Ondansetron-induced multifocal encephalopathy.

Abstract:

:We treated a patient who developed transient multifocal encephalopathy with extrapyramidal symptoms (oromandibular dystonia, oculogyric crisis, and limb dystonia) in temporal proximity to ondansetron administration on emergence from general anesthesia. No other medications known to cause extrapyramidal reactions were administered. Although these symptoms resolved fully, the presentation was dramatic and resembled the symptoms of structural brain injury. Ondansetron is used frequently as an antiemetic agent in many clinical settings and is not limited to surgical patients. Therefore, the entire medical community should be cognizant of this potential adverse reaction.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Ritter MJ,Goodman BP,Sprung J,Wijdicks EF

doi

10.4065/78.9.1150

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

1150-2

issue

9

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(11)62940-6

journal_volume

78

pub_type

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