当前位置： SCI文献检索 > MAYO CLINIC PROCEEDINGS期刊下所有文献 > Breast cancer in DES-exposed mothers: absence of association.

Breast cancer in DES-exposed mothers: absence of association.

Abstract：

:Reports in the popular press have suggested that exposure to diethylstilbestrol (DES) is followed by an abnormally high incidence of breast cancer. The reports were based on a reanalysis of data not considered ominous originally; and both data and analyses are summarized here. In addition, new data are presented on mothers of young women enrolled in the National DESAD Project at its Mayo Clinic Center. Among 408 women given DES, there were 8 confirmed instances of breast cancer, in comparison with an expected number of 8.1, based on breast cancer incidence rates among parous women in the local population. A previous case-control study of the possible association of antihypertensive therapy and breast cancer in the local population revealed DES exposure in 10% of the breast cancer group and 12% of the controls. These apparently negative results clearly indicate a need of further studies of the alleged effect of DES. :Preliminary data from the Mayo Clinic Center of the National DESAD Project (DESAD = DES plus Adenosis) bearing on the occurrence of breast cancer in women given DES (diethylstilbestrol) during pregnancy are reported. Data from 408 DES-exposed women were collected in a follow-up study. 8 cases of breast cancer were confirmed in the group. This compares with an expected rate of 8.1 for parous women in that county. These preliminary data do not show an excess of observed over expected cases of breast cancer among a DES-exposed population. A previous case-control study at the Mayo Clinic designed to determine any association between breast cancer and antihypertensive therapy had found a breast cancer rate of 10% in the DES-exposed portion of the group and 12% in the controls, also denying any DES association with breast cancer causation. It is pointed out that an earlier study at the University of Chicago which did find an association between DES usage and breast cancer had utilized higher doses of DES than the current study at Mayo. There is a clear need for further research into the association between DES usage and breast cancer, taking into account dosage and duration of therapy. Excess risk, if it does exist, seems to concentrate in the under-50 age group.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Brian DD,Tilley BC,Labarthe DR,O'Fallon WM,Noller KL,Kurland LT

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

89-93

issue

eissn

0025-6196

issn

1942-5546

journal_volume

pub_type

杂志文章

在线工具

Breast cancer in DES-exposed mothers: absence of association.