Abstract:
:Cyclooxygenase-2 (COX-2) is induced after the activation of cells by a variety of proinflammatory agents. Recently, evidence has shown that COX-2 may play a role in the pathogenesis of pulpal inflammation. However, little is known regarding the mechanism of pulpal inflammation at the site of bacterial infection. The purpose of this study was to determine the effects of the supernatants from black-pigmented Bacteroides (Porphyromonas endodontalis, Porphyromonas gingivalis, and Prevotella intermedia) on the COX-2 expression in primary human pulp cells in vitro. Investigations of the time dependence of COX-2 mRNA expression in black-pigmented Bacteroides-treated human pulp cells revealed a rapid accumulation of the transcript, a significant signal first detectable after 1 h of exposure. In addition, black-pigmented Bacteroides also up-regulated COX-2 protein expression in human pulp cells. Data from our in vitro experiment showed that black-pigmented Bacteroides were capable of stimulating COX-2 expression in human pulp cells. These results indicate that black-pigmented Bacteroides species may play an important role in the pathogenesis of pulpal inflammation. The activation of COX-2 may be one of the distinct host degradative pathways in the pathogenesis of microbial-induced pulpal/periapical inflammation.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Chang YC,Huang FM,Yang SF,Liu CM,Lai CC,Chan Y,Hsieh YSdoi
10.1097/00004770-200304000-00002keywords:
subject
Has Abstractpub_date
2003-04-01 00:00:00pages
240-3issue
4eissn
0099-2399issn
1878-3554pii
S0099-2399(05)60424-4journal_volume
29pub_type
杂志文章abstract:INTRODUCTION:The primary aim was to explore the criteria used in characterization of reparative cells and mineralized matrices formed after treatment of pulp exposures, and the sequence of relative events. The secondary aim was to evaluate whether the reparative events depend on the experimental model species, age, and...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2018.12.002
更新日期:2019-03-01 00:00:00
abstract:INTRODUCTION:Regenerative endodontic procedures are an alternative treatment for immature teeth with necrotic pulps. Typically, intracanal medicaments such as triple antibiotic paste (TAP) or double antibiotic paste (DAP) and calcium hydroxide (Ca[OH](2)) are used for disinfection. However, their effect on human stem c...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.06.018
更新日期:2012-10-01 00:00:00
abstract::Little is known about the effect of aging on characteristic functions of pulp cells. When damaged pulp is recovered and mineralized tissue is formed to protect remaining pulp tissue, the general responses of pulp tissue after adequate stimuli (pulp cell proliferation and activation of alkaline phosphatase [ALPase]) ar...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200301000-00003
更新日期:2003-01-01 00:00:00
abstract::Occlusal endodontic access preparations are occasionally made in teeth without removing the original restoration. However, microleakage between restorative materials that are placed at different times has not been extensively studied. Therefore, our objective was to compare microleakage at three areas: between an acce...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(99)80278-7
更新日期:1999-06-01 00:00:00
abstract::Forty freshly extracted human teeth were biomechanically prepared for endodontic obturation using a radioisotopically labeled EDTA-urea peroxide-Carbowax compound. The amount of radiolabeled mixture remaining in the canals after through cleansing was about 3.8% of that originally applied. The amount of residue did not...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(75)80137-3
更新日期:1975-09-01 00:00:00
abstract:INTRODUCTION:It has been reported that integrin-α5 (ITGA5) activity is related to cell proliferation, differentiation, migration, and organ development. However, the involvement of ITGA5 in the biological functions of human dental pulp stem cells (hDPSCs) has not been explored. The aim of this study was to investigate ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.08.011
更新日期:2014-02-01 00:00:00
abstract::Formocresol pulpotomy (FP) in the United States is most frequently used to treat asymptomatic caries near the pulp in primary teeth. Indirect pulp therapy (IPT) is also indicated and has a significantly higher long-term success. Pulpotomy is thought to be indicated for primary teeth with carious pulp exposures, but re...
journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2008.02.033
更新日期:2008-07-01 00:00:00
abstract::This in vitro study was carried out to determine (1) the hydrophobicity of selected oral bacteria, (2) the influence of growth media (saliva and serum) and mode of growth (planktonic or biofilm) on the hydrophobicity of Enterococcus faecalis, and (3) the influence of growth media and conditioning fluids on the adheren...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.07.035
更新日期:2007-12-01 00:00:00
abstract::The aim of this study was to determine the location of the root canal curvature and measure the distance from the CEJ to the first curvature using in vitro methods. Extracted maxillary premolars (n = 358) were fixed and digitally radiographed using the parallel technique. Excluded from further analysis were teeth with...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2005.09.011
更新日期:2006-04-01 00:00:00
abstract:INTRODUCTION:This study aimed to investigate the effects of 2 inorganic polyphosphates (poly[P]) are linear polymers of orthophosphate (Pi) residues linked by energy-rich phosphoanhydride poly(P) compounds, sodium triphosphate (STP, Na5P3O10) and sodium hexametaphosphate (SHMP, Na15P13O40 ∼ Na20P18O40) on the prolifera...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.01.038
更新日期:2015-06-01 00:00:00
abstract:INTRODUCTION:This study evaluated the biocompatibility of 5 and 10 μg/mL LL-37 in vitro and its effect on the differentiation of human dental pulp stem cells (DPSCs) into odontoblast-like cells. METHODS:Cell viability, genotoxicity, nitric oxide production, cell cycle, dentine sialophosphoprotein (DSPP) production, an...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.08.010
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:This retrospective study aimed to analyze the effect of repairing endodontic access cavities with composite on the survival of single crowns and retainer restorations of fixed or removable dental prostheses. METHODS:Dental records of patients attending a university dental clinic were retrospectively scree...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.11.012
更新日期:2020-03-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to visualize the stresses and strain distribution patterns in ProTaper Universal F2 files (Dentsply Maillefer, Ballaigues, Switzerland) and to establish the stress- and strain-curvature relationship for this instrument under various conditions by using a dynamic, three-dimensi...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.06.003
更新日期:2011-10-01 00:00:00
abstract::There is an increasing interest in the utility of dental pulp stem cells (DPSCs) for dentin regeneration. The mechanisms involved in DPSC differentiation remain poorly understood. The purpose of the study was to investigate the mineralization capacity of human dental pulp cells (DPCs) and identify potential markers fo...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.02.009
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVES:Dentists can choose between metal and fiber post systems to provide post-retained restorations. The risk of tooth loss and other complications differs between different post systems, as do the initial treatment costs. We aimed to assess the cost-effectiveness of (1) cast metal (MC), (2) preformed metal (MP),...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.01.002
更新日期:2017-05-01 00:00:00
abstract:INTRODUCTION:Fractured endodontic files present a major problem. A novel method has been proposed to retrieve fractured nickel-titanium (NiTi) endodontic files by using electrochemical dissolution. However, the effect of file dissolution on adjacent soft tissues such as the periodontal ligament (PDL) has not been inves...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.12.013
更新日期:2013-05-01 00:00:00
abstract:INTRODUCTION:Studies have found women try to avoid pain more than men, accept it less, and fear it more. The role of operator gender on subject gender pain in a clinical setting needs further study. The purpose of this randomized, double-blind investigation was to evaluate operator gender and its influence on reported ...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2014.10.001
更新日期:2015-02-01 00:00:00
abstract:INTRODUCTION:Idiopathic bone cavity (IBC) is an uncommon bone lesion that usually affects youngsters as an unilocular radiolucency with predilection for the posterior mandible. Because the lesion is frequently located in proximity to the adjacent teeth, chronic apical periodontitis is commonly included as a differentia...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.11.004
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:During the dental pulp repair process, human dental pulp cells (HDPCs) migrate to injury sites where they may differentiate into odontoblastlike cells. WNT6 plays a role in dental development and can activate a noncanonical pathway including the c-Jun N-terminal kinase (JNK) pathway. The mechanism of WNT6 ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.12.023
更新日期:2014-07-01 00:00:00
abstract:INTRODUCTION:The mental foramen (MF) is an important landmark in dentistry. Knowledge of its position is central to perform block anesthesia of the mental nerve or to avoid nerve damage during surgical procedures in the premolar area of the mandible. The present radiographic study aimed at evaluating the location and d...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.07.033
更新日期:2013-12-01 00:00:00
abstract:INTRODUCTION:Cell migration is an important step in pulpal wound healing. Although components in the resin-based dental materials are known to have adverse effects on pulp wound healing including proliferation and mineralization, their effects on cell migration have been scarcely examined. Here, we investigated the eff...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.06.004
更新日期:2013-09-01 00:00:00
abstract:INTRODUCTION:This study was to investigate the effects of tricalcium silicate (Ca(3)SiO(5)) on proliferation and odontogenic differentiation of human dental pulp cells (hDPCs) in vitro. METHODS:The hDPCs were seeded in culture medium with or without Ca(3)SiO(5) extract and calcium hydroxide (Ca(OH)(2)) extract. Prolif...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.05.035
更新日期:2011-09-01 00:00:00
abstract::Immunopathologic reactions play a significant role in inflammatory diseases of dental pulp. Interleukin-1beta (IL-1beta) is recognized as a key player in mediating cellular immune response. In this study, we measured the content of IL-1beta and its effect on collagen synthesis in cultures of fibroblasts derived from h...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200203000-00003
更新日期:2002-03-01 00:00:00
abstract::The apical sealing ability of amalgam, cold-burnished gutta-percha, amalgam with cavity varnish, and SuperEBA cement was evaluated in extracted human teeth. For each experimental group, the roots of 20 single-rooted teeth were sectioned from their crowns. Canals were cleaned, shaped, and obturated with vertically cond...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(89)80132-3
更新日期:1989-03-01 00:00:00
abstract::Etch-and-rinse adhesives can cause vasorelaxation via mechanisms occurring in the endothelium and smooth muscle, including the release of nitric oxide (NO). This effect might promote or aggravate bleeding if such adhesives are placed inadvertently on iatrogenic pulp microexposures. The present study assessed the vasoa...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.07.019
更新日期:2008-10-01 00:00:00
abstract:INTRODUCTION:A ferrule on anterior endodontic-treated teeth has been evaluated using clinical trials, in vitro tests, and finite element analysis (FEA). The patient-specific FEA with a nonuniform ferrule and nonlinear contact biting load associated with clinical validation can be used to predict failure. METHODS:A pat...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.04.024
更新日期:2017-09-01 00:00:00
abstract:INTRODUCTION:Irrigation dynamics and antibacterial activity determine the efficacy of root canal disinfection. Sonic or ultrasonic agitation of irrigants is expected to improve irrigation dynamics. This study examined the effects of microbubble emulsion (ME) combined with sonic or ultrasonic agitation on irrigation dyn...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.07.007
更新日期:2012-11-01 00:00:00
abstract::The purpose of this study was to compare Schick CDR and Trophy RVGui direct digital radiography (DDR) systems for the ability to detect periapical lesions in human cadaver mandibles. Digital radiographs were exposed of teeth with normal periapical areas and of teeth with artificially prepared periapical lesions using ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/01.don.0000140571.23012.ff
更新日期:2005-04-01 00:00:00
abstract::In vitro root surface temperatures produced during post space preparation were measured. The preparations were made using a GPX bur with rotational speeds of 6,500, 8,000, 9,500, 11,000, and 15,000 rpm. The overall mean temperature increase ranged from 0.66 degree to 4.81 degrees C and was greatest at 8,000 rpm. When ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80264-0
更新日期:1996-06-01 00:00:00
abstract:INTRODUCTION:Collagen dentin matrix may represent a suitable scaffold to be remineralized in the presence of bioactive materials. The purpose of this study was to determine if experimental resin cements containing bioactive fillers may modulate matrix metalloproteinase-mediated collagen degradation of etched dentin. M...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.05.011
更新日期:2012-09-01 00:00:00