当前位置： SCI文献检索 > Neural Regeneration Research期刊下所有文献 > Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.

Presenilin mutations and their impact on neuronal differentiation in Alzheimer's disease.

Abstract：

:The presenilin genes (PSEN1 and PSEN2) are mainly responsible for causing early-onset familial Alzheimer's disease, harboring ~300 causative mutations, and representing ~90% of all mutations associated with a very aggressive disease form. Presenilin 1 is the catalytic core of the γ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein, Notch-1, N- and E-cadherin, LRP, Syndecan, Delta, Jagged, CD44, ErbB4, and Nectin1a. Presenilin 1 plays an essential role in neural progenitor maintenance, neurogenesis, neurite outgrowth, synaptic function, neuronal function, myelination, and plasticity. Therefore, an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling, synaptic dysfunction, memory impairment, and increased Aβ42/Aβ40 ratio, contributing to neurodegeneration during the initial stages of Alzheimer's disease pathogenesis. This review focuses on the neuronal differentiation dysregulation mediated by PSEN1 mutations in Alzheimer's disease. Furthermore, we emphasize the importance of Alzheimer's disease-induced pluripotent stem cells models in analyzing PSEN1 mutations implication over the early stages of the Alzheimer's disease pathogenesis throughout neuronal differentiation impairment.

journal_name

Neural Regen Res

journal_title

Neural regeneration research

authors

Hernandez-Sapiens MA,Reza-Zaldívar EE,Márquez-Aguirre AL,Gómez-Pinedo U,Matias-Guiu J,Cevallos RR,Mateos-Díaz JC,Sánchez-González VJ,Canales-Aguirre AA

doi

10.4103/1673-5374.313016

keywords:

["Notch","PSEN1","familial Alzheimer’s disease","familial Alzheimer’s disease-induced pluripotent stem cells models","induced pluripotent stem cells","mutations","neurogenesis","neuronal differentiation","presenilin 1","γ-secretase complex"]

subject

Has Abstract

pub_date

2022-01-01 00:00:00

pages

31-37

issue

1

eissn

1673-5374

issn

1876-7958

pii

NeuralRegenRes_2022_17_1_31_313016

journal_volume

17

pub_type

杂志文章

相关文献

Neural Regeneration Research文献大全
  • Expression of netrin-1 and its receptors, deleted in colorectal cancer and uncoordinated locomotion-5 homolog B, in rat brain following focal cerebral ischemia reperfusion injury.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.01.008

    authors： Wang X,Xu J,Gong J,Shen H,Wang X

    更新日期：2013-01-05 00:00:00

  • Transcription factor changes following long term cerebral ischemia/reperfusion injury.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.10.006

    authors： Zhang H,Gao W,Qian T,Tang J,Li J

    更新日期：2013-04-05 00:00:00

  • Diazoxide preconditioning antagonizes cytotoxicity induced by epileptic seizures.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.11.005

    authors： Fu Q,Sun Z,Zhang J,Gao N,Qi F,Che F,Ma G

    更新日期：2013-04-15 00:00:00

  • Jiaweisinisan facilitates neurogenesis in the hippocampus after stress damage.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.12.004

    authors： Wu L,Ran C,Liu S,Liao L,Chen Y,Guo H,Wu W,Yan C

    更新日期：2013-04-25 00:00:00

  • Are human dental papilla-derived stem cell and human brain-derived neural stem cell transplantations suitable for treatment of Parkinson's disease?

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.13.004

    authors： Yoon HH,Min J,Shin N,Kim YH,Kim JM,Hwang YS,Suh JK,Hwang O,Jeon SR

    更新日期：2013-05-05 00:00:00

  • Olfactory ensheathing cell transplantation for spinal cord injury: An 18-year bibliometric analysis based on the Web of Science.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.14.005

    authors： Leng Z,He X,Li H,Wang D,Cao K

    更新日期：2013-05-15 00:00:00

  • Gastrodin promotes the secretion of brain-derived neurotrophic factor in the injured spinal cord.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.15.005

    authors： Song C,Fang S,Lv G,Mei X

    更新日期：2013-05-25 00:00:00

  • Application of sodium alginate microspheres in ischemic stroke modeling in miniature pigs.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.16.004

    authors： Cui Y,Tian Y,Tang Y,Jia L,Wu A,Peng P,Yang J,Du H,Wang X,Wu L

    更新日期：2013-06-05 00:00:00

  • Mechanical tension promotes skin nerve regeneration by upregulating nerve growth factor expression.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.17.005

    authors： Xiao H,Wang D,Huo R,Wang Y,Feng Y,Li Q

    更新日期：2013-06-15 00:00:00

  • Electroacupuncture at points Baliao and Huiyang (BL35) for post-stroke detrusor overactivity.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.18.004

    authors： Liu Y,Liu L,Wang X

    更新日期：2013-06-25 00:00:00

  • The effects of Xingnao Jieyu capsules on post-stroke depression are similar to those of fluoxetine.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.19.004

    authors： Yan Y,Fan W,Liu L,Yang R,Yang W

    更新日期：2013-07-05 00:00:00

  • 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.02.005

    authors： Mao Z,Song Z,Li G,Lv W,Zhao X,Li B,Feng X,Chen Y

    更新日期：2013-01-15 00:00:00

  • Approximate entropy and support vector machines for electroencephalogram signal classification.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.20.003

    authors： Zhang Z,Zhou Y,Chen Z,Tian X,Du S,Huang R

    更新日期：2013-07-15 00:00:00

  • Is X-linked methyl-CpG binding protein 2 a new target for the treatment of Parkinson's disease.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.21.003

    authors： Xie T,Zhang J,Yuan X,Yang J,Ding W,Huang X,Wu Y

    更新日期：2013-07-25 00:00:00

  • Resveratrol improves cognition and reduces oxidative stress in rats with vascular dementia.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.22.004

    authors： Ma X,Sun Z,Liu Y,Jia Y,Zhang B,Zhang J

    更新日期：2013-08-05 00:00:00

  • Anti-inflammatory and anti-thrombogenic effects of atorvastatin in acute ischemic stroke.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.23.004

    authors： Min L,Shao S,Wu X,Cong L,Liu P,Zhao H,Luo Y

    更新日期：2013-08-15 00:00:00

  • Combined transplantation of GDAs(BMP) and hr-decorin in spinal cord contusion repair.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.24.003

    authors： Wu L,Li J,Chen L,Zhang H,Yuan L,Davies SJ

    更新日期：2013-08-25 00:00:00

  • Buyang Huanwu Decoction regulates neural stem cell behavior in ischemic brain.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.25.004

    authors： Liu B,Cai G,Yi J,Chen X

    更新日期：2013-09-05 00:00:00

  • Ultrasound measurement of the corpus callosum and neural development of premature infants.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.26.004

    authors： Liu F,Cao S,Liu J,Du Z,Guo Z,Ren C

    更新日期：2013-09-15 00:00:00

  • Electrical stimulation modulates injury potentials in rats after spinal cord injury.

    abstract：:An injury potential is the direct current potential difference between the site of spinal cord injury and the healthy nerves. Its initial amplitude is a significant indicator of the severity of spinal cord injury, and many cations, such as sodium and calcium, account for the major portion of injury potentials. This in...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.27.004

    authors： Zhang G,Huo X,Wang A,Wu C,Zhang C,Bai J

    更新日期：2013-09-25 00:00:00

  • Persimmon leaf flavonoid promotes brain ischemic tolerance.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.28.004

    authors： Miao M,Zhang X,Bai M,Wang L

    更新日期：2013-10-05 00:00:00

  • Downregulation of caveolin-1 contributes to the synaptic plasticity deficit in the hippocampus of aged rats.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.29.004

    authors： Liu Y,Liang Z,Liu J,Zou W,Li X,Wang Y,An L

    更新日期：2013-10-15 00:00:00

  • Changes in compressed neurons from dogs with acute and severe cauda equina constrictions following intrathecal injection of brain-derived neurotrophic factor-conjugated polymer nanoparticles.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.03.005

    authors： Tan J,Shi J,Shi G,Liu Y,Liu X,Wang C,Chen D,Xing S,Shen L,Jia L,Ye X,He H,Li J

    更新日期：2013-01-25 00:00:00

  • How do Chinese medicines that tonify the kidney inhibit dopaminergic neuron apoptosis?

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.30.004

    authors： Lin S,Ye S,Huang J,Tian Y,Xu Y,Wu M,Wang J,Wu S,Cai J

    更新日期：2013-10-25 00:00:00

  • Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.31.005

    authors： Hao L,Chen L,Sai X,Liu Z,Yang G,Yan R,Wang L,Fu C,Xu X,Cheng Z,Wu Q,Li S

    更新日期：2013-11-05 00:00:00

  • Rho-associated protein kinase modulates neurite extension by regulating microtubule remodeling and vinculin distribution.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.32.006

    authors： Chen K,Zhang W,Chen J,Li S,Guo G

    更新日期：2013-11-15 00:00:00

  • Substance P and calcitonin gene-related peptide expression in dorsal root ganglia in sciatic nerve injury rats.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.33.006

    authors： Fu C,Yin Z,Yu D,Yang Z

    更新日期：2013-11-25 00:00:00

  • Decreased frontal lobe function in people with Internet addiction disorder.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.34.006

    authors： Liu J,Esmail F,Li L,Kou Z,Li W,Gao X,Wang Z,Tan C,Zhang Y,Zhou S

    更新日期：2013-12-05 00:00:00

  • Treatment of epilepsy in China: Formal or informal.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.35.006

    authors： Liu J,Liu Z,Chen T,Xu R

    更新日期：2013-12-15 00:00:00

  • Immediate versus delayed primary nerve repair in the rabbit sciatic nerve.

    abstract：:We report the complete mitochondrial genome of the fish Salminus brasiliensis, popularly known as dourado. It is a circular, 17,721 bp long DNA molecule, containing 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes and a non-coding Control Region of 2128 bp, a relatively large molecule when compared to other closel...

    journal_title：Neural regeneration research

    pub_type： 杂志文章

    doi：10.3969/j.issn.1673-5374.2013.36.006

    authors： Piskin A,Altunkaynak BZ,Çitlak A,Sezgin H,Yazιcι O,Kaplan S

    更新日期：2013-12-25 00:00:00