Abstract：
OBJECTIVE:To estimate the age- and sex-adjusted incidence of melanoma in adults 61 years or older in Olmsted County, Minnesota, from 1970 through 2009. PATIENTS AND METHODS:Using Rochester Epidemiology Project resources, 397 patients were identified who were 61 years or older and who received a first lifetime diagnosis of melanoma from January 1, 1970, through December 31, 2009, in Olmsted County. The incidence of melanoma and the overall and disease-specific survival rates were compared by age, sex, year of diagnosis, and stage of disease. RESULTS:From 1970 through 2009, age- and sex-adjusted incidence increased significantly (P<.001) from 17.0 (95% CI, 8.6-25.4) to 124.6 (95% CI, 108.9-140.3) per 100,000 person-years, with a 4-fold increase in women and a more than 11-fold increase in men. In men, incidence rates increased with age (P<.001) and over time (P<.001). In women, incidence rates increased over time (P<.001) but were constant across all age groups studied (P=.90). The dramatic increase in the incidence of melanoma was observed mainly for stages 0 and I tumors in both men and women (>55-fold increase). Disease-specific survival increased across the decades (P<.001); when year of diagnosis was compared to mortality, hazard ratios were 0.94 (95% CI, 0.90-0.99; P=.010) and 0.93 (95% CI, 0.89-0.98; P=.006) for men and women, respectively. CONCLUSION:The incidence of melanoma in older men and women increased significantly over the past 4 decades in Olmsted County, with men experiencing higher rates of increase than did women.
journal_name
Mayo Clin Procjournal_title
Mayo Clinic proceedingsauthors
Olazagasti Lourido JM,Ma JE,Lohse CM,Brewer JDdoi
10.1016/j.mayocp.2016.06.028subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1555-1562issue
11eissn
0025-6196issn
1942-5546pii
S0025-6196(16)30370-6journal_volume
91pub_type
杂志文章abstract：OBJECTIVE:To evaluate the treatment strategies for primary and secondary management of malignancy-related pericardial effusions. PATIENTS AND METHODS:Retrospective review of Mayo Clinic Rochester charts and external records of patients with pericardial effusion associated with malignant disease who required treatment ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/75.3.248
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To describe the differences in clinical characteristics and outcome between adult- and childhood-onset biopsy-proven IgA vasculitis (IgAV) in North America. PATIENTS AND METHODS:Patients with IgAV diagnosed from January 1, 1997, through December 31, 2016, were retrospectively identified. Data were abstracted...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2019.04.034
更新日期：2019-09-01 00:00:00
abstract：:Platelets from normal pigs and pigs with von Willebrand's disease were studied by ultrastructural and scanning electron microscopy. The majority of resting platelets were discoid or abortive-dendritic in gross morphology with an average size of 2.6 micrometer. The number of alpha-granules per platelet section was vari...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:A patient simulator has been developed for training, certification, modeling, and demonstrating problems in the management of critical-care patients. The Critical Care & Hemodynamic Monitoring Training System consists of a personal computer, software, and a replica of a human torso designed to enable students to pract...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)65158-1
更新日期：1990-07-01 00:00:00
abstract：:Almost all pacemakers currently implanted in patients in the United States are now capable of some degree of noninvasive programmability. Although programmability seems to be a very useful feature and allows flexibility in the patient's pacemaker system, the use of programmability in the late follow-up period has not ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61255-5
更新日期：1984-04-01 00:00:00
abstract：OBJECTIVE:To report the clinicopathologic findings in patients with Grover's disease. MATERIAL AND METHODS:We reviewed the medical records and biopsy specimens from 72 patients with transient acantholytic dermatosis (Grover's disease) examined at Mayo Clinic Rochester. Hematoxylin-eosin-stained biopsy specimens (from ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/74.3.229
更新日期：1999-03-01 00:00:00
abstract：:All women who enter menopause experience amenorrhea unless they receive hormone replacement therapy. In younger women, amenorrhea unrelated to pregnancy and lactation can be a distressing symptom. In addition to its psychologic morbidity, amenorrhea may be the manifesting feature of a wide array of anatomic and endocr...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/72.12.1161
更新日期：1997-12-01 00:00:00
abstract：OBJECTIVE:To investigate the association between physical activity (PA) and risk of mortality in a large middle-aged cohort stratified by inflammatory status. PATIENTS AND METHODS:A total of 336,560 individuals (mean age, 39.7 years; 58% male) who underwent comprehensive health screenings were enrolled in this prospec...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2016.08.003
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:To analyze the relationship of ideal cardiovascular health to disease-specific death. PATIENTS AND METHODS:We used data from the Aerobics Center Longitudinal Study from October 9, 1987, to March 3, 1999, to estimate the prevalence of ideal cardiovascular health in 11,993 individuals (24.3% women) and to exam...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2012.07.015
更新日期：2012-10-01 00:00:00
abstract：:Two entities of special interest in sleep disorders medicine are restless legs syndrome and periodic movements of sleep. Most patients with restless legs syndrome have periodic movements of sleep, but most patients with the nocturnal disorder do not have restless legs when awake. In both conditions, the underlying cau...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)65163-5
更新日期：1990-07-01 00:00:00
abstract：:Amyotrophic lateral sclerosis is an insidiously developing, adult-onset, progressive anterior horn cell degeneration with associated degeneration of descending motor pathways. It has been recognized as an important clinical syndrome since the middle of the 19th century. Despite increasing clinical and research interes...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)61175-6
更新日期：1991-01-01 00:00:00
abstract：:Advances in liver transplantation continue to evolve but are hampered by continued increasing shortages in donor organs. This has resulted in a high incidence of patients dying while on the United Network for Organ Sharing waiting list. Indeed, we continue to assess ways of expanding the donor pool by using marginal d...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/78.2.197
更新日期：2003-02-01 00:00:00
abstract：:The clinical impact of the association between oral contraceptive (OC) use and breast cancer risk is important given that OCs are the most commonly prescribed contraceptive agent and that more than a quarter of a million women are diagnosed as having breast cancer in the United States annually. Substantial changes to ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.4065/83.1.86
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To ascertain the incidence and timing of fever in patients at risk for temperature modulation of brain injury resulting from ischemia or trauma. DESIGN:We retrospectively reviewed the medical records of patients admitted between January 1991 and December 1994. MATERIAL AND METHODS:We investigated three grou...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/S0025-6196(11)64885-4
更新日期：1998-07-01 00:00:00
abstract：:Data from animal experiments and human studies implicate added sugars (eg, sucrose and high-fructose corn syrup) in the development of diabetes mellitus and related metabolic derangements that raise cardiovascular (CV) risk. Added fructose in particular (eg, as a constituent of added sucrose or as the main component o...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/j.mayocp.2014.12.019
更新日期：2015-03-01 00:00:00
abstract：:Autonomic failure and proximal skeletal myopathy are rare features of the Sjögren syndrome (SS). We describe a 51-year-old woman with primary SS who had development of esophageal dysmotility, urinary retention, severe orthostatism, and skeletal myopathy during a 3-month period after the diagnosis of SS. Her symptoms a...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/74.7.695
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVE:To assess whether caffeine intake is associated with all-cause and cause-specific mortality. PATIENTS AND METHODS:We conducted a prospective cohort study using data from the National Health and Nutrition Examination Survey 1999-2010. Cox proportional hazards models were used to compare the multivariate-adjus...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2017.03.010
更新日期：2017-08-01 00:00:00
abstract：:Arterial calcification in the coronary arteries frequently indicates concomitant atherosclerotic plaque but can be present in the medial layers with no evidence of plaque. Calcification of the medial layer of arteries is seen most often in the peripheral arteries but also is widely recognized In the coronary arteries....
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/S0025-6196(11)61536-X
更新日期：2005-06-01 00:00:00
abstract：:Recent experience with 40 patients with the Zollinger-Ellison syndrome at all Mayo Clinic suggests that traditional clinical criteria for diagnosis are often absent or invalid. Patients are younger have a shorter duration of symptoms, and often present without prior gastric surgery. Clinical, roentgenographic, and end...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：OBJECTIVE:To compare cardiovascular (CV) event rates and risk in patients without previous CV disease in whom atorvastatin or simvastatin was newly initiated in a managed care setting. PATIENTS AND METHODS:Patients aged 18 to 64 years in whom atorvastatin or simvastatin was newly initiated between January 1, 2003, and...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/S0025-6196(11)60779-9
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:To determine whether the use of a computerized bar code-based blood identification system resulted in a reduction in transfusion errors or near-miss transfusion episodes. PATIENTS AND METHODS:Our institution instituted a computerized bar code-based blood identification system in October 2006. After instituti...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2012.12.010
更新日期：2013-04-01 00:00:00
abstract：:Restless legs syndrome (RLS) is a common disorder with a prevalence of 5% to 15%. Primary care physicians must become familiar with management of this disorder. This algorithm for the management of RLS was written by members of the Medical Advisory Board of the Restless Legs Syndrome Foundation and is based on scienti...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/79.7.916
更新日期：2004-07-01 00:00:00
abstract：OBJECTIVE:To determine the separate effects of exercise intensity and amount on interindividual cardiorespiratory fitness (CRF) response. PARTICIPANTS AND METHODS:Participants were 121 (75 females, 62%) sedentary, middle-aged (mean [SD] age, 53.2 [7.5] years), abdominally obese adults who completed at least 90% of 5 w...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.mayocp.2015.07.024
更新日期：2015-11-01 00:00:00
abstract：OBJECTIVE:To investigate a recent association between the use of the angiotensin receptor-blocker (ARB) olmesartan and a severe enteropathy resembling celiac disease. PATIENTS AND METHODS:We searched our endoscopy database for all outpatient esophagogastroduodenoscopy (EGD) or colonoscopy examinations in patients aged...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/j.mayocp.2014.05.012
更新日期：2014-09-01 00:00:00
abstract：:Dyspnea is a common symptom that is difficult to define and can result from a wide variety of causes. This complex sensation that arises from multiple stimuli involves both subjective perceptions and objective reactions. In the assessment of patients with dyspnea, use of a systematic approach to determine the precipit...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章,评审
doi：10.1016/s0025-6196(12)61344-5
更新日期：1994-07-01 00:00:00
abstract：:We describe a woman with an unusual case of thromboembolism of the mesenteric artery in whom multiple thrombi were subsequently found in the aorta and right heart chambers on transesophageal echocardiography. Further evaluation revealed a deficiency of protein C and S plasma proteins, inhibitors of the clotting system...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/76.3.319
更新日期：2001-03-01 00:00:00
abstract：:The surgical treatment of Crohn's disease is necessitated by complications of the disease or by failure of medical therapy. Despite the fact that the patients with Crohn's disease who undergo operation have the most severe spectrum of problems, about half these patients may never need a further procedure, and the mort...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.1016/s0025-6196(12)61933-8
更新日期：1986-04-01 00:00:00
abstract：OBJECTIVE:To analyze the effect of adjuvant perfusion techniques of the distal aorta on the outcome of traumatic thoracic aortic transections. PATIENTS AND METHODS:From 1973 to 2004, 72 patients (mean age, 39 years) with thoracic aortic transections arrived alive at the emergency department. Nineteen patients arrived ...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/81.5.625
更新日期：2006-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of prior duration of diabetes, glycated hemoglobin level at study entry, and microalbuminuria or macroalbuminuria on the extent and severity of coronary artery disease (CAD) and peripheral arterial disease. PATIENTS AND METHODS:We studied baseline characteristics of the 2368 participan...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/mcp.2009.0265
更新日期：2010-01-01 00:00:00
abstract：OBJECTIVE:To analyze the influence of recent changes in Minnesota statutes that generally require prior authorization for use of medical records for research from patients who received medical care after Jan. 1, 1997. MATERIAL AND METHODS:In this Mayo Clinic Institutional Review Board-approved study, we obtained a str...
journal_title：Mayo Clinic proceedings
pub_type： 杂志文章
doi：10.4065/74.4.330
更新日期：1999-04-01 00:00:00
