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Toll-like receptor 2 expression in refractory periapical lesions.

Abstract：

AIM:To investigate the expression of TLR2 in refractory periapical lesions. METHODOLOGY:Refractory periapical lesion biopsies were histopathologically and clinically categorized into asymptomatic periapical granuloma (n=10), symptomatic periapical granuloma (n=10) or periapical cyst (n=10) and prepared for immunohistochemical staining using antibodies to TLR2, CD3 and CD19 or staining with methyl green pyronin. Sections were viewed under light microscopy and the presence or absence of the target cells was correlated with the histopathological and clinical data. Additionally, TLR2 expression was quantified by counting TLR(+) cells. RESULTS:Various mononuclear inflammatory cells in the bacteria-induced periapical lesions were reactive to TLR2 antibody, with many showing morphological similarities to lymphocytes and plasma cells. Lymphocytes were the most numerous cells in the inflammatory infiltrate. In refractory periapical granuloma, CD3(+) T cells were more numerous, whereas in periapical cysts, CD19(+) B cells were more numerous. There was a statistically significant (P<0.05) higher expression of TLR2 in symptomatic periapical granuloma than asymptomatic periapical granuloma or periapical cyst. CONCLUSION:The presence of TLR-expressing cells in periapical granulomas and cysts provides further evidence that periapical cysts are likely to be sustained by the immune system via reaction to bacterial antigens.

journal_name

Int Endod J

journal_title

International endodontic journal

authors

Desai SV,Love RM,Rich AM,Seymour GJ

doi

10.1111/j.1365-2591.2011.01893.x

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

907-16

issue

10

eissn

0143-2885

issn

1365-2591

journal_volume

44

pub_type

杂志文章

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