Abstract:
OBJECTIVE:To compare the efficacy and tolerability of extended-release oxybutynin chloride and tolterodine tartrate at 12 weeks in participants with overactive bladder. SUBJECTS AND METHODS:The OBJECT (Overactive Bladder: Judging Effective Control and Treatment) study was a prospective, randomized, double-blind, parallel-group study conducted between March and October 2000 at 37 US study sites. Participants who had between 7 and 50 episodes of urge incontinence per week and 10 or more voids in 24 hours received extended-release oxybutynin, 10 mg/d, or tolterodine, 2 mg twice daily. The outcome measures were the number of episodes of urge incontinence, total incontinence, and micturition frequency at 12 weeks adjusted for baseline. RESULTS:A total of 315 women and 63 men were randomized and treated, and 332 participants (276 women, 56 men) completed the study. At the end of the study, extended-release oxybutynin was significantly more effective than tolterodine in each of the main outcome measures: weekly urge incontinence (P=.03), total incontinence (P=.02), and micturition frequency episodes (P=.02) adjusted for baseline. Both drugs improved symptoms of overactive bladder significantly from baseline to the end of the study as assessed by the 3 main outcome measures (P<.001). Dry mouth, the most common adverse event, was reported by 28.1% and 33.2% of participants taking extended-release oxybutynin and tolterodine, respectively (P=.32). Rates of central nervous system and other adverse events were low and similar in both groups. CONCLUSIONS:Extended-release oxybutynin was more effective than tolterodine as measured by end-of-study urge incontinence, total incontinence, and micturition frequency episodes. Both groups had similar rates of dry mouth and other adverse events.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Appell RA,Sand P,Dmochowski R,Anderson R,Zinner N,Lama D,Roach M,Miklos J,Saltzstein D,Boone T,Staskin DR,Albrecht D,Overactive Bladder: Judging Effective Control and Treatment Study Group.keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
358-63issue
4eissn
0025-6196issn
1942-5546pii
S0025-6196(11)62382-3journal_volume
76pub_type
临床试验,杂志文章,随机对照试验abstract::Use of amiodarone, an investigational antidysrhythmic agent, has been associated with cases of pulmonary toxicity. The mechanism of amiodarone pulmonary toxicity is unknown, and recommendations for the assessment and treatment of patients with this condition continue to evolve. In two patients with clinically diagnose...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
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abstract::Hypochondriasis (HC), which involves preoccupation with the fear of having a serious illness despite appropriate medical examination, is often encountered in medical settings. The most conspicuous feature of this disorder is seeking excessive reassurance from physicians, medical references, or self-inspection; however...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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abstract:OBJECTIVE:To explore the current epidemiological profile of Marfan syndrome in a general population. PATIENTS AND METHODS:Patients who had received a diagnosis of Marfan syndrome were identified from the Taiwan National Health Insurance database records from January 1, 2000, through December 31, 2012 (average populati...
journal_title:Mayo Clinic proceedings
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abstract::Reperfusion therapy (by either administration of thrombolytic agents or immediate angioplasty) is the mainstay of treatment of acute myocardial infarction, yet it remains underutilized. Additionally, many patients do not experience optimal reperfusion because of suboptimal flow rate in the infarct-related artery, abno...
journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
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journal_title:Mayo Clinic proceedings
pub_type: 临床试验,杂志文章
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journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
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更新日期:2014-10-01 00:00:00
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journal_title:Mayo Clinic proceedings
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doi:10.4065/80.4.527
更新日期:2005-04-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章,评审
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journal_title:Mayo Clinic proceedings
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doi:
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journal_title:Mayo Clinic proceedings
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journal_title:Mayo Clinic proceedings
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00