Abstract:
:Epilepsy is a common condition that affects 0.5 to 1% of all children. Although most children with epilepsy have well-controlled seizures with use of one antiepileptic drug (AED), some children have medically refractory seizures. This situation can be the result of inaccurate classification of the paroxysmal event, use of an inappropriate AED, of a truly medically refractory seizure disorder. Paramount to the initial assessment of a child with presumed epilepsy is the appropriate classification of the paroxysmal event. Several nonepileptic conditions, such as motor tics or breath-holding spells, can cause paroxysmal abnormalities in children, which can be confused with epilepsy. The common pediatric epileptic and nonepileptic conditions are reviewed, and the standard and new AEDs and their side effects are discussed. When a child's seizure disorder is intractable despite adequate trials of AEDs, surgical treatment is increasingly becoming an effective option. Such procedures should ideally be performed at centers with extensive experience in this area and with a multidisciplinary team approach. With improved magnetic resonance imaging technology, increasing numbers of children with medically intractable localization-related epilepsy are being found to have underlying focal cortical dysplasia, tumors, or hippocampal atrophy. These abnormalities can often be surgically resected with excellent results. A generalized epilepsy may also be remediable with surgical treatment. Specifically, preliminary data suggest that infantile spasms, when triggered by an underlying focal cortical dysplasia, may be effectively treated by surgical resection. Patients with certain catastrophic seizure disorders, such as Sturge-Weber syndrome or hemimegalencephaly, require prompt intervention with hemispherectomy. The presurgical evaluation relies heavily on the magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography scan data as well as the electroencephalogram in identifying the area of epileptogenic abnormality.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Zupanc MLdoi
10.4065/71.9.899subject
Has Abstractpub_date
1996-09-01 00:00:00pages
899-916issue
9eissn
0025-6196issn
1942-5546pii
S0025-6196(11)63757-9journal_volume
71pub_type
杂志文章,评审abstract::Cirrhosis and its disease-related complications are the 12th leading cause of mortality among U.S. adults and are the 5th leading cause of death for individuals aged 45 to 54 years. Hospitalization costs for disease-related complications are estimated at 18,000 dollars per episode of care, and 10% of admitted patients...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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abstract::The extent of universal screening for gestational diabetes and the incidence of gestational diabetes mellitus (GDM) by diagnosis were analyzed in four primary-care sites. The medical records of 798 women were reviewed to identify the presence of historical risk factors, familial determinants, and biophysical attribute...
journal_title:Mayo Clinic proceedings
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abstract::A 4 1/2-year-old girl is described in whom the portal vein is absent and the venous return from the gastrointestinal tract, spleen, and pancreas is through the left renal vein into the inferior vena cava. She had a hepatoblastoma, which was treated surgically by right hepatic lobectomy. Regeneration occurred in the re...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1979-01-01 00:00:00
abstract:OBJECTIVE:To examine current therapeutic modalities for acute lymphocytic leukemia (ALL) in adults, analyze prognostic variables, and offer treatment recommendations. DESIGN:We reviewed our experience with 90 adult patients with ALL examined at the Mayo Clinic between 1982 and 1992 and used it as a background for disc...
journal_title:Mayo Clinic proceedings
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doi:10.1016/s0025-6196(12)61817-5
更新日期:1994-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/S0025-6196(11)60670-8
更新日期:2009-11-01 00:00:00
abstract::Multilocular cysts of the peritoneum diagnosed at the Mayo Clinic from 1907 through 1981 were examined and divided, on the basis of their light microscopic features, into two groups--cystic mesotheliomas and cystic lymphangiomas. There are apparent clinical differences between the two groups. Cystic mesotheliomas tend...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1982-10-01 00:00:00
abstract::Despite the emergence of clinical ethics consultation as a clinical service in recent years, little is known about how clinical ethics consultation differs from, or is the same as, other medical consultations. A critical assessment of the similarities and differences between these 2 types of consultations is important...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/j.mayocp.2011.10.010
更新日期:2012-04-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/70.6.526
更新日期:1995-06-01 00:00:00
abstract::Abdominal apoplexy is a clinical entity characterized by spontaneous intraperitoneal hemorrhage from rupture of a visceral vessel. We describe a 34-year-old man who presented with abdominal apoplexy due to rupture of an ileocolic aneurysm. Subsequent biochemical and genetic analysis confirmed the diagnosis of Ehlers-D...
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更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,随机对照试验
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更新日期:2020-11-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
doi:10.1016/j.mayocp.2017.01.002
更新日期:2017-03-13 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.4065/73.12.1133
更新日期:1998-12-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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更新日期:2008-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)60069-x
更新日期:1993-12-01 00:00:00
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pub_type: 杂志文章
doi:10.4065/80.11.1414
更新日期:2005-11-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1982-09-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:10.1016/s0025-6196(12)65222-7
更新日期:1987-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-12-01 00:00:00
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更新日期:2003-07-01 00:00:00
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更新日期:2005-01-01 00:00:00
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journal_title:Mayo Clinic proceedings
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更新日期:2012-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1975-12-01 00:00:00
abstract:OBJECTIVE:To determine whether blood type affects the risk of thromboembolic complications in patients with atrial fibrillation (AF). PATIENTS AND METHODS:The Mayo Clinic electronic medical record was searched (between January 1, 2004, and December 31, 2010) to identify all patients with AF with blood group assessment...
journal_title:Mayo Clinic proceedings
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doi:10.1016/j.mayocp.2014.11.013
更新日期:2015-02-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1976-02-01 00:00:00
abstract:OBJECTIVE:To assess whether dietary supplements that are herbal and/or animal-derived products, marketed for enhancing metabolism or promoting energy, "adrenal fatigue," or "adrenal support," contain thyroid or steroid hormones. METHODS:Twelve dietary adrenal support supplements were purchased. Pregnenolone, androsten...
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pub_type: 杂志文章
doi:10.1016/j.mayocp.2017.10.019
更新日期:2018-03-01 00:00:00
abstract::Live attenuated influenza vaccine (LAIV), commercially available since 2003, has not gained widespread acceptance among prescribers. This underuse can be traced to several misperceptions and fears regarding LAIV. This review examines both the facts (safety, immunogenicity, and effectiveness) and the most pervasive myt...
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pub_type: 杂志文章,评审
doi:10.4065/83.1.77
更新日期:2008-01-01 00:00:00