Interleukin-1beta activity and collagen synthesis in human dental pulp fibroblasts.


:Immunopathologic reactions play a significant role in inflammatory diseases of dental pulp. Interleukin-1beta (IL-1beta) is recognized as a key player in mediating cellular immune response. In this study, we measured the content of IL-1beta and its effect on collagen synthesis in cultures of fibroblasts derived from healthy and diseased dental pulps. We found that diseased pulp fibroblasts contain 2.5-fold greater amounts of IL-1beta and synthesized 80% greater amounts of collagen compared with healthy pulp fibroblasts. However, exogenous IL-1beta failed to stimulate collagen synthesis by diseased fibroblasts, whereas collagen synthesis by healthy pulp fibroblasts was stimulated by more than 2-fold. These observations imply that pulp disease induces abnormalities associated with fibroblast response toward IL-1beta.


J Endod


Journal of endodontics


Barkhordar RA,Ghani QP,Russell TR,Hussain MZ





Has Abstract


2002-03-01 00:00:00














  • Cyclic Fatigue Resistance of Reciproc Blue and Reciproc Files in an S-shaped Canal.

    abstract:INTRODUCTION:This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal. METHODS:A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Recip...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Topçuoğlu HS,Topçuoğlu G

    更新日期:2017-10-01 00:00:00

  • An immunohistological study on cyclooxygenase-2 in human dental pulp.

    abstract::Characteristics of cyclooxygenase-2 (COX-2) expressing cells in human dental pulp were immunohistologically studied. Extirpated pulpal tissues from extracted teeth were examined to elucidate the localization and distribution of COX-2. Pulpal tissues were examined by the labeled streptavidin biotin method using specifi...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Nakanishi T,Shimizu H,Hosokawa Y,Matsuo T

    更新日期:2001-06-01 00:00:00

  • Evaluation of size variation between endodontic finger spreaders and accessory gutta-percha cones.

    abstract::The diameter of nine sizes of three brands of endodontic spreaders was measured at D1 and D16 and compared with corresponding sizes of six brands of accessory gutta-percha cones. Two evaluators independently measured 20 randomly selected samples of each size of finger spreader and accessory gutta-percha cone. A standa...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Hartwell GR,Barbieri SJ,Gerard SE,Gunsolley JC

    更新日期:1991-01-01 00:00:00

  • Cytotoxicity comparison of three current direct pulp-capping agents with a new bioceramic root repair putty.

    abstract:INTRODUCTION:The purpose of this in vitro study was to compare the cytotoxicity of white mineral trioxide aggregate cement (AMTA, MTA-Angelus), Brasseler Endosequence Root Repair Putty (ERRM), Dycal, and Ultra-blend Plus (UBP) by using human dermal fibroblasts and a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Hirschman WR,Wheater MA,Bringas JS,Hoen MM

    更新日期:2012-03-01 00:00:00

  • Morphologic Change of Parvalbumin-positive Myelinated Axons in the Human Dental Pulp.

    abstract:INTRODUCTION:Information on the nerve fibers innervating the dental pulp is crucial for understanding dental pain and hypersensitivity. This study investigated the morphologic differences of parvalbumin (PV)-positive (+) myelinated fibers in 3 different regions of the human dental pulp. METHODS:Light and electron micr...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Kim TH,Park SK,Choi SY,Lee JS,Bae YC

    更新日期:2017-06-01 00:00:00

  • Comparison of five cone beam computed tomography systems for the detection of vertical root fractures.

    abstract:INTRODUCTION:This study compared the accuracy of cone beam computed tomography (CBCT) scans made by five different systems in detecting vertical root fractures (VRFs). It also assessed the influence of the presence of root canal filling (RCF), CBCT slice orientation selection, and the type of tooth (premolar/molar) on ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Hassan B,Metska ME,Ozok AR,van der Stelt P,Wesselink PR

    更新日期:2010-01-01 00:00:00

  • The deterioration of rotary nickel-titanium files under controlled conditions.

    abstract::It has been shown that rotary nickel-titanium files cannot be used indefinitely. Researchers and clinicians have not been able to agree on how many times a file can be used before being discarded, except if a file has fractured or become visibly distorted. This study used ISO size 20 files of 0.04 taper in the curved ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Svec TA,Powers JM

    更新日期:2002-02-01 00:00:00

  • Risk management in endodontics.

    abstract:INTRODUCTION:Endodontic claims are the most frequently filed malpractice claims in dentistry. The aim of this study was to categorize and review errors and complications related to endodontic procedures that resulted in legal actions against the treating practitioner. METHODS:All dental malpractice complaints reported...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Givol N,Rosen E,Taicher S,Tsesis I

    更新日期:2010-06-01 00:00:00

  • Effects of calcium silicate-based materials on collagen matrix integrity of mineralized dentin.

    abstract:INTRODUCTION:Calcium silicate-based materials (CSMs) are used in various endodontic procedures. The present study examined whether prolonged contact of mineralized dentin with recently commercialized versions of these materials adversely affects dentin collagen matrix integrity. METHODS:Dentin slabs prepared from extr...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Leiendecker AP,Qi YP,Sawyer AN,Niu LN,Agee KA,Loushine RJ,Weller RN,Pashley DH,Tay FR

    更新日期:2012-06-01 00:00:00

  • Outcome and Survival of Endodontically Treated Cracked Posterior Permanent Teeth: A Systematic Review and Meta-analysis.

    abstract:INTRODUCTION:The aim of the present systematic review and meta-analysis was to evaluate the success and survival rate of endodontically treated cracked posterior teeth and to assess the preoperative factors that affect teeth survival. METHODS:The study protocol was registered on the PROSPERO international prospective ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,meta分析


    authors: Olivieri JG,Elmsmari F,Miró Q,Ruiz XF,Krell KV,García-Font M,Durán-Sindreu F

    更新日期:2020-04-01 00:00:00

  • Endodontic management of a fused mandibular second molar and paramolar with the aid of spiral computed tomography: a case report.

    abstract::Fusion and gemination are developmental anomalies of the dental hard tissues that might require endodontic and surgical treatment for functional, orthodontic, or esthetic reasons. In this article, we report a rare case of successful endodontic management of unilateral fused mandibular second molar with a paramolar. Th...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Ballal S,Sachdeva GS,Kandaswamy D

    更新日期:2007-10-01 00:00:00

  • Microscopic evaluation of three endodontic files pre- and postinstrumentation.

    abstract::K-type files, Sureflex NiTi files, and FlexoFiles were evaluated morphometrically as they come from the manufacturer, and after being used to instrument root canals 1, 3, and 5 times in maxillary premolars. Evaluation was made using a stereomicroscope at x40 magnification and photomicrographs. The abnormalities found ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Bonetti Filho I,Miranda Esberard R,de Toledo Leonardo R,del Rio CE

    更新日期:1998-07-01 00:00:00

  • A comparison of torque required to fracture rotary files with tips bound in simulated curved canal.

    abstract::The purpose of this study was to compare torque force and rotation needed to fracture three types of nickel titanium alloy rotary instruments in a simulated curved root canal space that were bound at the file tip. Files of similar size tips were studied. The files studied were ProFiles with 0.04 taper diameters of 15,...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Guilford WL,Lemons JE,Eleazer PD

    更新日期:2005-06-01 00:00:00

  • An evaluation of setting time of mineral trioxide aggregate and EndoSequence root repair material in the presence of human blood and minimal essential media.

    abstract:INTRODUCTION:The purpose of this study was to compare the ability of MTA (Dentsply Maillefer, Tulsa, OK) and EndoSequence Root Repair Material (ESRRM; Brasseler USA, Savannah, GA) to set in the presence of human blood and minimal essential media. METHODS:A model was created using polymethyl methacrylate blocks each pr...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Charland T,Hartwell GR,Hirschberg C,Patel R

    更新日期:2013-08-01 00:00:00

  • Recovery of Oral In Vitro Biofilms after Exposure to Peptides and Chlorhexidine.

    abstract:INTRODUCTION:This study aimed to examine the dynamic recovery of established multispecies biofilms of oral bacteria after an initial treatment by D-enantiomeric peptide DJK-5, L-enantiomeric peptide 1018, or chlorhexidine digluconate (CHX). METHODS:Oral biofilms from 2 donors were grown on collagen-coated hydroxyapati...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Zhang T,Xia L,Wang Z,Hancock REW,Haapasalo M

    更新日期:2020-11-25 00:00:00

  • Progress and Challenges in Microengineering the Dental Pulp Vascular Microenvironment.

    abstract:INTRODUCTION:The dental pulp is highly vascularized and innervated tissue that is uniquely designed, being highly biologically active, while being enclosed within the calcified structure of the tooth. It is well-established that the dental pulp vasculature is a key requirement for the functional performance of the toot...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Bertassoni LE

    更新日期:2020-09-01 00:00:00

  • Comparison of iRoot BP Plus and Calcium Hydroxide as Pulpotomy Materials in Permanent Incisors with Complicated Crown Fractures: A Retrospective Study.

    abstract:INTRODUCTION:Calcium hydroxide has been used as a traditional pulpotomy agent for a long time but has some disadvantages. iRoot BP Plus (Innovative Bioceramix Inc, Vancouver, Canada) is a newly developed, ready-to-use calcium silicate-based bioactive ceramic with excellent bioactivity and sealing ability. However, whet...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Rao Q,Kuang J,Mao C,Dai J,Hu L,Lei Z,Song G,Yuan G

    更新日期:2020-03-01 00:00:00

  • Role of the extracellular signal-regulated kinase 1/2 pathway in driving tricalcium silicate-induced proliferation and biomineralization of human dental pulp cells in vitro.

    abstract:INTRODUCTION:The aim of this study was to investigate the role of the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in regulating tricalcium silicate (C3S)-driven proliferation and biomineralization of human dental pulp cells (hDPCs) in vitro. METHODS:Human DPCs were cultured in C3S-containing medium and ...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Du R,Wu T,Liu W,Li L,Jiang L,Peng W,Chang J,Zhu Y

    更新日期:2013-08-01 00:00:00

  • Induction of cyclooxygenase-2 mRNA and protein expression in human pulp cells stimulated with black-pigmented bacteroides.

    abstract::Cyclooxygenase-2 (COX-2) is induced after the activation of cells by a variety of proinflammatory agents. Recently, evidence has shown that COX-2 may play a role in the pathogenesis of pulpal inflammation. However, little is known regarding the mechanism of pulpal inflammation at the site of bacterial infection. The p...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Chang YC,Huang FM,Yang SF,Liu CM,Lai CC,Chan Y,Hsieh YS

    更新日期:2003-04-01 00:00:00

  • Effects of parathyroid hormone, 1,25-dihydroxyvitamin D3, and prostaglandin E2 on alkaline phosphatase activity in cultured dental pulp and gingiva cells of bovine calf.

    abstract::The effects of parathyroid hormone (PTH), 1,25-dihydroxyvitamin D3, and prostaglandin E2 (PGE2) on alkaline phosphatase activity on cultured dental pulp and gingiva cells of bovine calf were compared. In pulp cells, PTH, 1,25-dihydroxyvitamin D3, and PGE2 significantly increased alkaline phosphatase activity, but no i...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Kido J,Ishida H,Nagata T,Hamasaki A,Nishikawa S,Wakano Y

    更新日期:1991-04-01 00:00:00

  • Prevalence of Periapical Lesions in Patients with Osteoporosis.

    abstract:INTRODUCTION:Osteoporosis is a major systemic disease that can significantly deteriorate the quality of life of the affected individuals. It is more common in women, particularly after menopause. Osteoporosis may be associated with alterations in oral health. Treatment of osteoporotic patients mainly involves the admin...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Katz J,Rotstein I

    更新日期:2021-02-01 00:00:00

  • Behavior of nickel-titanium instruments manufactured with different thermal treatments.

    abstract:INTRODUCTION:The purpose of this study was to investigate if nickel-titanium instruments with similar designs manufactured by different thermal treatments would exhibit significantly different in vitro behavior. METHODS:Thirty-six instruments each of ProTaper Universal (PTU F1; Dentsply Maillefer, Ballaigues, Switzerl...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Pereira ÉS,Viana AC,Buono VT,Peters OA,Bahia MG

    更新日期:2015-01-01 00:00:00

  • Cyclic Adenosine Monophosphate Promotes Odonto/Osteogenic Differentiation of Stem Cells from the Apical Papilla via Suppression of Transforming Growth Factor Beta 1 Signaling.

    abstract:INTRODUCTION:Stem cells from the apical papilla (SCAPs) possess strong odonto/osteogenic differentiation potential. This study investigated the effect of cyclic adenosine monophosphate (cAMP) on odonto/osteogenic differentiation of SCAPs and the underlining interplay between cAMP and transforming growth factor beta 1 (...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Zhang J,Zhang CF,Li QL,Chu CH

    更新日期:2019-02-01 00:00:00

  • Orthodontic procedures after trauma.

    abstract::This review considers oral trauma and its relationship to orthodontics with respect to prevention and primary, secondary, and tertiary care. The level of evidence is not high in regard to this topic, but recommendable approaches to trauma at each stage are discussed on the basis of available literature and published g...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,评审


    authors: Fields HW,Christensen JR

    更新日期:2013-03-01 00:00:00

  • In vitro cytotoxicity evaluation of a novel root repair material.

    abstract:INTRODUCTION:This study examined the effect of a new bioactive dentin substitute material (Biodentine) on the viability of human gingival fibroblasts. METHODS:Biodentine, White ProRoot mineral trioxide aggregate (MTA), and glass ionomer cement were evaluated. Human gingival fibroblasts were incubated for 1, 3, and 7 d...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Zhou HM,Shen Y,Wang ZJ,Li L,Zheng YF,Häkkinen L,Haapasalo M

    更新日期:2013-04-01 00:00:00

  • In vitro cytotoxicity evaluation of a self-adhesive, methacrylate resin-based root canal sealer.

    abstract::This study compared the cytotoxicity of MetaSEAL (Parkell Inc, Farmington, NY), a methacrylate resin-based sealer with an epoxy resin-based (AH Plus Jet; Dentsply Caulk, Milford, DE) and a zinc oxide-eugenol-based sealer (Pulp Canal Sealer; SybronEndo, Orange, CA). Five-millimeter diameter disks prepared from the resp...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Pinna L,Brackett MG,Lockwood PE,Huffman BP,Mai S,Cotti E,Dettori C,Pashley DH,Tay FR

    更新日期:2008-09-01 00:00:00

  • Bonding of resin-based sealers to root dentin.

    abstract::This study compared the microshear bond strength of three resin-based sealers to root dentin and assessed whether sealer cements behave differently in thin and thick films. Extracted maxillary premolars were sectioned buccolingually, and 45 root halves were randomly allocated for microshear bond testing with the three...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Rahimi M,Jainaen A,Parashos P,Messer HH

    更新日期:2009-01-01 00:00:00

  • Outcomes of hospitalizations attributed to periapical abscess from 2000 to 2008: a longitudinal trend analysis.

    abstract:INTRODUCTION:Root canal therapy is a highly successful in-office treatment and preventive measure against periapical abscesses. Left untreated, periapical abscesses can have serious consequences that can lead to hospitalization. This study observes the trends of hospitalizations attributed to periapical abscesses. MET...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Shah AC,Leong KK,Lee MK,Allareddy V

    更新日期:2013-09-01 00:00:00

  • Pulp Innate Immune Defense: Translational Opportunities.

    abstract:INTRODUCTION:The improvement of regenerative endodontic procedures requires an understanding of the key clinical questions combined with a fundamental biological knowledge of how the dental tissues behave during health, disease, and repair. Therefore, partnerships between clinicians and basic scientists are essential t...

    journal_title:Journal of endodontics

    pub_type: 杂志文章,评审


    authors: Duncan HF,Cooper PR

    更新日期:2020-09-01 00:00:00

  • Comparison of push-out bond strengths of Resilon with three different sealers.

    abstract:INTRODUCTION:The purpose of this study was to evaluate the push-out bond strengths of different obturating materials. METHODS:Forty single-rooted human extracted teeth were used in this study. The teeth were instrumented and irrigated by using 5.25% NaOCl, 15% ethylenediaminetetraacetic acid, and sterile water. The te...

    journal_title:Journal of endodontics

    pub_type: 杂志文章


    authors: Stiegemeier D,Baumgartner JC,Ferracane J

    更新日期:2010-02-01 00:00:00