Immunohistochemical localization of cyclooxygenase-2 in radicular cysts.

Abstract:

AIM:The purpose of this study was to investigate the expression of cyclooxygenase-2 (COX-2) in radicular cysts. METHODOLOGY:Thirty biopsy specimens of radicular cysts were examined using immunohistochemistry. A peroxidase-labelled streptavidin-biotin technique was used for identification of the COX-2. Fisher's exact test (two-tail) was used for statistical analysis of the results. RESULTS:The result demonstrated that COX-2 expression was significantly higher in radicular cysts with higher levels of inflammatory infiltrates. COX-2 stain was detected in the lining epithelium, subepithelial fibroblasts, macrophages and endothelial cells in all specimens. CONCLUSIONS:COX-2 expression is significantly higher in radicular cysts. COX-2 may play an important role in the pathogenesis of radicular cysts.

journal_name

Int Endod J

authors

Tsai CH,Huang FM,Yang LC,Chou MY,Chang YC

doi

10.1046/j.1365-2591.2002.00584.x

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

854-8

issue

10

eissn

0143-2885

issn

1365-2591

pii

584

journal_volume

35

pub_type

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