Abstract:
:Prospective surveillance of nosocomial infection was conducted at seven skilled proprietary nursing facilities in Orange County, Calif., USA. The average incidence of facility-acquired infection was 5.2 infections/1,000 patient days. The most common source of infection was urinary tract (47%), followed by respiratory tract (26%) and skin (14%). The four most common pathogens isolated were Proteus spp. (20%), Escherichia coli (17%), Staphylococcus aureus (13%) and Pseudomonas spp. (11%). Trimethoprim-sulfamethoxazole (20%) was the most frequently used antibiotic among all prescriptions, followed by ampicillin (16%) and ciprofloxacin (14%). Among all residents surveyed, 33% received at least one course of antibiotics during the study. Of special significance was the fact that 4 (22%) of the 18 strains of Pseudomonas were gentamicin resistant as were 12 of 80 (15%) of the strains of Enterobacteriaceae. Furthermore, 9 of 29 (31%) strains of Pseudomonas tested were found resistant to norfloxacin as were 15 of 129 (12%) strains of enterobacteriaceae. Susceptibility patterns of the isolated pathogens were similar to those of the acute care hospital. This study indicates that infection continues to be a major problem in the skilled nursing facility and that antibiotic-resistant pathogens will be a challenge for the future.
journal_name
Gerontologyjournal_title
Gerontologyauthors
Lee YL,Thrupp LD,Friis RH,Fine M,Maleki P,Cesario TCdoi
10.1159/000213332keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
223-32issue
4eissn
0304-324Xissn
1423-0003journal_volume
38pub_type
杂志文章相关文献
GERONTOLOGY文献大全abstract:BACKGROUND:Werner's syndrome, a rare autosomal recessive disorder, is characterized by features of premature aging. Seventy-five percent of the alleles of Japanese patients with Werner's syndrome have one of three major mutations. OBJECTIVE:To determine the genotype of a patient with Werner's syndrome. METHODS:We dia...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000058353
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Falls are a major cause of morbidity among older people. Multifaceted interventions may be effective in preventing falls and related fractures. OBJECTIVE:To evaluate the cost-effectiveness alongside the REducing Falls with Orthoses and a Multifaceted podiatry intervention (REFORM) trial. METHODS:REFORM was...
journal_title:Gerontology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1159/000489171
更新日期:2018-01-01 00:00:00
abstract::The effect of centrophenixine has been studied on the monovalent electrolyte contents of the brain cortical cells of old female Wistar rats by means of energy dispersive x-ray microanalysis. The drug was administered in form of an intraperitoneal injection of 100 mg/kg body weight for 20 days. The treatment decreased ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212326
更新日期:1979-01-01 00:00:00
abstract::Although it is usually assumed that Lamarckian inheritance does not and cannot occur, molecular mechanisms by which non-mutational changes acquired in one generation can be transmitted to the next are now known. These mechanisms involve changes in chromatin structure, rather than changes in DNA base sequence. It is ar...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213217
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:A large proportion of falls in older people are caused by slipping. Previous occupational safety research suggests that inadequate footwear may contribute to slipping accidents; however, no studies have assessed the slip resistance of casual footwear. OBJECTIVE:To evaluate the slip resistance of different t...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052788
更新日期:2001-05-01 00:00:00
abstract::The activity of ceruloplasmin (CP) increased 3-fold in rat blood between 1 week and 20 months of age, but the difference in CP activity of adult and old rats was only 14%, which still is statistically significant (p less than 0.01). The increase in NaCl and KCl concentrations in vitro resulted in the same exponential ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213261
更新日期:1991-01-01 00:00:00
abstract::The hippocampus is a structure equipped with a high degree of flexibility and adaptation. In contrast to most structures of the adult central nervous system, the hippocampus can rely on a form of plasticity known as neurogenesis. The continuous provision of new neurons derived from resident adult neural stem cells app...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000323481
更新日期:2011-01-01 00:00:00
abstract::The Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disease characterized by a triad of oculocutaneous albinism, accumulation of auto-fluorescent ceroid-like pigments within macrophages, and bleeding tendency due to a storage pool disease of the platelets. We report an autopsy case (39y, male), who died of p...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213751
更新日期:1995-01-01 00:00:00
abstract::Still's disease is very rare in elderly patients. We report a case of Still's disease in an elderly patient that had an atypical initial presentation. A 76-year-old woman developed unexplained chronic anemia and thrombocytosis. Three years later she had acute onset of high fever, arthritis, maculopapular rash, pleurit...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000102949
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Due to aging, tissue regeneration gradually declines. Contemporary strategies to promote tissue-specific regeneration, in particular in elderly patients, often include synthetic material apt for implantation primarily aiming at upholding body functions and regaining appropriate anatomical and functional inte...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000494798
更新日期:2019-01-01 00:00:00
abstract::Demented elderly patients unable to eat independently and often refusing food are threatened by malnutrition. Therefore, we determined in 6 female patients aged 74-100 with senile dementia the average daily food consumption within a 3-week period by the exact weighing methods on six occasions. The average daily energy...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213107
更新日期:1983-01-01 00:00:00
abstract::Sera from 40 elderly individuals ranging in age from 60 to 94 years were tested for the presence of antibodies to varicella-zoster virus (VZV)-specific proteins. Sodium dodecylsulfate polyacrylamide gel electrophoresis analysis of lysates of VZV-infected BSC-1 cells labeled with either [35S]methionine or [3H]mannose a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212962
更新日期:1988-01-01 00:00:00
abstract:BACKGROUND:The oral cavity is a reservoir for colonization and infection of systemic organs by pathogenic bacteria. It is understood that aging, tooth eruption, hormonal changes, active disease, oral hygiene, and other factors have an influence on biofilm formation and bacterial accumulation in the oral cavity. OBJECT...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000071711
更新日期:2003-09-01 00:00:00
abstract::We evaluated quantitatively the efficiency and safety of, and influence of either prior arterial injury or immunity against adenovirus on adenovirus-mediated gene transfer into injured arteries of a relatively large animal model, the dog. A replication-defective adenovirus expressing bacterial lacZ was introduced perc...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213822
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Even though poor lighting at nighttime is an important risk factor for falls (and most falls occur during the night), lighting interventions to improve nightly lighting from bed to bathroom are rarely evaluated for fall prevention. OBJECTIVE:We tested the hypothesis that an automated guiding light would red...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000504883
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of peroxide-containing strip-based tooth whitening among subjects with medication-induced hyposalivation. METHODS:Eligibility for this tooth whitening study was limited to dentate adults takin...
journal_title:Gerontology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000235815
更新日期:2009-01-01 00:00:00
abstract::One of the problems associated with using random-source dogs to study in vivo vascular responses is their unknown background. Since aging is known to influence vascular responses, unknown variations in age could influence experimental results. The vast majority of aging studies examine arteries in vitro. This study wa...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213318
更新日期:1992-01-01 00:00:00
abstract::A group of clinical senile dementia patients underwent a series of cerebrovascular examinations. Some of them were standard examinations (fundus oculi, electroencephalogram, rheoencephalogram, cerebral angiogram and pneumonencephalogram) while the others were studying regional cerebral blood flow (rCBF) and modificati...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212183
更新日期:1977-01-01 00:00:00
abstract::To investigate the mechanisms of age-related decline in synthesis of adrenal androgen, we studied the contents of cortisol (F) and dehydroepiandrosterone (DHEA) and the amounts of cytochrome P450 17 alpha-hydroxylase (P450c17) mRNA and cytochrome P450 11 beta-hydroxylase (P450c11) mRNA in young (1 year old) and senesc...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213270
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Moderate physical exercise, dietary restriction as well as enriched environment in separate studies have been reported to delay some of the adverse effects of aging on brain function, parallel to an increase in brain-derived neurotrophic factor (BDNF). In order to elucidate these influences in a com...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000095117
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Malnutrition is a widespread but largely unrecognized problem in aged patients, more so as it is a contributing factor to the increased morbidity and mortality in this age group. Since direct measurements of body composition are not possible in a large number of patients, good anthropometric reference data a...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000052836
更新日期:2002-05-01 00:00:00
abstract::Historically, family ties have been understood as the primary source of support for aging adults, and past empirical and theoretical work has highlighted the tendency of older adults to focus on close family. However, in line with demographic changes and historical increases in the diversity of social structures, frie...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000505547
更新日期:2020-01-01 00:00:00
abstract::(Na+-K+)-ATPase is an enzyme responsible for ionic homeostasis in excitable tissues. Thus, the activity of this enzyme is essential for the maintenance of optimal function of the cerebral cortex. Although abnormalities of cerebral oxidative metabolism have been described in aging, these abnormalities do not appear to ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000213123
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Diabetes is common in elderly persons and is highly prevalent in Mexican Americans. Little is known about factors associated with the incidence of diabetes complications. OBJECTIVE:To examine the social, demographic and health factors associated with a 7-year incidence of diabetes complications among older ...
journal_title:Gerontology
pub_type: 杂志文章,多中心研究
doi:10.1159/000100443
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There are limited psychological data on the quality of life and activities of daily living among elderly Japanese who live alone. OBJECTIVE:The aim of this study was to examine the frequency of apathy and its correlation with activities of daily living and with subjective well-being in elderly people living...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022102
更新日期:1999-09-01 00:00:00
abstract::Lymphopenia is a common finding in old people admitted to medical and psychiatric wards. We describe a pilot study of the clinical associations, and prognostic significance of lymphopenia in elderly persons admitted to acute medical and psychiatric wards. Consecutive patients admitted to acute medical and psychiatric ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022003
更新日期:1998-01-01 00:00:00
abstract::In three mouse lineages it was found that during the 18- to 60-day interval after formalin fixation, brain weight was inversely proportional to the age at sacrifice, as was the decline in the weight of the brain during this period. In a second study using rat subjects it was confirmed that the aging difference is due ...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000212460
更新日期:1981-01-01 00:00:00
abstract::This review focuses on 3 allergic disorders of persons coming up against venerable age: asthma, allergic rhinitis, and atopic dermatitis. The prevalence of allergic diseases in the elderly ranges from 5 to 10% and appears to be rising. A gradual decline in immune function, termed immunosenescence, and age-related chan...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000355307
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:A quantitative study of dermal and arterial elastic fibers as a function of age was carried out by computerized image analysis. OBJECTIVE:We investigated whether any parallelism can be established between the morphometric parameters of elastic fibers from the skin and the temporal artery in elderly subjects...
journal_title:Gerontology
pub_type: 杂志文章
doi:10.1159/000022035
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:One of the earliest and most persistent inquiries in developmental psychology is that of the relative contributions of nature and nurture to human ontogeny. One way of studying this distinction is by doing cross-cultural studies, in which culture provides a powerful way to operationalize the influence of nur...
journal_title:Gerontology
pub_type: 杂志文章,评审
doi:10.1159/000094610
更新日期:2006-01-01 00:00:00