Willis-Ekbom Disease Foundation revised consensus statement on the management of restless legs syndrome.

Abstract:

:Restless legs syndrome (RLS)/Willis-Ekbom disease (WED) is a common disorder, occurring at least twice a week and causing at least moderate distress in 1.5% to 2.7% of the population. It is important for primary care physicians to be familiar with this disorder and its management. Much has changed in its management since our previous algorithm was published in 2004, including the availability of several new drugs. This revised algorithm was written by members of the Medical Advisory Board of the Willis-Ekbom Disease Syndrome Foundation based on scientific evidence and expert opinion. It considers the management of RLS/WED under intermittent RLS/WED, chronic persistent RLS/WED, and refractory RLS/WED. Nonpharmacological approaches, including mental alerting activities, avoiding substances or medications that may exacerbate RLS, and the role of iron supplementation, are outlined. Chronic persistent RLS/WED should be treated with either a nonergot dopamine agonist or a calcium channel α-2-δ ligand. We discuss the available drugs, the factors determining which to use, and their adverse effects. We define refractory RLS/WED and describe management approaches, including combination therapy and the use of high-potency opioids.

journal_name

Mayo Clin Proc

journal_title

Mayo Clinic proceedings

authors

Silber MH,Becker PM,Earley C,Garcia-Borreguero D,Ondo WG,Medical Advisory Board of the Willis-Ekbom Disease Foundation.

doi

10.1016/j.mayocp.2013.06.016

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

977-86

issue

9

eissn

0025-6196

issn

1942-5546

pii

S0025-6196(13)00559-4

journal_volume

88

pub_type

共识发展会议,杂志文章
  • Coryneform bacterial endocarditis: difficulties in diagnosis and treatment, presentation of three cases, and review of literature.

    abstract::Three patients who had coryneform bacterial endocarditis affecting a prosthetic valve are presented and 64 case reports are reviewed. Diagnostic difficulties occur because coryneform bacteria often are fastidiuos, with long incubation periods, and often contaminate blood cultures. Although some coryneform bacteria are...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:

    authors: Van Scoy RE,Cohen SN,Geraci JE,Washington JA 2nd

    更新日期:1977-04-01 00:00:00

  • Weekly cyclophosphamide and alternate-day prednisone: an effective, convenient, and well-tolerated oral treatment for relapsed multiple myeloma after autologous stem cell transplantation.

    abstract:OBJECTIVE:To assess the efficacy and tolerability of weekly oral cyclophosphamide in combination with alternate-day prednisone (CP) as salvage therapy for patients with relapsed multiple myeloma (MM) after autologous stem cell transplantation (ASCT). PATIENTS AND METHODS:We retrospectively reviewed the medical records...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/80.12.1578

    authors: Trieu Y,Trudel S,Pond GR,Mikhael J,Jaksic W,Reece DE,Chen CI,Stewart AK

    更新日期:2005-12-01 00:00:00

  • Attitude and disposition: do they make a difference in cancer survival?

    abstract::Psychosocial and spiritual factors influence a broad spectrum of medical and surgical disorders. The adverse effects of stress have been most clearly documented in cardiovascular disease. In cancer, unresolved questions include the following: Do emotional factors have a causal role in either initiating or promoting a ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/72.2.160

    authors: Creagan ET

    更新日期:1997-02-01 00:00:00

  • Albuminocytologic Dissociation in Posterior Reversible Encephalopathy Syndrome.

    abstract:OBJECTIVES:To describe cerebrospinal fluid (CSF) findings in patients with posterior reversible encephalopathy syndrome (PRES) and to study its association with vasogenic edema. PATIENTS AND METHODS:Retrospective review of 73 consecutive prospectively collected adults diagnosed with PRES from January 1, 2000, through ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/j.mayocp.2015.07.018

    authors: Datar S,Singh TD,Fugate JE,Mandrekar J,Rabinstein AA,Hocker S

    更新日期:2015-10-01 00:00:00

  • Calcium embolism of the coronary arteries after percutaneous mitral balloon valvuloplasty.

    abstract::Two cases of rare, catastrophic calcium emboli to the coronary arteries immediately after percutaneous mitral balloon valvuloplasty are presented. Preoperative echocardiographic findings may identify patients at risk for this complication. These cases should increase the awareness of calcium emboli and lead to conside...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/76.7.753

    authors: Powell BD,Holmes DR Jr,Nishimura RA,Rihal CS

    更新日期:2001-07-01 00:00:00

  • Frequency and Appropriateness of Fasting Orders in the Hospital.

    abstract:OBJECTIVE:To evaluate the frequency and appropriateness of nil per os (nothing by mouth) (NPO) orders and determine the number of meals missed because of these orders among hospitalized patients. PATIENTS AND METHODS:We retrospectively analyzed inpatient NPO orders at an academic institution in the United States. The ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/j.mayocp.2015.07.013

    authors: Sorita A,Thongprayoon C,Ahmed A,Bates RE,Ratelle JT,Rieck KM,Devalapalli AP,Issa M,Shah RM,Lalama MA,Wang Z,Murad MH,Kashiwagi DT

    更新日期:2015-09-01 00:00:00

  • Diagnostic role of serum CA 19-9 for cholangiocarcinoma in patients with primary sclerosing cholangitis.

    abstract::Primary sclerosing cholangitis (PSC) predisposes to the development of cholangiocarcinoma, a usually fatal complication that is difficult to diagnose. Serum concentrations of CA 19-9, a tumor-associated antigen, are frequently increased in patients with only cholangiocarcinoma. The aim of this study was to assess the ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)60696-x

    authors: Nichols JC,Gores GJ,LaRusso NF,Wiesner RH,Nagorney DM,Ritts RE Jr

    更新日期:1993-09-01 00:00:00

  • Binocular vertical diplopia.

    abstract::The assessment of a patient with binocular vertical diplopia begins with a thorough history and neuro-ophthalmologic examination. The neuro-ophthalmologic examination includes observation for a compensatory head, face, or chin position; ocular ductions and versions in the nine cardinal positions of gaze; the three-ste...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/S0025-6196(11)63620-3

    authors: Brazis PW,Lee AG

    更新日期:1998-01-01 00:00:00

  • Recent advances in liver transplantation.

    abstract::Advances in liver transplantation continue to evolve but are hampered by continued increasing shortages in donor organs. This has resulted in a high incidence of patients dying while on the United Network for Organ Sharing waiting list. Indeed, we continue to assess ways of expanding the donor pool by using marginal d...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/78.2.197

    authors: Wiesner RH,Rakela J,Ishitani MB,Mulligan DC,Spivey JR,Steers JL,Krom RA

    更新日期:2003-02-01 00:00:00

  • Primer on medical genomics. Part XII: Pharmacogenomics--general principles with cancer as a model.

    abstract::The Human Genome Project has resulted in a new era in the field of pharmacogenetics in which researchers are rapidly discovering new genetic variation, which may help to explain interindividual variability in drug efficacy and toxicity. Pharmacogenetics is the study of the role of genetic inheritance in individual var...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/79.3.376

    authors: Goetz MP,Ames MM,Weinshilboum RM

    更新日期:2004-03-01 00:00:00

  • Effect of 16-hour duty periods on patient care and resident education.

    abstract:OBJECTIVE:To measure the effect of duty periods no longer than 16 hours on patient care and resident education. PATIENTS AND METHODS:As part of our Educational Innovations Project, we piloted a novel resident schedule for an inpatient service that eliminated shifts longer than 16 hours without increased staffing or de...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/mcp.2010.0745

    authors: McCoy CP,Halvorsen AJ,Loftus CG,McDonald FS,Oxentenko AS

    更新日期:2011-03-01 00:00:00

  • Cerebrospinal fluid physiology and the management of increased intracranial pressure.

    abstract::Increased intracranial pressure can result in irreversible injury to the central nervous system. Among the many functions of the cerebrospinal fluid, it provides protection against acute changes in venous and arterial blood pressure or impact pressure. Nevertheless, trauma, tumors, infections, neurosurgical procedures...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-6196(12)65131-3

    authors: Lyons MK,Meyer FB

    更新日期:1990-05-01 00:00:00

  • Clinical value of the bile acid breath test. Evaluation of the Mayo Clinic experience.

    abstract::The Mayo Clinic experience with more than 200 bile acid breath tests was analyzed retrospectively to assess its clinical value. In patients with suspected bacterial overgrowth, the result of the bile acid breath test was compared with that of culture of aspirates of small bowel, and the test was found to have a sensit...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:

    authors: Lauterburg BH,Newcomer AD,Hofmann AF

    更新日期:1978-04-01 00:00:00

  • Bedside estimation of risk from percutaneous coronary intervention: the new Mayo Clinic risk scores.

    abstract:OBJECTIVE:To derive risk models for percutaneous coronary intervention (PCI) outcomes from clinical and laboratory variables available before the procedure so they can be used for preprocedure risk stratification. PATIENTS AND METHODS:Using the Mayo Clinic registry, we analyzed 9035 PCIs on 7640 unique patients from J...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/82.6.701

    authors: Singh M,Rihal CS,Lennon RJ,Spertus J,Rumsfeld JS,Holmes DR Jr

    更新日期:2007-06-01 00:00:00

  • Associations of conference attendance with internal medicine in-training examination scores.

    abstract:OBJECTIVE:To examine the association of medical knowledge acquisition with attendance at specific conference types during internal medicine residency. PARTICIPANTS AND METHODS:Attendance at residency core curriculum, morbidity and mortality, and medical grand rounds conferences was tracked for 195 residents who took t...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/83.4.449

    authors: McDonald FS,Zeger SL,Kolars JC

    更新日期:2008-04-01 00:00:00

  • Coronary revascularization on balance: Robert L. Frye lecture.

    abstract::The first generation of multicenter randomized controlled trials of coronary artery bypass surgery vs medical treatment in the 1970s found survival advantage only in patients with left main coronary artery disease or with multiple risk factors. Over time, these results have remained reproducible and biologically plaus...

    journal_title:Mayo Clinic proceedings

    pub_type:

    doi:10.4065/77.1.72

    authors: Detre KM,Holubkov R

    更新日期:2002-01-01 00:00:00

  • Update on Treatment of Clostridioides difficile Infection.

    abstract::Clostridioides difficile infection (CDI) is the leading cause of health care-associated infections in the United States. The increasing incidence and recurrence rates of CDI together with its associated morbidity and mortality are great concerns. Newer treatment methods, such as narrow-spectrum antibiotics, monoclonal...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.mayocp.2019.08.006

    authors: Cho JM,Pardi DS,Khanna S

    更新日期:2020-04-01 00:00:00

  • An overview of the diagnosis and pharmacologic treatment of migraine.

    abstract::Migraine, an episodic headache disorder, is one of the most common complaints encountered by primary-care physicians and neurologists. Nevertheless, it remains underdiagnosed and undertreated. Rational migraine treatment necessitates an accurate diagnosis, identification and removal of potential triggering factors, an...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/71.11.1055

    authors: Capobianco DJ,Cheshire WP,Campbell JK

    更新日期:1996-11-01 00:00:00

  • REM Sleep Behavior Disorder: Diagnosis, Clinical Implications, and Future Directions.

    abstract::Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especi...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.mayocp.2017.09.007

    authors: St Louis EK,Boeve BF

    更新日期:2017-11-01 00:00:00

  • Whole-Exome Sequencing of 10 Scientists: Evaluation of the Process and Outcomes.

    abstract:OBJECTIVE:To understand motivations, educational needs, and concerns of individuals contemplating whole-exome sequencing (WES) and determine what amount of genetic information might be obtained by sequencing a generally healthy cohort so as to more effectively counsel future patients. PATIENTS AND METHODS:From 2012 to...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/j.mayocp.2015.05.021

    authors: Lindor NM,Schahl KA,Johnson KJ,Hunt KS,Mensink KA,Wieben ED,Klee E,Black JL,Highsmith WE Jr,Thibodeau SN,Ferber MJ,Aypar U,Ji Y,Graham RP,Fiksdal AS,Sarangi V,Ormond KE,Riegert-Johnson DL,McAllister TM,Farrugia G,

    更新日期:2015-10-01 00:00:00

  • An integrated approach to evaluation of the solitary pulmonary nodule.

    abstract::In this article, we describe an integrated approach for detection and evaluation of solitary pulmonary nodules. Initial evaluation of the solitary pulmonary nodule includes tomography, fluoroscopy, and comparison with previously obtained roentgenograms. Subsequently, thin-section computed tomography and phantom densit...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/s0025-6196(12)65012-5

    authors: Swensen SJ,Jett JR,Payne WS,Viggiano RW,Pairolero PC,Trastek VF

    更新日期:1990-02-01 00:00:00

  • High Exercise Capacity Attenuates the Risk of Early Mortality After a First Myocardial Infarction: The Henry Ford Exercise Testing (FIT) Project.

    abstract:OBJECTIVE:To examine the effect of objectively measured exercise capacity (EC) on early mortality (EM) after a first myocardial infarction (MI). PATIENTS AND METHODS:This retrospective cohort study included 2061 patients without a history of MI (mean age, 62±12 years; 38% [n=790] women; 56% [n=1153] white) who underwe...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/j.mayocp.2015.11.012

    authors: Shaya GE,Al-Mallah MH,Hung RK,Nasir K,Blumenthal RS,Ehrman JK,Keteyian SJ,Brawner CA,Qureshi WT,Blaha MJ

    更新日期:2016-02-01 00:00:00

  • Aortic valve homografts in adults: a clinical perspective.

    abstract::Aortic valve replacement is a lifesaving measure in patients with severe aortic valve disease. In the United States, the most commonly used prostheses are the mechanical and bioprosthetic valves. With mechanical valves, long-term anticoagulation is necessary because of high thrombogenic potential. Bioprosthetic valves...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.4065/73.3.231

    authors: Staab ME,Nishimura RA,Dearani JA,Orszulak TA

    更新日期:1998-03-01 00:00:00

  • Matched comparison of radical nephrectomy vs nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contralateral kidney.

    abstract:OBJECTIVE:To report the long-term follow-up of a matched comparison of radical nephrectomy (RN) and nephron-sparing surgery (NSS) in patients with single unilateral renal cell carcinoma (RCC) and a normal contralateral kidney. PATIENTS AND METHODS:Between August 1966 and March 1999, 1492 and 189 patients with unilater...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/75.12.1236

    authors: Lau WK,Blute ML,Weaver AL,Torres VE,Zincke H

    更新日期:2000-12-01 00:00:00

  • Providing Appropriate End-of-Life Care to Religious and Ethnic Minorities.

    abstract::There is overwhelming evidence that racial and ethnic minorities face multiple health care disparities. Recognizing and addressing cultural and religious/spiritual (RS) values is a critical aspect of providing goal-concordant care for patients facing a serious illness, especially at the end of life. Failure to address...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.mayocp.2016.08.024

    authors: Partain DK,Ingram C,Strand JJ

    更新日期:2017-01-01 00:00:00

  • Enteric protein loss after the Fontan operation.

    abstract:OBJECTIVE:The current study was undertaken to assess the frequency of excessive enteric protein loss and protein-losing enteropathy in the relatively early period after the Fontan operation. DESIGN:Protein excretion was determined in 26 of 27 consecutive patients who underwent the Fontan procedure between January and ...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)61035-0

    authors: Davis CA,Driscoll DJ,Perrault J,Greenwood DH,Schaff HV,Puga FJ,Danielson GK,Feldt RH

    更新日期:1994-02-01 00:00:00

  • Causes of death in patients with tuberous sclerosis.

    abstract::Of the 355 patients with tuberous sclerosis complex (TSC) examined at the Mayo Clinic, 49 had died (9 of causes other than TSC). We attempted to determine what pattern of organ involvement occurred most often in the 40 patients who died of TSC. One baby died of cardiac failure due to cardiac rhabdomyomas, and one chil...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)61196-3

    authors: Shepherd CW,Gomez MR,Lie JT,Crowson CS

    更新日期:1991-08-01 00:00:00

  • Pretruncal nonaneurysmal subarachnoid hemorrhage.

    abstract:OBJECTIVE:To review the diagnostic evaluation and the clinical course of patients with pretruncal nonaneurysmal subarachnoid hemorrhage. MATERIAL AND METHODS:The study population consisted of a consecutive series of patients with a pretruncal nonaneurysmal subarachnoid hemorrhage encountered at Mayo Clinic Rochester d...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.4065/73.8.745

    authors: Wijdicks EF,Schievink WI,Miller GM

    更新日期:1998-08-01 00:00:00

  • Pancreatic pseudocyst that compressed the inferior vena cava and resulted in edema of the lower extremities.

    abstract::To our knowledge, edema of the lower extremities has not previously been reported as a sign of a pancreatic pseudocyst. In this case report, we describe a 66-year-old man in whom such a lesion compressed the inferior vena cava and caused pronounced leg swelling. After drainage of the pseudocyst, the edema did not recu...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)61125-2

    authors: Browman MW,Litin SC,Binkovitz LA,Mohr DN

    更新日期:1992-11-01 00:00:00

  • Thoracic manifestations after esophageal variceal sclerotherapy.

    abstract::Endoscopic esophageal variceal sclerotherapy (EVS) is often used in the treatment of upper gastrointestinal hemorrhage due to esophageal varices. We retrospectively reviewed the Mayo Clinic experience with EVS between 1980 and 1989 to determine the incidence of thoracic manifestations and chest roentgenographic abnorm...

    journal_title:Mayo Clinic proceedings

    pub_type: 杂志文章

    doi:10.1016/s0025-6196(12)62086-2

    authors: Zeller FA,Cannan CR,Prakash UB

    更新日期:1991-07-01 00:00:00