abstract：Background:The public health consequence of increased intestinal permeability (IP) is currently limited by the lack of patient-centred research. This study aims to describe the health-seeking behaviour of Australian adults with suspected IP. Methods:A cross-sectional survey of 589 Australian adults who have been diagn...

authors： Leech B,McIntyre E,Steel A,Sibbritt D

更新日期：2022-03-01 00:00:00

abstract：:Retinitis pigmentosa (RP) is a group of inherited retinal disorders that lead to photoreceptor loss. RP has been reported to be related to oxidative stress, autophagy, and inflammation. (-)-Epigallocatechin gallate (EGCG), the most abundant catechin-based flavonoid in green tea leaves, has significant antioxidant, ant...

authors： Perdices L,Fuentes-Broto L,Segura F,Cavero A,Orduna-Hospital E,Insa-Sánchez G,Sánchez-Cano AI,Fernández-Sánchez L,Cuenca N,Pinilla I

更新日期：2022-03-01 00:00:00

abstract：:When the temperature is increased, the heat-shock response is activated to protect the cellular environment. The transcriptomics and proteomics of this process are intensively studied, while information about how the cell responds structurally to heat stress is mostly lacking. Here, Saccharomyces cerevisiae were subje...

authors： Keuenhof KS,Larsson Berglund L,Malmgren Hill S,Schneider KL,Widlund PO,Nyström T,Höög JL

更新日期：2022-03-01 00:00:00

abstract：:Motor endplates (MEPs) are important sites of information exchange between motor neurons and skeletal muscle, and are distributed in an organized pattern of lamellae in the muscle. Delayed repair of peripheral nerve injury typically results in unsatisfactory functional recovery because of MEP degeneration. In this stu...

authors： Li DD,Deng J,Jin B,Han S,Gu XY,Zhou XF,Yin XF

更新日期：2022-02-01 00:00:00

abstract：:Evidence suggests that rapid changes to supporting glia may predispose individuals with spinal cord injury (SCI) to such comorbidities. Here, we interrogated the expression of astrocyte- and microglial-specific markers glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba1) in the ...

authors： Mandwie M,Piper JA,Gorrie CA,Keay KA,Musumeci G,Al-Badri G,Castorina A

更新日期：2022-02-01 00:00:00

abstract：:Neuroinflammation and neurodegeneration are key components in the establishment and progression of neurodegenerative diseases including Alzheimer's Disease (AD). Over the past decade increasing evidence is emerging for the use of components of the canonical autophagy machinery in pathways that are characterized by LC3...

authors： Rickman AD,Hilyard A,Heckmann BL

更新日期：2022-02-01 00:00:00

abstract：:Novel technologies revealed a nontrivial spatial organization of the chromosomes within the cell nucleus, which includes different levels of compartmentalization and architectural patterns. Notably, such complex three-dimensional structure plays a crucial role in vital biological functions and its alterations can prod...

authors： Conte M,Fiorillo L,Bianco S,Chiariello AM,Esposito A,Musella F,Flora F,Abraham A,Nicodemi M

更新日期：2022-01-01 00:00:00

abstract：:Since their first discovery more than 20 years ago, miRNAs have been subject to deliberate research and analysis for revealing their physiological or pathological involvement. Regulatory roles of miRNAs in signal transduction, gene expression, and cellular processes in development, differentiation, proliferation, apop...

authors： Olcum M,Tufekci KU,Genc S

更新日期：2022-01-01 00:00:00

abstract：:Processing, storing, and visualizing high-resolution Hi-C data required development of efficient data formats. A sparse matrix format saving only nonzero values has become the norm. A "zoomable" matrix style also became popular, storing multiple resolutions in a single file for interactive visualization. This chapter ...

authors： Lee S

更新日期：2022-01-01 00:00:00

abstract：:MicroRNAs (miRNAs) are endogenous small noncoding RNAs that are involved in most biological signaling pathways, including the cell cycle, apoptosis, proliferation, immune response, metabolism as well as in biological processes including organ development and in human diseases like cancers. During the past two decades,...

authors： Dweep H,Showe LC,Kossenkov AV

更新日期：2022-01-01 00:00:00

abstract：Background:Total laboratory automation (TLA) is an innovation in laboratory technology; however, the high up-front costs restrict its widespread adoption. To examine whether the capital investment for TLA is worthwhile, we analyzed its clinical- and cost-effectiveness for the expected payback period. Methods:Clinical ...

authors： Kim K,Lee SG,Kim TH,Lee SG

更新日期：2022-01-01 00:00:00

abstract：:Teammate invitation networks are foundational for team assembly, and recommender systems (similar to dating websites, but for selecting potential teammates) can aid the formation of such networks. This paper extends Hinds, Carley, Krackhardt, and Wholey's (2000) influential model of team member selection by incorporat...

authors： Twyman M,Newman DA,DeChurch L,Contractor N

更新日期：2022-01-01 00:00:00

abstract：:Ghrelin is a neuropeptide that has various physiological functions and has been demonstrated to be neuroprotective in a number of neurological disease models. However, the underlying mechanisms of ghrelin in Parkinson's disease remain largely unexplored. The current study aimed to study the effects of ghrelin in a 6-h...

authors： He X,Yuan W,Yang CQ,Zhu L,Liu F,Feng J,Xue YX

更新日期：2022-01-01 00:00:00

abstract：:The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex that conducts the ...

authors： Hernandez-Sapiens MA,Reza-Zaldívar EE,Márquez-Aguirre AL,Gómez-Pinedo U,Matias-Guiu J,Cevallos RR,Mateos-Díaz JC,Sánchez-González VJ,Canales-Aguirre AA

更新日期：2022-01-01 00:00:00

abstract：:ObjectThe current study was performed to construct a model with microRNA (miRNA/miR) expression profile and TNM staging system for prognosis predicting in patients with lung adenocarcinoma (LUAD). MethodsDifferentially expressed miRNAs were identified from miRNA data of LUAD in The Cancer Genome Atlas (TCGA) database....

authors： Thiamwong L

更新日期：2021-12-30 00:00:00

abstract：:In response to the rapid spread of coronavirus disease-2019 (COVID-19) within and across countries and the need to protect public health, governments worldwide introduced unprecedented measures such as restricted road and air travel and reduced human mobility in 2020. The curtailment of personal travel and economic ac...

authors： Adam MG,Tran PTM,Balasubramanian R

更新日期：2021-12-15 00:00:00

abstract：:This study aimed to clarify the bioavailability mechanism of theaflavins by using the Caco-2 monolayer in vitro model. Prior to the transport of theaflavin (TF), theaflavin-3-gallate (TF3G), theaflavin-3'-gallate (TF3'G), and theaflavin-3, 3'-digallate (TFDG), we found the cytotoxicity of theaflavins was in the order ...

authors： Qu F,Ai Z,Liu S,Zhang H,Chen Y,Wang Y,Ni D

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:The purpose was to investigate experiences of men who were living with chronic pain in relation to masculine identity and their experiences of treatment at a Chronic Pain Clinic in South Africa. METHODS:A purposive sample of 14 male patients from an outpatient Chronic Pain Clinic participated in the study in 2...

authors： Blackbeard D,Aldous C

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:The aim of this study was to elucidate meanings of participation in care for older people after hip fracture surgery and nurses working in an orthopaedic ward. METHODS:A qualitative phenomenological hermeneutical design was used. We conducted personal interviews with a narrative approach with 11 older people r...

authors： Segevall C,Björkman Randström K,Söderberg S

更新日期：2021-12-01 00:00:00

abstract：:Prions are self-propagating proteins that cause fatal neurodegenerative diseases in humans. However, increasing evidence suggests that eukaryotic cells exploit prion conformational conversion for functional purposes. A recent study delineated a group of twenty prion-like proteins in humans, characterized by the presen...

authors： Behbahanipour M,García-Pardo J,Ventura S

更新日期：2021-12-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most conspicuous chronic neurodegenerative syndrome, which has become a significant challenge for the global healthcare system. Multiple studies have corroborated a clear association of neurotoxicants with AD pathogenicity, such as Amyloid beta (Aβ) proteins and neurofibrillary tangles ...

authors： Nisa FY,Rahman MA,Hossen MA,Khan MF,Khan MAN,Majid M,Sultana F,Haque MA

更新日期：2021-12-01 00:00:00

abstract：AIM:Endometriosis is one of the most common reproductive system diseases, but the mechanisms of disease progression are still unclear. Due to its high recurrence rate, searching for potential therapeutic biomarkers involved in the pathogenesis of endometriosis is an urgent issue. METHODS:Due to the similarities betwee...

authors： Lu Z,Gao Y

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:18β-Glycyrrhetinic acid (18β-GA), a pentacyclic triterpenoid saponin metabolite of glycyrrhizin, exhibits several biological activities. OBJECTIVE:We investigated the effects of 18β-GA on MA104 cells infected with rotavirus (RV) and its potential mechanism of action. MATERIALS AND METHODS:Cell Counting Kit-8 ...

authors： Wang X,Xie F,Zhou X,Chen T,Xue Y,Wang W

更新日期：2021-12-01 00:00:00

abstract：:Systemic inflammatory response (SIRS) can be used as a potential prognostic marker in patients with colorectal cancer (CRC). The purpose of this study was to examine the predictive role of the C-reactive protein (CRP)-lymphocyte ratio (CLR) in the prognosis of CRC. We retrospectively analyzed the data of CRC patients ...

authors： Meng Y,Long C,Huang X,Huang L,Liao L,Tang W,Liu J

更新日期：2021-12-01 00:00:00

abstract：...

authors： Aggarwal V,Singer Z,Ledingham D,Othman I

更新日期：2021-12-01 00:00:00

abstract：:Background: The coronavirus disease 2019 (COVID-19) pandemic has caused deaths and shortages in medical resources worldwide, making the prediction of patient prognosis and the identification of risk factors very important. Increasing age is already known as one of the main risk factors for poor outcomes, but the effec...

authors： Cho Y,Cho Y,Choi HJ,Lee H,Lim TH,Kang H,Ko BS,Oh J

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Triple-negative breast cancer (TNBC) represents about 19% of all breast cancer cases in the Chinese population. Lack of targeted therapy contributes to the poorer outcomes compared with other breast cancer subtypes. Comprehensive genomic profiling helps to explore the clinically relevant genomic alterations ...

authors： Wang L,Zhai Q,Lu Q,Lee K,Zheng Q,Hong R,Wang S

更新日期：2021-12-01 00:00:00

abstract：:The relative proportional increase of the elderly population within many countries will become one of the most significant social transformations of the twenty-first century and, for the first time in history, persons aged 65 or above outnumbered children under five years of age globally. One in four persons living in...

authors： Lunenfeld B,Mskhalaya G,Zitzmann M,Corona G,Arver S,Kalinchenko S,Tishova Y,Morgentaler A

更新日期：2021-12-01 00:00:00

abstract：:Drug-resistant pathogenic Staphylococcus aureus (S. aureus) has severely threatened human health and arouses widespread concern. Sortase A (SrtA) is an essential virulence factor of S. aureus, which is responsible for the covalent anchoring of a variety of virulence-related proteins to the cell wall. SrtA has always b...

authors： Wang L,Jing S,Qu H,Wang K,Jin Y,Ding Y,Yang L,Yu H,Shi Y,Li Q,Wang D

更新日期：2021-12-01 00:00:00

abstract：...

authors： Kim K,Islam M,Jung HW,Lim D,Kim K,Lee SG,Park C,Lee JC,Shin M

更新日期：2021-12-01 00:00:00

abstract：:Pseudopodium enriched atypical kinase 1(PEAK1) is a non-receptor tyrosine kinase, which is enriched in the pseudopodia of migrating cells and plays an important role in regulating cell migration and proliferation. In the study, we investigate the therapeutic effect of PEAK1 on melanoma cells in vitro and in vivo. We u...

authors： Pan M,Yin X,Huang YC

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Streblus asper Lour. (Moraceae) is used for the treatment of different ailments, including diabetes, and requires scientific validation. OBJECTIVE:The study evaluates antidiabetic effects, antioxidant potential, and cytotoxicity of leaf and bark extracts of S. asper. MATERIALS AND METHODS:Antidiabetic effects...

authors： Rahman MO,Alqahtani AS,Huda SB,Siddiqui SA,Noman OM,Nasr F,Hassan MA,Islam SN

更新日期：2021-12-01 00:00:00

abstract：CONTEXT:Eriodictyol (EDT) is a flavonoid with strong anti-inflammatory, anti-apoptotic, and antioxidant properties. OBJECTIVE:To investigate the protective effect and mechanism of EDT in ulcerative colitis (UC). MATERIALS AND METHODS:UC model was induced by 3% dextran sulphate sodium (DSS) solution for 7 days, meanwh...

authors： Wang R,Shen L,Li H,Peng H

更新日期：2021-12-01 00:00:00

abstract：:Viral vectors for vaccine delivery are challenged by recently reported safety issues like immunogenicity and risk for cancer development, and thus there is a growing need for the development of non-viral vectors. Cell penetrating peptides (CPPs) are non-viral vectors that can enter plasma membranes efficiently and del...

authors： Chen L,Guo X,Wang L,Geng J,Wu J,Hu B,Wang T,Li J,Liu C,Wang H

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:Farm-based daycare (FDC) is a type of daycare service for people with dementia. The aim of the present study was to explore the next of kin's experiences with FDC and how the service may affect their daily life. METHODS:The study has a qualitative, descriptive design. Eight semi-structured interviews with next...

authors： Taranrød LB,Pedersen I,Kirkevold Ø,Eriksen S

更新日期：2021-12-01 00:00:00

abstract：:The aim of this study was to delve into the clinical significance and biological function of miR-2355-3p in LUAD. Tissues and blood samples from 116 LUAD patients and blood samples of 90 healthy volunteers were collected. The relative expression of miR-2355-3p was evaluated by quantitative real-time polymerase chain r...

authors： Zhao Y,Zhang W,Yang Y,Dai E,Bai Y

更新日期：2021-12-01 00:00:00

abstract：:In recent years, the increasing incidence of pancreatic carcinoma (PC) patients has become one of the hot issues in the world. microRNAs (miRNAs) can act as oncogenes or tumor suppressor genes and have unpredictable effects on tumors, thus affecting the prognosis and survival of cancer patients. In this paper, we main...

authors： Long K,Dong Q,Zeng W

更新日期：2021-12-01 00:00:00

abstract：:We previously demonstrated that F4 peptide (CNPEDCLYPVSHAHQR) from collagen XIX was able to inhibit melanoma cell migrationin vitro and cancer progression in a mouse melanoma model. The aim of the present work was to study the anti-angiogenic properties of F4 peptide. We demonstrated that F4 peptide inhibited VEGF-ind...

authors： Oudart JB,Villemin M,Brassart B,Sellier C,Terryn C,Dupont-Deshorgue A,Monboisse JC,Maquart FX,Ramont L,Brassart-Pasco S

更新日期：2021-12-01 00:00:00

abstract：:We aimed to assess the effect of feeding Bacillus subtilis C-3102 on the growth and rumen microbiota in the preweaned calves. Twelve newborn Japanese Black calves were randomly allocated to either the control (n = 6) or the treatment (n = 6) groups in the present study. Calves in the treatment group were offered B. su...

authors： Koike S,Ueno M,Ashida N,Imabayashi T,Kobayashi Y

更新日期：2021-12-01 00:00:00

abstract：:Gut microbiota are the candidate biomarkers for neurogenic bowel dysfunction (NBD) in patients with spinal cord injury (SCI). We aimed to identify the common features between patients with varying degree of thoracic SCI and healthy individuals and subpopulations of microbiota correlated with the serum biomarkers. Twen...

authors： Yu B,Qiu H,Cheng S,Ye F,Li J,Chen S,Zhou L,Yang Y,Zhong C,Li J

更新日期：2021-12-01 00:00:00