Abstract:
INTRODUCTION:The body mass gain is conditioned by lifestyle, as well as many environmental and genetic factors. Recent studies suggest that renin-angiotensin system (RAS) plays a fundamental role in process of growth and differentiation of adipocytes through the acting of angiotensin II and seems to be a significant factor in excessive weight gain development. The purpose of this study was to determine the frequency and significance of insertion/deletion polymorphism (I/D) of the ACE gene in pregnant women with excessive weight gain. MATERIALS AND METHODS:The examined group consisted of 212 pregnant women, including 107 women with normal (DeltaBMI< or =5) and 105 women with excessive weight gain (DeltaBMI>5). Genomic DNA was extracted from venous blood. The I/D polymorphism of ACE gene was determined by polymerase chain reaction (PCR). RESULTS:During the course of the study we did not observe the statistically significant higher frequency of ACE genotypes in any of the two investigated groups of women with normal and excessive weight gain. Nevertheless, an overrepresentation of II genotype frequency in group with excessive weight gain has been observed (33.3 vs 21.5%, p=ns). The same findings were visible as far as the frequency of I allele in group with excessive weight gain was concerned (55.2 vs 45.8%, p=ns). The frequency of observed genotypes was in agreement with Hardy-Weinberg equilibrium. CONCLUSIONS:Although overrepresentation of II genotype and I allele in the group of pregnant women with excessive weight gain (DeltaBMI>5) has been observed, a close correlation between II genotype and higher risk of overweight could be not indicated (due to the lack of significant difference). The results should be confirmed in a more numerous group of pregnant women. At this stage the results of the study did not suggested the presence of association of I/D polymorphism of ACE gene with weight gain in investigated group of pregnant women.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Drews K,Seremak-Mrozikiewicz A,Nowocień G,Bogacz A,Kurzawińska G,Kaluba-Skotarczak Asubject
Has Abstractpub_date
2007-07-01 00:00:00pages
539-43issue
7eissn
0017-0011issn
2543-6767journal_volume
78pub_type
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journal_title:Ginekologia polska
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journal_title:Ginekologia polska
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journal_title:Ginekologia polska
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journal_title:Ginekologia polska
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journal_title:Ginekologia polska
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更新日期:2002-11-01 00:00:00
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journal_title:Ginekologia polska
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更新日期:1994-01-01 00:00:00
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journal_title:Ginekologia polska
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更新日期:1998-12-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
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journal_title:Ginekologia polska
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更新日期:2001-12-01 00:00:00
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journal_title:Ginekologia polska
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doi:
更新日期:2005-08-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1996-08-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/1610
更新日期:2013-07-01 00:00:00
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journal_title:Ginekologia polska
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doi:
更新日期:2005-07-01 00:00:00
abstract::Uterine arteriovenous malformations are uncommon but potentially life-threatening conditions. They can be congenital or acquired and should be suspected in cases of severe or persistent uterine bleeding. In recent years, there has been an in-creasing number of reports of acquired vascular lesions of the uterus followi...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:10.5603/GP.a2018.0047
更新日期:2018-01-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.2016.0031
更新日期:2016-01-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1992-01-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1994-06-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2004-06-01 00:00:00
abstract::Three thousand and twelve (3012) diagnostic laparoscopies in children, girls and women were carried out during the period 1970--1992. The age of the patients was between 6--49 years. The present studies show that laparoscopy fills up the space between the clinical investigation and laparotomy probatoria. It helps to s...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.a2020.0129
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journal_title:Ginekologia polska
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doi:
更新日期:2006-04-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-01 00:00:00
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journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
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journal_title:Ginekologia polska
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doi:
更新日期:2014-10-01 00:00:00
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journal_title:Ginekologia polska
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pub_type: 杂志文章,评审
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journal_title:Ginekologia polska
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更新日期:2008-09-01 00:00:00