Abstract:
INTRODUCTION:Various factors may influence intracanal calcification in teeth treated with regenerative endodontic procedures. Bioactive materials, including ProRoot MTA (MTA; Dentsply Tulsa Dental Specialties, Memphis, TN) and Biodentine (BD; Septodont, Saint-Maur-des-Fossés, France), have been widely used as a coronal barrier in the final step of regenerative endodontic procedures. The purposes of this study were to evaluate the effect of either MTA or BD after application as a coronal barrier on transforming growth factor beta 1 (TGF-β1) release from root canal dentin and to observe the impact of these materials on human apical papilla cell (APC) mineralization. METHODS:Either MTA or BD was applied in enlarged root canals of human root segments. After storing for 14 days in phosphate-buffered saline, TGF-β1 release was evaluated using an enzyme-linked immunosorbent assay. To investigate the effect of the materials on APC mineralization, APCs were grown in the presence of either the materials alone or material-filled root segments. Cell mineralization was quantified after 14 and 21 days using alizarin red S staining. Calcium deposits were quantitatively analyzed. Statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests with the significance level at .05. RESULTS:The greatest amount of TGF-β1 release was observed in the root segments treated with BD. BD, used either alone or as a coronal barrier, promoted greater APC mineralization than did MTA on both days 14 and 21. Interestingly, when BD was applied as a coronal barrier, the mineralization effect was significantly reduced compared with the use of the materials alone (P < .05). CONCLUSIONS:When used as a coronal barrier, BD promoted the release of TGF-β1 from the root canal dentin. A higher mineralization effect was observed with BD than with MTA.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Wattanapakkavong K,Srisuwan Tdoi
10.1016/j.joen.2019.03.011subject
Has Abstractpub_date
2019-06-01 00:00:00pages
701-705issue
6eissn
0099-2399issn
1878-3554pii
S0099-2399(19)30251-1journal_volume
45pub_type
杂志文章abstract:INTRODUCTION:The aim of this prospective study was to evaluate the postoperative pain that followed root canal treatments performed with a single-file reciprocating system on asymptomatic uniradicular necrotic teeth with and without foraminal enlargements (FEs). METHODS:Forty-six volunteers were randomly divided into ...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2015.09.018
更新日期:2016-01-01 00:00:00
abstract::Amalgam, IRM, and a mineral trioxide aggregate were tested for repair of experimentally created root perforations. Fifty sound, extracted mandibular and maxillary molars were used in this study. A perforation was created on the mesial root surface at about a 45-degree angle to the long axis of each tooth. The tooth wa...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81282-3
更新日期:1993-11-01 00:00:00
abstract::Cytotoxicity was compared between new root canal sealers (New A, New B, and New B-2) and conventional root canal sealers (AH26, Diaket, Canals, Tubi-Seal, and Sealapex). Dental pulp cells of rats, obtained through primary cell culture, were used. In the experiments with the freshly prepared sealers, the incorporation ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(89)80109-8
更新日期:1989-02-01 00:00:00
abstract::The purpose of this study was to evaluate the integrity of resected root-end surfaces of extracted human teeth after using ultrasonic tips at low or high frequencies for root-end preparation. Thirty bilaterally matched pairs of single-rooted human teeth had root-end resections using a low-speed diamond saw and were ex...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80091-4
更新日期:1996-04-01 00:00:00
abstract::This study investigated the sealing properties of cold laterally compacted gutta percha and Thermafil applied over different apically fractured rotary nickel-titanium files. Extracted human premolars were prepared by using ProTaper (Dentsply-Maillefer, Ballaigues, Switzerland) or ProFile (Dentsply-Maillefer) systems (...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.10.023
更新日期:2008-02-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the antimicrobial effects of root canal sealers on Enterococcus faecalis biofilms in dentinal tubules by using a novel dentin infection model. METHODS:Cells of E. faecalis were introduced into the dentinal tubules by centrifugation and incubated in brain-heart inf...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.10.042
更新日期:2014-04-01 00:00:00
abstract:BACKGROUND:The aim of this in vitro study was to evaluate the depth of penetration of 4 different endodontic resin sealers into the radicular dentinal tubules with the aid of confocal microscopy. METHODS:Eighty single-rooted teeth were instrumented and divided into 4 groups composed of 20 teeth each. The samples were ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.05.017
更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.joen.2020.04.015
更新日期:2020-08-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.11.004
更新日期:2021-02-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to investigate the release of growth factors into root canal space after the irrigation procedure of regenerative endodontic procedure. METHODS:Sixty standardized root segments were prepared from extracted single-root teeth. Nail varnish was applied to all surfaces except the roo...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.04.029
更新日期:2016-12-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2014.01.009
更新日期:2014-05-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.10.008
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:Complement activation is considered a major mechanism in innate immunity. Although it is mainly involved in initiating inflammation, recent data reported its involvement in other processes such as tissue regeneration. In the dental pulp, complement C5a fragment has been shown to be involved in the recruitm...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.06.011
更新日期:2016-09-01 00:00:00
abstract:INTRODUCTION:The study was designed as a randomized double-blind trial to evaluate the anesthetic efficacy of 4% articaine with 1:100,000 epinephrine in inferior alveolar nerve block (IANB) and infiltration anesthetic techniques to anesthetize mandibular molars with irreversible pulpitis. METHODS:The study was compose...
journal_title:Journal of endodontics
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.joen.2011.09.009
更新日期:2011-12-01 00:00:00
abstract::An in vitro, flow-through optical system was designed to measure hemoglobin (Hb) concentrations in the pulp space. The system included light-emitting diodes and a silicon photodetector positioned on opposing surfaces of human teeth. A syringe pump allowed a controlled flow of blood through the pulp chamber. The Hb con...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(96)80230-5
更新日期:1996-01-01 00:00:00
abstract:INTRODUCTION:This study was conducted to evaluate and compare the fracture resistance of roots obturated with various contemporary canal-filling systems. METHODS:Fifty single-rooted extracted mandibular premolars were decoronated to obtain 13-mm root segments. Ten roots were left unprepared and unfilled (negative cont...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.08.008
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:Failure in endodontic treatment is often caused by the persistence of microorganisms in the root canal after therapy. When treatment fails, an immune response develops that is characterized by an extensive network of immunologic mechanisms that lead to the production of cytokines and chemokines. METHODS:T...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.08.007
更新日期:2011-12-01 00:00:00
abstract:INTRODUCTION:The mental foramen (MF) is an important landmark in dentistry. Knowledge of its position is central to perform block anesthesia of the mental nerve or to avoid nerve damage during surgical procedures in the premolar area of the mandible. The present radiographic study aimed at evaluating the location and d...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.07.033
更新日期:2013-12-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.04.028
更新日期:2010-08-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.08.011
更新日期:2019-12-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.08.016
更新日期:2011-11-01 00:00:00
abstract::The purpose of this investigation was to compare the antimicrobial effect of MTAD (a mixture of a tetracycline isomer, an acid, and a detergent) with that of NaOCl with and without EDTA. Eighty-five extracted human teeth were contaminated with Enterococcus faecalis for 4 weeks. After biomechanical instrumentation usin...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200309000-00008
更新日期:2003-09-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)80488-7
更新日期:1992-07-01 00:00:00
abstract:INTRODUCTION:Newer antibacterial alternatives such as chitosan nanoparticles (CSnps) and photodynamic therapy (PDT) have been investigated to achieve effective root canal disinfection. The current study aims to assess the effect of various tissue inhibitors such as dentin, dentin matrix, pulp tissue, bacterial lipopoly...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.05.006
更新日期:2012-09-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章,评审
doi:10.1016/j.joen.2011.01.011
更新日期:2011-04-01 00:00:00
abstract::The aim of this study was to evaluate the presence of bacterial biofilm on the external surface of the root apex in teeth with pulp necrosis, with and without radiographically visible periapical lesions, and in teeth with a vital pulp. Twenty-one teeth were extracted, eight with pulp necrosis and periapical lesions, e...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200212000-00006
更新日期:2002-12-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章,meta分析,评审
doi:10.1016/j.joen.2012.09.026
更新日期:2013-01-01 00:00:00
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journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2016.05.012
更新日期:2016-09-01 00:00:00
abstract::Retrograde (or apical/periapical) peri-implantitis (RPI) presents with radiographic signs of bone loss at the periapical area of endosteal implants and may also present with clinical signs of abscess formation or a sinus tract traceable to the implant periapex. The lesion may form days up to several years after the in...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2019.01.002
更新日期:2019-05-01 00:00:00
abstract:INTRODUCTION:This study examined the dynamic fracture behavior of nickel-titanium rotary instruments in torsional or cyclic loading at continuous or reciprocating rotation by means of high-speed digital video imaging. METHODS:The ProFile instruments (size 30, 0.06 taper; Dentsply Maillefer, Ballaigues, Switzerland) we...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.03.024
更新日期:2017-08-01 00:00:00