当前位置： SCI文献检索 > INTERNATIONAL ENDODONTIC JOURNAL期刊下所有文献 > Activated platelets increase proliferation and protein synthesis of human dental pulp-derived cells.

Activated platelets increase proliferation and protein synthesis of human dental pulp-derived cells.

Abstract：

AIM:To evaluate the impact of activated platelets on the mitogenic expansion of human dental pulp-derived cells (DPC) in vitro. METHODOLOGY:The effect of supernatants released from activated platelets (PRS) and the corresponding platelet membranes (MEM) on proliferation and protein synthesis of DPC was evaluated. The contributions of the phosphoinositide 3-kinase (PI3K)/AKT and mitogen-activated protein kinase (MAPK) pathways to the response of DPC were assessed using kinase inhibitors. Also examined was whether the presence of calcium hydroxide or the inflammatory mediators tumour necrosis factor alpha, interleukin-1, interleukin-6 and lipopolysaccharide of Escherichia coli modulated the expansion of DPC. RESULTS:Physiologic concentrations of PRS and MEM stimulated proliferation and protein synthesis by 18.4-fold (P < 0.01) and 2.9-fold (P < 0.01), respectively. This mitogenic expansion was paralleled by activation of AKT and the MAP kinases extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and p38. Inhibitor studies revealed that the mitogenic response of DPC involved PI3K/AKT, JNK and p38 signalling (P < 0.05). Calcium hydroxide and inflammatory factors did not significantly modulate the mitogenic response of DPC to PRS and MEM. CONCLUSION:Supernatants released from activated platelets and the corresponding platelet membranes stimulated DPC proliferation and protein synthesis involving PI3K/AKT and MAPK signalling. These findings may serve as a basis for preclinical studies that address the role of activated platelets in dental pulp repair.

journal_name

Int Endod J

journal_title

International endodontic journal

authors

Agis H,Stampfl B,Watzek G,Gruber R

doi

10.1111/j.1365-2591.2009.01650.x

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

115-24

issue

2

eissn

0143-2885

issn

1365-2591

pii

IEJ1650

journal_volume

43

pub_type

杂志文章

相关文献

INTERNATIONAL ENDODONTIC JOURNAL文献大全
  • Root canal treatment of a root-fractured incisor tooth with internal resorption: a case report.

    abstract：:A case is described in which root canal treatment with calcium hydroxide was used successfully to repair a fracture site with internal resorption of the tooth. ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1996.tb01404.x

    authors： Calişkan MK,Türkün M

    更新日期：1996-11-01 00:00:00

  • Effect of sodium hypochlorite on mechanical properties of dentine and tooth surface strain.

    abstract：AIM:The aim of this study was to test the null hypothesis that sodium hypochlorite irrigation of root canals does not alter the properties of dentine and contribute to the weakening of root-treated teeth. METHODOLOGY:The effect of two concentrations (0.5%, 5.25%) of sodium hypochlorite (NaOCl) and saline on (i) the el...

    journal_title：International endodontic journal

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2591.2001.00357.x

    authors： Sim TP,Knowles JC,Ng YL,Shelton J,Gulabivala K

    更新日期：2001-03-01 00:00:00

  • Successful pulp revascularization of an autotransplantated mature premolar with fragile fracture apicoectomy and plasma rich in growth factors: a 3-year follow-up.

    abstract：AIM:This case report demonstrates a positive outcome of the adjuvant use of fragile fracture (FF), which is a technique used to harvest dental pulp stem cells (DPSCs), and platelet-rich plasma (PRP) in a mandibular premolar (tooth 44) with a completely formed root that was transplanted into a surgically created socket ...

    journal_title：International endodontic journal

    pub_type：

    doi：10.1111/iej.13230

    authors： Gaviño Orduña JF,García García M,Dominguez P,Caviedes Bucheli J,Martin Biedma B,Abella Sans F,Manzanares Céspedes MC

    更新日期：2020-03-01 00:00:00

  • European Society of Endodontology position statement: Management of deep caries and the exposed pulp.

    abstract：:This position statement on the management of deep caries and the exposed pulp represents the consensus of an expert committee, convened by the European Society of Endodontology (ESE). Preserving the pulp in a healthy state with sustained vitality, preventing apical periodontitis and developing minimally invasive biolo...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13080

    authors： European Society of Endodontology (ESE) developed by:.,Duncan HF,Galler KM,Tomson PL,Simon S,El-Karim I,Kundzina R,Krastl G,Dammaschke T,Fransson H,Markvart M,Zehnder M,Bjørndal L

    更新日期：2019-07-01 00:00:00

  • Do pre-existing microcracks play a role in the fracture resistance of roots in a laboratory setting?

    abstract：AIM:To investigate a potential cause-effect relationship between dentinal microcracks and fracture resistance of mandibular incisors that had not been endodontically treated. METHODOLOGY:Sixty mandibular incisors with circular-shaped canals were selected based on micro-computed tomographic scans to create a homogeneou...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13370

    authors： Cavalcante DM,Belladonna FG,Simões-Carvalho M,Carvalhal JCA,Souza EM,Lopes RT,Silva EJNL,Dummer PMH,De-Deus G

    更新日期：2020-11-01 00:00:00

  • Radiopacity of root filling materials using digital radiography.

    abstract：AIM:To evaluate radiopacity of root filling materials using digital radiography. METHODOLOGY:The sealers tested were AH Plus, Endofill, EndoREZ and Epiphany. Gutta-percha (Dentsply Maillefer) and Resilon cones were also tested. Acrylic plates, containing six wells, measuring 1 mm in depth and 5 mm in diameter, were pr...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2007.01246.x

    authors： Carvalho-Junior JR,Correr-Sobrinho L,Correr AB,Sinhoreti MA,Consani S,Sousa-Neto MD

    更新日期：2007-07-01 00:00:00

  • Effect of delayed scanning on imaging and on the diagnostic accuracy of vertical root fractures in two photostimulable phosphor plates digital systems.

    abstract：AIM:To evaluate the influence of delayed scanning on images obtained with two PSPs digital systems and on the diagnostic accuracy of vertical root fracture (VRF) by means of objective and subjective analyses. METHODOLOGY:Forty single-rooted human teeth were divided into two groups, one without VRFs and another with VR...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12547

    authors： Nascimento HA,Visconti MA,Ferreira LM,Suarez MA,Haiter Neto F,Freitas DQ

    更新日期：2016-10-01 00:00:00

  • Shaping ability of BioRace, ProTaper NEXT and Genius nickel-titanium instruments in curved canals of mandibular molars: a MicroCT study.

    abstract：AIM:To evaluate and compare the canal shaping ability of BioRace, ProTaper NEXT and Genius engine-driven nickel-titanium (NiTi) file systems in extracted mandibular first molars using micro-computed tomography (MCT). METHODOLOGY:Sixty mesial root canals of mandibular first molars were randomly divided into three equal...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12961

    authors： Drukteinis S,Peciuliene V,Dummer PMH,Hupp J

    更新日期：2019-01-01 00:00:00

  • Assessment of coronal leakage in teeth root filled with gutta-percha and a glass of ionomer root canal sealer.

    abstract：:The effect on coronal leakage of the use of either a single gutta-percha cone or cold lateral condensation of gutta-percha, with a glass ionomer sealer cement was studied. In addition, the effect of the removal of the smear layer was also determined. Eighty-eight single-rooted teeth were prepared chemomechanically usi...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1994.tb00255.x

    authors： Tidswell HE,Saunders EM,Saunders WP

    更新日期：1994-07-01 00:00:00

  • The antibacterial properties of four elements released from dental restorative materials.

    abstract：:The antibacterial activity of four elements (zinc, copper, fluoride and mercury), previously reported to be released from dental restorative materials, was investigated. This was carried out using two aerobic micro-organisms isolated from dentine beneath cavities in the ferret. These were grown in the presence of the ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1989.tb00499.x

    authors： Nourollahi M,Meryon SD

    更新日期：1989-01-01 00:00:00

  • Atomic force microscopic evaluation of nanostructure alterations of rotary NiTi instruments after immersion in irrigating solutions.

    abstract：AIM:To compare the effect of 5.25% NaOCl or 17% EDTA solutions on the surface topography and roughness of GTX, TF, RaCe and Hero Shaper instruments using atomic force microscopy (AFM) analysis. METHODOLOGY:Four new files of each brand were subjected to AMF analysis; then each group was subdivided into two subgroups (n...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12189

    authors： Fayyad DM,Mahran AH

    更新日期：2014-06-01 00:00:00

  • Canal configuration of the mesiobuccal root of the maxillary first molar of a Japanese sub-population.

    abstract：AIM:The aim of this study was to determine the percentage of anatomical canal configurations of the mesiobuccal root of the maxillary first molar in Japanese patients. METHODOLOGY:Three hundred teeth were obtained from general dentists who knew absolutely that they were extracted from Japanese patients. The distobucca...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1046/j.1365-2591.1999.00186.x

    authors： Weine FS,Hayami S,Hata G,Toda T

    更新日期：1999-03-01 00:00:00

  • Ten-year follow-up of root filled teeth: a radiographic study of a Danish population.

    abstract：AIM:To assess the long-term outcome of root filled teeth in a general adult population examined in 1997, 2003 and 2008. METHODOLOGY:The study provides longitudinal, observational information on endodontic status for 327 randomly selected individuals from a general Danish population receiving three consecutive full-mou...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12245

    authors： Kirkevang LL,Vaeth M,Wenzel A

    更新日期：2014-10-01 00:00:00

  • Expression of MMP-8 and MMP-13 in the development of periradicular lesions.

    abstract：AIM:To elucidate the expressions of MMP-8 and MMP-13 in experimentally induced rat periradicular lesions by means of the reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical staining. METHODOLOGY:Thirty rats were used and periradicular lesions in mandibular first molar teeth were establishe...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2011.01880.x

    authors： Matsui H,Yamasaki M,Nakata K,Amano K,Nakamura H

    更新日期：2011-08-01 00:00:00

  • Antimicrobial 2-hydroxyisocaproic acid and chlorhexidine resist inactivation by dentine.

    abstract：AIM:To compare the antibacterial activity of 2-hydroxyisocaproic acid (HICA) with currently used root canal medicaments and to examine their interactions with potential inhibitors in nutrient-deficient and nutrient-rich conditions. METHODOLOGY:First, the antibacterial activity of single concentrations of HICA, calcium...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12465

    authors： Sakko M,Tjäderhane L,Sorsa T,Hietala P,Rautemaa R

    更新日期：2016-04-01 00:00:00

  • A new classification system for the restoration of root filled teeth.

    abstract：:The aim of this report is to (i) review the current literature on the status of root filled teeth, (ii) analyse the most important factors in decision-making, (iii) discuss the current restorative concepts, and (iv) classify both the evidence and clinical practice in a way that seeks to be clear, understandable and he...

    journal_title：International endodontic journal

    pub_type： 杂志文章,评审

    doi：10.1111/iej.12847

    authors： Zarow M,Ramírez-Sebastià A,Paolone G,de Ribot Porta J,Mora J,Espona J,Durán-Sindreu F,Roig M

    更新日期：2018-03-01 00:00:00

  • Comparison of centring ability and transportation between four nickel titanium instrumentation techniques by micro-computed tomography.

    abstract：AIM:To compare the centring ability and transportation of ProTaper Next (PTN), ProTaper Universal (PTU), Race 123 and RevoS using micro-computed tomography (μCT). METHODOLOGY:Sixty mesial root canals of thirty mandibular molars were divided virtually into coronal, middle and apical thirds, and two reproducible referen...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.12658

    authors： Saberi N,Patel S,Mannocci F

    更新日期：2017-06-01 00:00:00

  • Cone beam computed tomography in Endodontics - a review of the literature.

    abstract：:The use of cone beam computed tomography (CBCT) in the diagnosis and/or management of endodontic problems is increasing and is reflected in the exponential rise in publications on this topic in the last two decades. The aim of this paper is to: (i) Review current literature on the endodontic applications of CBCT; (ii)...

    journal_title：International endodontic journal

    pub_type： 杂志文章,评审

    doi：10.1111/iej.13115

    authors： Patel S,Brown J,Pimentel T,Kelly RD,Abella F,Durack C

    更新日期：2019-08-01 00:00:00

  • Endodontic retreatment behaviour: the influence of disease concepts and personal values.

    abstract：:To explain dentists' variation in endodontic retreatment decision making a praxis concept (PC) has been generated. PC assumes that practitioners operate along a health continuum. Various periapical conditions are then perceived as different stages on a continuous health scale, based on their radiographic appearance. P...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1046/j.1365-2591.1998.00170.x

    authors： Reit C,Kvist T

    更新日期：1998-09-01 00:00:00

  • An apical leakage study in the presence and absence of the smear layer.

    abstract：:The apical seal produced by low-temperature injection of gutta-percha, with or without root canal sealer, in the presence or absence of the smear layer was evaluated quantitatively using an electrochemical technique. The root canals of 44 teeth were prepared with the smear layer intact following a final flush of NaOCl...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1994.tb00236.x

    authors： Karagöz-Küçükay I,Bayirli G

    更新日期：1994-03-01 00:00:00

  • Capacity of anaerobic bacteria enclosed in a simulated root canal to induce inflammation.

    abstract：:In an effort to simulate the infected dental root canal, bacteria were enclosed in polyethylene tubes that were subcutaneously implanted into rats. Four different bacterial combinations, selected from nine oral species, were tested. The contents of 144 inoculated and implanted 'root canals' were analysed after 2 and 4...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.1989.tb00931.x

    authors： Wu MK,Moorer WR,Wesselink PR

    更新日期：1989-11-01 00:00:00

  • Relationship between unintentional canal overfilling and the long-term outcome of primary root canal treatments and nonsurgical retreatments: a retrospective radiographic assessment.

    abstract：AIM:To determine retrospectively the long-term radiographic outcome of root canal treatments and root canal retreatments with unintentional root canal overfilling. METHODOLOGY:A total of 220 root canal treatments (143 primary/77 retreatments) with postoperative unintentional canal overfilling and performed by two endo...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/iej.13209

    authors： Goldberg F,Cantarini C,Alfie D,Macchi RL,Arias A

    更新日期：2020-01-01 00:00:00

  • An in-vitro investigation of the antibacterial effect of nisin in root canals and canal wall radicular dentine.

    abstract：AIM:To determine whether nisin, a bacteriocin, would be effective at killing Enterococcus faecalis and Streptococcus gordonii cells in solution and within the root canal system. METHODOLOGY:Bacterial isolates of E. faecalis and S. gordonii were grown from glycerol stocks in closed tubes containing BHY broth at 37 degr...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2004.00846.x

    authors： Turner SR,Love RM,Lyons KM

    更新日期：2004-10-01 00:00:00

  • Comparative investigation of two rotary nickel-titanium instruments: ProTaper versus RaCe. Part 2. Cleaning effectiveness and shaping ability in severely curved root canals of extracted teeth.

    abstract：AIM:To determine the cleaning effectiveness and shaping ability of ProTaper and RaCe nickel-titanium rotary instruments during the preparation of curved root canals in extracted human teeth. METHODOLOGY:A total of 48 root canals of mandibular and maxillary molars with curvatures ranging between 25 degrees and 35 degre...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.0143-2885.2004.00783.x

    authors： Schäfer E,Vlassis M

    更新日期：2004-04-01 00:00:00

  • Prevalence of persistent pain after endodontic treatment and factors affecting its occurrence in cases with complete radiographic healing.

    abstract：AIMS:To (i) determine the prevalence of persistent dento-alveolar pain following nonsurgical and/or surgical endodontic treatment conducted in a teaching dental hospital and (ii) identify the risk factors associated with persistent pain after apparently successful root canal treatment. STUDY DESIGN:A total of 175 pati...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2004.00923.x

    authors： Polycarpou N,Ng YL,Canavan D,Moles DR,Gulabivala K

    更新日期：2005-03-01 00:00:00

  • Push-out strength of root fillings with or without thermomechanical compaction.

    abstract：AIM:To evaluate the influence of thermomechanical compaction (Tagger's hybrid technique - THT) on the push-out strength of several root filling materials to root dentine. METHODOLOGY:Root canals of eighty roots in human canines were prepared with the ProTaper system and filled with one of the following materials, usin...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2012.02039.x

    authors： Carneiro SM,Sousa-Neto MD,Rached FA Jr,Miranda CE,Silva SR,Silva-Sousa YT

    更新日期：2012-09-01 00:00:00

  • The design and development of surgical templates for premolar transplants in adolescents.

    abstract：:The aim of designing and fabricating the surgical templates was to assist the surgical component of premolar transplantation, by establishing and replicating the root dimensions of the donor premolar tooth. The correct template could be used to assess the socket preparation (width and depth) prior to placement of the ...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2012.02077.x

    authors： Day PF,Lewis BR,Spencer RJ,Barber SK,Duggal M

    更新日期：2012-11-01 00:00:00

  • A comparative study on the disinfection potentials of bioactive glass S53P4 and calcium hydroxide in contra-lateral human premolars ex vivo.

    abstract：AIM:To evaluate the effects of bioactive glass S53P4 versus calcium hydroxide when used as dressings in contra-lateral human premolars infected with Enterococcus faecalis ATCC 29212. METHODOLOGY:Pairs of contra-lateral premolar teeth plus single control premolars were obtained from 23 individuals aged 10-26 years unde...

    journal_title：International endodontic journal

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1365-2591.2006.01173.x

    authors： Zehnder M,Luder HU,Schätzle M,Kerosuo E,Waltimo T

    更新日期：2006-12-01 00:00:00

  • Effect of EDTA conditioning upon the retention of fibre posts luted with resin cements.

    abstract：AIM:To determine if a final rinse with EDTA improves the short-term in-tooth retentive strength of adhesively luted fibre-reinforced composite posts. METHODOLOGY:Six different commercial fibre post systems were tested. Post spaces in extracted human anterior teeth were irrigated with either 6% NaOCl or 6% NaOCl follow...

    journal_title：International endodontic journal

    pub_type： 杂志文章

    doi：10.1111/j.1365-2591.2008.01482.x

    authors： Rasimick BJ,Shah RP,Musikant BL,Deutsch AS

    更新日期：2008-12-01 00:00:00

  • Apical negative pressure irrigation versus syringe irrigation: a systematic review of cleaning and disinfection of the root canal system.

    abstract：:The aim of this study was to systematically review and critically analyse the published data on the treatment outcome (primary outcome) and on the cleaning and disinfection of root canals (secondary outcomes) achieved by negative pressure irrigation as compared to syringe irrigation. An electronic search was conducted...

    journal_title：International endodontic journal

    pub_type： 杂志文章,评审

    doi：10.1111/iej.12725

    authors： Konstantinidi E,Psimma Z,Chávez de Paz LE,Boutsioukis C

    更新日期：2017-11-01 00:00:00