F4, a collagen XIX-derived peptide, inhibits tumor angiogenesis through αvβ3 and α5β1 integrin interaction.

Abstract:

:We previously demonstrated that F4 peptide (CNPEDCLYPVSHAHQR) from collagen XIX was able to inhibit melanoma cell migrationin vitro and cancer progression in a mouse melanoma model. The aim of the present work was to study the anti-angiogenic properties of F4 peptide. We demonstrated that F4 peptide inhibited VEGF-induced pseudo-tube formation on Matrigel by endothelial cells and endothelial sprouting in a rat aortic ring assay. By affinity chromatography, we identified αvβ3 and α5β1 integrins as potential receptors for F4 peptide on endothelial cell surface. Using solid phase assays, we proved the direct interaction between F4 and both integrins. Taken together, our results demonstrate that F4 peptide is a potent antitumor agent inhibiting both angiogenesis and tumor cell migration.

journal_name

Cell Adh Migr

authors

Oudart JB,Villemin M,Brassart B,Sellier C,Terryn C,Dupont-Deshorgue A,Monboisse JC,Maquart FX,Ramont L,Brassart-Pasco S

doi

10.1080/19336918.2021.1951425

keywords:

["Extracellular matrix","angiogenesis","collagen XIX","integrin","matrikine"]

subject

Has Abstract

pub_date

2021-12-01 00:00:00

pages

215-223

issue

1

eissn

1933-6918

issn

1933-6926

journal_volume

15

pub_type

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