Abstract:
OBJECTIVES:Supplementary assays are needed for determination of relationships between sperm biomarkers and fertility potential. Therefore, our research was designed to determine the extent of sperm DNA fragmentation (SDF) and establish a discriminating threshold of SDF for fertility potential. MATERIAL AND METHODS:Semen characteristics were evaluated according to World Health Organization recommendations, and SDF was assessed by sperm chromatin dispersion test on ejaculated spermatozoa from infertile and healthy normozoospermic men. RESULTS:A higher proportion of SDF was noted in infertile men (median 23.00%) than normozoospermic (median 14.00%). Significantly less subjects (17.03%) with low SDF level (≤ 15%) and more (35.17%) with high SDF level ( > 30%) were found for the infertile group vs the normooospermic (57.90% and 5.26%, respectively). Infertile group had significantly lower odds ratio (OR) for having a low SDF level (OR: 0.1493) and higher OR for having a high SDF level (OR: 9.7627). Receiver operating characteristic analysis [area under curve (AUC) = 0.785] revealed that 20% SDF is predictive value for discriminating between infertile and normozoospermic subjects. SDF was negatively correlated with the sperm number, morphology, progressive motility and vitality but positively with the teratozoospermia index. CONCLUSIONS:Our study demonstrates: (1) a significant difference in the extent of SDF and in the risk for having damaged sperm DNA between infertile and normozoospermic men, (2) > 20% SDF has negative predictive value for fertility potential, (3) coexistence of abnormal standard sperm parameters with sperm chromatin damages. Therefore, SDF should be considered as a highly valuable indicator of male fertility potential.
journal_name
Ginekol Poljournal_title
Ginekologia polskaauthors
Gill K,Rosiak-Gill A,Jakubik J,Patorski L,Lukaszuk M,Piasecka Mdoi
10.5603/GP.2019.0117subject
Has Abstractpub_date
2019-01-01 00:00:00pages
684-691issue
12eissn
0017-0011issn
2543-6767pii
VM/OJS/J/65071journal_volume
90pub_type
杂志文章abstract::Following the first successful cord blood transplantation in 1988, several hundreds of patients were treated using same protocol. The main limitation of the wide use of cord blood as a source of haematopoietic cells is the number of available units of this tissue. To make possible selection of HLA-matched cells for in...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:Abdominal obesity is a risk factor for endometrial cancer. The negative impact of individual parameters of obesity on the procedural effects of endometrial cancer surgical treatment has been suggested. The aim of the current study was to estimate the relationship of particular parameters of obesity and in-ho...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.2019.0095
更新日期:2019-01-01 00:00:00
abstract::This case report describes a 40-year-old woman, primigravida. On 13,3 weeks of gestation we diagnosed an abnormal flow pattern in the umbilical artery and abnormal hyperechogenic structure in fetal abdomen. In next sonographic examination on 16 weeks of gestation we diagnosed ventriculomegaly and ahydramnion. We also ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2006-05-01 00:00:00
abstract:MATERIAL AND METHODS:It was a retrospective analysis of fetal echocardiography results (analysis of congenital heart defect (CHD) and functional abnormalities in normal heart anatomy) in 83 fetuses diagnosed and treated in the same institution. RESULTS:In our group of fetuses, the most common structural defect, in add...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2008-09-01 00:00:00
abstract:UNLABELLED:The purpose of our study was to analyze the efficacy of serum C-reactive protein (CRP), white blood cell count (WBC) and erythrocyte sedimentation rate (ESR) serial evaluations in the prediction of chorioamnionitis in cases of premature rupture of membranes (PROM). MATERIALS AND METHODS:A group of 80 patien...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Accurate diagnosis and proper monitoring of cancer patients remain important obstacles for successful cancer treatment. The search for cancer biomarkers is carried out in order to quickly identify tumor cells and predict treatment response, ultimately leading to a favorable therapeutic outcome. One such prognostic mar...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2012-07-01 00:00:00
abstract::Leiomyomatosis peritonealis disseminata(LPD) is a rare smooth muscle pathology, characterized by the presence of multiple tumors in peritoneal cavity mimicking a malignant process with metastases. The diagnosis may be difficult in some cases as the results of ultrasonography and CT imaging may suggest malignancy. The ...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract::The presence of estrogens, their function and targets in male reproductive tract are still not fully understood. Recent studies, basic and clinical indicate an important role of estrogens during germ cell development. In this study the efforts have been made to immunolocalize aromatase P450 as well as estrogen recepto...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Worldwide screening for early detection of ovarian cancer in both, the general population and the group of women at high risk for ovarian cancer including BRCA genes mutations carriers, has proven to be ineffective. The recommended screening methods, including a pelvic examination, transvaginal ultrasound, and CA125 p...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:10.17772/gp/1735
更新日期:2014-05-01 00:00:00
abstract::An increase in alpha-amylase activity with parallel decrease in glucose concentration in amniotic fluid is observed during pregnancy. This interdependence is a theoretical basis for using an alpha-amylase/glucose index in fetal maturity evaluation. The aim of the study was to investigate usefulness of the alpha-amylas...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVES:There are some data concerning homocysteine influence on fertilization and early embryogenesis, especially in women experiencing recurrent pregnancy loss (RSA). However, limited data support hypothesis that the ovum might be exposed to high homocysteine concentration what may be important in egg-sperm intera...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2003-09-01 00:00:00
abstract::Concentrations of glucose, bilirubin, H+ ions, estriol, HPL were determined in the samples of amniotic fluid from post term and near term pregnancies. Investigated group consisted of samples taken between 42-43 week of gestation, control group between 38-40 week. In both groups biochemical tests of pulmonary maturatio...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:UNLABELLED:The aim of the study was evaluation, whether cord blood insulin (Ic) and erythropoietin (EPO) levels differ in accordance with mode of delivery: cesarean section (CS) or vaginal delivery (VD). MATERIAL AND METHODS:The study was performed in the diabetic group consisted of 148 newborns of diabetic mothers (N...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVES:Richter operation is used for the enterocele and high rectocoele treatment. There are many modifications of the procedure. Alas, not much data concerning complications and the learning curve of Richter operation is currently at our disposal. DESIGN:The aim of the study is to analyze the course of sacrospino...
journal_title:Ginekologia polska
pub_type: 临床试验,杂志文章
doi:
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Pregnancy induced hypertension is believed to be a state of neutrophil overactivity, however all previous studies were done on isolated cells. DESIGN:To study neutrophil activity in whole blood of PIH women. MATERIALS AND METHODS:Neutrophil activity was estimated without isolation, in peripheral whole bloo...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract::The first results of laser therapy in treatment of condylomata acuminata of male reproductive organs are reported. Between November 1991 and December 1993 in Department of Reproduction, Institute of Gynecology and Obstetrics, Karol Marcinkowski University School of Medical Sciences, Poznań in nine patients with condyl...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVES:G-CSF is a stimulatory factor of granulocyte colony formation. In vitro and in vivo G-CSF stimulates the proliferation of granulocyte precursors and enhances phagocytic functions of mature cells. Indirect evidence of this might be the increase of the activity of granulocyte enzymes participating in phagocyto...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract::Sensibility and specificity of transvaginal ultrasonography and diagnostic hysteroscopy were compared in 211 infertile women. Examinations were performed between 1996-2000 in I-st Department of Obstetrics and Gynecology Warsaw Medical University--Poland. Comparing results we concluded high compatibility of transvagina...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVES:The aim of the study is to determine the results of our initial experience of 32 cases who underwent single incision total laparoscopic hysterectomy MATERIALS AND METHODS:Thirty-two patients who underwent transumbilical single incision total laparoscopic hysterectomy between March 2009 and February 2011 wer...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2012-08-01 00:00:00
abstract::The paper presents the course of treatment and results of pathological changes in the uterine cervix in 41 patients who underwent cryotherapy by means of a cryotherapeutic apparatus UK-32, using liquid nitrogen as cryogenic fluid. Complete recovery in the form of typical stratified squamous epithelium was achieved in ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1989-03-01 00:00:00
abstract::The paper presents a simple and cheap method of transvaginal hydro-laparoscopy used for the observation women pelvic organs. The method may be useful to diagnose sterility, indefinite pains the pelvis or to control the patients previously undergoing operations. Hydro-laparoscopy was carried out in 12 patients by means...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::Small intestinal tumors are relatively rare, and notoriously difficult to diagnose. In our case 64 years old female was operated because suspicion of ovarian tumor. The complained on recurrent gastrointestinal bleeding. An arteriogram of superior mesenteric artery revealed arteriovenous malformation in the distal part...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:Angiogenesis in malignant tumors is a prognostic factor associated with tumor growth and metastasis. Studies of angiogenesis in breast, prostate and lung cancer showed that neovascularisation correlates with likelihood of metastasis and recurrence. Our study was to evaluate microvessel density as a prognostic...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2002-11-01 00:00:00
abstract::182 hysteroscopic operations with electroresectoscope use performed in Ist Department of Obstetrics and Gynaecology (Warsaw) between 1996-1999 were analyzed. Myomectomy was performed in 117 patients, resection of uterine septum in 25 and deliberation of intrauterine adhesions in 40 patients. Abnormal bleeding and infe...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::The aim of the work were changes of serum ferritin and iron concentrations in women with leiomyoma of the uterus treated surgically. We took the growth of the leiomyomatous uterus under concern. We observed the lower serum ferritin and iron concentrations before the surgical treatment, and the correlation with the gro...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract:OBJECTIVES:Preterm premature rupture of membranes (PPROM) complicates about 5% of pregnancies. Ureaplasma species is the most common pathogen found in the amniotic fluid in pregnancieneonatal outcome. The aim of the following study was to evaluate the impact of colonization with the Ureaplasma spp. on pregnant women wi...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.17772/gp/57857
更新日期:2015-09-01 00:00:00
abstract::Preterm labor remains to be one of the most important challenges of contemporary perinatology and constitutes the main reason of perinatal mortality and prematurity of neonates. Studies on preterm labor have confirmed the mutual interactions of several different hormonal systems while the activation of hypothalamic- p...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2014-02-01 00:00:00
abstract::Three different variants of biologically agressive cervical cancers, such as: basaloid carcinoma, glassy cell carcinoma and small cell endocrine carcinoma, have been reported. Hematoxylin and eosin, periodic acid-Schiff and immunohistochemical stains were used. The course of disease and aplication of treatment has bee...
journal_title:Ginekologia polska
pub_type: 杂志文章,评审
doi:
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVES:To assess the impact of pelvic magnetic resonance imaging (MRI) findings in the indication for uterine-artery embolization in women with fibroids, as well as the correlation between MRI and ultrasound (US) examinations for diagnosing adenomyosis. MATERIAL AND METHODS:A retrospective observational study was ...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:10.5603/GP.a2017.0024
更新日期:2017-01-01 00:00:00
abstract::Between 1994-1999 at the Department for Diagnosis of Congenital Malformations at the PPMH Institute there were ultrasound and echocardiography examinations performed in 40 fetuses with Down Syndrome. In our study most of the cases come from low risk groups of pregnant women. Congenital heart defects (AV-canal in 13/18...
journal_title:Ginekologia polska
pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00