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Comparison of neurotoxicity of root canal sealers on spontaneous bioelectrical activity in identified Helix neurones using an intracellular recording technique.

Abstract：

AIM:To evaluate the neurotoxic effects of two endodontic sealers, AH-26 and Roth 801, on firing excitability and action potential configuration of F1 neural cells in the suboesophageal ganglia of Helix aspersa. METHODOLOGY:A conventional intracellular current clamp technique was used to study the blocking effects of AH-26 and Roth 801 on ionic currents underlying the action potential of F1 nerve cells. The sealers were prepared according to the manufacturers' directions and were applied to the bathing media in two ways: invasive (0.05 mL of total mixture of each sealer was applied at a distance of 3 mm from the cell), or gradual (0.05 mL of the extract of each dissolved mixture of sealers in normal Ringers solution was perfused). RESULTS:When applied in an invasive mode, both sealers reduced the duration, the amplitude of action potentials and the amplitude of after-hyperpolarization potentials significantly and led to dramatic changes in action potential configuration. In the gradual mode of application, AH-26 showed a biphasic action; it first increased the excitability and then decreased the action potential parameters, while Roth 801 exhibited solely blocking effects. CONCLUSIONS:Both sealers had significant inhibitory effects on excitability of F1 neuronal cells.

journal_name

Int Endod J

journal_title

International endodontic journal

authors

Asgari S,Janahmadi M,Khalilkhani H

doi

10.1111/j.1365-2591.2003.00751.x

keywords:

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

891-7

issue

12

eissn

0143-2885

issn

1365-2591

pii

751

journal_volume

36

pub_type

杂志文章

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