The role of visfatin in pathogenesis of gestational diabetes (GDM).

Abstract:

:Gestational diabetes (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. Two major metabolic disorders: insulin resistance and β-cells dysfunction, play currently major role in pathogenesis of GDM. Adipose tissue is an organ involved in production of adipokines, which have various influence on metabolism of glucose and lipids. Visfatin is an adipokine mainly produced and secreted by the fat tissue. It exerts an insulin-like effect by binding to the insulin receptor-1 and have hypoglycemic effect. Visfatin appears to be an important factor in the pathophysiology of GDM. The aim of this article is to review the literature concerning the relationship between the adipokine mentioned above and GDM, and to clarify its role in the pathophysiology of GDM.

journal_name

Ginekol Pol

journal_title

Ginekologia polska

authors

Radzicka S,Pietryga M,Iciek R,Brązert J

doi

10.5603/GP.a2018.0088

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

518-521

issue

9

eissn

0017-0011

issn

2543-6767

pii

VM/OJS/J/58984

journal_volume

89

pub_type

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