Interleukin-1beta activity and collagen synthesis in human dental pulp fibroblasts.

Abstract:

:Immunopathologic reactions play a significant role in inflammatory diseases of dental pulp. Interleukin-1beta (IL-1beta) is recognized as a key player in mediating cellular immune response. In this study, we measured the content of IL-1beta and its effect on collagen synthesis in cultures of fibroblasts derived from healthy and diseased dental pulps. We found that diseased pulp fibroblasts contain 2.5-fold greater amounts of IL-1beta and synthesized 80% greater amounts of collagen compared with healthy pulp fibroblasts. However, exogenous IL-1beta failed to stimulate collagen synthesis by diseased fibroblasts, whereas collagen synthesis by healthy pulp fibroblasts was stimulated by more than 2-fold. These observations imply that pulp disease induces abnormalities associated with fibroblast response toward IL-1beta.

journal_name

J Endod

journal_title

Journal of endodontics

authors

Barkhordar RA,Ghani QP,Russell TR,Hussain MZ

doi

10.1097/00004770-200203000-00003

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

157-9

issue

3

eissn

0099-2399

issn

1878-3554

pii

S0099-2399(05)60602-4

journal_volume

28

pub_type

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