Treatment options for breast cancer resistant to anthracycline and taxane.

Abstract:

:Breast cancer is the most common noncutaneous malignancy among every major ethnic group of women in the United States. Anthracyclines and taxanes are the most active and widely used chemotherapeutic agents for breast cancer, but the increased use of these agents at an early stage of disease often renders tumors resistant to these drugs by the time the disease recurs, thereby reducing the number of treatment options for metastatic disease. Moreover, even when these agents can be used in the metastatic setting, treatment failure occurs in most cases, and as a result the 5-year survival rates of patients with metastatic breast cancer are low. This outcome underscores the need for new, effective treatments of metastatic breast cancer and has led to investigation of novel ways to overcome the problem of drug resistance. This article reviews the current treatment options for breast cancer resistant to anthracycline and taxane and provides recommendations for disease management. Published sources for this review were found by searching PubMed (https://www.ncbi.nlm.nih.gov/pubmed) and congress Web sites.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Moreno-Aspitia A,Perez EA

doi

10.1016/S0025-6196(11)60585-5

subject

Has Abstract

pub_date

2009-06-01 00:00:00

pages

533-45

issue

6

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)60585-5

journal_volume

84

pub_type

杂志文章,评审
  • Binocular vertical diplopia.

    abstract::The assessment of a patient with binocular vertical diplopia begins with a thorough history and neuro-ophthalmologic examination. The neuro-ophthalmologic examination includes observation for a compensatory head, face, or chin position; ocular ductions and versions in the nine cardinal positions of gaze; the three-ste...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-6196(11)63620-3

    authors: Brazis PW,Lee AG

    更新日期:1998-01-01 00:00:00

  • Horseshoe kidney associated with surgery of the abdominal aorta.

    abstract::Of 53 patients with horseshoe kidney (9 in the present series), 45 underwent operation for an abdominal aortic aneurysm: 40 electively and 5 on an emergency basis. The remaining eight patients underwent revascularization for arteriosclerosis obliterans. Of the 53 patients, 35 (66%) had renal artery anomalies. The anom...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:

    authors: Sidell PM,Pairolero PC,Payne WS,Bernatz PE,Spittel JA Jr

    更新日期:1979-02-01 00:00:00

  • Paradoxical embolization in an adult patient with cystic fibrosis.

    abstract::To our knowledge, we describe the first reported case of paradoxical embolization via a patent foramen ovale (PFO) in an adult with moderately severe cystic fibrosis (CF) and advanced lung disease. Fluctuating neurologic symptoms and signs suggestive of cerebrovascular disease in an adult patient with advanced CF may ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/75.10.1100

    authors: Espiritu JD,Kleinhenz ME

    更新日期:2000-10-01 00:00:00

  • Medication adherence: WHO cares?

    abstract::The treatment of chronic illnesses commonly includes the long-term use of pharmacotherapy. Although these medications are effective in combating disease, their full benefits are often not realized because approximately 50% of patients do not take their medications as prescribed. Factors contributing to poor medication...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/mcp.2010.0575

    authors: Brown MT,Bussell JK

    更新日期:2011-04-01 00:00:00

  • Hypoxic liver injury.

    abstract::Hypoxic liver injury is defined as a massive, but transient, increase in serum transaminase levels due to an imbalance between hepatic oxygen supply and demand in the absence of other acute causes of liver damage. It typically occurs in elderly individuals with right-sided congestive heart failure and low cardiac outp...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/81.9.1232

    authors: Ebert EC

    更新日期:2006-09-01 00:00:00

  • A contemporary conceptual model of hypochondriasis.

    abstract::Hypochondriasis (HC), which involves preoccupation with the fear of having a serious illness despite appropriate medical examination, is often encountered in medical settings. The most conspicuous feature of this disorder is seeking excessive reassurance from physicians, medical references, or self-inspection; however...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/77.12.1323

    authors: Abramowitz JS,Schwartz SA,Whiteside SP

    更新日期:2002-12-01 00:00:00

  • Tissue ablation technologies for localized prostate cancer.

    abstract::Traditional treatments for men with localized prostate cancer have included both surgical removal and radiation therapy, with their potential adverse effects on patient quality of life. Thus, there has been increasing interest in the development of minimally invasive procedures that use various technologies to deliver...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/79.12.1547

    authors: Gillett MD,Gettman MT,Zincke H,Blute ML

    更新日期:2004-12-01 00:00:00

  • Class of immunoglobulin deposition and prognosis in lupus nephritis.

    abstract::In the three major morphologic groups of lupus nephritis--diffuse, focal proliferative, and membranous--glomerular deposition of immunoglobulins is usually a combination of IgG, IgM, and IgA and is not a good indicator of initial renal severity or outcome. In this study of 60 patients with systemic lupus erythematosus...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:

    authors: Donadio JV Jr,Conn DL,Holley KE,Ilstrup DM

    更新日期:1978-06-01 00:00:00

  • Recently developed elastomers for facial prostheses.

    abstract::Ever since ancient times, man has been searching for the proper artificial substitute for living tissue. This has been a most frustrating and challenging task for the scientific community involved. Prosthetic restoration is the only alternative to reconstructive surgery for the facially deformed. This paper reviews th...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:

    authors: Gonzalez JB

    更新日期:1978-07-01 00:00:00

  • Bladder replacement with use of a detubularized right colonic segment: preliminary report of a new technique.

    abstract::Dissatisfaction with the long-term results of cutaneous urinary diversion and a demand for a more socially acceptable solution have prompted the development of procedures that allow continent urinary diversion. Creation of an internal reservoir from reconstructed bowel segments, which is anastomosed to the patient's u...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)62024-2

    authors: Goldwasser B,Barrett DM,Benson RC Jr

    更新日期:1986-08-01 00:00:00

  • Risk of breast cancer and breast cancer characteristics in women treated with supradiaphragmatic radiation for Hodgkin lymphoma: Mayo Clinic experience.

    abstract:OBJECTIVE:To evaluate the overall risk of breast cancer and breast cancer characteristics in women given supradiaphragmatic radiation therapy for Hodgkin lymphoma. PATIENTS AND METHODS:Medical records of 653 female patients who received supradiaphragmatic radiation therapy for Hodgkin lymphoma at the Mayo Clinic in Ro...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/78.6.708

    authors: Wahner-Roedler DL,Nelson DF,Croghan IT,Achenbach SJ,Crowson CS,Hartmann LC,O'Fallon WM

    更新日期:2003-06-01 00:00:00

  • Cardiac papillary fibroelastoma: a treatable cause of transient ischemic attack and ischemic stroke detected by transesophageal echocardiography.

    abstract::Transesophageal echocardiography (TEE) is used frequently in patients with cerebrovascular ischemia. On TEE, a typical appearance of a cardiac fibroelastoma is that of a pedunculated, mobile mass attached to a leaflet of a valve. Surgical excision of the lesion may lead to resolution of the symptoms and prevent furthe...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/S0025-6196(11)63944-X

    authors: Brown RD Jr,Khandheria BK,Edwards WD

    更新日期:1995-09-01 00:00:00

  • Effects of referral bias on surgical outcomes: a population-based study of surgical patients 90 years of age or older.

    abstract::During the 11-year period 1975 through 1985, 1,063 surgical procedures were performed on 795 Mayo Clinic patients 90 years of age or older. Preoperative conditions, surgical setting, and perioperative morbidity and mortality were analyzed in a comparison of the local residents of Olmsted County, Minnesota (N = 224), w...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)62742-6

    authors: Warner MA,Hosking MP,Lobdell CM,Offord KP,Melton LJ 3rd

    更新日期:1990-09-01 00:00:00

  • Targeting TMPRSS2 in SARS-CoV-2 Infection.

    abstract::Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has rapidly caused a global pandemic associated with a novel respiratory infection: coronavirus disease-19 (COVID-19). Angiotensin-converting enzyme-2 (ACE2) is necessary to facilitate SARS-CoV-2 infection, but-owing to its essential metabolic roles-it may b...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/j.mayocp.2020.06.018

    authors: Baughn LB,Sharma N,Elhaik E,Sekulic A,Bryce AH,Fonseca R

    更新日期:2020-09-01 00:00:00

  • Management of urinary retention: rapid versus gradual decompression and risk of complications.

    abstract::The literature was reviewed to quantify the risk of complications related to the relief of obstruction in urinary retention. We also sought to determine whether the risk of complications is higher with rapid or gradual decompression (or "clamping") of the obstructed urinary bladder. The medical literature was identifi...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-6196(11)63368-5

    authors: Nyman MA,Schwenk NM,Silverstein MD

    更新日期:1997-10-01 00:00:00

  • Separate Effects of Intensity and Amount of Exercise on Interindividual Cardiorespiratory Fitness Response.

    abstract:OBJECTIVE:To determine the separate effects of exercise intensity and amount on interindividual cardiorespiratory fitness (CRF) response. PARTICIPANTS AND METHODS:Participants were 121 (75 females, 62%) sedentary, middle-aged (mean [SD] age, 53.2 [7.5] years), abdominally obese adults who completed at least 90% of 5 w...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.mayocp.2015.07.024

    authors: Ross R,de Lannoy L,Stotz PJ

    更新日期:2015-11-01 00:00:00

  • Gycemic control, mealtime glucose excursions, and diabetic complications in type 2 diabetes mellitus.

    abstract::Type 2 diabetes mellitus is a heterogeneous disorder characterized by 2 pathogenic defects, impaired insulin secretion and insulin resistance. The resultant hyperglycemia causes microvascular and macrovascular complications that increase morbidity and mortality in patients with diabetes mellitus. Optimum glycemic cont...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Palumbo PJ

    更新日期:2001-06-01 00:00:00

  • Primary and revision total hip arthroplasty for patients 90 years of age and older.

    abstract:OBJECTIVE:To assess the reliability, durability, and safety of primary and revision total hip arthroplasty (THA) in patients 90 years of age and older. PATIENTS AND METHODS:Between 1970 and 1997, 66 THAs, 48 primary and 18 revision, were done for 65 patients aged 90 to 104 years (mean, 92 years). The Harris hip score ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/78.3.285

    authors: Pagnano MW,McLamb LA,Trousdale RT

    更新日期:2003-03-01 00:00:00

  • Ultrastructure of platelets in Bernard-Soulier syndrome.

    abstract::The platelets of a patient with the Bernard-Soulier syndrome were studied by electron microscopy. The main abnormalities were the presence of giant and often round platelets, hypertrophic and frequently widely dilated open canalicular system, disorganized microtubules, and platelets with sparse or absent granulation....

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:

    authors: Maldonado JE,Gilchrist GS,Brigden LP,Bowie EJ

    更新日期:1975-07-01 00:00:00

  • Ehlers-Danlos syndrome type IV and a novel mutation of the type III procollagen gene as a cause of abdominal apoplexy.

    abstract::Abdominal apoplexy is a clinical entity characterized by spontaneous intraperitoneal hemorrhage from rupture of a visceral vessel. We describe a 34-year-old man who presented with abdominal apoplexy due to rupture of an ileocolic aneurysm. Subsequent biochemical and genetic analysis confirmed the diagnosis of Ehlers-D...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/77.8.861

    authors: Hassan I,Rasmussen TE,Schwarze U,Rose PS,Whiteman DA,Gloviczki P

    更新日期:2002-08-01 00:00:00

  • Bedside estimation of risk from percutaneous coronary intervention: the new Mayo Clinic risk scores.

    abstract:OBJECTIVE:To derive risk models for percutaneous coronary intervention (PCI) outcomes from clinical and laboratory variables available before the procedure so they can be used for preprocedure risk stratification. PATIENTS AND METHODS:Using the Mayo Clinic registry, we analyzed 9035 PCIs on 7640 unique patients from J...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/82.6.701

    authors: Singh M,Rihal CS,Lennon RJ,Spertus J,Rumsfeld JS,Holmes DR Jr

    更新日期:2007-06-01 00:00:00

  • Tinnitus.

    abstract::Tinnitus, a common complaint, reportedly affects more than 37 million Americans. Most often, it is associated with a sensorineural hearing loss in the high-frequency range. Tinnitus, however, is a symptom and not a disease. Complacency about this symptom complex may cause physicians to overlook a severe underlying pat...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-6196(12)60521-7

    authors: Marion MS,Cevette MJ

    更新日期:1991-06-01 00:00:00

  • Acute disseminated encephalomyelitis after accidental injection of a hog vaccine: successful treatment with plasmapheresis.

    abstract::Acute disseminated encephalomyelitis, an inflammatory demyelinating disease of the central nervous system, can occur after viral infections or vaccinations. We report the clinical and neuroimaging findings in a 52-year-old man in whom acute disseminated encephalomyelitis developed after accidental self-injection of an...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/73.12.1193

    authors: Dodick DW,Silber MH,Noseworthy JH,Wilbright WA,Rodriguez M

    更新日期:1998-12-01 00:00:00

  • Dehydroepiandrosterone replacement therapy in hypoadrenal women: protein anabolism and skeletal muscle function.

    abstract:OBJECTIVE:To determine whether dehydroepiandrosterone (DHEA) replacement therapy in hypoadrenal women improves performance, muscle protein accretion, and mitochondrial functions. PARTICIPANTS AND METHODS:Thirty-three hypoadrenal women were enrolled in the study from May 1, 2002, through May 31, 2003. Twenty-eight comp...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.4065/83.11.1218

    authors: Dhatariya KK,Greenlund LJ,Bigelow ML,Thapa P,Oberg AL,Ford GC,Schimke JM,Nair KS

    更新日期:2008-11-01 00:00:00

  • Alterations in blood pressure by derangement of the mechanisms that regulate sodium excretion.

    abstract::Understanding the sequence of events responsible for pressure-related natriuresis and their pathophysiologic alterations may be useful in distinguishing various types of essential hypertension of renal origin. The perturbation of a distal step in the sequence is likely to be reflected in a simple physiologic defect. F...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-6196(12)65384-1

    authors: Romero JC,Bentley MD,Textor SC,Knox FG

    更新日期:1989-11-01 00:00:00

  • The Impact of a 20-Minute Animal-Assisted Activity Session on the Physiological and Emotional States in Patients With Fibromyalgia.

    abstract:OBJECTIVE:To study the direct physiological and emotional impact of an animal-assisted activity (AAA) session (a form of complementary and integrative medicine) in patients with fibromyalgia (FM). PATIENTS AND METHODS:The study population consisted of 221 participants with FM who were attending Mayo Clinic's Fibromyal...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.mayocp.2020.04.037

    authors: Clark S,Martin F,McGowan RTS,Smidt J,Anderson R,Wang L,Turpin T,Langenfeld-McCoy N,Bauer B,Mohabbat AB

    更新日期:2020-11-01 00:00:00

  • Testosterone and Cardiovascular Health.

    abstract::There is an ongoing debate in the medical community regarding the effects of testosterone on cardiovascular (CV) health. For decades, there has been conflicting evidence regarding the association of endogenous testosterone levels and CV disease (CVD) events that has resulted in much debate and confusion among health c...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.mayocp.2017.11.006

    authors: Elagizi A,Köhler TS,Lavie CJ

    更新日期:2018-01-01 00:00:00

  • Survey of physician leadership and management education.

    abstract::Health-care organizations have recognized the need to prepare physicians for various leadership and management positions within their own institutions. In the past, those who desired further education had to search beyond the boundaries of their practice to fulfill this need. The demands of a dynamic and changing heal...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/S0025-6196(11)63574-X

    authors: Scott HM,Tangalos EG,Blomberg RA,Bender CE

    更新日期:1997-07-01 00:00:00

  • Valvular heart disease in patients taking pergolide.

    abstract:OBJECTIVE:To Investigate the frequency of valvular heart disease in patients taking pergolide. PATIENTS AND METHODS:The medical records of patients seen at the Mayo Clinic in Jacksonville, Fla, between 1998 and 2003 were searched electronically for the word pergolide and the presence of a 2-dimensional echocardiogram....

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/80.8.1016

    authors: Waller EA,Kaplan J,Heckman MG

    更新日期:2005-08-01 00:00:00

  • Chronic Constipation.

    abstract::Constipation is a common symptom that may be primary (idiopathic or functional) or associated with a number of disorders or medications. Although most constipation is self-managed by patients, 22% seek health care, mostly to primary care physicians (>50%) and gastroenterologists (14%), resulting in large expenditures ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.mayocp.2019.01.031

    authors: Bharucha AE,Wald A

    更新日期:2019-11-01 00:00:00