Abstract:
INTRODUCTION:This study aimed to investigate the effects of 2 inorganic polyphosphates (poly[P]) are linear polymers of orthophosphate (Pi) residues linked by energy-rich phosphoanhydride poly(P) compounds, sodium triphosphate (STP, Na5P3O10) and sodium hexametaphosphate (SHMP, Na15P13O40 ∼ Na20P18O40) on the proliferation, odontoblastic differentiation, and angiogenic potential of human dental pulp cells (HDPCs). METHODS:Differentiation was measured by alkaline phosphatase activity, calcified nodule formation by alizarin red staining, and marker messenger RNA (mRNA) levels by reverse-transcription polymerase chain reaction. In vitro angiogenesis was quantified by migration, mRNA levels of angiogenic genes, and endothelial tube formation. RESULTS:STP and SHMP dose dependently increased the proliferation and ALP activity and enhanced mineralized nodule formation and odontoblast marker mRNAs of HDPCs. STP and SHMP resulted in the up-regulation of angiogenic genes in HDPCs. Endothelial cells treated with conditioned medium collected from STP- and SHMP-exposed HDPCs showed an increase in migration and capillary tube formation. Knockdown of the expression of the genes encoding of inorganic pyrophosphate by small interfering RNA attenuated the STP- and SHMP-induced odontogenic differentiation and angiogenic potential. CONCLUSIONS:This study showed that STP and SHMP promote the growth, differentiation, and angiogenic potential of HDPCs. These results suggest that STP and SHMP may be candidates for dental pulp tissue engineering and regenerative endodontics.
journal_name
J Endodjournal_title
Journal of endodonticsauthors
Bae WJ,Jue SS,Kim SY,Moon JH,Kim ECdoi
10.1016/j.joen.2015.01.038subject
Has Abstractpub_date
2015-06-01 00:00:00pages
896-902issue
6eissn
0099-2399issn
1878-3554pii
S0099-2399(15)00105-3journal_volume
41pub_type
杂志文章abstract:INTRODUCTION:Pain present 6 months after root canal treatment (RCT) may be of odontogenic or nonodontogenic origin. This is important because treatments and prognoses are different; therefore, the aim of this study was to provide specific diagnoses of patients reporting pain 6 months after receiving initial orthograde ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.12.012
更新日期:2015-04-01 00:00:00
abstract:INTRODUCTION:This study was to investigate the effects of tricalcium silicate (Ca(3)SiO(5)) on proliferation and odontogenic differentiation of human dental pulp cells (hDPCs) in vitro. METHODS:The hDPCs were seeded in culture medium with or without Ca(3)SiO(5) extract and calcium hydroxide (Ca(OH)(2)) extract. Prolif...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.05.035
更新日期:2011-09-01 00:00:00
abstract::Cyclooxygenase-2 (COX-2) is induced after the activation of cells by a variety of proinflammatory agents. Recently, evidence has shown that COX-2 may play a role in the pathogenesis of pulpal inflammation. However, little is known regarding the mechanism of pulpal inflammation at the site of bacterial infection. The p...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200304000-00002
更新日期:2003-04-01 00:00:00
abstract:INTRODUCTION:Newer antibacterial alternatives such as chitosan nanoparticles (CSnps) and photodynamic therapy (PDT) have been investigated to achieve effective root canal disinfection. The current study aims to assess the effect of various tissue inhibitors such as dentin, dentin matrix, pulp tissue, bacterial lipopoly...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.05.006
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:This retrospective study assessed the effects of microsurgical treatment of post-treatment endodontic disease using SuperEBA (Bosworth, Skokie, IL) as the root-end filling material and evaluated the potential prognostic factors in relation to outcome. METHODS:Data were collected from patients diagnosed wi...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.11.001
更新日期:2014-03-01 00:00:00
abstract:INTRODUCTION:The success of endodontic regeneration lies in the appropriate combination of stem cells and bioactive materials. Several novel dental materials are available on the market in this regard. Hence, the current study aimed to evaluate the proliferation, differentiation, and osteogenic potential of human bone ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.11.016
更新日期:2018-03-01 00:00:00
abstract:INTRODUCTION:Information on the nerve fibers innervating the dental pulp is crucial for understanding dental pain and hypersensitivity. This study investigated the morphologic differences of parvalbumin (PV)-positive (+) myelinated fibers in 3 different regions of the human dental pulp. METHODS:Light and electron micr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.01.010
更新日期:2017-06-01 00:00:00
abstract::The aim of this study was to determine the effects of patient's age on the prevalence and depth of bacterial penetration inside dentinal tubules. Fifty-six single-rooted teeth were divided in two groups based on the patient's age: young (ages 18-25) and old (age >or=60). Teeth were instrumented and inoculated with a s...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2008.10.004
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Difficult handling, long setting time, and potential discoloration are important drawbacks of white mineral trioxide aggregate (WMTA). The development of Biodentine, a recently developed calcium silicate-based material (CSM), has overcome some of these shortcomings; however, there are no available data on ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2012.12.021
更新日期:2013-04-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to determine the prevalence and characteristics of postoperative pain after endodontic microsurgery and to identify potential predictors for severe pain. METHODS:One hundred seventy-three patients who underwent endodontic microsurgery at a private practice were included in the st...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.12.012
更新日期:2020-12-23 00:00:00
abstract:INTRODUCTION:We performed a micro-computed tomographic assessment of the preparation of moderately single- and double-curved root canals using 3 single-file reciprocating nickel-titanium systems: S1 Plus Standard (Sendoline, Täby, Sweden), WaveOne Gold Primary (Dentsply Sirona, Ballaigues, Switzerland), and Reciproc R2...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.05.005
更新日期:2020-08-01 00:00:00
abstract::It is known that many factors participate in the process of inflammation and pain transmission. Recently, various neuropeptides have been demonstrated in the intrapulpal nerve fibers immunobiohistochemically. These neuropeptides may play some role in the process of inflammation and transmission of pain sensation. In t...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(06)81566-9
更新日期:1990-02-01 00:00:00
abstract:INTRODUCTION:External apical root resorption (EARR) is a frequent iatrogenic effect of orthodontic treatment. The way root-filled teeth respond to orthodontic forces with respect to EARR has been reported as varying widely between individuals. Genetic variants in the interleukin-1 gene have been associated with an incr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.12.022
更新日期:2012-03-01 00:00:00
abstract:INTRODUCTION:Optical coherence tomography (OCT) is a noninvasive modality to obtain in-depth images of biological structures. A dental OCT system has become available for chairside application. This in vitro study hypothesized that swept-source OCT can be used to measure the remaining dentin thickness (RDT) at the roof...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.03.016
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Recent evidence finds mineral trioxide aggregate (MTA) more effective than calcium hydroxide (CH) for direct pulp capping (DPC). The present study assessed the cost-effectiveness of MTA versus CH for DPC using a model-based simulation approach. METHODS:A mixed public/private payer perspective in the conte...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2015.08.019
更新日期:2015-12-01 00:00:00
abstract::The aim of this study was to investigate the correlation between endodontic clinical signs and symptoms and the presence of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia or their association by nested polymerase chain reaction assay. Microbial samples were taken from 50 cases with necrotic pu...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2007.05.017
更新日期:2007-09-01 00:00:00
abstract::One hundred single-rooted teeth were instrumented with Lightspeed, Profile .04 Taper Series 29, and NT McXIM instruments according to the recommendations of the manufacturers, and Flex-R files using the balanced force technique. Groups were comparable with respect to average curvature, canal length, and major and mino...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/S0099-2399(98)80086-1
更新日期:1998-02-01 00:00:00
abstract:INTRODUCTION:An evaluation was made of the connective tissue reaction in rats after subcutaneous implantation of methacrylate resin-based sealers (EndoREZ [Ultradent Products, Inc, South Jordan, UT] with a polymerization accelerator and RealSeal [Sybron Dental Specialties, Orange, CA]) and Pulp Canal Sealer (Sybron Den...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.06.019
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to compare the ability of MTA (Dentsply Maillefer, Tulsa, OK) and EndoSequence Root Repair Material (ESRRM; Brasseler USA, Savannah, GA) to set in the presence of human blood and minimal essential media. METHODS:A model was created using polymethyl methacrylate blocks each pr...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.04.041
更新日期:2013-08-01 00:00:00
abstract::The 4- to 6-yr outcome of initial (first-time) endodontic treatment was assessed for Phase II of the "Toronto Study." In total, 442 teeth were treated by using flared preparation and vertical compaction of warm gutta-percha or step-back preparation and lateral compaction. With 126 teeth excluded (discontinuers: deceas...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200405000-00002
更新日期:2004-05-01 00:00:00
abstract::The anatomy of third molars has been described as unpredictable. However restorative, prosthetic, and orthodontic considerations often require endodontic treatment of third molars in order for them to be retained as functional components of the dental arch. The purpose of this study was to investigate and characterize...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200011000-00011
更新日期:2000-11-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of different irrigating solutions on smear layer removal and dentinal tubule opening on root canal surfaces after post space preparation and to study whether additional ultrasonic irrigation has any effect on smear layer removal. Forty-eight anterior teeth were trea...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.01.006
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to perform a descriptive analysis of the occurrence of external cervical resorption (ECR) in relation to the patients' characteristics (sex, age, and tooth type) and the potentially involved predisposing factors. METHODS:This study includes data on 284 patients (337 teeth with ev...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2017.05.026
更新日期:2017-10-01 00:00:00
abstract:INTRODUCTION:The alterations in dentin tissue depending on increasing age might cause different adhesion capability of bacteria, yielding differences in clinical approaches regarding root canal irrigation. This study, therefore, aimed to evaluate the effects of ethylenediaminetetraacetic acid (EDTA) and sodium hypochlo...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2010.01.008
更新日期:2010-05-01 00:00:00
abstract::A new endodontic obturation and retrofilling material has been invented to satisfy Grossman's requirements for an ideal material. Methylene blue dye leakage studies were carried out to compare the new material with conventional products, for both obturation and retrofilling. The experimental material when used in root...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1097/00004770-200207000-00008
更新日期:2002-07-01 00:00:00
abstract:INTRODUCTION:This study compared the accuracy of cone beam computed tomography (CBCT) scans made by five different systems in detecting vertical root fractures (VRFs). It also assessed the influence of the presence of root canal filling (RCF), CBCT slice orientation selection, and the type of tooth (premolar/molar) on ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2009.09.013
更新日期:2010-01-01 00:00:00
abstract:INTRODUCTION:In recent years, the inflammasome has been determined to play an important role in inflammatory diseases. However, the role of the inflammasome in pulpitis remains unclear. Absent in melanoma 2 (AIM2) is a type of inflammasome that recognizes cytosolic double stranded DNA and forms a caspase-1-activating i...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2013.07.003
更新日期:2013-11-01 00:00:00
abstract:INTRODUCTION:This study was done to evaluate the mechanism involved in stem cell factor (SCF) expression and production by lipopolysaccharide (LPS)-stimulated odontoblast (OD)-like cells and to investigate the signal transduction pathway activated in the process. METHODS:ODs-like cells (MDPC-23) were stimulated with d...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2011.10.030
更新日期:2012-05-01 00:00:00
abstract:INTRODUCTION:This study radiographically analyzed the prevalence of root canal treatment (RCT) and apical periodontitis (AP) in type 1 diabetes mellitus (T1DM) and nondiabetic individuals and its association with the history/current status of T1DM. METHODS:In a cross-sectional paired study, the radiographic records of...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2020.02.010
更新日期:2020-06-01 00:00:00
abstract:INTRODUCTION:The purpose of this study was to evaluate the effect of various degrees of cyclic fatigue on torsional failure and torsional preloading on the cyclic fatigue life of heat-treated K3XF nickel-titanium (NiTi) instruments (SybronEndo, Orange, CA). METHODS:The mean number of cycles until failure (Nf) of K3XF ...
journal_title:Journal of endodontics
pub_type: 杂志文章
doi:10.1016/j.joen.2014.10.008
更新日期:2015-04-01 00:00:00