Abstract:
AIM:To compare the antibacterial activity of 2-hydroxyisocaproic acid (HICA) with currently used root canal medicaments and to examine their interactions with potential inhibitors in nutrient-deficient and nutrient-rich conditions. METHODOLOGY:First, the antibacterial activity of single concentrations of HICA, calcium hydroxide solution or slurry, chlorhexidine digluconate or acetate was tested against Enterococcus faecalis with and without potential inhibitors: dentine powder (DP), hydroxyapatite or bovine serum albumin, in a low concentration of peptone water. Relative viable counts were determined by culture at 1, 24 and 48 h. In the second set of experiments, the activity of three concentrations of HICA was evaluated against two isolates of E. faecalis with and without potential inhibitors in nutrient-rich thioglycollate broth using a modification of a standard microdilution method. The minimum bactericidal concentration was determined by culture at 1, 24 and 48 h. RESULTS:Concentrations of ≥33 mg mL(-1) of HICA were found to be bactericidal against E. faecalis in both nutrient-deficient and nutrient-rich environments at 24- to 48-h incubation, whereas the initial activity of Ca(OH)2 slurry was lost at 48-h incubation. HICA tolerated well all tested potential inhibitors up to 19 mg mL(-1) . DP concentrations higher than this inhibited its activity in a dose-dependent manner in both environments. DP demonstrated moderate antibacterial activity, and it enhanced the otherwise limited activity of Ca(OH)2 slurry and solution. DP did not impact on the activity of chlorhexidine. CONCLUSIONS:These results support the long-term antibacterial activity of HICA and indicate its tolerance to clinically relevant concentrations of dentine and other inhibitors commonly present in the root canal system. Therefore, HICA may have potential as an interappointment medication in the treatment of root canal infections.
journal_name
Int Endod Jjournal_title
International endodontic journalauthors
Sakko M,Tjäderhane L,Sorsa T,Hietala P,Rautemaa Rdoi
10.1111/iej.12465subject
Has Abstractpub_date
2016-04-01 00:00:00pages
352-60issue
4eissn
0143-2885issn
1365-2591journal_volume
49pub_type
杂志文章abstract:AIM:To investigate differences in the root canal morphology of permanent mandibular molar teeth at various ages. METHODOLOGY:Four hundred and eighty permanent mandibular first and second molars were examined. First and second molars were divided into six and five groups, respectively, according to the age of the patie...
journal_title:International endodontic journal
pub_type: 杂志文章
doi:10.1111/j.1365-2591.2008.01428.x
更新日期:2008-10-01 00:00:00
abstract:AIM:To determine the effect of intracoronal bleaching agents on adhesion of bonding agents to pulp chamber dentine. METHODOLOGY:Forty extracted human maxillary anterior teeth were randomly divided into four groups of 10 teeth each. Bleaching agents were sealed in pulp chambers for 7 days, as in clinical use. Group 1 (...
journal_title:International endodontic journal
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doi:10.1111/j.1365-2591.2004.00931.x
更新日期:2005-04-01 00:00:00
abstract::Animal testing is crucial in situations when research on humans is not allowed because of unknown health risks and ethical concerns. The current project aims to develop reporting guidelines exclusively for animal studies in Endodontology, using an established consensus-based methodology. The guidelines have been named...
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更新日期:2021-01-15 00:00:00
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更新日期:2013-11-01 00:00:00
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journal_title:International endodontic journal
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更新日期:2010-12-01 00:00:00
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doi:10.1111/iej.12058
更新日期:2013-08-01 00:00:00
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journal_title:International endodontic journal
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更新日期:2017-02-01 00:00:00
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journal_title:International endodontic journal
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更新日期:2016-01-01 00:00:00
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更新日期:2012-07-01 00:00:00
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更新日期:2019-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2591.2009.01609.x
更新日期:2009-11-01 00:00:00
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journal_title:International endodontic journal
pub_type: 杂志文章
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更新日期:1996-11-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:International endodontic journal
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更新日期:2021-01-01 00:00:00
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journal_title:International endodontic journal
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更新日期:1992-05-01 00:00:00
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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