Refractory acquired thrombotic thrombocytopenic purpura in a patient with sickle cell trait successfully treated with caplacizumab.

abstract：:Molecular Medicine and Molecular Pathology are integral parts of Haematology as we enter the new millennium. Their origins can be linked to fundamental developments in the basic sciences, particularly genetics, chemistry and biochemistry. The structure of DNA and the genetic code that it encrypts are the critical star...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lawler M

更新日期：1999-01-01 00:00:00

abstract：:Hereditary haemochromatosis (HH) is an autosomal recessive disorder leading to excessive absorption of dietary iron. The gene affected in the common variety has recently been identified near the HLA-A locus on chromosome 6 and designated HFE. The HFE mutation, C282Y, responsible for most cases of HH is found in as man...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Charlton R,Bothwell T

更新日期：1999-01-01 00:00:00

abstract：:The use of all-transretinoic acid (ATRA) in APL is a great advance in the treatment of acute leukemia, driving the maturation steps until adult form. The effect of this medication in pregnant women with APL is being a safe and effective treatment only after the first trimester of pregnancy. If used in the first three ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Delgado-Lamas JL,Garcés-Ruiz OM

更新日期：2000-01-01 00:00:00

abstract：:Hematopoietic stem cell (HSC) gene therapy will require efficient transfer of genes to HSCs and long term engraftment and proliferation of genetically modified HSCs following adoptive transfer. We evaluated whether fractionation of grafts into 4-5 weekly infusions to non-myeloablated, autologous canine recipients woul...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Lutzko C,Abrams-Ogg AC,Li L,Zhao Y,Lau K,Kruth S,Dubé ID

更新日期：2000-01-01 00:00:00

abstract：:Anemia is a frequently observed manifestation during the clinical course of chronic liver disease. In this study, we retrospectively reviewed the hospital files of 500 chronic liver disease patients and assessed the frequency, etiology and morphology of anemia in 50 patients who fulfilled the criteria to be included i...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Özatli D,Köksal AS,Haznedaroglu IC,Simsek H,Karakus S,Büyükasik Y,Kosar A,Özcebe O,Dündar S

更新日期：2000-01-01 00:00:00

abstract：:Combination high-dose cytosine arabinoside (ARA-C) and daunorubicin (DNR) for primary remission induction of patients with acute myeloblastic leukemia (AML) was evaluated in a single institution study. Patients aged 55 or less with an HLA-sibling received an allogeneic bone marrow transplant (alloBMT) in first remissi...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Curtis JE,Hao Y,Messner HA,Lipton JH,Lowsky R,Quirt IC,Sturgeon JF,Zanke B,Keating A,Minden MD

更新日期：2000-01-01 00:00:00

abstract：:Sarcoidosis is a granulomatous disease of undetermined origin. The association of sarcoidosis with malignant lymphoma is a rare but possibly nonfortuitous event. The authors report on the case of a 26-year-old male patient presenting with lymphnode sarcoidosis which evolved into neurosarcoidosis. The evolution was res...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Alliot C,Desablens B,Tabuteau S

更新日期：2000-01-01 00:00:00

abstract：:The mechanism of action of hydroxyurea (HU) in decreasing the frequency of pain crisis in sickle cell disease (SCD) has not been fully elucidated. In vitro and in vivo studies suggest that nitric oxide (NO), a potent vasodilator, may partly be responsible for the beneficial effect of HU. This study was designed to det...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Nahavandi M,Wyche MQ,Perlin E,Tavakkoli F,Castro O

更新日期：2000-01-01 00:00:00

abstract：:Inactivation of tumor suppressor genes, whose products exert an inhibitory influence on cell cycle progression, can lead to neoplastic transformation. In acute myeloid leukemia (AML), the frequency of p53 gene mutations ranges from 4 to 15% in populations from USA and Europe. In an attempt to investigate the frequency...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Melo MB,Ahmad NN,Lima CS,Pagnano KB,Bordin S,Lorand-Metze I,SaAd ST,Costa FF

更新日期：2002-02-01 00:00:00

abstract：:Immune thrombocytopenic purpura (ITP) is a heterogeneous disorder with wide variability in response rates to treatments including corticosteroids, splenectomy and intravenous immune globulins. The nature of the underlying predisposing causes for this autoimmune disorder are not known. We have HLA typed 71 adult Caucas...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Stanworth SJ,Turner DM,Brown J,McCloskey D,Brown C,Provan D,Navarrete CV,Newland AC

更新日期：2002-04-01 00:00:00

abstract：:Skin infiltration with B-lymphocyte chronic lymphocytic leukemia (B-CLL) is rare. In contrast to Richters transformation of CLL or myeloid leukemias, skin involvement in CLL may be consistent with prolonged survival, as illustrated by the currently reported two cases. As in these patients, local therapy for skin disea...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Colburn DE,Welch MA,Giles FJ

更新日期：2002-06-01 00:00:00

abstract：:We have evaluated recovery of CD56 positive and other cell types following allogeneic stem cell transplantation and have found that the recovery of CD56 positive cells was faster than other lymphoid cells after allogeneic stem cell transplantation, while the recovery of CD4 positive cells was markedly delayed. Chimeri...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Imamura M,Tsutsumi Y,Miura Y,Toubai T,Tanaka J

更新日期：2003-02-01 00:00:00

abstract：:The approach for treatment of hematological cancers had changed in the last decade from non-specific eradication of tumor cells by chemotherapy to more specific strategies by activation of immune system. There are number of potential targets of immune responses in patients with hematological malignancies. Some have be...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Owaidah TM,Aljurf MD

更新日期：2002-10-01 00:00:00

abstract：BACKGROUND:The antiphospholipid syndrome (APS) is a thrombophillic disorder characterized by the presence of antiphospholipid antibodies (APA). It often occurs in patients with systemic lupus erythematosus (SLE) and may be associated with recurrent abortions and thrombocytopenia and, occasionally, catastrophic thrombot...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Owaidah TM,Qurashi FH,Al Nounou RM,Al Zahrani H,Al Mussa A,Tbakhi AI,Al Daama S,Elkum N,Roberts GT

更新日期：2003-08-01 00:00:00

abstract：:Autologous peripheral blood stem cell (PBSC) transplantation has a low treatment-related morbidity and mortality when using appropriate criteria for patient selection and graft quality evaluation. It will be important to use simple and standardised procedures for evaluation of progenitor cell numbers when considering ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Motorin D,Bakken A,Foss Abrahamsen J,Ernst P,Bruserud Ø

更新日期：2003-10-01 00:00:00

abstract：:Extracellular proteolytic enzymes of the urokinase-type plasminogen activator (uPA) and metalloproteinase (MMP) family play a crucial role in the matrix degradation and tissue remodeling process characteristic of malignant disorders. The receptor for urokinase plasminogen activator (uPAR) serves to localize and intens...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Aref S,El-Sherbiny M,Mabed M,Menessy A,El-Refaei M

更新日期：2003-12-01 00:00:00

abstract：:There is a wide array of recommendations for the management of anticoagulant therapy in patients with mechanical heart valves. Especially the optimal intensity of vitamin K antagonists (VKA) is a ongoing matter of debate. On the basis of several studies, recommendations for daily clinical practice can be made. In this...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Vink R,Van Den Brink RB,Levi M

更新日期：2004-02-01 00:00:00

abstract：:Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematologic disorder which is manifest by complement-mediated hemolysis, venous thrombosis, and bone marrow failure. Complement-mediated hemolysis in PNH is explained by the deficiency of glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Shichishima T,Noji H

更新日期：2002-08-01 00:00:00

abstract：:This study aims to assess total plasma homocysteine levels in diabetic and non-diabetic patients who underwent coronary artery bypass grafting (CABG) and to determine the effect of cardiopulmonary bypass (CPB) on homocysteine levels. Twenty diabetic and twenty non-diabetic patients who had CABG were enrolled in the st...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Yilmaz M,Ozkan M,Demircin M,Haznedaroglu IC,Guvener M,Pasaoglu I

更新日期：2004-04-01 00:00:00

abstract：PURPOSE:Antifungal prophylaxis is an important component of induction therapy for patients with acute myeloid leukemia (AML). Azole antifungal agents are increasingly used in this context. In vitro assays were performed to assess whether cytochrome P450 (CYP450) enzymes were affected by combinations of cytarabine or id...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Colburn DE,Giles FJ,Oladovich D,Smith JA

更新日期：2004-06-01 00:00:00

abstract：:HHT, one of the alkaloids from a Chinese natural plant, Cephalotaxus, has shown its potential in leukemia treatment. This compound demonstrated strong growth-inhibiting activities in vitro and in animal experiments, and obtained encouraging results in some clonal proliferative disease such as in chronic myeloid leukem...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Luo CY,Tang JY,Wang YP

更新日期：2004-08-01 00:00:00

abstract：:Thrombocytopenia is a common problem complicating the course of liver disease. One of the postulated mechanisms in chronic liver disease is impaired production of the hormone, thrombopoietin (TPO). The aim of present study was to evaluate the role of TPO on the occurrence of thrombocytopenia. Serum TPO levels was dete...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Aref S,Mabed M,Selim T,Goda T,Khafagy N

更新日期：2004-10-01 00:00:00

abstract：:A literature review reports increased erythrocyte indices [hemoglobin concentration, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin (MCH), MCH concentration] in subjects with hereditary hemochromatosis (HH). We, therefore, screened 52 consecutive patients with polycythemia vera for 12 HH gene mutatio...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Franchini M,de Matteis G,Federici F,Solero P,Veneri D

更新日期：2004-10-01 00:00:00

abstract：:Numerous immunophenotypic features have been examined for their potential prognostic significance in predicting treatment outcome in leukaemias. These include the immunophenotypic subgroups of acute lymphoblastic leukaemia (ALL). However, only a few examples exist in developing Asian countries of the value of determin...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Wiwanitkit V

更新日期：2005-02-01 00:00:00

abstract：:Campath, the subject of this review, is an example of a broadly targeted biologic agent, approved for patients with B-CLL, which may combine immunosuppressive as well as immunoablative properties. For many years Campath has been in clinical use as an immunosuppressive agent for various autoimmune diseases and as part ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Reiff A

更新日期：2005-04-01 00:00:00

abstract：:The identification of defectives genes underlying inherited diseases has made it clear that patients with the same genotype can have variable clinical expression. Suggestions proposing that the protein AHSP, a alpha-globin specific chaperone could influence disease severity in patients with beta-thalassemia, an inheri...

journal_title：Hematology (Amsterdam, Netherlands)

authors： dos Santos CO,Costa FF

更新日期：2005-04-01 00:00:00

abstract：:Stem cells reside in a physical niche, a particular microenvironment. The organization of cellular niches has been shown to play a key role in regulating normal stem cell differentiation, maintenance and regeneration. Hematopoietic stem cells (HSC) emerge at distinct allocation territories during ontogenesis, notably ...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Heissig B,Ohki Y,Sato Y,Rafii S,Werb Z,Hattori K

更新日期：2005-06-01 00:00:00

abstract：:Kinase domain receptor (KDR) and Semaphorin3 (Sema3) have a functional relationship and are expressed in human bone marrow (BM). We cultured in vitro bone marrow stromal cells (BMSCs) and collected nonadherent cells from patients with acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), acute lymphoblasti...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Wang Z,Li Y,Wu X,Cheng S,Yang L,Wu Y

更新日期：2005-08-01 00:00:00

abstract：:Platelets are circulating blood cells that will normally not interact with the intact vessel wall but that may swiftly respond to vascular disruption by adhering to subendothelial structures, followed by interaction with each other, thereby forming a platelet aggregate. The activated platelet (phospholipid) membrane m...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Levi M

更新日期：2005-01-01 00:00:00

abstract：:Primary gastrointestinal system lymphomas constitute about one third of all extranodal lymphomas. Duodenal involvement of the lymphoma is a rare condition. Periampullary lymphoma or lymphomatous involvement of ampulla of Vater is even rarer. Since, periampullary lymphoma is not easy to differentiate from epithelial ca...

journal_title：Hematology (Amsterdam, Netherlands)

authors： Yildirim N,Oksüzoğlu B,Budakoğlu B,Vural M,Abali H,Uncu D,Zengin N

更新日期：2005-10-01 00:00:00