Abstract：
OBJECTIVES AND DESIGN:Leptin, a product of adipocytes, is a cytokine with multiple effects on the reproductive axis. Leptin causes the activation of STAT proteins within target cells. The aromatase gene promoter in adipose stromal cells contains a functional STAT binding region, leading to the hypothesis that leptin may regulate aromatase activity in fat tissue. To test this hypothesis, adipose stromal cells were isolated from subcutaneous abdominal fat or breast fat then placed into tissue culture. MATERIALS AND METHODS:The cells were treated for three days with increasing concentrations of recombinant human leptin. Aromatase activity in the stromal cells was measured by the release of 3H2O from radiolabeled androstenedione precursor. RESULTS:Basal aromatase activity varied markedly between, but there were no differences between abdominal fat and breast fat. Leptin concentrations in the physiological range of normal weight or thin women (10 ng/ml) had no effect on aromatase activity. In 2 of 8 abdominal fat cultures and 1 of 2 breast fat cultures, a high obese concentration of leptin (100 ng/ml) stimulated a significant increase in aromatase activity. In the remaining subjects there was no effect of leptin, even at high concentrations. CONCLUSIONS:These data demonstrate that in approximately 30 percent of our subject population leptin was able to stimulate aromatase activity in adipose stromal cells at high concentrations. The elevated levels of aromatase activity may contribute to increase circulating estrogen levels in certain obese women and suggest that elevated leptin concentrations in obese women may cause locally elevated estrogen concentrations in the breast and thereby promote tumor formation.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Magoffin DA,Weitsman SR,Aagarwal SK,Jakimiuk AJkeywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
1-7issue
1eissn
0017-0011issn
2543-6767journal_volume
70pub_type
杂志文章abstract：OBJECTIVES:The "gold standard" in surgical treatment of stress urinary incontinence (SUI) is sling operation with polypropylene tape appliance under the mid urethra. There are two types of polypropylene tape which are the most popular nowadays. These two tapes are differently knitted so they have different biomechanica...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Between 1994-1999 at the Department for Diagnosis of Congenital Malformations at the PPMH Institute there were ultrasound and echocardiography examinations performed in 40 fetuses with Down Syndrome. In our study most of the cases come from low risk groups of pregnant women. Congenital heart defects (AV-canal in 13/18...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：OBJECTIVES:The study was designed to evaluate the effectiveness of cervical cancer prophylactics by identification of the time of last cervical cytological examination as well as by recognition of frequency of repeated cervical cytological examinations and reimbursement for the examination costs in representative sampl...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2005-11-01 00:00:00
abstract：:Worldwide screening for early detection of ovarian cancer in both, the general population and the group of women at high risk for ovarian cancer including BRCA genes mutations carriers, has proven to be ineffective. The recommended screening methods, including a pelvic examination, transvaginal ultrasound, and CA125 p...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/1735
更新日期：2014-05-01 00:00:00
abstract：:Theoretically, a woman could bear unlimited number of fetuses. Practically, the human being on the top of his phylogenetic spread, has chosen the singleton birth as its dominant. The anatomical constitution of the woman let her feed no more than two children at the same time. This were probably the reasons for conside...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-11-01 00:00:00
abstract：:The most important benefit of tocolysis is a 48-hour prolongation of gestational age in order to administer corticosteroids to reduce perinatal mortality and morbidity as well as, if necessary to gain time for "in utero" transfer to a tertiary centre with neonatal facilities. The tocolytic agents used in clinical prac...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2010-02-01 00:00:00
abstract：:The expression of c-MYC gene has been detected by using the method of in situ hybridization. It has been detected mainly in glandular cells but also in stromal cells in atypical endometrial hyperplasia in women after menopause regardless of their age. A similar expression has been found to occur in nonatypical case of...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVES:Therapeutic hypothermia TH became broadly used in the management of the asphyxiated newborns. Although two cooling methods are used, so far the superiority of none of them has been established. The purpose of the study is to compare two cooling methods: selective head cooling (SHC) and whole body cooling (WB...
journal_title：Ginekologia polska
pub_type： 杂志文章,多中心研究
doi：10.5603/GP.2019.0069
更新日期：2019-01-01 00:00:00
abstract：DESIGN:The aim of our study was a currently clinical analysis of menarche. MATERIALS AND METHODS:The mean age of menarche was investigated in 4497 girls between 1975-1997 69 girls were examined throughly in the course of menarche. Age at menarche, body weight, height, body mass index (BMI), some of the hormones and ul...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
abstract：:Various therapheutic strategies employing stem cells have been proposed as the alternative, effective methods for therapy of multitude diseases, difficult to treat using standard, well-established methods. Advancing regenerative medicine, which is becoming a novel branch of clinical medicine, has high hopes of stem ce...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2009-12-01 00:00:00
abstract：:Legal abortions have reduced the number of miscarriages by 20%, and of abandoned children by 56%; but at the same time, can be hazardous to the mother both initially (loss of blood, punctured uterus, damaged cervix) and later (infections in the reproductive system, infertility, extrauterine pregnancy, psychological di...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1979-02-01 00:00:00
abstract：:Doppler evaluation of the fetal venous system at present improves assessment of fetal well-being in many conditions. Actually, analysis of ductus venosus waveforms seems to be the most important. It place role in detection of genetic abnormalities (in low pregnancies), prediction of outcomes growth-restricted fetuses,...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2005-06-01 00:00:00
abstract：:Obesity-related metabolic and functional disorders may disturb adaptation process taking place in pregnant women body. Insufficient adaptation may lead to development of several medical complications during pregnancy, labor, delivery, and puerperium. Maternal obesity is associated with increased frequencies of hyperte...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：1999-06-01 00:00:00
abstract：OBJECTIVES:To analyze the correlation between ultrasound typing and treatment modality of patients with an intrauterine ectopic pregnancy (cervical and cesarean scar). MATERIAL AND METHODS:We retrospectively enrolled 65 patients diagnosed with cesarean scar pregnancy (CSP) or cervical pregnancy (CP) between February 2...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2020.0026
更新日期：2020-01-01 00:00:00
abstract：INTRODUCTION:Perinatal hysterectomy (PH) is usually a life-saving procedure, which is performed after all conservative treatment options fail. The PH frequency rate ranges from 0.04 to 0.23%. The most frequent indications for this procedure include: abnormal placental implantation, placenta previa, uterine rupture and ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：10.17772/gp/1712
更新日期：2014-03-01 00:00:00
abstract：:The premenstrual syndrome occurs in the second phase of period and strain, sensitivity, nervousness, anxiety, sleeplessness, headaches, sickness, swollen breasts are the typical symptoms of the syndrome. 143 high school girls have been subjected to the anonymous questionnaire. They were divided into two groups: A--tho...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-08-01 00:00:00
abstract：:We report an unusual case of adenomyosis with asymptomatic thoracic endometriosis. A 30-year old woman had a history of nephroblastoma, two missed abortions and one childbirth by caesarean section. The pregnancy was complicated with asymmetric fetus hipotrophy. Two years after delivery she had assessments for dysmenor...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Conditions under which episodes of eclampsia occurred in puerperal, who were than admitted to the Intensive Care Units for treatment are presentation the paper. Multidirectional diagnostic procedures introduced in those 30 patients are discussed. In the analysed group of patients various types of organ complications w...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:14 patients suffered from endometriosis and retroflected uterus were presented. They were treated with laparoscopic ante-fixation of the uterus and Danazol-therapy. Combined treatment was successful, the pain had ceased. ...
journal_title：Ginekologia polska
pub_type： 临床试验,杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:32 patients with hydatid mole were subjected to serological tests to determine the concentration of chorionic gonadotropin (HCG) in the urine. The patients were divided into 2 groups, depending on the duration of the amenorrhea. Group 1 (20 cases) showed a uterus size not exceeding the volume of the 12th week of ges...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：:The aim of the work is to present regenerative medicine achievement as an alternative SUI treatment and the variety of injected cells type as well as injection techniques itself with the analysis of their quality and possible the mechanism in which they reduce urinary incontinence symptoms. For over a decade numerous ...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：10.17772/gp/60973
更新日期：2016-01-01 00:00:00
abstract：:The influence of hormone replacement therapy (HRT) on coagulation system has not been completely explained yet. We measured plasma activities of antithrombin III, protein C and protein S before and after 6 and 12 months of HRT in 48 postmenopausal women. HRT consisted of transdermal estradiol and orally medroxyprogest...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1996-08-01 00:00:00
abstract：UNLABELLED:The aim of the study was to compare frequency of four gynecological operations: myomectomy, tubal surgery, cystectomy and operative management of ectopic pregnancy, performed by laparotomy or laparoscopy, by the same team of surgeons. In the years 1994-1997 in Division of Reproduction Poznań University Medic...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2001-04-01 00:00:00
abstract：:The population of 49 young, secondary amenorrheic women aged 17 to 20 was divided according to reaction on i.m. injection of progesterone in oil. The positive category was subdivided into I--polycystic ovarian disease with elevated serum LH and II--hypothalamic-pituitary dysfunction (HPD) with normal (or decreased) le...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:The incidence of multiple pregnancies increases with concomitant increased risk in maternal and fetal complications. Delayed delivery is still a rare occurrence in the literature despite advances in reproductive medicine and increasing number of multiple gestations. Authors report a case of delayed delivery in a dicho...
journal_title：Ginekologia polska
pub_type： 杂志文章,评审
doi：
更新日期：2004-12-01 00:00:00
abstract：:The aim of this study was to evaluate the predictive value of respiratory distress syndrome-RDS evidence using amniotic fluid diagnostic tests. 200 amniotic fluid samples obtained by amniocentesis were study to evaluate pulmonary tissue maturity status. The PG test was 30% specific and 100% sensitive; FLM test showed ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:The author describes the experiences and observations of 80 women with the Spider Cu, a Polish IUD. The Spider Cu is a copperbearing spatial IUD which demonstrates high elasticity, resilience, as well as a low pregnancy rate. (author's modified) ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：OBJECTIVES:Supplementary assays are needed for determination of relationships between sperm biomarkers and fertility potential. Therefore, our research was designed to determine the extent of sperm DNA fragmentation (SDF) and establish a discriminating threshold of SDF for fertility potential. MATERIAL AND METHODS:Sem...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：10.5603/GP.2019.0117
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:The aim of the study was an evaluation of the frequency and distribution of congenital malformations in infants born at the Obstetrics and Gynecology Department of Wołomin District Hospital in the years 1991-95 and 2000-2004 and a comparison of occurrence frequency of defects' types in the analyzed periods. ...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：2006-09-01 00:00:00
abstract：:Study aimed at obtaining answer to the question if antiestrogenic treatment (tamoxifen or clomiphene) of men having oligozoospermia has an impact on the pregnancy course. The pregnancy courses were live analysed of 34 healthy women, who had been treated with the artificial insemination by husband, having received tamo...
journal_title：Ginekologia polska
pub_type： 杂志文章
doi：
更新日期：1993-10-01 00:00:00
