Abstract:
:Because fasting nerve myo-inositol (myo-Ins) is not decreased in patients with diabetes treated conventionally, in whom neuropathy may develop or may have already developed, it seems unlikely that myo-Ins is the metabolic abnormality that initiates diabetic neuropathy, if nerve myo-Ins is not spuriously high during fasting. At 6 weeks after induction of diabetes with streptozotocin in Sprague-Dawley rats we found that endoneurial glucose, sorbitol, and fructose were substantially increased and myo-Ins was decreased, as reported by others. By use of multiple linear regression to assess the effect of disease condition, time after feeding (1.5, 4, and 20 hours), and duration of diabetes (1,2,6 and 12 weeks) on nerve sugars and alcohol sugars, for nerve glucose, sorbitol, and fructose only disease condition was statistically significant factor. For nerve myo-Ins, disease group (control or diabetic rats) (P = 0.08), duration of diabetes (P = 0.02), time after feeding (P less than 0.001), duration x time (P = 0.01), group x duration (P = 0.03), and group x time (P = 0.05) were significant variables. Because nerve myo-Ins was lower at 20 hours than at 1.5 or 4 hours after feeding for all durations of diabetes, one can infer that in human nerve the lowest nerve myo-Ins, not high values, occur in the fasting state. Therefore, one would not expect to find lower nerve myo-Ins levels in human diabetics at times other than the fasting condition.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Dyck PJ,Minnerath SR,O'Brien PCdoi
10.1016/s0025-6196(12)61217-8subject
Has Abstractpub_date
1989-08-01 00:00:00pages
905-10issue
8eissn
0025-6196issn
1942-5546pii
S0025-6196(12)61217-8journal_volume
64pub_type
杂志文章abstract:OBJECTIVE:To describe the Mayo Clinic experience with emergency video telemedicine consultations for high-risk newborn deliveries. PATIENTS AND METHODS:From March 26, 2013, through December 31, 2015, the Division of Neonatal Medicine offered newborn telemedicine consultations to 6 health system sites. A wireless table...
journal_title:Mayo Clinic proceedings
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更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of brief couples support groups offered concurrently with in vitro fertilization (IVF) treatment. PATIENTS AND METHODS:Couples in IVF treatment were given the option of participating in a biweekly support group at the IVF clinic at Wilford Hall Medical Center, San Antonio, Tex. At leas...
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journal_title:Mayo Clinic proceedings
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更新日期:2016-08-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:1987-01-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:2016-07-01 00:00:00
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更新日期:2019-03-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:1976-05-01 00:00:00
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更新日期:1993-04-01 00:00:00
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更新日期:1993-10-01 00:00:00
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更新日期:2014-10-01 00:00:00
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更新日期:2013-12-01 00:00:00
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更新日期:2007-03-01 00:00:00
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更新日期:2017-09-01 00:00:00
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更新日期:2018-03-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
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更新日期:2011-11-01 00:00:00
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更新日期:1999-07-01 00:00:00
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更新日期:2003-06-01 00:00:00
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更新日期:2020-09-01 00:00:00