Abstract:
:We previously demonstrated that F4 peptide (CNPEDCLYPVSHAHQR) from collagen XIX was able to inhibit melanoma cell migrationin vitro and cancer progression in a mouse melanoma model. The aim of the present work was to study the anti-angiogenic properties of F4 peptide. We demonstrated that F4 peptide inhibited VEGF-induced pseudo-tube formation on Matrigel by endothelial cells and endothelial sprouting in a rat aortic ring assay. By affinity chromatography, we identified αvβ3 and α5β1 integrins as potential receptors for F4 peptide on endothelial cell surface. Using solid phase assays, we proved the direct interaction between F4 and both integrins. Taken together, our results demonstrate that F4 peptide is a potent antitumor agent inhibiting both angiogenesis and tumor cell migration.
journal_name
Cell Adh Migrjournal_title
Cell adhesion & migrationauthors
Oudart JB,Villemin M,Brassart B,Sellier C,Terryn C,Dupont-Deshorgue A,Monboisse JC,Maquart FX,Ramont L,Brassart-Pasco Sdoi
10.1080/19336918.2021.1951425keywords:
["Extracellular matrix","angiogenesis","collagen XIX","integrin","matrikine"]subject
Has Abstractpub_date
2021-12-01 00:00:00pages
215-223issue
1eissn
1933-6918issn
1933-6926journal_volume
15pub_type
杂志文章abstract::We analyzed existing research on the prognosis of patients who have had a transient ischemic attack to identify studies that adhere to basic methodological principles and to identify underinvestigated questions. Studies were eligible for analysis if they were published in peer-reviewed journals after 1950, written in ...
journal_title:Cell adhesion & migration
pub_type: 杂志文章,评审
doi:10.4161/cam.1.1.4081
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abstract::We analyzed existing research on the prognosis of patients who have had a transient ischemic attack to identify studies that adhere to basic methodological principles and to identify underinvestigated questions. Studies were eligible for analysis if they were published in peer-reviewed journals after 1950, written in ...
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abstract::We analyzed existing research on the prognosis of patients who have had a transient ischemic attack to identify studies that adhere to basic methodological principles and to identify underinvestigated questions. Studies were eligible for analysis if they were published in peer-reviewed journals after 1950, written in ...
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abstract::We analyzed existing research on the prognosis of patients who have had a transient ischemic attack to identify studies that adhere to basic methodological principles and to identify underinvestigated questions. Studies were eligible for analysis if they were published in peer-reviewed journals after 1950, written in ...
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abstract::We analyzed existing research on the prognosis of patients who have had a transient ischemic attack to identify studies that adhere to basic methodological principles and to identify underinvestigated questions. Studies were eligible for analysis if they were published in peer-reviewed journals after 1950, written in ...
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doi:10.4161/cam.3.4.9912
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journal_title:Cell adhesion & migration
pub_type: 杂志文章
doi:10.4161/cam.3.4.9951
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pub_type: 评论,杂志文章
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pub_type: 杂志文章,评审
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