgA titers. Furthermore, the combined use of HPV-E7 and LT strongly induced E7-specific CTL responses. CONCLUSIONS:LT can be effective for intranasal immunized HPV-E7 to improve E7-specific immune responses to HPV infection. It is new approach to eradicate chronic HPV infection capable of inducing an effective anti-infection method.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Liu YH,Chen HL,Xu BQ,Wei K,Ying XYdoi
10.5603/GP.2020.0055subject
Has Abstractpub_date
2020-01-01 00:00:00pages
301-307issue
6eissn
0017-0011issn
2543-6767pii
VM/OJS/J/66602journal_volume
91pub_type
杂志文章abstract：OBJECTIVES:The aim of the study was to analyze the course of labor of grand multiparas (4 deliveries and more) in comparison to multiparas (2 or 3 deliveries). MATERIALS AND METHODS:A group of 400 grand multiparas were included in the study and compared with a group of 393 multiparas. All the deliveries took place in ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-12-01 00:00:00
abstract：:EPH-gestosis is accompanied by an extensive remodeling of the extracellular matrix of Wharton's jelly. The gelatinolytic and proteolytic activities were measured. A decrease in gelatinolityc activity and an increase in proteolytic activity in EPH-gestosis were observed. The decrease in gelatinase activity in EPH-gesto...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-05-01 00:00:00
abstract：:Among 64 women undergoing tubal-ovarian surgery 40.6% became pregnant spontaneously. Because of 47% of the remainder patients demonstrated anovulation the induction of ovulation was performed except the cases with hypergonadotrophic hypogonadism (9.4%). After treatment the total population with ovulatory cycles increa...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:The presence of estrogens, their function and targets in male reproductive tract are still not fully understood. Recent studies, basic and clinical indicate an important role of estrogens during germ cell development. In this study the efforts have been made to immunolocalize aromatase P450 as well as estrogen recepto...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Between 1994-1999 at the Department for Diagnosis of Congenital Malformations at the PPMH Institute there were ultrasound and echocardiography examinations performed in 40 fetuses with Down Syndrome. In our study most of the cases come from low risk groups of pregnant women. Congenital heart defects (AV-canal in 13/18...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Uterine arteriovenous malformations are uncommon but potentially life-threatening conditions. They can be congenital or acquired and should be suspected in cases of severe or persistent uterine bleeding. In recent years, there has been an in-creasing number of reports of acquired vascular lesions of the uterus followi...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.5603/GP.a2018.0047
更新日期：2018-01-01 00:00:00
abstract：OBJECTIVES:Hypertension remains a very serious obstetric problem and a severe pregnancy complication. Hypertension in pregnancy influences the intrauterine fetal growth. Proper monitoring of antihypertensive therapy effects enables us to make suitable modifications of the treatment. The aim of the study was to evaluate...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses. MATERIAL AND METHODS:Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, A...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2016.0045
更新日期：2016-01-01 00:00:00
abstract：:576 patients with preterm deliveries that occurred between the 22nd to 37th gestation weeks were undergone clinical analysis. The material was collected in the years 1995 to 1999 at Clinic of Obstetric and Perinatology of Pomeranian Academy of Medicine in Szczecin. In our study the rate of preterm delivery was 10.5%. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:The purpose of the study was to estimate blood flow in uterine arteries in patients with uterus cervix invasive carcinoma. In the study the colour Doppler ultrasonography was used. It was found out that in the group of patients with uterus cervix carcinoma pulsation index (PI)--1.82 +/- 1.44 as well as resistance inde...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：1995-09-01 00:00:00
abstract：OBJECTIVES:The aim of our study was clinical analysis of patients operated with squamous cell carcinoma of the uterine cervix. MATERIALS AND METHODS:Between 1972 and 1991 at the 2nd Department of Obstetrics and Gynecology Medical University of Gdańsk 687 total hysterectomies in Wertheim-Meigs method were performed in ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:The results of large randomized trials such as the Women's Health Initiative (WHI), Heart and Estrogen / Progestin Replacement Study (HERS) or Estrogen Replacement and Atherosclerosis Study (ERAS) as well as the Million Women Study (MWS) which does not meet criteria RCT, concerning, among others the impact of HRT on b...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/61022
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Angiogenesis is of crucial importance for endometrial tumor growth and Vascular Endothelial Growth Factor (VEGF) is the key mediator of angiogenesis. OBJECTIVE:The purpose of our study was to assess the prognostic value of VEGF and its receptors in relation to endometrioid endometrial carcinomas. MATERIAL ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：UNLABELLED:The purpose of our study was to analyze the efficacy of serum C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) serial evaluations in the prediction of chorioamnionitis in cases of premature rupture of membranes (PROM). MATERIALS AND METHODS:A group of 80 patien...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：BACKGROUND:The ultrasound, serum beta-HCG and progesterone titres are widely used to assess the risk of miscarriage at the early stages of pregnancy. Though very useful, they are not considered as satisfactorily accurate predictors of imminent abortion during the first three months of pregnancy. AIM OF STUDY:Prospecti...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:127 pregnant patients between 20 and 37 week of gestation were studied. Cervical estimation was done by using transvaginal ultrasonography. An accurate estimation was possible in all investigation patients. Statistically significant distinctions in uterine cervical length during pregnancy progress were noticed (p < 0....
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1994-08-01 00:00:00
abstract：:The aim of the work is to present regenerative medicine achievement as an alternative SUI treatment and the variety of injected cells type as well as injection techniques itself with the analysis of their quality and possible the mechanism in which they reduce urinary incontinence symptoms. For over a decade numerous ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/60973
更新日期：2016-01-01 00:00:00
abstract：:According to the European Dialysis and Transplantation Association at least 250 patients on each 1 million of inhabitants in Europe is treated with renal replacement therapy. One can assumed that if only half of above mentioned are women then from 5 to 10 of them can conceive pregnant. It's likely that number of pregn...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：AIM:To evaluate the a-chemokine stromal cell-derived factor-1 (SDF-1)/CXCL12 levels in the peritoneal fluid (PF) and plasma of patients with epithelial ovarian cancer (EOC, n=101), serous cyst (n=34) or normal controls (n=20). SDF-1alpha concentrations were correlated to myeloid (M) and lymphoid (L) dendritic cells (DC...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Hypoxic-ischemic encephalopathy (ENN) concerns neonates born after 35 completed weeks of gestation. The incidence rate has been shown to be 1-6/1000 births and can lead to significant permanent neurological damage, cerebral palsy and even death. Until the whole body cooling and selective brain cooling methods have bee...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
abstract：:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogest...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVES:The aim of the study was to evaluate the concentrations of kynurenic acid (KYNA) in blood and urine during the normal pregnancy. MATERIALS AND METHODS:Under the study were 37 pregnant women. Level of KYNA was measured by high performance liquid chromatography (HPLC). RESULTS:The KYNA concentration in blood...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-12-01 00:00:00
abstract：DESIGN:The aim of our study was estimation of frequency of occurrence endometriosis at girls operated from different indications, research of predisposing factors and estimation of selected biophysical parameters. MATERIAL AND METHODS:Material determined 14 of patients in 13 to 21 years old of life operated on account...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Most pregnant women have little interest in thinking about the prospect of death. Mortality related to the pregnancy itself is rare, occurring in an estimated 1 of every 30 000 deliveries. Although cardiopulmonary arrest rarely occurs in pregnant women, it is important that the health care team knows the appropriate a...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-09-01 00:00:00
abstract：:A retrospective study about frequency of occurrence of endometrial adenocarcinoma in postmenopausal women which are associated with diabetes mellitus, overweight and hypertension was performed. The aim of the study was to have risk factors for carcinoma of endometrium estimated. The nonparametric statistics such as: 2...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：OBJECTIVES:Newborns hyperbilirubinemia is an interesting, complicated and controversial clinical problem. An elevated concentration of it can be connected with increased risk of jaundice. Also, maternal bilirubin can play a part in the development of jaundice in mature newborns. MATERIAL AND METHODS:The research inclu...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-08-01 00:00:00
abstract：:The purpose of the study was to present the symptoms, diagnostic methods, and treatment in retroperitoneal fibrosis (RPF). We present a case of a 53-year-old woman admitted to the hospital due to low back and abdominal pain complaints lasting a year. Ultrasonography revealed a myoma located along the right bank of the...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/60465
更新日期：2015-11-01 00:00:00
abstract：UNLABELLED:Infertility has been recognized by WHO a disease concerning males and females. It is a serious social problem, therefore the evaluation of its reasons, its prevention and treatment is a subject of clinical studies. OBJECTIVE:To define the reasons of infertility and factors affecting fertility. MATERIAL AND...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2005-12-01 00:00:00
abstract：:Two cases of the Meckel-Gruber syndrome were described at two subsequent pregnancies. Suspicion of this syndrome was established by ultrasonography and confirmed by histopathological findings. Both of the pregnancies were terminated by premature induced delivery. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：:The paper contains the description of the modification of simplified method for caesarean section, based on the Joel-Cohen and Misgav Ladach method. Advantages of the simplified methods are described on the basis of the cited papers. Following stages of procedure are described in details. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
