Clopidogrel-induced systemic inflammatory response syndrome.

Abstract:

:Clopidogrel bisulfate, a widely used inhibitor of platelet aggregation, is considered at least as safe as aspirin. We describe a patient who developed a systemic inflammatory response syndrome consisting of high fever, tachycardia, cellulitis-like rash, impaired liver function, and mild leukopenia after receiving clopidogrel before coronary angiography and stent implantation. The reaction resolved promptly after withdrawal of the drug and recurred shortly after a rechallenge dose was administered, thus making the diagnosis of a clopidogrel-induced reaction highly probable. Recognition of this clopidogrel-induced syndrome is extremely important, both for rapid discontinuation of the offending drug and for avoidance of unnecessary drug therapy or invasive procedures.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Wolf I,Mouallem M,Rath S,Farfel Z

doi

10.4065/78.5.618

keywords:

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

618-20

issue

5

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)61932-0

journal_volume

78

pub_type

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